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Volume 292:221-223 January 30, 1975 Number 5 Next

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Abstract

To learn whether in vitro blastogenesis of lymphocytes is affected by in vivo salicylate ingestion, blood samples were obtained from 19 normal volunteers before and after therapeutic doses of aspirin. Lymphocyte transformation studies performed on these blood samples showed marked and statistically significant suppression of blastogenesis. Maximum suppression was observed in blood samples obtained 12 hours after the last aspirin ingestion. As compared to controls, samples obtained at this time showed mean blastogenic responses to phytohemagglutinin and pokeweed mitogens of 49 and 56 per cent respectively. No correlation could be demonstrated between the plasma salicylic acid level and the degree of suppression of blastogenesis. Aspirin ingestion altered neither the proportions of circulating T and B cells nor the viability of lymphocytes in culture.

This article has been cited by other articles:

• Hackstein, H., Morelli, A. E., Larregina, A. T., Ganster, R. W., Papworth, G. D., Logar, A. J., Watkins, S. C., Falo, L. D., Thomson, A. W. (2001). Aspirin Inhibits In Vitro Maturation and In Vivo Immunostimulatory Function of Murine Myeloid Dendritic Cells. J. Immunol. 166: 7053-7062 [Abstract] [Full Text]  
• SMITH, M. J., HOTH, M., DAVIS, K. (1975). Aspirin and Lymphocyte Transformation. ANN INTERN MED 83: 509-511 [Abstract]