We found a human reovirus-like agent in the stools of 42 per cent of 143 infants and young children hospitalized with acute gastroenteritis between January, 1974, and June, 1975. Half the patients studied by electron microscopy and serologic technics had evidence of infection with the agent. The infection had a seasonal pattern: 59 per cent of those admitted during the cooler months (November to April) shed the agent, with a peak of 78 per cent in December, 1974, and January, 1975, combined. None of the patients admitted during the warmer months (May to October) shed the agent. None of 275 Escherichia coli isolates from 32 patients with diarrhea produced heat-labile enterotoxin, whereas 17 of the 32 had evidence of infection with the reovirus-like agent. In addition, 14 of 40 parents of 37 patients with diarrhea associated with the reovirus-like agent were also infected, but most infectious were inapparent. This agent appears to be the major cause of diarrheal illness in the young during the cooler months.
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Duffy, L. C., Riepenhoff-Talty, M., Byers, T. E., Scolea, L. J. L., Zielezny, M. A., Dryja, D. M., Ogra, P. L.
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Dennehy, P. H., Peter, G.
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134: 785-792
[Abstract]
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(1980). Human rotavirus type 2: cultivation in vitro. Science
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[Abstract]
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132: 853-858
[Abstract]
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[Abstract]
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88: 707-708
[Abstract]
Steinhoff, M. C.
(1978). Viruses and Diarrhea--A Review. Arch Pediatr Adolesc Med
132: 302-307
[Abstract]
Lecce, J., King, M., Dorsey, W.
(1978). Rearing regimen producing piglet diarrhea (rotavirus) and its relevance to acute infantile diarrhea. Science
199: 776-778
[Abstract]
Gurwith, M., Bourque, C., Cameron, E., Forrest, G., Green, M.
(1977). Cholera-like Diarrhea in Canada: Report of a Case Associated With Enterotoxigenic Escherichia coli and a Toxin-Producing Aeromonas hydrophila. Arch Intern Med
137: 1461-1464
[Abstract]
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(1977). Human Reovirus-like Agent Infection: Occurrence in Adult Contacts of Pediatric Patients With Gastroenteritis. JAMA
238: 404-407
[Abstract]
ROSENBERG, M. L., KOPLAN, J. P., WACHSMUTH, I. K., WELLS, J. G., GANGAROSA, E. J., GUERRANT, R. L., SACK, D. A.
(1977). Epidemie Diarrhea at Crater Lake from Enterotoxigenic Escherichia coli A Large Waterborne Outbreak. ANN INTERN MED
86: 714-718
[Abstract]
