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Previous Volume 294:1256-1259 June 3, 1976 Number 23 Next

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Abstract

Data obtained from two multipurpose surveys of hospitalized patients were examined to determine the risk of nonfatal acute myocardial infarction in post-menopausal women 40 to 75 years of age in relation to use of estrogen-containing drugs. Eight (2.4 per cent) of 336 myocardial infarction patients and 330 (4.9 per cent) of 6730 reference patients were regular estrogen users (crude rate ratio, 0.47) at the time of hospitalization. After control for confounding variables -- among them, age, past history of myocardial in farction, angina, diabetes, and hypertension (alone or in combination) and cigarette smoking -- the summary point estimate of rate ratio was 0.97 with 95 per cent confidence limits of 0.48 and 1.95. Thus, there was no evidence of a statistically significant association between current regular use of estrogens and nonfatal acute myocardial infarction.

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• Stampfer, M. J, Colditz, G. A (2004). Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Int J Epidemiol 33: 445-453 [Full Text]  
• Sorensen, K. E., Dorup, I., Hermann, A. P., Mosekilde, L. (1998). Combined Hormone Replacement Therapy Does Not Protect Women Against the Age-Related Decline in Endothelium-Dependent Vasomotor Function. Circulation 97: 1234-1238 [Abstract] [Full Text]  
• Belchetz, P. E. (1994). Hormonal Treatment of Postmenopausal Women. NEJM 330: 1062-1071 [Full Text]