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Previous Volume 295:977-981 October 28, 1976 Number 18 Next

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Abstract

Whether or not poststreptococcal glomerulonephritis advances over the long term to uremia remains an unsettled issue. We documented ultimate progression to renal failure in six patients who were observed at onset with the typical clinical and morphologic features of acute nephritis after proved beta-hemolytic streptococcal infection. Within one year, renal function returned essentially to normal in all, as the proliferative changes in glomeruli subsided, Subsequently, increasing renal failure developed in these patients over periods ranging from two to 12 years, during which all were hypertensive. As the renal disease progressed, glomeruli showed increasing sclerosis in the absence of proliferation, and fibrohyaline thickening of renal arterioles appeared.

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• Vinen, C S, Oliveira, D B G (2003). Acute glomerulonephritis. Postgrad. Med. J. 79: 206-213 [Abstract] [Full Text]  
• Hricik, D. E., Chung-Park, M., Sedor, J. R. (1998). Glomerulonephritis. NEJM 339: 888-899 [Full Text]  
• Pasinski, R., Pasinski, M. (1987). End-Stage Renal Disease Among the Zuni Indians: 1973-1983. Arch Intern Med 147: 1093-1096 [Abstract]  
• RODRIGUEZ-ITURBE, B., RABIDEAU, D., GARCIA, R., RUBIO, L., McINTOSH, R. M. (1980). Characterization of the Glomerular Antibody in Acute Poststreptococcal Glomerulonephritis. ANN INTERN MED 92: 478-481 [Abstract]