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Previous Volume 295:1455-1457 December 23, 1976 Number 26 Next

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Abstract

With a sensitive radioimmunoassay that can measure as little as 2 ng of basic protein in cerebrospinal fluid we studied 303 patients with a variety of neurologic diseases. Patients with active demyelinating diseases had high levels (17 to 100 ng per milliliter) of basic protein. Moreover, patients with multiple sclerosis in acute exacerbation had these high levels, those with slowly progressive multiple sclerosis had lower levels (6 to 16 ng per milliliter), and those in remission had less than 4 ng per milliliter, comparable to the control population. Thus, the assay appears to be a useful index of active demyelination.

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• Ohta, M., Ohta, K., Ma, J., Takeuchi, J., Saida, T., Nishimura, M., Itoh, N. (2000). Clinical and Analytical Evaluation of an Enzyme Immunoassay for Myelin Basic Protein in Cerebrospinal Fluid. Clin. Chem. 46: 1326-1330 [Abstract] [Full Text]  
• Mata, S., Lolli, F., Soderstrom, M., Pinto, F., Link, H. (1999). Multiple sclerosis is associated with enhanced B cell responses to the ganglioside GD I a. Mult Scler 5: 379-388 [Abstract]  
• Lamers, K J., de Reus, H P., Jongen, P J. (1998). Myelin basic protein in CSF as indicator of disease activity in multiple sclerosis. Mult Scler 4: 124-126 [Abstract]  
• Giovannoni, G, Green, A J., Thompson, E J (1998). Are there any body fluid markers of brain atrophy in multiple sclerosis?. Mult Scler 4: 138-142 [Abstract]  
• Whitaker, J. N (1998). Myelin basic protein in cerebrospinal fluid and other body fluids. Mult Scler 4: 16-21 [Abstract]  
• Jongen, P. J H, Lamers, K. J B, Doesburg, W. H, Lemmens, W. A J G, Hommes, O. R (1997). Cerebrospinal fluid analysis differentiates between relapsing-remitting and secondary progressive multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 63: 446-451 [Abstract] [Full Text]  
• Whitaker, J., McFarland, H., Rudge, P, Reingold, S. (1995). Outcomes assessment in multiple sclerosis clinical trials: a critical analysis. Mult Scler 1: 37-47 [Abstract]  
• Naidu, S., Bresnan, M. J., Griffin, D., O'Toole, S., Moser, H. W. (1988). Childhood Adrenoleukodystrophy: Failure of Intensive Immunosuppression to Arrest Neurologic Progression. Arch Neurol 45: 846-848 [Abstract]  
• MARTON, K. I., GEAN, A. D. (1986). The Spinal Tap: A New Look at an Old Test. ANN INTERN MED 104: 840-848 [Abstract]  
• (1986). The Diagnostic Spinal Tap. ANN INTERN MED 104: 880-885 [Abstract]  
• Hauser, S. L., Dawson, D. M., Lehrich, J. R., Beal, M. F., Kevy, S. V., Weiner, H. L. (1983). Immunosuppression and Plasmapheresis in Chronic Progressive Multiple Sclerosis: Design of a Clinical Trial. Arch Neurol 40: 687-690 [Abstract]  
• WADE, J. C., MEYERS, J. D. (1983). Neurologic Symptoms Associated with Parenteral Acyclovir Treatment After Marrow Transplantation. ANN INTERN MED 98: 921-925 [Abstract]  
• Poser, C. M. (1980). Exacerbations, Activity, and Progression in Multiple Sclerosis. Arch Neurol 37: 471-474 [Abstract]  
• Panitch, H. S., Hooper, C. J., Johnson, K. P. (1980). CSF Antibody to Myelin Basic Protein: Measurement in Patients With Multiple Sclerosis and Subacute Sclerosing Panencephalitis. Arch Neurol 37: 206-209 [Abstract]  
• Gutstein, H., Cohen, SR (1978). Spinal fluid differences in experimental allergic encephalomyelitis and multiple sclerosis. Science 199: 301-303 [Abstract]