During hemodialysis, cardiopulmonary decompensation may appear in uremic patients, possibly caused by plugging of pulmonary vessels by leukocytes. In 34 patients we noted leukopenia (20% of initial levels) during hemodialysis that in 15 was associated with impaired pulmonary function. When we infused autologous plasma, incubated with dialyzer cellophane, into rabbits and sheep, sudden leukopenia and hypoxia occurred, with doubling of pulmonary-artery pressures and quintupling of pulmonary-lymph effluent. Histologic examination showed severe pulmonary-vessel-leukostasis and interstitial edema. The syndrome was prevented by preinactivation of complement but was reproduced by infusions of plasma in which complement was activated by zymosan. Thus, acute pulmonary dysfunction from complement-mediated leukostasis may play a major part in the acute cardiopulmonary complications of cellophane-membrane hemodialysis.
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(1997). Effect of Cardiopulmonary Bypass on Cytokine Release and Adhesion Molecule Expression in Alveolar Macrophages . Preliminary Report In Six Cases. Am. J. Respir. Crit. Care Med.
156: 932-938
[Abstract][Full Text]
Xiao, F., Eppihimer, M. J., Willis, B. H., Carden, D. L.
(1997). Complement-mediated lung injury and neutrophil retention after intestinal ischemia-reperfusion. J. Appl. Physiol.
82: 1459-1465
[Abstract][Full Text]
Daggett, C. W., Yeatman, M., Lodge, A. J., Chen, E. P., Van Trigt, P., Byrne, G. W., Logan, J. S., Lawson, J. H., Platt, J. L., Davis, R. D.
(1997). SWINE LUNGS EXPRESSING HUMAN COMPLEMENT-REGULATORY PROTEINS ARE PROTECTED AGAINST ACUTE PULMONARY DYSFUNCTION IN A HUMAN PLASMA PERFUSION MODEL. J. Thorac. Cardiovasc. Surg.
113: 390-398
[Abstract][Full Text]
Moen, O., Fosse, E., Braten, J., Andersson, C., Fagerhol, M. K., Venge, P., Hegasen, K., Mollnes, T. E.
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9: 109-117
[Abstract]
Bergman, P., Friberg, G., Liu, B., Al-Khaja, N., Belboul, A., Heideman, M., Mellgren, G., Roberts, D.
(1992). Blood cell rheologic deterioration by complement activation during experimental prolonged perfusion with membrane oxygenation. Perfusion
7: 13-19
[Abstract]
Ide, H., Ino, T., Hasegawa, T., Matsumoto, H.
(1990). The Role of Leukocyte Depletion by in Vivo Use of Leukocyte Filter in Lung Preservation After Warm Ischemia. ANGIOLOGY
41: 318-327
[Abstract]
Agostoni, A., Gardinali, M., Cantaluppi, A.
(1989). Complement Activation During Hemodialysis. J Biomater Appl
4: 102-122
[Abstract]
Heyman, S. J., Rinaldo, J. E.
(1989). Multiple System Organ Failure in the Adult Respiratory Distress Syndrome. J Intensive Care Med
4: 192-200
[Abstract]
Miyamoto, Y., Matsuda, H., Kawashima, Y.
(1989). Deleterious Effects of Complement Activation on the Lungs during Extracorporeal Circulation and Its Inhibition by FUT-175. J Biomater Appl
4: 56-68
[Abstract]
Miyauchi, M., Shionoya, S.
(1988). Complement Activation by Vascular Prostheses and Its Role in Progression of Arteriosclerotic Lesions. ANGIOLOGY
39: 881-890
[Abstract]
Mickleborough, L. L, Arnold, G., Chiu, R. C-J
(1986). Complement consumption during cardiopulmonary bypass: bubble versus membrane oxygenators. Perfusion
1: 261-269
[Abstract]
