We studied blood pressure in relation to known drinking habits of 83,947 men and women of three races (83.5 per cent white). Using health-check-up questionnaire responses, we classified persons as nondrinkers or according to usual daily number of drinks: two or fewer per day, three to five per day, or six or more per day. As compared to nondrinkers blood pressures of men taking two or fewer drinks per day were similar. Women who took two or fewer drinks per day had slightly lower pressures. Men and women who took three or more drinks per day had higher systolic pressures (P less than 10(-24) in white men, and less than 10(-12) in white women), higher diastolic pressures (P less than 10(-24) in white men, and less than 10(-6) in white women), and substantially higher prevalence of pressures greater than or equal to 160/95 mm Hg. The associations of blood pressure and drinking were independent of age, sex, race, smoking, coffee use, former "heavy" drinking, educational attainment and adiposity. The findings strongly suggest that regular use of three or more drinks of alcohol per day is a risk factor for hypertension.
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[Abstract][Full Text]
El-Mas, M. M., Zhang, J., Abdel-Rahman, A. A.
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100: 1011-1018
[Abstract][Full Text]
Appel, L. J., Brands, M. W., Daniels, S. R., Karanja, N., Elmer, P. J., Sacks, F. M.
(2006). Dietary Approaches to Prevent and Treat Hypertension: A Scientific Statement From the American Heart Association. Hypertension
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Svetkey, L. P.
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[Full Text]
Fuchs, F. D.
(2005). Vascular Effects of Alcoholic Beverages: Is It Only Alcohol That Matters?. Hypertension
45: 851-852
[Full Text]
Stranges, S., Wu, T., Dorn, J. M., Freudenheim, J. L., Muti, P., Farinaro, E., Russell, M., Nochajski, T. H., Trevisan, M.
(2004). Relationship of Alcohol Drinking Pattern to Risk of Hypertension: A Population-Based Study. Hypertension
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[Abstract][Full Text]
Sanchez, F., Korine, C., Pinshow, B., Dudley, R.
(2004). The Possible Roles of Ethanol in the Relationship Between Plants and Frugivores: First Experiments with Egyptian Fruit Bats. Integr. Comp. Biol.
44: 290-294
[Abstract][Full Text]
Kannan, M., Wang, L., Kang, Y. J.
(2004). Myocardial Oxidative Stress and Toxicity Induced by Acute Ethanol Exposure in Mice. Exp. Biol. Med.
229: 553-559
[Abstract][Full Text]
Tawakol, A., Omland, T., Creager, M. A.
(2004). Direct effect of ethanol on human vascular function. Am. J. Physiol. Heart Circ. Physiol.
286: H2468-H2473
[Abstract][Full Text]
Malinski, M. K., Sesso, H. D., Lopez-Jimenez, F., Buring, J. E., Gaziano, J. M.
(2004). Alcohol Consumption and Cardiovascular Disease Mortality in Hypertensive Men. Arch Intern Med
164: 623-628
[Abstract][Full Text]
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40: 679-686
[Abstract][Full Text]
Thadhani, R., Camargo, C. A. Jr, Stampfer, M. J., Curhan, G. C., Willett, W. C., Rimm, E. B.
(2002). Prospective Study of Moderate Alcohol Consumption and Risk of Hypertension in Young Women. Arch Intern Med
162: 569-574
[Abstract][Full Text]
Walsh, C. R., Larson, M. G., Evans, J. C., Djousse, L., Ellison, R. C., Vasan, R. S., Levy, D.
(2002). Alcohol Consumption and Risk for Congestive Heart Failure in the Framingham Heart Study. ANN INTERN MED
136: 181-191
[Abstract][Full Text]
Conigrave, K. M., Hu, B. F., Camargo, C. A., Stampfer, M. J., Willett, W. C., Rimm, E. B.
(2001). A Prospective Study of Drinking Patterns in Relation to Risk of Type 2 Diabetes Among Men. Diabetes
50: 2390-2395
[Abstract][Full Text]
Stradling, J R, Pepperell, J C T, Davies, R J O
(2001). Sleep apnoea and hypertension: proof at last?. Thorax
56: ii45-49
[Full Text]
Ruigrok, Y. M., Buskens, E., Rinkel, G. J. E.
(2001). Attributable Risk of Common and Rare Determinants of Subarachnoid Hemorrhage. Stroke
32: 1173-1175
[Abstract][Full Text]
Fuchs, F. D., Chambless, L. E., Whelton, P. K., Nieto, F. J., Heiss, G.
(2001). Alcohol Consumption and the Incidence of Hypertension : The Atherosclerosis Risk in Communities Study. Hypertension
37: 1242-1250
[Abstract][Full Text]
Abramson, J. L., Williams, S. A., Krumholz, H. M., Vaccarino, V.
(2001). Moderate Alcohol Consumption and Risk of Heart Failure Among Older Persons. JAMA
285: 1971-1977
[Abstract][Full Text]
Solomon, C. G., Hu, F. B., Stampfer, M. J., Colditz, G. A., Speizer, F. E., Rimm, E. B., Willett, W. C., Manson, J. E.
(2000). Moderate Alcohol Consumption and Risk of Coronary Heart Disease Among Women With Type 2 Diabetes Mellitus. Circulation
102: 494-499
[Abstract][Full Text]
Di Gennaro, C., Barilli, A., Giuffredi, C., Gatti, C., Montanari, A., Vescovi, P. P.
(2000). Sodium Sensitivity of Blood Pressure in Long-Term Detoxified Alcoholics. Hypertension
35: 869-874
[Abstract][Full Text]
Papadakis, J.A., Ganotakis, E.S., Mikhailidis, D.P.
(2000). Beneficial effect of moderate alcohol consumption on vascular disease: myth or reality?. The Journal of the Royal Society for the Promotion of Health
120: 11-15
[Abstract]
Gibbs, C.R., Beevers, D.G., Lip, G.Y.H.
(1999). The management of hypertensive disease in Black patients. QJM
92: 187-192
[Abstract][Full Text]
Broderick, J. P., Adams, H. P. Jr, Barsan, W., Feinberg, W., Feldmann, E., Grotta, J., Kase, C., Krieger, D., Mayberg, M., Tilley, B., Zabramski, J. M., Zuccarello, M.
(1999). Guidelines for the Management of Spontaneous Intracerebral Hemorrhage : A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association. Stroke
30: 905-915
[Full Text]
Teresa Aguilera, M., de la Sierra, A., Coca, A., Estruch, R., Fernandez-Sola, J., Urbano-Marquez, A.
(1999). Effect of Alcohol Abstinence on Blood Pressure : Assessment by 24-Hour Ambulatory Blood Pressure Monitoring. Hypertension
33: 653-657
[Abstract][Full Text]
Seppa, K., Sillanaukee, P.
(1999). Binge Drinking and Ambulatory Blood Pressure. Hypertension
33: 79-82
[Abstract][Full Text]
Bush, K., Kivlahan, D. R., McDonell, M. B., Fihn, S. D., Bradley, K. A., for the Ambulatory Care Quality Improvement Projec,
(1998). The AUDIT Alcohol Consumption Questions (AUDIT-C): An Effective Brief Screening Test for Problem Drinking. Arch Intern Med
158: 1789-1795
[Abstract][Full Text]
British Cardiac Society, , British Hyperlipidaemia Association, , British Hypertension Society, , endorsed by the British Diabetic Association,
(1998). Joint British recommendations on prevention of coronary heart disease in clinical practice. Heart
80: 1S-29
[Full Text]
Cushman, W. C., Cutler, J. A., Hanna, E., Bingham, S. F., Follmann, D., Harford, T., Dubbert, P., Allender, P. S., Dufour, M., Collins, J. F., Walsh, S. M., Kirk, G. F., Burg, M., Felicetta, J. V., Hamilton, B. P., Katz, L. A., Perry, H. M. Jr, Willenbring, M. L., Lakshman, R., Hamburger, R. J., for the PATHS Group,
(1998). Prevention and Treatment of Hypertension Study (PATHS): Effects of an Alcohol Treatment Program on Blood Pressure. Arch Intern Med
158: 1197-1207
[Abstract][Full Text]
Pearson, T. A.
(1996). Alcohol and Heart Disease. Circulation
94: 3023-3025
[Full Text]
Ekstrand, K., Bostrom, P.-A., Arborelius, M., Nilsson, J.-A., Lindell, S.-E.
(1996). Cardiovascular Risk Factors in Commercial Flight Aircrew Officers Compared with Those in the General Population. ANGIOLOGY
47: 1089-1094
[Abstract]
Cirillo, M., Laurenzi, M., Panarelli, W., Trevisan, M., Dyer, A. R., Stamler, R., Stamler, J.
(1996). Sodium-Lithium Countertransport and Blood Pressure Change Over Time : The Gubbio Study. Hypertension
27: 1305-1311
[Abstract][Full Text]
Beghi, E., Bogliun, G., Cosso, P., Fiorelli, G., Lorini, C., Mandelli, M., Bellini, A.
(1995). Stroke and Alcohol Intake in a Hospital Population : A Case-Control Study. Stroke
26: 1691-1696
[Abstract][Full Text]
Lardinois, C. K.
(1995). Nutritional Factors and Hypertension. Arch Fam Med
4: 707-713
[Abstract]
Randin, D., Vollenweider, P., Tappy, L., Jequier, E., Nicod, P., Scherrer, U.
(1995). Suppression of Alcohol-Induced Hypertension by Dexamethasone. NEJM
332: 1733-1738
[Abstract][Full Text]
Rich-Edwards, J. W., Manson, J. E., Hennekens, C. H., Buring, J. E.
(1995). The Primary Prevention of Coronary Heart Disease in Women. NEJM
332: 1758-1766
[Full Text]
Gillman, M. W., Cook, N. R., Evans, D. A., Rosner, B., Hennekens, C. H.
(1995). Relationship of Alcohol Intake With Blood Pressure in Young Adults. Hypertension
25: 1106-1110
[Abstract][Full Text]
Grossman, E., Messerli, F. H.
(1995). High Blood Pressure: A Side Effect of Drugs, Poisons, and Food. Arch Intern Med
155: 450-460
[Abstract]
McGarry, G W, Gatehouse, S, Hinnie, J
(1994). Relation between alcohol and nose bleeds. BMJ
309: 640-640
[Full Text]
Marmot, M G, Elliott, P, Shipley, M J, Dyer, A R, Ueshima, H U, Beevers, D G, Stamler, R, Kesteloot, H, Rose, G, Stamler, J
(1994). Alcohol and blood pressure: the INTERSALT study. BMJ
308: 1263-1267
[Abstract][Full Text]
Grogan, J. R., Kochar, M. S.
(1994). Alcohol and Hypertension. Arch Fam Med
3: 150-154
[Abstract]
Bradley, K. A., Donovan, D. M., Larson, E. B.
(1993). How Much Is Too Much? Advising Patients About Safe Levels of Alcohol Consumption. Arch Intern Med
153: 2734-2740
[Abstract]
Friedman, G. D., Klatsky, A. L.
(1993). Is Alcohol Good for Your Health?. NEJM
329: 1882-1883
[Full Text]
(1993). National High Blood Pressure Education Program Working Group Report on Primary Prevention of Hypertension. Arch Intern Med
153: 186-208
[Abstract]
Moushmoush, B., Abi-Mansour, P.
(1991). Alcohol and the Heart: The Long-term Effects of Alcohol on the Cardiovascular System. Arch Intern Med
151: 36-42
[Abstract]
Sesoko, S., Akema, N., Matsukawa, T., Kaneko, Y.
(1987). Predisposing Factors for the Development of Malignant Essential Hypertension. Arch Intern Med
147: 1721-1724
[Abstract]
Winickoff, R. N., Murphy, P. K.
(1987). The Persistent Problem of Poor Blood Pressure Control. Arch Intern Med
147: 1393-1396
[Abstract]
MACMAHON, S. W., NORTON, R. N.
(1986). Alcohol and Hypertension: Implications for Prevention and Treatment. ANN INTERN MED
105: 124-126
[Abstract]
Oleckno, W. A.
(1986). Selected Factors and Stroke in Young Adults, 15-40 Years of. Age. The Journal of the Royal Society for the Promotion of Health
106: 102-107
[Abstract]
Donahue, R. P., Abbott, R. D., Reed, D. M., Yano, K.
(1986). Alcohol and Hemorrhagic Stroke: The Honolulu Heart Program. JAMA
255: 2311-2314
[Abstract]
Gordon, T., Doyle, J. T.
(1986). Alcohol Consumption and Its Relationship to Smoking, Weight, Blood Pressure, and Blood Lipids: The Albany Study. Arch Intern Med
146: 262-265
[Abstract]
Peitzman, S. J., Bodison, W., Ellis, I.
(1985). Moonshine Drinking Among Hypertensive Veterans in Philadelphia. Arch Intern Med
145: 632-634
[Abstract]
KAPLAN, N. M.
(1985). Non-Drug Treatment of Hypertension. ANN INTERN MED
102: 359-373
[Abstract]
Haglund, B. J. A.
(1985). Geographical and Socioeconomic Distribution of High Blood Pressure and Borderline High Blood Pressure in a Swedish Rural County. Scand J Public Health
13: 53-66
[Abstract]
WEST, L. J., MAXWELL, D. S., NOBLE, E. P., SOLOMON, D. H.
(1984). Alcoholism. ANN INTERN MED
100: 405-416
[Abstract]
Gordon, T., Kannel, W. B.
(1983). Drinking and Its Relation to Smoking, BP, Blood Lipids, and Uric Acid: The Framingham Study. Arch Intern Med
143: 1366-1374
[Abstract]
FRIEDMAN, G. D., KLATSKY, A. L., SIEGELAUB, A. B.
(1983). Alcohol Intake and Hypertension. ANN INTERN MED
98: 846-849
[Abstract]
KNOCHEL, J. P.
(1983). Cardiovascular Effects of Alcohol. ANN INTERN MED
98: 849-854
[Abstract]
Altura, B., Altura, B., Gebrewold, A
(1983). Alcohol-induced spasms of cerebral blood vessels: relation to cerebrovascular accidents and sudden death. Science
220: 331-333
[Abstract]
Larbi, E. B., Cooper, R. S., Stamler, J.
(1983). Alcohol and Hypertension. Arch Intern Med
143: 28-29
[Abstract]
Eckardt, M. J., Harford, T. C., Kaelber, C. T., Parker, E. S., Rosenthal, L. S., Ryback, R. S., Salmoiraghi, G. C., Vanderveen, E., Warren, K. R.
(1981). Health Hazards Associated With Alcohol Consumption. JAMA
246: 648-666
[Abstract]
KLATSKY, A. L., FRIEDMAN, G. D., SIEGELAUB, A. B.
(1981). Alcohol and Mortality: A Ten-Year Kaiser-Permanente Experience. ANN INTERN MED
95: 139-145
[Abstract]
Messerli, F. H., Frohlich, E. D.
(1979). High Blood Pressure: A Side Effect of Drugs, Poisons, and Food. Arch Intern Med
139: 682-687
[Abstract]