FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 297:414-418 August 25, 1977 Number 8 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

The risk to the transplanted kidney of vesicoureteric reflux was evaluated in 150 consecutive first cadaveric renal allografts surviving for over three months. Of the 119 (79 per cent) allografts studied by micturating cystography 29 (24 per cent) were shown to reflux. The presence of reflux was associated with urine leakage and reoperation, and with ureteric insertion involving a short intramural tunnel. Graft failure (graft nephrectomy or death from renal failure) occurred in 14 of 29 refluxing grafts as compared to 14 failures in 90 nonrefluxing grafts (P less than 0.01). Graft failure in the refluxing group was typically slow, and commonly associated with proteinuria, microscopic hematuria, hypertension and a biopsy appearance of mesangiocapillary glomerular change. Urinary infection, though frequent (69 per cent), was not more common in the group with than in that without reflux. Vesicoureteric reflux is an important cause of late renal-graft failure.

This article has been cited by other articles:

• Ranchin, B., Chapuis, F., Dawhara, M., Canterino, I., Hadj-Aissa, A., Said, M.-H., Parchoux, B., Dubourg, L., Pouillaude, J.-M., Floret, D., Martin, X., Cochat, P. (2000). Vesicoureteral reflux after kidney transplantation in children. Nephrol Dial Transplant 15: 1852-1858 [Abstract] [Full Text]  
• Hanevold, C. D., Kaiser, B. A., Palmer, J., Polinsky, M. S., Baluarte, H. J. (1987). Vesicoureteral Reflux and Urinary Tract Infections in Renal Transplant Recipients. Arch Pediatr Adolesc Med 141: 982-984 [Abstract]  
• TORRES, V. E., VELOSA, J. A., HOLLEY, K. E., KELALIS, P. P., STICKLER, G. B., KURTZ, S. B. (1980). The Progression of Vesicoureteral Reflux Nephropathy. ANN INTERN MED 92: 776-784 [Abstract]