The diagnosis of coronary-artery disease has become increasingly complex. Many different results, obtained from tests with substantial imperfections, must be integrated into a diagnostic conclusion about the probability of disease in a given patient. To approach this problem in a practical manner, we reviewed the literature to estimate the pretest likelihood of disease (defined by age, sex and symptoms) and the sensitivity and specificity of four diagnostic tests: stress electrocardiography, cardiokymography, thallium scintigraphy and cardiac fluoroscopy. With this information, test results can be analyzed by use of Bayes' theorem of conditional probability. This approach has several advantages. It pools the diagnostic experience of many physicians ans integrates fundamental pretest clinical descriptors with many varying test results to summarize reproducibly and meaningfully the probability of angiographic coronary-artery disease. This approach also aids, but does not replace, the physician's judgment and may assit in decisions on cost effectiveness of tests.
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[Abstract]
Plana, J. C., Mikati, I. A., Dokainish, H., Lakkis, N., Abukhalil, J., Davis, R., Hetzell, B. C., Zoghbi, W. A.
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Abdulla, J., Abildstrom, S. Z., Gotzsche, O., Christensen, E., Kober, L., Torp-Pedersen, C.
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28: 3042-3050
[Abstract][Full Text]
Meijboom, W. B., van Mieghem, C. A.G., Mollet, N. R., Pugliese, F., Weustink, A. C., van Pelt, N., Cademartiri, F., Nieman, K., Boersma, E., de Jaegere, P., Krestin, G. P., de Feyter, P. J.
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50: 1469-1475
[Abstract][Full Text]
Kaufmann, P. A., Rimoldi, O. E., Gnecchi-Ruscone, T., Luscher, T. F., Camici, P. G.
(2007). Systemic nitric oxide synthase inhibition improves coronary flow reserve to adenosine in patients with significant stenoses. Am. J. Physiol. Heart Circ. Physiol.
293: H2178-H2182
[Abstract][Full Text]
Min, J. K., Shaw, L. J., Devereux, R. B., Okin, P. M., Weinsaft, J. W., Russo, D. J., Lippolis, N. J., Berman, D. S., Callister, T. Q.
(2007). Prognostic Value of Multidetector Coronary Computed Tomographic Angiography for Prediction of All-Cause Mortality. J Am Coll Cardiol
50: 1161-1170
[Abstract][Full Text]
Range, F. T., Schafers, M., Acil, T., Schafers, K. P., Kies, P., Paul, M., Hermann, S., Brisse, B., Breithardt, G., Schober, O., Wichter, T.
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28: 2223-2230
[Abstract][Full Text]
Herzog, C., Zwerner, P. L., Doll, J. R., Nielsen, C. D., Nguyen, S. A., Savino, G., Vogl, T. J., Costello, P., Schoepf, U. J.
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244: 112-120
[Abstract][Full Text]
Santana, C. A., Folks, R. D., Garcia, E. V., Verdes, L., Sanyal, R., Hainer, J., Di Carli, M. F., Esteves, F. P.
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[Abstract][Full Text]
Peters, R. J G, Mehta, S., Yusuf, S.
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334: 1265-1269
[Full Text]
Bobba, R. K., Arsura, E. L., Bollu, M., Katyal, P.
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167: 970-971
[Full Text]
Sampson, U. K., Dorbala, S., Limaye, A., Kwong, R., Di Carli, M. F.
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49: 1052-1058
[Abstract][Full Text]
Dorbala, S., Vangala, D., Sampson, U., Limaye, A., Kwong, R., Di Carli, M. F.
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48: 349-358
[Abstract][Full Text]
Metz, L. D., Beattie, M., Hom, R., Redberg, R. F., Grady, D., Fleischmann, K. E.
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49: 227-237
[Abstract][Full Text]
Schuijf, J. D., Wijns, W., Jukema, J. W., Atsma, D. E., de Roos, A., Lamb, H. J., Stokkel, M. P.M., Dibbets-Schneider, P., Decramer, I., De Bondt, P., van der Wall, E. E., Vanhoenacker, P. K., Bax, J. J.
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48: 2508-2514
[Abstract][Full Text]
Chaowalit, N., McCully, R. B., Callahan, M. J., Mookadam, F., Bailey, K. R., Pellikka, P. A.
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27: 3039-3044
[Abstract][Full Text]
Sequist, T. D., Marshall, R., Lampert, S., Buechler, E. J., Lee, T. H.
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166: 2237-2243
[Abstract][Full Text]
Filho, J A O, Salvetti, X M, de Mello, M T, da Silva, A C, Filho, B L
(2006). Coronary risk in a cohort of Paralympic athletes. Br. J. Sports. Med.
40: 918-922
[Abstract][Full Text]
Akram, M. R., Handler, C. E., Williams, M., Carulli, M. T., Andron, M., Black, C. M., Denton, C. P., Coghlan, J. G.
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[Abstract][Full Text]
Hendel, R. C., Patel, M. R., Kramer, C. M., Poon, M., Hendel, R. C., Carr, J. C., Gerstad, N. A., Gillam, L. D., Hodgson, J. McB., Kim, R. J., Kramer, C. M., Lesser, J. R., Martin, E. T., Messer, J. V., Redberg, R. F., Rubin, G. D., Rumsfeld, J. S., Taylor, A. J., Weigold, Wm. G., Woodard, P. K., Brindis, R. G., Hendel, R. C., Douglas, P. S., Peterson, E. D., Wolk, M. J., Allen, J. M., Patel, M. R.
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48: 1475-1497
[Full Text]
Greenland, P.
(2006). Who is a candidate for noninvasive coronary angiography?. ANN INTERN MED
145: 466-467
[Full Text]
Jagathesan, R, Barnes, E, Rosen, S D, Foale, R, Camici, P G
(2006). Dobutamine-induced hyperaemia inversely correlates with coronary artery stenosis severity and highlights dissociation between myocardial blood flow and oxygen consumption. Heart
92: 1230-1237
[Abstract][Full Text]
Bonow, R. O., Carabello, B. A., Chatterjee, K., de Leon, A. C. Jr, Faxon, D. P., Freed, M. D., Gaasch, W. H., Lytle, B. W., Nishimura, R. A., O'Gara, P. T., O'Rourke, R. A., Otto, C. M., Shah, P. M., Shanewise, J. S., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Faxon, D. P., Fuster, V., Halperin, J. L., Hiratzka, L. F., Hunt, S. A., Lytle, B. W., Nishimura, R., Page, R. L., Riegel, B.
(2006). ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease) Developed in Collaboration With the Society of Cardiovascular Anesthesiologists Endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. J Am Coll Cardiol
48: e1-e148
[Full Text]
Berman, D. S., Hachamovitch, R., Shaw, L. J., Friedman, J. D., Hayes, S. W., Thomson, L. E.J., Fieno, D. S., Germano, G., Wong, N. D., Kang, X., Rozanski, A.
(2006). Roles of Nuclear Cardiology, Cardiac Computed Tomography, and Cardiac Magnetic Resonance: Noninvasive Risk Stratification and a Conceptual Framework for the Selection of Noninvasive Imaging Tests in Patients with Known or Suspected Coronary Artery Disease. JNM
47: 1107-1118
[Abstract][Full Text]
Johnson, B. D., Shaw, L. J., Pepine, C. J., Reis, S. E., Kelsey, S. F., Sopko, G., Rogers, W. J., Mankad, S., Sharaf, B. L., Bittner, V., Bairey Merz, C. N.
(2006). Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: results from the NIH-NHLBI-sponsored Women's Ischaemia Syndrome Evaluation (WISE) study. Eur Heart J
27: 1408-1415
[Abstract][Full Text]
Authors/Task Force Members, , Fox, K., Garcia, M. A. A., Ardissino, D., Buszman, P., Camici, P. G., Crea, F., Daly, C., De Backer, G., Hjemdahl, P., Lopez-Sendon, J., Marco, J., Morais, J., Pepper, J., Sechtem, U., Simoons, M., Thygesen, K., ESC Committee for Practice Guidelines (CPG), , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, J., Dean, V., Deckers, J., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J., Zamorano, J. L., Document Reviewers, , Zamorano, J. L, Andreotti, F., Becher, H., Dietz, R., Fraser, A., Gray, H., Antolin, R. A. H., Huber, K., Kremastinos, D. T., Maseri, A., Nesser, H.-J., Pasierski, T., Sigwart, U., Tubaro, M., Weis, M.
(2006). Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur Heart J
27: 1341-1381
[Full Text]
Schindler, T. H., Cardenas, J., Prior, J. O., Facta, A. D., Kreissl, M. C., Zhang, X.-L., Sayre, J., Dahlbom, M., Licinio, J., Schelbert, H. R.
(2006). Relationship Between Increasing Body Weight, Insulin Resistance, Inflammation, Adipocytokine Leptin, and Coronary Circulatory Function. J Am Coll Cardiol
47: 1188-1195
[Abstract][Full Text]
Shaw, L. J., Bairey Merz, C. N., Pepine, C. J., Reis, S. E., Bittner, V., Kelsey, S. F., Olson, M., Johnson, B. D., Mankad, S., Sharaf, B. L., Rogers, W. J., Wessel, T. R., Arant, C. B., Pohost, G. M., Lerman, A., Quyyumi, A. A., Sopko, G., for the WISE Investigators,
(2006). Insights From the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part I: Gender Differences in Traditional and Novel Risk Factors, Symptom Evaluation, and Gender-Optimized Diagnostic Strategies. J Am Coll Cardiol
47: S4-S20
[Abstract][Full Text]
Namdar, M., Koepfli, P., Grathwohl, R., Siegrist, P. T., Klainguti, M., Schepis, T., Delaloye, R., Wyss, C. A., Fleischmann, S. P., Gaemperli, O., Kaufmann, P. A.
(2006). Caffeine Decreases Exercise-Induced Myocardial Flow Reserve. J Am Coll Cardiol
47: 405-410
[Abstract][Full Text]
Berman, D. S., Hachamovitch, R., Shaw, L. J., Friedman, J. D., Hayes, S. W., Thomson, L. E.J., Fieno, D. S., Germano, G., Slomka, P., Wong, N. D., Kang, X., Rozanski, A.
(2006). Roles of Nuclear Cardiology, Cardiac Computed Tomography, and Cardiac Magnetic Resonance: Assessment of Patients with Suspected Coronary Artery Disease. JNM
47: 74-82
[Abstract][Full Text]
Herzog, C., Arning-Erb, M., Zangos, S., Eichler, K., Hammerstingl, R., Dogan, S., Ackermann, H., Vogl, T. J.
(2006). Multi-Detector Row CT Coronary Angiography: Influence of Reconstruction Technique and Heart Rate on Image Quality. Radiology
238: 75-86
[Abstract][Full Text]
Elhendy, A., Schinkel, A. F.L., van Domburg, R. T., Bax, J. J., Valkema, R., Huurman, A., Feringa, H. H., Poldermans, D.
(2005). Risk Stratification of Patients with Angina Pectoris by Stress 99mTc-Tetrofosmin Myocardial Perfusion Imaging. JNM
46: 2003-2008
[Abstract][Full Text]
Abidov, A., Rozanski, A., Hachamovitch, R., Hayes, S. W., Aboul-Enein, F., Cohen, I., Friedman, J. D., Germano, G., Berman, D. S.
(2005). Prognostic significance of dyspnea in patients referred for cardiac stress testing.. NEJM
353: 1889-1898
[Abstract][Full Text]
Marwick, T. H.
(2005). Dyspnea and risk in suspected coronary disease.. NEJM
353: 1963-1965
[Full Text]
Brindis, R. G., Douglas, P. S., Hendel, R. C., Peterson, E. D., Wolk, M. J., Allen, J. M., Patel, M. R., Raskin, I. E., Hendel, R. C., Bateman, T. M., Cerqueira, M. D., Gibbons, R. J., Gillam, L. D., Gillespie, J. A., Hendel, R. C., Iskandrian, A. E., Jerome, S. D., Krumholz, H. M., Messer, J. V., Spertus, J. A., Stowers, S. A.
(2005). ACCF/ASNC Appropriateness Criteria for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging (SPECT MPI): A Report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group and the American Society of Nuclear Cardiology Endorsed by the American Heart Association. J Am Coll Cardiol
46: 1587-1605
[Full Text]
Sicari, R., Palinkas, A., Pasanisi, E. G., Venneri, L., Picano, E.
(2005). Long-term survival of patients with chest pain syndrome and angiographically normal or near-normal coronary arteries: the additional prognostic value of dipyridamole echocardiography test (DET). Eur Heart J
26: 2136-2141
[Abstract][Full Text]
Biagini, E., Elhendy, A., Schinkel, A. F.L., Bax, J. J., Vittoria, R., van Domburg, R. T., Rapezzi, C., Simoons, M. L., Poldermans, D.
(2005). Risk Stratification of Patients With Classic Angina Pectoris and No History of Coronary Artery Disease by Dobutamine Stress Echocardiography. J Am Coll Cardiol
46: 730-732
[Full Text]
Roy, P.-M., Colombet, I., Durieux, P., Chatellier, G., Sors, H., Meyer, G.
(2005). Systematic review and meta-analysis of strategies for the diagnosis of suspected pulmonary embolism. BMJ
331: 259-
[Abstract][Full Text]
Chow, B. J.W., Ananthasubramaniam, K., deKemp, R. A., Dalipaj, M. M., Beanlands, R. S.B., Ruddy, T. D.
(2005). Comparison of treadmill exercise versus dipyridamole stress with myocardial perfusion imaging using rubidium-82 positron emission tomography. J Am Coll Cardiol
45: 1227-1234
[Abstract][Full Text]
Ohtake, T., Kobayashi, S., Moriya, H., Negishi, K., Okamoto, K., Maesato, K., Saito, S.
(2005). High Prevalence of Occult Coronary Artery Stenosis in Patients with Chronic Kidney Disease at the Initiation of Renal Replacement Therapy: An Angiographic Examination. J. Am. Soc. Nephrol.
16: 1141-1148
[Abstract][Full Text]
Mushlin, A. I., Kern, L. M., Paris, M., Lambert, D. R., Williams, G.
(2005). The Value of Diagnostic Information to Patients with Chest Pain Suggestive of Coronary Artery Disease. Med Decis Making
25: 149-157
[Abstract]
Mieres, J. H., Shaw, L. J., Arai, A., Budoff, M. J., Flamm, S. D., Hundley, W. G., Marwick, T. H., Mosca, L., Patel, A. R., Quinones, M. A., Redberg, R. F., Taubert, K. A., Taylor, A. J., Thomas, G. S., Wenger, N. K.
(2005). Role of Noninvasive Testing in the Clinical Evaluation of Women With Suspected Coronary Artery Disease: Consensus Statement From the Cardiac Imaging Committee, Council on Clinical Cardiology, and the Cardiovascular Imaging and Intervention Committee, Council on Cardiovascular Radiology and Intervention, American Heart Association. Circulation
111: 682-696
[Abstract][Full Text]
Beinfeld, M. T., Wittenberg, E., Gazelle, G. S.
(2005). Cost-effectiveness of Whole-Body CT Screening. Radiology
234: 415-422
[Abstract][Full Text]
Sajjadieh, H. R., Sajjadieh, V., Aminorroaya, A., Amini, M., Oveisgharan, S., Reisifar, M., Adibi, A., Siavash, M., Nazem, M., Peyman, M.
(2005). Value of Sonography in Determining the Nature of Thyroid Nodules: Evaluation of the Sonographic Characteristics. Journal of Diagnostic Medical Sonography
21: 38-44
[Abstract]
Abidov, A., Bax, J. J., Hayes, S. W., Cohen, I., Nishina, H., Yoda, S., Kang, X., Aboul-Enein, F., Gerlach, J., Friedman, J. D., Hachamovitch, R., Germano, G., Berman, D. S.
(2004). Integration of Automatically Measured Transient Ischemic Dilation Ratio into Interpretation of Adenosine Stress Myocardial Perfusion SPECT for Detection of Severe and Extensive CAD. JNM
45: 1999-2007
[Abstract][Full Text]
Schuijf, J. D., Bax, J. J., Jukema, J. W., Lamb, H. J., Vliegen, H. W., Salm, L. P., de Roos, A., van der Wall, E. E.
(2004). Noninvasive Angiography and Assessment of Left Ventricular Function Using Multislice Computed Tomography in Patients With Type 2 Diabetes. Diabetes Care
27: 2905-2910
[Abstract][Full Text]
Sampietro, T, Bigazzi, F, Pino, B D., Rossi, G, Chella, E, Lusso, S, Puntoni, M, Tuoni, M, Bionda, A
(2004). Up regulation of C3, C4, and soluble intercellular adhesion molecule-1 co-expresses with high sensitivity C reactive protein in familial hypoalphalipoproteinaemia: further evidence of inflammatory activation. Heart
90: 1438-1442
[Abstract][Full Text]
Kaufmann, P. A., Rimoldi, O., Gnecchi-Ruscone, T., Bonser, R. S., Luscher, T. F., Camici, P. G.
(2004). Systemic Inhibition of Nitric Oxide Synthase Unmasks Neural Constraint of Maximal Myocardial Blood Flow in Humans. Circulation
110: 1431-1436
[Abstract][Full Text]
Moir, S., Haluska, B. A., Jenkins, C., Fathi, R., Marwick, T. H.
(2004). Incremental Benefit of Myocardial Contrast to Combined Dipyridamole-Exercise Stress Echocardiography for the Assessment of Coronary Artery Disease. Circulation
110: 1108-1113
[Abstract][Full Text]
Jorg-Ciopor, M., Namdar, M., Turina, J., Jenni, R., Schwitter, J., Turina, M., Hess, O. M., Kaufmann, P. A.
(2004). Regional myocardial ischemia in hypertrophic cardiomyopathy: Impact of myectomy. J. Thorac. Cardiovasc. Surg.
128: 163-169
[Abstract][Full Text]
Borges-Neto, S., Tuttle, R. H., Shaw, L. K., Smith, W. T. IV, Jain, D., Coleman, R. E., Whellan, D.
(2004). Outcome Prediction in Patients at High Risk for Coronary Artery Disease: Comparison between 99mTc Tetrofosmin and 99mTc Sestamibi. Radiology
232: 58-65
[Abstract][Full Text]
Bodegard, J, Erikssen, G, Bjornholt, J V, Thelle, D, Erikssen, J
(2004). Possible angina detected by the WHO angina questionnaire in apparently healthy men with a normal exercise ECG: coronary heart disease or not? A 26 year follow up study. Heart
90: 627-632
[Abstract][Full Text]
Sicari, R., Cortigiani, L., Bigi, R., Landi, P., Raciti, M., Picano, E., for the Echo-Persantine International Cooperative,
(2004). Prognostic Value of Pharmacological Stress Echocardiography Is Affected by Concomitant Antiischemic Therapy at the Time of Testing. Circulation
109: 2428-2431
[Abstract][Full Text]
Honda, O., Sugiyama, S., Kugiyama, K., Fukushima, H., Nakamura, S., Koide, S., Kojima, S., Hirai, N., Kawano, H., Soejima, H., Sakamoto, T., Yoshimura, M., Ogawa, H.
(2004). Echolucent carotid plaques predict future coronary events in patients with coronary artery disease. J Am Coll Cardiol
43: 1177-1184
[Abstract][Full Text]
Heller, R. F, Sandars, J. E, Patterson, L., McElduff, P.
(2004). GPs' and physicians' interpretation of risks, benefits and diagnostic test results. Fam Pract
21: 155-159
[Abstract][Full Text]
Poornima, I. G., Miller, T. D., Christian, T. F., Hodge, D. O., Bailey, K. R., Gibbons, R. J.
(2004). Utility of myocardial perfusion imaging in patients with low-risk treadmill scores. J Am Coll Cardiol
43: 194-199
[Abstract][Full Text]
Gibbons, R. J.
(2003). Nitroglycerin: Should We Still Ask?. ANN INTERN MED
139: 1036-1037
[Full Text]
Narayanan, M. V., King, M. A., Pretorius, P. H., Dahlberg, S. T., Spencer, F., Simon, E., Ewald, E., Healy, E., MacNaught, K., Leppo, J. A.
(2003). Human-Observer Receiver-Operating-Characteristic Evaluation of Attenuation, Scatter, and Resolution Compensation Strategies for 99mTc Myocardial Perfusion Imaging. JNM
44: 1725-1734
[Abstract][Full Text]
Sabharwal, N K, Lahiri, A
(2003). Role of myocardial perfusion imaging for risk stratification in suspected or known coronary artery disease. Heart
89: 1291-1297
[Abstract][Full Text]
Cahan, A., Gilon, D., Manor, O., Paltiel, O.
(2003). Probabilistic reasoning and clinical decision-making: do doctors overestimate diagnostic probabilities?. QJM
96: 763-769
[Abstract][Full Text]
Wyss, C. A., Koepfli, P., Fretz, G., Seebauer, M., Schirlo, C., Kaufmann, P. A.
(2003). Influence of Altitude Exposure on Coronary Flow Reserve. Circulation
108: 1202-1207
[Abstract][Full Text]
Marwick, T. H, Case, C., Short, L., Thomas, J. D
(2003). Prediction of mortality in patients without angina: Use of an exercise score and exercise echocardiography. Eur Heart J
24: 1223-1230
[Abstract][Full Text]
Kurl, S., Laukkanen, J.A., Tuomainen, T.-P., Rauramaa, R., Lakka, T.A., Salonen, R., Eranen, J., Sivenius, J., Salonen, J.T.
(2003). Association of Exercise-Induced, Silent ST-Segment Depression With the Risk of Stroke and Cardiovascular Diseases in Men. Stroke
34: 1760-1765
[Abstract][Full Text]
Battaglia, M., Pewsner, D.
(2003). Commentary: Black and white or shades of grey?. Int J Epidemiol
32: 314-315
[Full Text]
Sicari, R., Pasanisi, E., Venneri, L., Landi, P., Cortigiani, L., Picano, E., Echo Persantine International Cooperative (EPIC) a,
(2003). Stress echo results predict mortality: a large-scale multicenter prospective international study. J Am Coll Cardiol
41: 589-595
[Abstract][Full Text]
Wyss, C. A., Koepfli, P., Mikolajczyk, K., Burger, C., von Schulthess, G. K., Kaufmann, P. A.
(2003). Bicycle Exercise Stress in PET for Assessment of Coronary Flow Reserve: Repeatability and Comparison with Adenosine Stress. JNM
44: 146-154
[Abstract][Full Text]
Trowbridge, R. L., Rutkowski, N. K., Shojania, K. G.
(2003). Does This Patient Have Acute Cholecystitis?. JAMA
289: 80-86
[Abstract][Full Text]
Grunkemeier, G. L., Payne, N.
(2002). Bayesian analysis: A new statistical paradigm for new technology. Ann. Thorac. Surg.
74: 1901-1908
[Abstract][Full Text]
Erhardt, L., Herlitz, J., Bossaert, L., Halinen, M., Keltai, M., Koster, R., Marcassa, C., Quinn, T., van Weert, H.
(2002). Task force on the management of chest pain. Eur Heart J
23: 1153-1176
[Full Text]
Reilly, B. M., Evans, A. T., Schaider, J. J., Das, K., Calvin, J. E., Moran, L. A., Roberts, R. R., Martinez, E.
(2002). Impact of a Clinical Decision Rule on Hospital Triage of Patients With Suspected Acute Cardiac Ischemia in the Emergency Department. JAMA
288: 342-350
[Abstract][Full Text]
Marwick, T. H., Case, C., Sawada, S., Vasey, C., Short, L., Lauer, M.
(2002). Use of Stress Echocardiography to Predict Mortality in Patients With Diabetes and Known or Suspected Coronary Artery Disease. Diabetes Care
25: 1042-1048
[Abstract][Full Text]
Abraham, T. P., Belohlavek, M., Thomson, H. L., Pislaru, C., Khandheria, B., Seward, J. B., Pellikka, P. A.
(2002). Time to onset of regional relaxation: feasibility, variability and utility of a novel index of regional myocardial function by strain rate imaging. J Am Coll Cardiol
39: 1531-1537
[Abstract][Full Text]
Arruda-Olson, A. M., Mahoney, D. W., Nehra, A., Leckel, M., Pellikka, P. A.
(2002). Cardiovascular Effects of Sildenafil During Exercise in Men With Known or Probable Coronary Artery Disease: A Randomized Crossover Trial. JAMA
287: 719-725
[Abstract][Full Text]
Jenni, R., Wyss, C. A., Oechslin, E. N., Kaufmann, P. A.
(2002). Isolated ventricular noncompaction is associated with coronary microcirculatory dysfunction. J Am Coll Cardiol
39: 450-454
[Abstract][Full Text]
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