We studied the biologic activity of a long-acting analogue of luteinizing hormone-releasing hormone, D-Trp6-Pro9-NEt-LHRH (LHRHa), in five normal men and four hypogonadotropic men previously unresponsive to natural LHRH. All subjects responded to LHRAa, but there were quantitative and qualitative differences between the normal and hypogonadotropic men. Normal men showed a linear dose-response relation, endogenous gonadal steroid secretion, and an adult pattern of gonadotropin secretion characterized by a high ratio of luteinizing hormone (LH) to follicle-stimulating hormone (FSH). Hypogonadotropic men had improving pituitary responses to each dose of LHRHa (priming response), no demonstrable gonadal steroid secretion, and a prepubertal pattern of gonadotropin release characterized by reversal of the normal ratio of LH to FSH. When compared with native LHRH, LHRHa had an augmented ability to discharge gonadotropins acutely and to sustain their release in normal and hypogonadotropic men.
This article has been cited by other articles:
Welt, C. K., Falorni, A., Taylor, A. E., Martin, K. A., Hall, J. E.
(2005). Selective Theca Cell Dysfunction in Autoimmune Oophoritis Results in Multifollicular Development, Decreased Estradiol, and Elevated Inhibin B Levels. J. Clin. Endocrinol. Metab.
90: 3069-3076
[Abstract][Full Text]
Hall, J. E., Sullivan, J. P., Richardson, G. S.
(2005). Brief Wake Episodes Modulate Sleep-Inhibited Luteinizing Hormone Secretion in the Early Follicular Phase. J. Clin. Endocrinol. Metab.
90: 2050-2055
[Abstract][Full Text]
Welt, C. K., Hall, J. E., Adams, J. M., Taylor, A. E.
(2005). Relationship of Estradiol and Inhibin to the Follicle-Stimulating Hormone Variability in Hypergonadotropic Hypogonadism or Premature Ovarian Failure. J. Clin. Endocrinol. Metab.
90: 826-830
[Abstract][Full Text]
Welt, C. K., Smith, P. C., Taylor, A. E.
(2004). Evidence of Early Ovarian Aging in Fragile X Premutation Carriers. J. Clin. Endocrinol. Metab.
89: 4569-4574
[Abstract][Full Text]
Welt, C. K., Taylor, A. E., Martin, K. A., Hall, J. E.
(2002). Serum Inhibin B in Polycystic Ovary Syndrome: Regulation by Insulin and Luteinizing Hormone. J. Clin. Endocrinol. Metab.
87: 5559-5565
[Abstract][Full Text]
Pitteloud, N., Hayes, F. J., Boepple, P. A., DeCruz, S., Seminara, S. B., MacLaughlin, D. T., Crowley, W. F. Jr.
(2002). The Role of Prior Pubertal Development, Biochemical Markers of Testicular Maturation, and Genetics in Elucidating the Phenotypic Heterogeneity of Idiopathic Hypogonadotropic Hypogonadism. J. Clin. Endocrinol. Metab.
87: 152-160
[Abstract][Full Text]
Wang, H., Andoh, K., Hagiwara, H., Xiaowei, L., Kikuchi, N., Abe, Y., Yamada, K., Fatima, R., Mizunuma, H.
(2001). Effect of Adrenal and Ovarian Androgens on Type 4 Follicles Unresponsive to FSH in Immature Mice. Endocrinology
142: 4930-4936
[Abstract][Full Text]
Perkins, R. B., Hall, J. E., Martin, K. A.
(2001). Aetiology, previous menstrual function and patterns of neuro-endocrine disturbance as prognostic indicators in hypothalamic amenorrhoea. Hum Reprod
16: 2198-2205
[Abstract][Full Text]
Kikuchi, N., Andoh, K., Abe, Y., Yamada, K., Mizunuma, H., Ibuki, Y.
(2001). Inhibitory Action of Leptin on Early Follicular Growth Differs in Immature and Adult Female Mice. Biol. Reprod.
65: 66-71
[Abstract][Full Text]
Gill, S., Taylor, A. E., Martin, K. A., Welt, C. K., Adams, J. M., Hall, J. E.
(2001). Specific Factors Predict the Response to Pulsatile Gonadotropin-Releasing Hormone Therapy in Polycystic Ovarian Syndrome. J. Clin. Endocrinol. Metab.
86: 2428-2436
[Abstract][Full Text]
Beranova, M., Oliveira, L. M. B., BÉdÉcarrats, G. Y., Schipani, E., Vallejo, M., Ammini, A. C., Quintos, J. B., Hall, J. E., Martin, K. A., Hayes, F. J., Pitteloud, N., Kaiser, U. B., Crowley, W. F. Jr., Seminara, S. B.
(2001). Prevalence, Phenotypic Spectrum, and Modes of Inheritance of Gonadotropin-Releasing Hormone Receptor Mutations in Idiopathic Hypogonadotropic Hypogonadism. J. Clin. Endocrinol. Metab.
86: 1580-1588
[Abstract][Full Text]
Hall, J. E., Lavoie, H. B., Marsh, E. E., Martin, K. A.
(2000). Decrease in Gonadotropin-Releasing Hormone (GnRH) Pulse Frequency with Aging in Postmenopausal Women. J. Clin. Endocrinol. Metab.
85: 1794-1800
[Abstract][Full Text]
Seminara, S. B., Beranova, M., Oliveira, L. M. B., Martin, K. A., Crowley, W. F. Jr., Hall, J. E.
(2000). Successful Use of Pulsatile Gonadotropin-Releasing Hormone (GnRH) for Ovulation Induction and Pregnancy in a Patient with GnRH Receptor Mutations. J. Clin. Endocrinol. Metab.
85: 556-562
[Abstract][Full Text]
(1999). X-Linked Adrenal Hypoplasia Congenita: A Mutation in DAX1Expands the Phenotypic Spectrum in Males and Females. J. Clin. Endocrinol. Metab.
84: 4501-4509
[Abstract][Full Text]
Perkins, R. B., Hall, J. E., Martin, K. A.
(1999). Neuroendocrine Abnormalities in Hypothalamic Amenorrhea: Spectrum, Stability, and Response to Neurotransmitter Modulation. J. Clin. Endocrinol. Metab.
84: 1905-1911
[Abstract][Full Text]
Welt, C. K., Adams, J. M., Sluss, P. M., Hall, J. E.
(1999). Inhibin A and Inhibin B Responses to Gonadotropin Withdrawal Depends on Stage of Follicle Development. J. Clin. Endocrinol. Metab.
84: 2163-2169
[Abstract][Full Text]
Hayes, F. J., McNicholl, D. J., Schoenfeld, D., Marsh, E. E., Hall, J. E.
(1999). Free {alpha}-Subunit Is Superior to Luteinizing Hormone as a Marker of Gonadotropin-Releasing Hormone Despite Desensitization at Fast Pulse Frequencies. J. Clin. Endocrinol. Metab.
84: 1028-1036
[Abstract][Full Text]
Sharpless, J. L., Supko, J. G., Martin, K. A., Hall, J. E.
(1999). Disappearance of Endogenous Luteinizing Hormone Is Prolonged in Postmenopausal Women. J. Clin. Endocrinol. Metab.
84: 688-694
[Abstract][Full Text]
Hall, J. E., Weltand, C. K., Cramer, D. W.
(1999). Inhibin A and inhibin B reflect ovarian function in assisted reproduction but are less useful at predicting outcome. Hum Reprod
14: 409-415
[Abstract][Full Text]
Welt, C. K., McNicholl, D. J., Taylor, A. E., Hall, J. E.
(1999). Female Reproductive Aging Is Marked by Decreased Secretion of Dimeric Inhibin. J. Clin. Endocrinol. Metab.
84: 105-111
[Abstract][Full Text]
Gipson, I. K., Spurr-Michaud, S., Moccia, R., Zhan, Q., Toribara, N., Ho, S. B., Gargiulo, A. R., Hill III, J. A.
(1999). MUC4 and MUC5B Transcripts Are the Prevalent Mucin Messenger Ribonucleic Acids of the Human Endocervix. Biol. Reprod.
60: 58-64
[Abstract][Full Text]
Hayes, F. J., Taylor, A. E., Martin, K. A., Hall, J. E.
(1998). Use of a Gonadotropin-Releasing Hormone Antagonist as a Physiologic Probe in Polycystic Ovary Syndrome: Assessment of Neuroendocrine and Androgen Dynamics. J. Clin. Endocrinol. Metab.
83: 2343-2349
[Abstract][Full Text]
Liu, X., Andoh, K., Yokota, H., Kobayashi, J., Abe, Y., Yamada, K., Mizunuma, H., Ibuki, Y.
(1998). Effects of Growth Hormone, Activin, and Follistatin on the Development of Preantral Follicle from Immature Female Mice. Endocrinology
139: 2342-2347
[Abstract][Full Text]
Lavoie, H. B., Martin, K. A., Taylor, A. E., Crowley, W. F., Hall, J. E.
(1998). Exaggerated Free {alpha}-Subunit Levels during Pulsatile Gonadotropin-Releasing Hormone Replacement in Women with Idiopathic Hypogonadotropic Hypogonadism. J. Clin. Endocrinol. Metab.
83: 241-247
[Abstract][Full Text]
Yokota, H., Yamada, K., Liu, X., Kobayashi, J., Abe, Y., Mizunuma, H., Ibuki, Y.
(1997). Paradoxical Action of Activin A on Folliculogenesis in Immature and Adult Mice. Endocrinology
138: 4572-4576
[Abstract][Full Text]
Welt, C. K., Martin, K. A., Taylor, A. E., Lambert-Messerlian, G. M., Crowley, W. F. Jr., Smith, J. A., Schoenfeld, D. A., Hall, J. E.
(1997). Frequency Modulation of Follicle-Stimulating Hormone (FSH) during the Luteal-Follicular Transition: Evidence for FSH Control of Inhibin B in Normal Women. J. Clin. Endocrinol. Metab.
82: 2645-2652
[Abstract][Full Text]
Taylor, A. E., McCourt, B., Martin, K. A., Anderson, E. J., Adams, J. M., Schoenfeld, D., Hall, J. E.
(1997). Determinants of Abnormal Gonadotropin Secretion in Clinically Defined Women with Polycystic Ovary Syndrome. J. Clin. Endocrinol. Metab.
82: 2248-2256
[Abstract][Full Text]
Previous
