We investigated the spread of viral hepatitis in day-care centers in Maricopa County, Ariz. Over a 10-month period, 398 (40 per cent) of 1008 reported cases of hepatitis Type A or viral hepatitis of unspecified type occurred in persons closely associated with day-care centers. Outbreaks of hepatitis comprising 310 cases were identified in 30 of 308 centers in the county. In 28 outbreaks investigated, the majority of symptomatic cases occurred in household contacts or close relatives of children who attended day-care centers, with 16 per cent of the cases occurring in children who attended the centers and 15 per cent occurring in employees. Hepatitis in both employees and household contacts was strongly related to contact with children one to two years of age who attended the centers (P less than 0.001). Day-care centers appear to be important in the spread of hepatitis A in the United States.
This article has been cited by other articles:
Victor, J. C., Monto, A. S., Surdina, T. Y., Suleimenova, S. Z., Vaughan, G., Nainan, O. V., Favorov, M. O., Margolis, H. S., Bell, B. P.
(2007). Hepatitis A Vaccine versus Immune Globulin for Postexposure Prophylaxis. NEJM
357: 1685-1694
[Abstract][Full Text]
Wasley, A., Fiore, A., Bell, B. P.
(2006). Hepatitis A in the Era of Vaccination. Epidemiol Rev
28: 101-111
[Abstract][Full Text]
Victor, J. C., Surdina, T. Y., Suleimenova, S. Z., Favorov, M. O., Bell, B. P., Monto, A. S.
(2006). Person-to-Person Transmission of Hepatitis A Virus in an Urban Area of Intermediate Endemicity: Implications for Vaccination Strategies. Am J Epidemiol
163: 204-210
[Abstract][Full Text]
Nainan, O. V., Xia, G., Vaughan, G., Margolis, H. S.
(2006). Diagnosis of Hepatitis A Virus Infection: a Molecular Approach. Clin. Microbiol. Rev.
19: 63-79
[Abstract][Full Text]
DERYA, A., NECMI, A., EMRE, A., AKGUN, Y.
(2005). DECLINE OF MATERNAL HEPATITIS A ANTIBODIES DURING THE FIRST 2 YEARS OF LIFE IN INFANTS BORN IN TURKEY. Am J Trop Med Hyg
73: 457-459
[Abstract][Full Text]
Dagan, R., Leventhal, A., Anis, E., Slater, P., Ashur, Y., Shouval, D.
(2005). Incidence of Hepatitis A in Israel Following Universal Immunization of Toddlers. JAMA
294: 202-210
[Abstract][Full Text]
Costa-Mattioli, M., Napoli, A. D., Ferre, V., Billaudel, S., Perez-Bercoff, R., Cristina, J.
(2003). Genetic variability of hepatitis A virus. J. Gen. Virol.
84: 3191-3201
[Abstract][Full Text]
Armstrong, G. L., Bell, B. P.
(2002). Hepatitis A Virus Infections in the United States: Model-Based Estimates and Implications for Childhood Immunization. Pediatrics
109: 839-845
[Abstract][Full Text]
Alagappan, K., Barnett, B., Napolitano, A., Gressin, J., Auerbach, C.
(2001). Seroprevalence of Hepatitis A Among Hospital Dietary Workers: Implications for Screening and Immunization. American Journal of Medical Quality
16: 145-148
[Abstract]
Cuthbert, J. A.
(2001). Hepatitis A: Old and New. Clin. Microbiol. Rev.
14: 38-58
[Abstract][Full Text]
Lemon, S. M.
(1997). Type A viral hepatitis: epidemiology, diagnosis, and prevention. Clin. Chem.
43: 1494-1499
[Abstract][Full Text]
Lemon, S. M.
(1994). Inactivated Hepatitis A Vaccines. JAMA
271: 1363-1364
[Abstract]
Goh, K T, Wong, L Y., Oon, C J, Kumarapathy, S
(1987). The Prevalence of Antibody to Hepatitis A Virus in Singapore. Asia Pac J Public Health
1: 9-11
[Abstract]
Brunell, P. A.
(1987). Infections in Day-care Centers. Arch Pediatr Adolesc Med
141: 404-405
[Abstract]
(1985). Recommendations for Protection Against Viral Hepatitis: Recommendation of the Immunization Practices Advisory Committee. ANN INTERN MED
103: 391-402
[Abstract]
(1985). Leads from the MMWR. JAMA
254: 29-36
Noble, R. C., Kane, M. A., Reeves, S. A., Roeckel, I.
(1984). Posttransfusion Hepatitis A in a Neonatal Intensive Care Unit. JAMA
252: 2711-2715
[Abstract]
Klein, B. S., Michaels, J. A., Rytel, M. W., Berg, K. G., Davis, J. P.
(1984). Nosocomial Hepatitis A: A Multinursery Outbreak in Wisconsin. JAMA
252: 2716-2721
[Abstract]
Hadler, S. C., Erben, J. J., Matthews, D., Starko, K., Francis, D. P., Maynard, J. E.
(1983). Effect of Immunoglobulin on Hepatitis A in Day-care Centers. JAMA
249: 48-53
[Abstract]