We evaluated the prophylactic effect of antiarrhythmic agents against induction of ventricular tachycardia by extrastimulation in 51 patients with recurrent ventricular tachycardia. These patients subsequently underwent 58 long-term trials with tested agents. In 39 trials an agent predicted to be effective by electrophysiologic study was administered, and in 19 a drug predicted to be ineffective was used. There were no clinical differences between the two treatment groups. During a mean follow-up period of 8.2 months, arrhythmias recurred significantly less frequently in the group treated with drugs predicted to be effective than in the other group (P < 0.001); at six months 80 per cent of the patients in the former group were successfully treated, as compared with 33 per cent in the latter group. At 18 months the corresponding figures were 68 per cent and 11 per cent. We conclude that the arrhythmia-induction technique accurately predicts the clinical effectiveness of drugs used in the long-term treatment of recurrent ventricular tachycardia.
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Singh, B. N.
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1: 89-94
Hine, L. K., Gross, T. P., Kennedy, D. L.
(1989). Outpatient Antiarrhythmic Drug Use From 1970 Through 1986. Arch Intern Med
149: 1524-1527
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Antman, E.
(1987). Tachyarrhythmia Management. J Intensive Care Med
2: 61-63
Nygaard, T. W., Sellers, T. D., Cook, T. S., DiMarco, J. P.
(1986). Adverse Reactions to Antiarrhythmic Drugs During Therapy for Ventricular Arrhythmias. JAMA
256: 55-57
[Abstract]
Somberg, J. C., Butler, B., Torres, V., Tepper, D., Keren, G., Siegel, L., Jentzer, J., Miura, D. S.
(1985). Therapy for Late Post Infarction Ventricular Tachycardia. ANGIOLOGY
36: 181-190
[Abstract]
NADEMANEE, K., SINGH, B. N., HENDRICKSON, J., INTARACHOT, V., LOPEZ, B., FELD, G., CANNOM, D. S., WEISS, J. L.
(1983). Amiodarone in Refractory Life-Threatening Ventricular Arrhythmias. ANN INTERN MED
98: 577-584
[Abstract]
(1983). Cardiovascular Diseases: An Annotated Bibliography of Recent Literature: References to Journal Articles and Other Papers. ANN INTERN MED
98: 679-685
[Abstract]
DIMARCO, J. P., GARAN, H., RUSKIN, J. N.
(1982). Complications in Patients Undergoing Cardiac Electrophysiologic Procedures. ANN INTERN MED
97: 490-493
[Abstract]
Ruffy, R., Avioli, L. V.
(1982). Advances in the Treatment of Life-Threatening Ventricular Rhythm Disturbances. Arch Intern Med
142: 1697-1701
[Abstract]
MICHELSON, E. L.
(1981). Canine Models for Ventricular Tachyarrhythmia. ANN INTERN MED
95: 648-649
[Abstract]
ENGEL, T. R.
(1981). Endocardial Surgery for Ventricular Tachycardia: The Inside Story. ANN INTERN MED
94: 402-404
[Abstract]
