The average length of life has risen from 47 to 73 years in this century, but the maximum life span has not increased. Therefore, survival curves have assumed an ever more rectangular form. Eighty per cent of the years of life lost to nontraumatic, premature death have been eliminated, and most premature deaths are now due to the chronic diseases of the later years. Present data allow calculation of the ideal average life span, approximately 85 years. Chronic illness may presumably be postponed by changes in life style, and it has been shown that the physiologic and psychologic markers of aging may be modified. Thus, the average age at first infirmity can be raised, thereby making the morbidity curve more rectangular. Extension of adult vigor far into a fixed life span compresses the period of senescence near the end of life. Health-research strategies to improve the quality of life require careful study of the variability of the phenomena of aging and how they may be modified.
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[Abstract][Full Text]
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[Abstract]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Full Text]
Rosen, M., Haglund, B.
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
Walker, A R P, Walker, B F, Segal, I
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124: 40-46
[Abstract]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
Ghezzi, E.M., Ship, J.A.
(2003). Aging and Secretory Reserve Capacity of Major Salivary Glands. JDR
82: 844-848
[Abstract][Full Text]
Janssen, F., Nusselder, W. J., Looman, C. W. N., Mackenbach, J. P., Kunst, A. E.
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[Abstract][Full Text]
Tate, R. B., Lah, L., Cuddy, T. E.
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[Abstract][Full Text]
Fries, J. F.
(2003). Measuring and Monitoring Success in Compressing Morbidity. ANN INTERN MED
139: 455-459
[Abstract][Full Text]
Lynch, S. M., Brown, J. S., Harmsen, K. G.
(2003). Black-White Differences in Mortality Compression and Deceleration and the Mortality Crossover Reconsidered. Research on Aging
25: 456-483
[Abstract]
Romoren, T. I., Blekeseaune, M.
(2003). Trajectories of Disability among the Oldest Old. J Aging Health
15: 548-566
[Abstract]
Lynch, S. M., Brown, J. S., Harmsen, K. G.
(2003). The Effect of Altering ADL Thresholds on Active Life Expectancy Estimates for Older Persons. Journals of Gerontology Series B: Psychological Sciences and Social Science
58: S171-178
[Abstract][Full Text]
Sulander, T. T., Rahkonen, O. J., Uutela, A. K.
(2003). Functional ability in the elderly Finnish population: time period differences and associations, 1985--99. Scand J Public Health
31: 100-106
[Abstract]
Haveman-Nies, A., de Groot, L. C.P.G.M., van Staveren, W. A.
(2003). Relation of Dietary Quality, Physical Activity, and Smoking Habits to 10-Year Changes in Health Status in Older Europeans in the SENECA Study. AJPH
93: 318-323
[Abstract][Full Text]
Freedman, V. A., Martin, L. G., Schoeni, R. F.
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288: 3137-3146
[Abstract][Full Text]
Fries, J. F.
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288: 3164-3166
[Full Text]
Wang, B. W. E., Ramey, D. R., Schettler, J. D., Hubert, H. B., Fries, J. F.
(2002). Postponed Development of Disability in Elderly Runners: A 13-Year Longitudinal Study. Arch Intern Med
162: 2285-2294
[Abstract][Full Text]
Liang, J., Bennett, J., Krause, N., Kobayashi, E., Kim, H., Brown, J. W., Akiyama, H., Sugisawa, H., Jain, A.
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57: S294-307
[Abstract][Full Text]
Olshansky, S. J., Hayflick, L., Carnes, B. A.
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57: B292-297
[Abstract][Full Text]
Palloni, A., Pinto-Aguirre, G., Pelaez, M.
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31: 762-771
[Full Text]
Kaplan, H. S., Robson, A. J.
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99: 10221-10226
[Abstract][Full Text]
Olshansky, S. J., Hayflick, L., Carnes, B. A.
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2002: pe9-9
[Abstract][Full Text]
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57: M347-351
[Abstract][Full Text]
Busse, R, Krauth, C, Schwartz, F W
(2002). Use of acute hospital beds does not increase as the population ages: results from a seven year cohort study in Germany. J. Epidemiol. Community Health
56: 289-293
[Abstract][Full Text]
Kesteloot, H., Sans, S., Kromhout, D.
(2002). Evolution of all-causes and cardiovascular mortality in the age-group 75-84 years in Europe during the period 1970-1996. A comparison with worldwide changes. Eur Heart J
23: 384-398
[Abstract][Full Text]
Minkler, M., Fadem, P.
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12: 229-235
[Abstract]
Gee, E. M.
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49: 5-11
[Abstract]
Idler, E. L., Kasl, S. V., Hays, J. C.
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56: S326-334
[Abstract][Full Text]
Giesecke, A. H., Gessert, C., Beasley, J. W., Shahady, E., Michaud, C., Nathan, D. G., Fontanarosa, P. B., Wilson, J. D.
(2001). Medical Research in the 21st Century. JAMA
286: 1833-1835
[Full Text]
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56: B432-442
[Abstract][Full Text]
Levinsky, N. G., Yu, W., Ash, A., Moskowitz, M., Gazelle, G., Saynina, O., Emanuel, E. J.
(2001). Influence of Age on Medicare Expenditures and Medical Care in the Last Year of Life. JAMA
286: 1349-1355
[Abstract][Full Text]
Bostrom, G., Persson, G.
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29: 17-36
Persson, G., Bostrom, G., Allebeck, P., Andersson, L., Berg, S., Johansson, L., Thille, A.
(2001). Chapter 5. Elderly People's Health - 65 and After. Scand J Public Health
29: 117-131
Bronnum-Hansen, H., Juel, K.
(2001). Abstention from smoking extends life and compresses morbidity: a population based study of health expectancy among smokers and never smokers in Denmark. Tobacco Control
10: 273-278
[Abstract][Full Text]
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