Endogenous modulators of platelet aggregability and vascular tone may play a part in coronary-artery disease. We therefore measured the release of prostaglandins and thromboxane into the coronary circulation in patients with various kinds of cardiac disease. Simultaneous coronary-sinus (CS) and ascending-aortic (AO) blood samples were obtained from 60 patients for measurement of 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha, a prostaglandin I2 metabolite) and of thromboxane B2 (TxB2). Samples from 45 of these patients were also tested for prostaglandin E2 (PGE2) and lactate. Patients with unstable angina pectoris who reported chest pain within 24 hours of study had higher TxB2 CS/AO ratios (5.8 +/- 2.8, mean +/- S.D.) than patients whose most recent anginal pain was more than 96 hours before study (1.3 +/- 0.6; P less than 0.05), than those with nonischemic chest pain (1.2 +/- 0.4; P less than 0.05), or with valvular or congenital nonischemic heart disease (1.2 +/- 0.6; P less than 0.05). Those whose most recent anginal pain occurred 24 to 96 hours before study were distributed bimodally: the majority had low TxB2 CS/AO ratios (range, 0.5 to 2.1) like the patients in the three aforementioned groups, whereas a few had markedly elevated values (range, 10.5 to 46.6). The 6-keto-PGF1 alpha and PGE2 CS/AO ratios and myocardial lactate extraction were not significantly different among the five groups. These data suggest that local thromboxane release is associated with recent episodes of angina in patients with unstable angina pectoris, but whether this release is a cause or an effect is not yet known.
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293: 755-760
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101: 570-580
[Full Text]
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[Abstract][Full Text]
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19: 212-219
[Abstract][Full Text]
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41: 267-274
[Abstract][Full Text]
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[Abstract][Full Text]
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98: 2219-2222
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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(1998). Antithrombotic Effects of Recombinant Human, Active Site–Blocked Factor VIIa in a Rabbit Model of Recurrent Arterial Thrombosis. Circ. Res.
82: 39-46
[Abstract][Full Text]
Topol, E. J.
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97: 211-218
[Full Text]
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96: 3215-3223
[Full Text]
Olausson, K., Magnusdottir, H., Lurje, L., Wennerblom, B., Emanuelsson, H., Ricksten, S.-E.
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
Mousa, S. A., Mu, D.-X., Lucchesi, B. R.
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28: 830-836
[Abstract][Full Text]
Neri Serneri, G. G., Prisco, D., Martini, F., Gori, A., Brunelli, T., Poggesi, L., Rostagno, C., Gensini, G. F., Abbate, R.
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95: 1806-1812
[Abstract][Full Text]
Ueyama, T., Ikeda, H., Haramaki, N., Kuwano, K., Imaizumi, T.
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[Abstract][Full Text]
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(1996). Effects of Integrelin, a Platelet Glycoprotein IIb/IIIa Receptor Antagonist, in Unstable Angina: A Randomized Multicenter Trial. Circulation
94: 2083-2089
[Abstract][Full Text]
Willerson, J. T.
(1996). Inhibitors of Platelet Glycoprotein IIb/IIIa Receptors: Will They Be Useful When Given Chronically?. Circulation
94: 866-868
[Full Text]
D'Angelo, D. D., Oliver, B. G., Davis, M. G., McCluskey, T. S., Dorn, G. W. II
(1996). Novel Role for Sp1 in Phorbol Ester Enhancement of Human Platelet Thromboxane Receptor Gene Expression. J. Biol. Chem.
271: 19696-19704
[Abstract][Full Text]
Takase, B., Maruyama, T., Kurita, A., Uehata, A., Nishioka, T., Mizuno, K., Nakamura, H., Katsura, K., Kanda, Y.
(1996). Arachidonic Acid Metabolites in Acute Myocardial Infarction. ANGIOLOGY
47: 649-661
[Abstract]
Maalej, N., Folts, J. D.
(1996). Increased Shear Stress Overcomes the Antithrombotic Platelet Inhibitory Effect of Aspirin in Stenosed Dog Coronary Arteries. Circulation
93: 1201-1205
[Abstract][Full Text]
Mousa, S. A., DeGrado, W. F., Mu, D.-X., Kapil, R. P., Lucchesi, B. R., Reilly, T. M.
(1996). Oral Antiplatelet, Antithrombotic Efficacy of DMP 728, a Novel Platelet GPIIb/IIIa Antagonist. Circulation
93: 537-543
[Abstract][Full Text]
Gawaz, M., Neumann, F.-J., Ott, I., Schiessler, A., Schomig, A.
(1996). Platelet Function in Acute Myocardial Infarction Treated With Direct Angioplasty. Circulation
93: 229-237
[Abstract][Full Text]
Frederick, L. G., Suleymanov, O. D., King, L. W., Salyers, A. K., Nicholson, N. S., Feigen, L. P.
(1996). The Protective Dose of the Potent GPIIb/IIIa Antagonist SC-54701A Is Reduced When Used in Combination With Aspirin and Heparin in a Canine Model of Coronary Artery Thrombosis. Circulation
93: 129-134
[Abstract][Full Text]
Reilly, T. M., Mousa, S. A., Racanelli, A. L., Thoolen, M. J., Flint, S. K., Bozarth, J. M., Mu, D. X., Walton, H. L.
(1995). A Monoclonal Antibody That Recognizes the GPIIb/IIIa Antagonist DMP 728 : Reversal of the Effects of DMP 728 on Platelet Aggregation and Bleeding Time in the Dog. Arterioscler. Thromb. Vasc. Bio.
15: 2195-2199
[Abstract][Full Text]
Wang, J.-s., Jen, C. J., Chen, H.-i.
(1995). Effects of Exercise Training and Deconditioning on Platelet Function in Men. Arterioscler. Thromb. Vasc. Bio.
15: 1668-1674
[Abstract][Full Text]
Ikeda, H., Takajo, Y., Ichiki, K., Ueno, T., Maki, S., Noda, T., Sugi, K., Imaizumi, T.
(1995). Increased Soluble Form of P-Selectin in Patients With Unstable Angina. Circulation
92: 1693-1696
[Abstract][Full Text]
Mueller, H. W., Haught, C. A., McNatt, J. M., Cui, K., Gaskell, S. J., Johnston, D. A., Willerson, J. T.
(1995). Measurement of Platelet-Activating Factor in a Canine Model of Coronary Thrombosis and in Endarterectomy Samples From Patients With Advanced Coronary Artery Disease. Circ. Res.
77: 54-63
[Abstract][Full Text]
Anderson, H. V., Willerson, J. T.
(1993). Thrombolysis in Acute Myocardial Infarction. NEJM
329: 703-709
[Full Text]
Wacker, M. J., Tehrani, R. N., Smoot, R. L., Orr, J. A.
(2002). Thromboxane A2 mimetic evokes a bradycardia mediated by stimulation of cardiac vagal afferent nerves. Am. J. Physiol. Heart Circ. Physiol.
282: H482-H490
[Abstract][Full Text]
