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Previous Volume 304:448-453 February 19, 1981 Number 8 Next

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Abstract

To assess the value of simple protective isolation, we prospectively compared it with standard hospital care in 43 episodes of severe granulocytopenia, most occurring in patients with acute nonlymphocytic leukemia. Sterilized food and prophylactic oral antibiotics were not used. Twenty episodes in 17 patients were randomized to simple protective isolation (437 days), and 23 episodes in 20 patients to standard care (611 days). No statistically significant differences were observed in the overall incidence of infection, time to onset of first infection, or days with fever. Twenty-seven infections occurred in recipients of standard care (4.42 per 100 days), and 28 infections in isolated patients (6.41 per 100 days). Except for a threefold higher rate of bacteremia in patients in isolation (2.06 vs. 0.65 per 100 days), the profile of infection was similar in the two groups. Neither response to antileukemic therapy nor survival was improved by isolation. We conclude that protective isolation alone, as practiced in most hospitals, appears not to benefit granulocytopenic patients.

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