FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 308:800-805 April 7, 1983 Number 14 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

We studied the ability of a single oral dose of aspirin to inhibit prostacyclin synthesis by human arterial and venous tissue and to inhibit thromboxane A2 synthesis by platelets in 70 patients who were undergoing aortocoronary bypass. A dose of 40, 80, or 325 mg of aspirin was administered 12 to 16 hours before surgery. The generation of thromboxane in serum--which provides an estimate of platelet thromboxane production--was reduced from the control value by 77, 95, and 99 per cent after single doses of 40, 80, and 325 mg of aspirin, respectively. By contrast, prostacyclin production in aortic tissue that was removed at operation was reduced by only 35, 38, and 75 per cent, respectively, in response to these doses. Production of prostacyclin in saphenous-vein tissue (not tested after 40 mg of aspirin) fell only slightly and not significantly after 80 mg but was reduced by 85 per cent after 325 mg. These findings indicate that a low dose of aspirin (40 to 80 mg) can largely inhibit platelet aggregation and thromboxane synthesis but has much less effect on prostacyclin production in arterial and venous endothelium.

This article has been cited by other articles:

• Rousseau, P., Tartas, M., Fromy, B., Godon, A., Custaud, M.-A., Saumet, J. L., Abraham, P. (2008). Platelet inhibition by low-dose aspirin but not by clopidogrel reduces the axon-reflex current-induced vasodilation in humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294: R1420-R1426 [Abstract] [Full Text]  
• Tseeng, S., Arora, R. (2008). Aspirin Resistance: Biological and Clinical Implications. J CARDIOVASC PHARMACOL THER 13: 5-12 [Abstract]  
• Berger, J. S., Stebbins, A., Granger, C. B., Ohman, E. M., Armstrong, P. W., Van de Werf, F., White, H. D., Simes, R. J., Harrington, R. A., Califf, R. M., Peterson, E. D. (2008). Initial Aspirin Dose and Outcome Among ST-Elevation Myocardial Infarction Patients Treated With Fibrinolytic Therapy. Circulation 117: 192-199 [Abstract] [Full Text]  
• Berger, J. S., Roncaglioni, M. C., Avanzini, F., Pangrazzi, I., Tognoni, G., Brown, D. L. (2006). Aspirin for the Primary Prevention of Cardiovascular Events in Women and Men: A Sex-Specific Meta-analysis of Randomized Controlled Trials. JAMA 295: 306-313 [Abstract] [Full Text]  
• Mason, P. J., Jacobs, A. K., Freedman, J. E. (2005). Aspirin Resistance and Atherothrombotic Disease. J Am Coll Cardiol 46: 986-993 [Abstract] [Full Text]  
• Antman, E. M., DeMets, D., Loscalzo, J. (2005). Cyclooxygenase Inhibition and Cardiovascular Risk. Circulation 112: 759-770 [Full Text]  
• Juhlin, T., Bjorkman, S., Gunnarsson, B., Fyge, A., Roth, B., Hoglund, P. (2004). Acute administration of diclofenac, but possibly not long term low dose aspirin, causes detrimental renal effects in heart failure patients treated with ACE-inhibitors. Eur J Heart Fail 6: 909-916 [Abstract] [Full Text]  
• Patrono, C., Coller, B., FitzGerald, G. A., Hirsh, J., Roth, G. (2004). Platelet-Active Drugs: The Relationships Among Dose, Effectiveness, and Side Effects: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126: 234S-264S [Abstract] [Full Text]  
• Lim, E., Ali, Z., Ali, A., Routledge, T., Edmonds, L., Altman, D. G, Large, S. (2003). Indirect comparison meta-analysis of aspirin therapy after coronary surgery. BMJ 327: 1309- [Abstract] [Full Text]  
• Nishimura, M., Hashimoto, T., Kobayashi, H., Fukuda, T., Okino, K., Yamamoto, N., Iwamoto, N., Nakamura, N., Yoshikawa, T., Ono, T. (2003). The high incidence of left atrial appendage thrombosis in patients on maintenance haemodialysis. Nephrol Dial Transplant 18: 2339-2347 [Abstract] [Full Text]  
• Brunner-La Rocca, H. P. (2003). Interaction of Angiotensin-Converting Enzyme Inhibition and Aspirin in Congestive Heart Failure: Long Controversy Finally Resolved?. Chest 124: 1192-1194 [Full Text]  
• Meune, C., Mourad, J.-J., Bergmann, J.-F., Spaulding, C. (2003). Interaction between cyclooxygenase and the renin-angiotensin-aldosterone system: rationale and clinical relevance. Journal of Renin-Angiotensin-Aldosterone System 4: 149-154 [Abstract]  
• Meune, C., Mahe, I., Mourad, J.-J., Cohen-Solal, A., Levy, B., Kevorkian, J.-P., Jondeau, G., Habib, A., Lebret, M., Knellwolf, A.-L., Simoneau, G., Caulin, C., Bergmann, J.-F. (2003). Aspirin alters arterial function in patients with chronic heart failure treated with ACE inhibitors: a dose-mediated deleterious effect. Eur J Heart Fail 5: 271-279 [Abstract] [Full Text]  
• Sharma, R.A. (2002). Translational medicine: targetting cyclo-oxygenase isozymes to prevent cancer. QJM 95: 267-273 [Full Text]  
• Bruno, A., McConnell, J. P., Mansbach, III, H. H., Cohen, S. N., Tietjen, G. E., Bang, N. U. (2002). Aspirin and Urinary 11-Dehydrothromboxane B2 in African American Stroke Patients. Stroke 33: 57-60 [Abstract] [Full Text]  
• Lindenfeld, J., Robertson, A. D., Lowes, B. D., Bristow, M. R., for the MOCHA Investigators, (2001). Aspirin impairs reverse myocardial remodeling in patients with heart failure treated with beta-blockers. J Am Coll Cardiol 38: 1950-1956 [Abstract] [Full Text]  
• Hurlen, M., Hole, T., Seljeflot, I., Arnesen, H. (2001). Aspirin does not influence the effect of angiotensin-converting enzyme inhibition on left ventricular ejection fraction 3 months after acute myocardial infarction. Eur J Heart Fail 3: 203-207 [Abstract] [Full Text]  
• Patrono, C., Coller, B., Dalen, J. E., FitzGerald, G. A., Fuster, V., Gent, M., Hirsh, J., Roth, G. (2001). Platelet-Active Drugs : The Relationships Among Dose, Effectiveness, and Side Effects. Chest 119 : 39S-63S [Full Text]  
• Stys, T., Lawson, W. E., Smaldone, G. C., Stys, A. (2000). Does Aspirin Attenuate the Beneficial Effects of Angiotensin-Converting Enzyme Inhibition in Heart Failure?. Arch Intern Med 160: 1409-1413 [Abstract] [Full Text]  
• The ARDS Network Authors for the ARDS Network, (2000). Ketoconazole for Early Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial. JAMA 283: 1995-2002 [Abstract] [Full Text]  
• Awtry, E. H., Loscalzo, J. (2000). Aspirin. Circulation 101: 1206-1218 [Full Text]  
• Iso, H., Hennekens, C. H., Stampfer, M. J., Rexrode, K. M., Colditz, G. A., Speizer, F. E., Willett, W. C., Manson, J. E. (1999). Prospective Study of Aspirin Use and Risk of Stroke in Women. Stroke 30: 1764-1771 [Abstract] [Full Text]  
• Katz, S. D., Radin, M., Graves, T., Hauck, C., Block, A., LeJemtel, T. H., for the Ifetroban Study Group, (1999). Effect of aspirin and ifetroban on skeletal muscle blood flow in patients with congestive heart failure treated with enalapril. J Am Coll Cardiol 34: 170-176 [Abstract] [Full Text]  
• Spaulding, C., Charbonnier, B., Cohen-Solal, A., Juilliere, Y., Kromer, E. P., Benhamda, K., Cador, R., Weber, S. (1998). Acute Hemodynamic Interaction of Aspirin and Ticlopidine With Enalapril : Results of a Double-Blind, Randomized Comparative Trial. Circulation 98: 757-765 [Abstract] [Full Text]  
• Patrono, C., Roth, G. J. (1996). Aspirin in Ischemic Cerebrovascular Disease : How Strong Is the Case for a Different Dosing Regimen?. Stroke 27: 756-760 [Abstract] [Full Text]  
• Minar, E., Ahmadi, A., Koppensteiner, R., Maca, Th., Stumpflen, A., Ugurluoglu, A., Ehringer, H. (1995). Comparison of Effects of High-Dose and Low-Dose Aspirin on Restenosis After Femoropopliteal Percutaneous Transluminal Angioplasty. Circulation 91: 2167-2173 [Abstract] [Full Text]  
• Panza, J. A., Garcia, C. E., Kilcoyne, C. M., Quyyumi, A. A., Cannon, R. O. III (1995). Impaired Endothelium-Dependent Vasodilation in Patients With Essential Hypertension : Evidence That Nitric Oxide Abnormality Is Not Localized to a Single Signal Transduction Pathway. Circulation 91: 1732-1738 [Abstract] [Full Text]  
• Patrono, C. (1994). Aspirin as an Antiplatelet Drug. NEJM 330: 1287-1294 [Full Text]  
• Kearon, C., Hirsh, J. (1993). Optimal Dose for Starting and Maintaining Low-Dose Aspirin. Arch Intern Med 153: 700-702 [Abstract]  
• Shebuski, R. J. (1993). Interruption of Thrombosis and Hemostasis by Anti-Platelet Agents. Toxicol Pathol 21: 180-189 [Abstract]  
• Becker, W. L., Burde, R. M. (1988). Carotid Artery Disease: A Therapeutic Enigma. Arch Ophthalmol 106: 34-39 [Abstract]  
• Numano, F., Maruyama, Y., Koyama, T., Numano, F. (1986). Antiaggregative Aspirin Dosage at the Affected Vessel Wall. ANGIOLOGY 37: 695-701 [Abstract]  
• Zucker, M. L., Trowbridge, C., Woodroof, J., Chernoff, S. B., Reynoso, L., Dujovne, C. A. (1986). Low- vs High-Dose Aspirin: Effects on Platelet Function in Hyperlipoproteinemic and Normal Subjects. Arch Intern Med 146: 921-925 [Abstract]  
• Satiani, B. (1985). A Prospective Randomized Trial of Aspirin in Femoral Popiteal and Tibial Bypass Grafts. ANGIOLOGY 36: 608-616 [Abstract]  
• Borhani, N. O. (1985). Prevention of Coronary Heart Disease in Practice: Implications of the Results of Recent Clinical Trials. JAMA 254: 257-262 [Abstract]  
• Poole, M. D., Pillsbury, H. C. III (1985). Prostaglandins and Other Metabolites of Arachidonic Acid: An Overview for the Otolaryngologist. Arch Otolaryngol Head Neck Surg 111: 317-321 [Abstract]  
• OLIVA, P. B. (1984). Unstable Rest Angina with ST-Segment Depression: Pathophysiologic Considerations and Therapeutic Implications. ANN INTERN MED 100: 424-440 [Abstract]