Because the current outbreak of acquired immunodeficiency syndrome (AIDS) among previously healthy adults may be caused by a transmissible biologic agent, and because it may be preceded by immunologic abnormalities with or without a prodromal illness, we studied seven female sexual partners of male patients with the syndrome. The male patients were all drug abusers. One of the seven women was found to have the full-blown syndrome, a second had an illness consistent with the prodrome of AIDS (generalized lymphadenopathy, lymphopenia, and a decreased ratio of helper to suppressor T cells), and four others had generalized lymphadenopathy or lymphopenia, with or without a decreased ratio of helper to suppressor T cells. Only one woman had no abnormalities. These findings suggest that AIDS may be transmitted between heterosexual men and women.
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[Abstract]
Sloand, E. M., Pitt, E., Chiarello, R. J., Nemo, G. J.
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[Abstract]
Brettler, D. B., Forsberg, A. D., Levine, P. H., Andrews, C. A., Baker, S., Sullivan, J. L.
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108: 321-327
[Abstract]
Peterman, T. A., Stoneburner, R. L., Allen, J. R., Jaffe, H. W., Curran, J. W.
(1988). Risk of Human Immunodeficiency Virus Transmission From Heterosexual Adults With Transfusion-Associated Infections. JAMA
259: 55-58
[Abstract]
Coates, R. A., Schechter, M. T.
(1988). Sexual Modes of Transmission of the Human Immunodeficiency Virus (HIV). Sex Abuse
1: 115-137
[Abstract]
Padian, N., Marquis, L., Francis, D. P., Anderson, R. E., Rutherford, G. W., O'Malley, P. M., Winkelstein, W. Jr
(1987). Male-to-Female Transmission of Human Immunodeficiency Virus. JAMA
258: 788-790
[Abstract]
VOGT, M. W., WITT, D. J., CRAVEN, D. E., BYINGTON, R., CRAWFORD, D. F., HUTCHINSON, M. S., SCHOOLEY, R. T., HIRSCH, M. S.
(1987). Isolation Patterns of the Human Immunodeficiency Virus from Cervical Secretions During the Menstrual Cycle of Women at Risk for the Acquired Immunodeficiency Syndrome. ANN INTERN MED
106: 380-382
[Abstract]
The Collaborative Study Group of AIDS in Haitian-A,
(1987). Risk Factors for AIDS Among Haitians Residing in the United States: Evidence of Heterosexual Transmission. JAMA
257: 635-639
[Abstract]
Fischl, M. A., Dickinson, G. M., Scott, G. B., Klimas, N., Fletcher, M. A., Parks, W.
(1987). Evaluation of Heterosexual Partners, Children, and Household Contacts of Adults With AIDS. JAMA
257: 640-644
[Abstract]
RAGNI, M. V., SPERO, J. A., BONTEMPO, F. A., LEWIS, J. H.
(1986). Recurrent Infections and Lymphadenopathy in the Child of a Hemophiliac: A Survey of Children of Hemophiliacs Positive for Human Immunodeficiency Virus Antibody. ANN INTERN MED
105: 886-887
[Abstract]
Quinn, T., Mann, J., Curran, J., Piot, P
(1986). AIDS in Africa: an epidemiologic paradigm. Science
234: 955-963
[Abstract]
Mann, J. M., Quinn, T. C., Francis, H., Nzilambi, N., Bosenge, N., Bila, K., McCormick, J. B., Ruti, K., Asila, P. K., Curran, J. W.
(1986). Prevalence of HTLV-III/LAV in Household Contacts of Patients With Confirmed AIDS and Controls in Kinshasa, Zaire. JAMA
256: 721-724
[Abstract]
Padian, N., Pickering, J.
(1986). Female-to-Male Transmission of AIDS: A Reexamination of the African Sex Ratio of Cases. JAMA
256: 590-590
[Abstract]
Gill, P. S., Levine, A. M., Meyer, P. R., Aguilar, S. L., Rarick, M., Parker, J. W., Rasheed, S.
(1986). Human T-Cell Lymphotropic Virus Type III Associated Disorders: The Spectrum in the Heterosexual Population. Arch Intern Med
146: 1501-1504
[Abstract]
Whittington, W. L., Kraus, S. J., Lee, F., Nahmias, A. J.
(1986). The Prevalence of HTLV-III/LAV Antibodies in Heterosexuals. JAMA
255: 1702-1703
[Abstract]
Jason, J. M., McDougal, J. S., Dixon, G., Lawrence, D. N., Kennedy, M. S., Hilgartner, M., Aledort, L., Evatt, B. L.
(1986). HTLV-III/LAV Antibody and Immune Status of Household Contacts and Sexual Partners of Persons With Hemophilia. JAMA
255: 212-215
[Abstract]
Ebbesen, P., Melbye, M., Beckmann, J.
(1986). Fear of AIDS: A Communication from Biologists to Psychologists/Sociologists. Scand J Public Health
14: 113-118
LEDERMAN, M. M.
(1986). Transmission of the Acquired Immunodeficiency Syndrome Through Heterosexual Activity. ANN INTERN MED
104: 115-117
[Abstract]
PAPE, J. W., LIAUTAUD, B., THOMAS, F., MATHURIN, J.-R., ST. AMAND, M.-M. A., BONCY, M., PEAN, V., PAMPHILE, M., LAROCHE, A. C., DEHOVITZ, J., JOHNSON, W. D.
(1985). The Acquired Immunodeficiency Syndrome in Haiti. ANN INTERN MED
103: 674-678
[Abstract]
(1985). Leads from the MMWR. JAMA
254: 2051-2054
Redfield, R. R., Markham, P. D., Salahuddin, S. Z., Wright, D. C., Sarngadharan, M. G., Gallo, R. C.
(1985). Heterosexually Acquired HTLV-III/LAV Disease (AIDS-Related Complex and AIDS) Epidemiologic Evidence for Female-to-Male Transmission. JAMA
254: 2094-2096
[Abstract]
Echenberg, D. F.
(1985). A New Strategy to Prevent the Spread of AIDS Among Heterosexuals. JAMA
254: 2129-2130
[Abstract]
West, T. E., Papasian, C. J., Park, B. H., Parker, S. W.
(1985). Adenovirus Type 2 Encephalitis and Concurrent Epstein-Barr Virus Infection in an Adult Man. Arch Neurol
42: 815-817
[Abstract]
Friedland, G. H., Harris, C., Butkus-Small, C., Shine, D., Moll, B., Darrow, W., Klein, R. S.
(1985). Intravenous Drug Abusers and the Acquired Immunodeficiency Syndrome (AIDS) Demographic, Drug Use, and Needle-Sharing Patterns. Arch Intern Med
145: 1413-1417
[Abstract]
FAUCI, A. S., MASUR, H., GELMANN, E. P., MARKHAM, P. D., HAHN, B. H., LANE, H. C.
(1985). The Acquired Immunodeficiency Syndrome: An Update. ANN INTERN MED
102: 800-813
[Abstract]
KREISS, J. K., KITCHEN, L. W., PRINCE, H. E., KASPER, C. K., ESSEX, M.
(1985). Antibody to Human T-Lymphotropic Virus Type III in Wives of Hemophiliacs: Evidence for Heterosexual Transmission. ANN INTERN MED
102: 623-626
[Abstract]
Profeta, S., Forrester, C., Eng, R. H. K., Liu, R., Johnson, E., Palinkas, R., Smith, S. M.
(1985). Salmonella Infections in Patients With Acquired Immunodeficiency Syndrome. Arch Intern Med
145: 670-672
[Abstract]
Redfield, R. R., Markham, P. D., Salahuddin, S. Z., Sarngadharan, M. G., Bodner, A. J., Folks, T. M., Ballou, W. R., Wright, D. C., Gallo, R. C.
(1985). Frequent Transmission of HTLV-III Among Spouses of Patients With AIDS-Related Complex and AIDS. JAMA
253: 1571-1573
[Abstract]
Levine, A. M., Burkes, R. L., Walker, M., Meyer, P. R., Gill, P. S., Nichols, P. W., Dworsky, R., Parker, J. W., Lukes, R. J.
(1985). B-Cell Lymphoma in Two Monogamous Homosexual Men. Arch Intern Med
145: 479-481
[Abstract]
Quinn, T. C.
(1985). Perspectives on the Future of AIDS. JAMA
253: 247-249
[Abstract]
GROOPMAN, J. E., SARNGADHARAN, M. G., SALAHUDDIN, S. Z., BUXBAUM, R., HUBERMAN, M. S., KINNIBURGH, J., SLISKI, A., McLANE, M. F., ESSEX, M., GALLO, R. C.
(1985). Apparent Transmission of Human T-Cell Leukemia Virus Type III to a Heterosexual Woman with the Acquired Immunodeficiency Syndrome. ANN INTERN MED
102: 63-66
[Abstract]
(1984). Leads from the MMWR. JAMA
252: 3355-3356
CHAMBERLAND, M. E., CASTRO, K. G., HAVERKOS, H. W., MILLER, B. I., THOMAS, P. A., REISS, R., WALKER, J., SPIRA, T. J., JAFFE, H. W., CURRAN, J. W.
(1984). Acquired Immunodeficiency Syndrome in the United States: An Analysis of Cases Outside High-Incidence Groups. ANN INTERN MED
101: 617-623
[Abstract]
Ho, D., Schooley, R., Rota, T., Kaplan, J., Flynn, T, Salahuddin, S., Gonda, M., Hirsch, M.
(1984). HTLV-III in the semen and blood of a healthy homosexual man. Science
226: 451-453
[Abstract]
Council on Scientific Affairs,
(1984). The Acquired Immunodeficiency Syndrome: Commentary. JAMA
252: 2037-2043
[Abstract]
Thomas, P. A., Jaffe, H. W., Spira, T. J., Reiss, R., Guerrero, I. C., David,
(1984). Unexplained Immunodeficiency in Children: A Surveillance Report. JAMA
252: 639-644
[Abstract]
Cole, E. L., Meisler, D. M., Calabrese, L. H., Holland, G. N., Mondino, B. J., Conant, M. A.
(1984). Herpes Zoster Ophthalmicus and Acquired Immune Deficiency Syndrome. Arch Ophthalmol
102: 1027-1029
[Abstract]
ABRAMS, D. I., LEWIS, B. J., BECKSTEAD, J. H., CASAVANT, C. A., DREW, W. L.
(1984). Persistent Diffuse Lymphadenopathy in Homosexual Men: Endpoint or Prodrome?. ANN INTERN MED
100: 801-808
[Abstract]
Kreiss, J. K., Kasper, C. K., Fahey, J. L., Weaver, M., Visscher, B. R., Stewart, J. A., Lawrence, D. N.
(1984). Nontransmission of T-Cell Subset Abnormalities From Hemophiliacs to Their Spouses. JAMA
251: 1450-1454
[Abstract]
KREISS, J. K., LAWRENCE, D. N., KASPER, C. K., GOLDSTEIN, A. L., NAYLOR, P. H., McLANE, M. F., LEE, T.-H., ESSEX, M.
(1984). Antibody to Human T-Cell Leukemia Virus Membrane Antigens, Beta2-Microglobulin Levels, and Thymosin Alpha1 Levels in Hemophiliacs and Their Spouses. ANN INTERN MED
100: 178-182
[Abstract]
GUINAN, M. E., THOMAS, P. A., PINSKY, P. F., GOODRICH, J. T., SELIK, R. M., JAFFE, H. W., HAVERKOS, H. W., NOBLE, G., CURRAN, J. W.
(1984). Heterosexual and Homosexual Patients with the Acquired Immunodeficiency Syndrome: A Comparison of Surveillance, Interview, and Laboratory Data. ANN INTERN MED
100: 213-218
[Abstract]
CURRAN, J. W., BARKER, L. F.
(1984). The Acquired Immunodeficiency Syndrome Associated with Transfusions: The Evolving Perspective. ANN INTERN MED
100: 298-300
[Abstract]
Mavligit, G. M., Talpaz, M., Hsia, F. T., Wong, W., Lichtiger, B., Mansell, P. W. A., Mumford, D. M.
(1984). Chronic Immune Stimulation by Sperm Alloantigens: Support for the Hypothesis That Spermatozoa Induce Immune Dysregulation in Homosexual Males. JAMA
251: 237-241
[Abstract]
PITCHENIK, A. E., SHAFRON, R. D., GLASSER, R. M., SPIRA, T. J.
(1984). The Acquired Immunodeficiency Syndrome in the Wife of a Hemophiliac. ANN INTERN MED
100: 62-65
[Abstract]
FAUCI, A. S., MACHER, A. M., LONGO, D. L., LANE, H. C., ROOK, A. H., MASUR, H., GELMANN, E. P.
(1984). Acquired Immunodeficiency Syndrome: Epidemiologic, Clinical, Immunologic, and Therapeutic Considerations. ANN INTERN MED
100: 92-106
[Abstract]
Rosner, F., Giron, J. A.
(1983). Immune Deficiency Syndrome in Children. JAMA
250: 3046-3046
[Abstract]
Landesman, S. H., Vieira, J.
(1983). Acquired Immune Deficiency Syndrome (AIDS) A Review. Arch Intern Med
143: 2307-2309
[Abstract]
JETT, J. R., KURITSKY, J. N., KATZMANN, J. A., HOMBURGER, H. A.
(1983). Acquired Immunodeficiency Syndrome Associated with Blood-Product Transfusions. ANN INTERN MED
99: 621-624
[Abstract]
METROKA, C. E., MOURADIAN, J., CUNNINGHAM-RUNDLES, S.
(1983). The Acquired Immunodeficiency Syndrome. ANN INTERN MED
99: 734-736
[Abstract]
KLEIN, R. S., MANN, D. N., FRIEDLAND, G. H., SURKS, M. I.
(1983). Adrenocortical Function in the Acquired Immunodeficiency Syndrome. ANN INTERN MED
99: 566-566
[Abstract]
KAUR, J., MYERS, A. M.
(1983). Homosexuality, Steroid Therapy, and Histoplasmosis. ANN INTERN MED
99: 567-567
[Abstract]
BEACH, R. S., LAURA, P. F.
(1983). Nutrition and the Acquired Immunodeficiency Syndrome. ANN INTERN MED
99: 565-566
[Abstract]
Pitchenik, A. E., Fischl, M. A., Spira, T. J.
(1983). Acquired Immune Deficiency Syndrome in Low-Risk Patients: Evidence for Possible Transmission by an Asymptomatic Carrier. JAMA
250: 1310-1312
[Abstract]
RUBINSTEIN, A.
(1983). Acquired Immunodeficiency Syndrome in Infants. Arch Pediatr Adolesc Med
137: 825-827
[Abstract]
GOTTLIEB, M. S., GROOPMAN, J. E., WEINSTEIN, W. M., FAHEY, J. L., DETELS, R.
(1983). The Acquired Immunodeficiency Syndrome. ANN INTERN MED
99: 208-220
[Abstract]
