FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 308:1502-1505 June 23, 1983 Number 25 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

Two adults and 13 children with exercise-induced asthma had both immediate and late reductions in forced expiratory volume in one second (FEV1) after treadmill exercise. The late reactions developed 4 to 10 hours after exercise and in each instance were associated with wheezing or chest tightness (or both). Increases in neutrophil chemotactic activity, measured in the 2 adults and in 11 of the children, accompanied the reductions in FEV1 in all these subjects. In contrast, four other adults with only an immediate fall in FEV1 after exercise had only an initial elevation in neutrophil chemotactic activity, with no subsequent increase for the remaining 24-hour period. The agent responsible for the neutrophil chemotactic activity released during exercise-induced late reactions appeared to be identical to that released during immediate reactions. These observations suggest that some patients with exercise-induced asthma have late reactions that, as in the case of antigen-induced bronchoconstriction, are accompanied by the release of neutrophil chemotactic activity.

This article has been cited by other articles:

• Tsao, C.-H., Chen, L.-C., Yeh, K.-W., Huang, J.-L. (2003). Concomitant Chronic Sinusitis Treatment in Children With Mild Asthma: The Effect on Bronchial Hyperresponsiveness. Chest 123: 757-764 [Abstract] [Full Text]  
• Davis, M. S., Royer, C. M., Payton, M., Buttress, B. (2002). Modeling the acute- and late-phase responses to peripheral airway cooling and desiccation. J. Appl. Physiol. 93: 195-200 [Abstract] [Full Text]  
• SUZUKI, R., FREED, A. N. (2002). Heparin Inhibits Hyperventilation-Induced Late-Phase Hyperreactivity in Dogs. Am. J. Respir. Crit. Care Med. 165: 27-33 [Abstract] [Full Text]