FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 309:344-347 August 11, 1983 Number 6 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

The thiazide diuretics are known to cause calcium retention. In order to study the effect of thiazides on bone mineralization, we have measured the mineral content of bone at five sites (the distal radius, the distal ulna, the proximal radius, the proximal ulna, and the os calcis) in 1368 men with a mean age of 68 years, including 323 who were taking thiazides for hypertension. The results were adjusted for age and body-mass index. Thiazide users had significantly more bone mineral content at all five sites than did non-users. Untreated hypertensive patients and persons without hypertension had comparable bone mineral content, indicating that the higher mineral content found among thiazide users is related to the drug and not to the underlying hypertension. These findings suggest the possibility of a preventive or therapeutic role for thiazides in osteoporosis.

This article has been cited by other articles:

• Dvorak, M. M., De Joussineau, C., Carter, D. H., Pisitkun, T., Knepper, M. A., Gamba, G., Kemp, P. J., Riccardi, D. (2007). Thiazide Diuretics Directly Induce Osteoblast Differentiation and Mineralized Nodule Formation by Interacting with a Sodium Chloride Co-Transporter in Bone. J. Am. Soc. Nephrol. 18: 2509-2516 [Abstract] [Full Text]  
• Hoenderop, J. G. J., Nilius, B., Bindels, R. J. M. (2005). Calcium Absorption Across Epithelia. Physiol. Rev. 85: 373-422 [Abstract] [Full Text]  
• Schoofs, M. W.C.J., van der Klift, M., Hofman, A., de Laet, C. E.D.H., Herings, R. M.C., Stijnen, T., Pols, H. A.P., Stricker, B. H.Ch. (2003). Thiazide Diuretics and the Risk for Hip Fracture. ANN INTERN MED 139: 476-482 [Abstract] [Full Text]  
• Hackam, D. G, Ashcroft, J. S (2003). Drug treatment of hypertension. BMJ 326: 764-764 [Full Text]  
• Bobrow, R. S., Cappuccio, F. P., Klibanski, A. (2001). Thiazide Use and Reduced Sodium Intake for Prevention of Osteoporosis. JAMA 285: 2323-2324 [Full Text]  
• LaCroix, A. Z., Ott, S. M., Ichikawa, L., Scholes, D., Barlow, W. E. (2000). Low-Dose Hydrochlorothiazide and Preservation of Bone Mineral Density in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. ANN INTERN MED 133: 516-526 [Abstract] [Full Text]  
• Adams, J. S., Song, C. F., Kantorovich, V. (1999). Rapid Recovery of Bone Mass in Hypercalciuric, Osteoporotic Men Treated with Hydrochlorothiazide. ANN INTERN MED 130: 658-660 [Abstract] [Full Text]  
• Carasiti, M. E. (1990). Diuretics--Current Issues and Updates. Journal of Pharmacy Practice 3: 295-304