FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 309:396-403 August 18, 1983 Number 7 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

We conducted a multicenter, double-blind, placebo-controlled randomized trial of aspirin treatment (324 mg in buffered solution daily) for 12 weeks in 1266 men with unstable angina (625 taking aspirin and 641 placebo). The principal end points were death and acute myocardial infarction diagnosed by the presence of creatine kinase MB or pathologic Q-wave changes on electrocardiograms. The incidence of death or acute myocardial infarction was 51 per cent lower in the aspirin group than in the placebo group: 31 patients (5.0 per cent) as compared with 65 (10.1 per cent); P = 0.0005. Nonfatal acute myocardial infarction was 51 per cent lower in the aspirin group: 21 patients (3.4 per cent) as compared with 44 (6.9 per cent); P = 0.005. The reduction in mortality in the aspirin group was also 51 per cent--10 patients (1.6 per cent) as compared with 21 (3.3 per cent)--although it was not statistically significant; P = 0.054. There was no difference in gastrointestinal symptoms or evidence of blood loss between the treatment and control groups. Our data show that aspirin has a protective effect against acute myocardial infarction in men with unstable angina, and they suggest a similar effect on mortality.

This article has been cited by other articles:

• Nappi, J. (2008). Benefits and limitations of current antiplatelet therapies. Am J Health Syst Pharm 65: S5-S10 [Abstract] [Full Text]  
• Patrono, C., Baigent, C., Hirsh, J., Roth, G. (2008). Antiplatelet Drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133: 199S-233S [Abstract] [Full Text]  
• Harrington, R. A., Becker, R. C., Cannon, C. P., Gutterman, D., Lincoff, A. M., Popma, J. J., Steg, G., Guyatt, G. H., Goodman, S. G. (2008). Antithrombotic Therapy for Non-ST-Segment Elevation Acute Coronary Syndromes: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133: 670S-707S [Abstract] [Full Text]  
• FitzGerald, G. A. (2008). Summary. Arterioscler. Thromb. Vasc. Bio. 28: s51-s52 [Full Text]  
• Patrono, C., Rocca, B. (2008). Aspirin: Promise and Resistance in the New Millennium. Arterioscler. Thromb. Vasc. Bio. 28: s25-s32 [Abstract] [Full Text]  
• Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E. Jr, Chavey, W. E. II, Fesmire, F. M., Hochman, J. S., Levin, T. N., Lincoff, A. M., Peterson, E. D., Theroux, P., Wenger, N. K., Wright, R. S., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2007). ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol 50: e1-e157 [Full Text]  
• Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E. Jr, Chavey, W. E. II, Fesmire, F. M., Hochman, J. S., Levin, T. N., Lincoff, A. M., Peterson, E. D., Theroux, P., Wenger, N. K., Wright, R. S., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2007). ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol 50: 652-726 [Full Text]  
• Meadows, T. A., Bhatt, D. L. (2007). Clinical Aspects of Platelet Inhibitors and Thrombus Formation. Circ. Res. 100: 1261-1275 [Abstract] [Full Text]  
• Elwood, P. (2006). The first randomized trial of aspirin for heart attack and the advent of systematic overviews of trials. JRSM 99: 586-588 [Full Text]  
• Mehta, S. R. (2006). Clopidogrel in non-ST-segment elevation acute coronary syndromes. Eur Heart J Suppl 8: G25-G30 [Abstract] [Full Text]  
• (2005). Part 5: Acute Coronary Syndromes. Circulation 112: III-55-III-72 [Full Text]  
• Masoudi, F. A., Wolfe, P., Havranek, E. P., Rathore, S. S., Foody, J. M., Krumholz, H. M. (2005). Aspirin Use in Older Patients With Heart Failure and Coronary Artery Disease: National Prescription Patterns and Relationship With Outcomes. J Am Coll Cardiol 46: 955-962 [Abstract] [Full Text]  
• Saseen, J. J. (2005). ASHP Therapeutic Position Statement on the Daily Use of Aspirin for Preventing Cardiovascular Events. Am J Health Syst Pharm 62: 1398-1405 [Full Text]  
• Gluckman, T. J., Sachdev, M., Schulman, S. P., Blumenthal, R. S. (2005). A Simplified Approach to the Management of Non-ST-Segment Elevation Acute Coronary Syndromes. JAMA 293: 349-357 [Abstract] [Full Text]  
• Spratt, J C, Camenzind, E (2004). Plaque stabilisation by systemic and local drug administration. Heart 90: 1392-1394 [Full Text]  
• Tran, H., Anand, S. S. (2004). Oral Antiplatelet Therapy in Cerebrovascular Disease, Coronary Artery Disease, and Peripheral Arterial Disease. JAMA 292: 1867-1874 [Abstract] [Full Text]  
• Wiggins, B. S., Spinler, S. (2004). Antiplatelet and Antithrombin Therapy for Early Management of Acute Coronary Syndromes. Journal of Pharmacy Practice 17: 347-369 [Abstract]  
• Lappe, J. M., Muhlestein, J. B., Lappe, D. L., Badger, R. S., Bair, T. L., Brockman, R., French, T. K., Hofmann, L. C., Horne, B. D., Kralick-Goldberg, S., Nicponski, N., Orton, J. A., Pearson, R. R., Renlund, D. G., Rimmasch, H., Roberts, C., Anderson, J. L. (2004). Improvements in 1-Year Cardiovascular Clinical Outcomes Associated with a Hospital-Based Discharge Medication Program. ANN INTERN MED 141: 446-453 [Abstract] [Full Text]  
• Casey, K., Tonnessen, B. H., Sternbergh, W. C. III, Money, S. R. (2004). Medical Management of Intermittent Claudication. VASC ENDOVASCULAR SURG 38: 391-399 [Abstract]  
• Patrono, C., Coller, B., FitzGerald, G. A., Hirsh, J., Roth, G. (2004). Platelet-Active Drugs: The Relationships Among Dose, Effectiveness, and Side Effects: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126: 234S-264S [Abstract] [Full Text]  
• Harrington, R. A., Becker, R. C., Ezekowitz, M., Meade, T. W., O'Connor, C. M., Vorchheimer, D. A., Guyatt, G. H. (2004). Antithrombotic Therapy for Coronary Artery Disease: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126: 513S-548S [Abstract] [Full Text]  
• Quinn, M. J., Aronow, H. D., Califf, R. M., Bhatt, D. L., Sapp, S., Kleiman, N. S., Harrington, R. A., Kong, D. F., Kandzari, D. E., Topol, E. J. (2004). Aspirin dose and six-month outcome after an acute coronary syndrome. J Am Coll Cardiol 43: 972-978 [Abstract] [Full Text]  
• Lepantalo, A., Virtanen, K. S, Heikkila, J., Wartiovaara, U., Lassila, R. (2004). Limited early antiplatelet effect of 300 mg clopidogrel in patients with aspirin therapy undergoing percutaneous coronary interventions. Eur Heart J 25: 476-483 [Abstract] [Full Text]  
• Behan, M W H, Storey, R F (2004). Antiplatelet therapy in cardiovascular disease. Postgrad. Med. J. 80: 155-164 [Abstract] [Full Text]  
• Gurfinkel, E. P., Leon de la Fuente, R., Mendiz, O., Mautner, B. (2004). Flu vaccination in acute coronary syndromes and planned percutaneous coronary interventions (FLUVACS) Study: One-year follow-up. Eur Heart J 25: 25-31 [Abstract] [Full Text]  
• Kramer, J. M, Newby, L.K., Chang, W.-C., Simes, R.J., Van de Werf, F., Granger, C. B, Lee, K. L, White, H. D, Piegas, L. S, Topol, E. J, Califf, R. M, Armstrong, P. W, for the SYMPHONY and 2nd SYMPHONY Investigators, (2003). International variation in the use of evidence-based medicines for acute coronary syndromes. Eur Heart J 24: 2133-2141 [Abstract] [Full Text]  
• Peters, R. J.G., Mehta, S. R., Fox, K. A.A., Zhao, F., Lewis, B. S., Kopecky, S. L., Diaz, R., Commerford, P. J., Valentin, V., Yusuf, S., for the Clopidogrel in Unstable angina to prevent, (2003). Effects of Aspirin Dose When Used Alone or in Combination With Clopidogrel in Patients With Acute Coronary Syndromes: Observations From the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Study. Circulation 108: 1682-1687 [Abstract] [Full Text]  
• Jneid, H., Bhatt, D. L., Corti, R., Badimon, J. J., Fuster, V., Francis, G. S. (2003). Aspirin and Clopidogrel in Acute Coronary Syndromes: Therapeutic Insights From the CURE Study. Arch Intern Med 163: 1145-1153 [Abstract] [Full Text]  
• Hersi, A., Fu, Y., Wong, B., Mahaffey, K.W., Harrington, R.A., Califf, R.M., Van de Werf, F., Armstrong, P.W., for the PARAGON-B Investigators, (2003). Does the discharge ECG provide additional prognostic insight(s) in non-ST elevation ACS patients from that acquired on admission?. Eur Heart J 24: 522-531 [Abstract] [Full Text]  
• Mehta, S. R., Yusuf, S. (2003). Short- and long-term oral antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention. J Am Coll Cardiol 41: 79S-88S [Abstract] [Full Text]  
• Herth, F. J.F., Becker, H.D., Ernst, A. (2002). Aspirin Does Not Increase Bleeding Complications After Transbronchial Biopsy. Chest 122: 1461-1464 [Abstract] [Full Text]  
• Steg, P G, Iung, B, Feldman, L J, Cokkinos, D, Deckers, J, Fox, K A A, Keil, U, Maggioni, A P (2002). Impact of availability and use of coronary interventions on the prescription of aspirin and lipid lowering treatment after acute coronary syndromes. Heart 88: 20-24 [Abstract] [Full Text]  
• Roffi, M., Chew, D. P., Mukherjee, D., Bhatt, D. L., White, J. A., Heeschen, C., Hamm, C. W., Moliterno, D. J., Califf, R. M., White, H. D., Kleiman, N. S., Theroux, P., Topol, E. J. (2001). Platelet Glycoprotein IIb/IIIa Inhibitors Reduce Mortality in Diabetic Patients With Non-ST-Segment-Elevation Acute Coronary Syndromes. Circulation 104: 2767-2771 [Abstract] [Full Text]  
• Vila, J. M, Martinez-Leon, J. B, Medina, P., Segarra, G., Ballester, R. M, Otero, E., Lluch, S. (2001). U-46619-induced potentiation of noradrenergic constriction in the human saphenous vein: antagonism by thromboxane receptor blockade. Cardiovasc Res 52: 462-467 [Abstract] [Full Text]  
• Woollard, M, Smith, A, Elwood, P (2001). Pre-hospital aspirin for suspected myocardial infarction and acute coronary syndromes: A headache for paramedics?. Emerg. Med. J. 18: 478-481 [Abstract] [Full Text]  
• Fihn, S. D., Williams, S. V., Daley, J., Gibbons, R. J. (2001). Guidelines for the Management of Patients with Chronic Stable Angina: Treatment. ANN INTERN MED 135: 616-632 [Abstract] [Full Text]  
• Newby, D. E, Fox, K. A A (2001). Unstable angina: the first 48 hours and later in-hospital management. Br Med Bull 59: 69-87 [Abstract] [Full Text]  
• Gum, P. A., Thamilarasan, M., Watanabe, J., Blackstone, E. H., Lauer, M. S. (2001). Aspirin Use and All-Cause Mortality Among Patients Being Evaluated for Known or Suspected Coronary Artery Disease: A Propensity Analysis. JAMA 286: 1187-1194 [Abstract] [Full Text]  
• Fleming, D. J, Jacques, P. F, Massaro, J. M, D'Agostino, R. B Sr, Wilson, P. W., Wood, R. J (2001). Aspirin intake and the use of serum ferritin as a measure of iron status. Am. J. Clin. Nutr. 74: 219-226 [Abstract] [Full Text]  
• Cruz-Fernandez, J.M. (2001). Antiplatelet drugs in the treatment of acute coronary syndromes: Focus on cyclooxygenase inhibitors. Eur Heart J Suppl 3: I23-I30 [Abstract]  
• Zvara, D. A. (2001). Treatment of Perioperative Myocardial Ischemia. SEMIN CARDIOTHORAC VASC ANESTH 5: 166-183 [Abstract]  
• Turpie, A. G. G., Antman, E. M. (2001). Low-Molecular-Weight Heparins in the Treatment of Acute Coronary Syndromes. Arch Intern Med 161: 1484-1490 [Abstract] [Full Text]  
• Levine, G. N., Ali, M. N., Schafer, A. I. (2001). Antithrombotic Therapy in Patients With Acute Coronary Syndromes. Arch Intern Med 161: 937-948 [Abstract] [Full Text]  
• Meagher, E. A., Barry, O. P., Lawson, J. A., Rokach, J., FitzGerald, G. A. (2001). Effects of Vitamin E on Lipid Peroxidation in Healthy Persons. JAMA 285: 1178-1182 [Abstract] [Full Text]  
• Rauch, U., Osende, J. I., Fuster, V., Badimon, J. J., Fayad, Z., Chesebro, J. H. (2001). Thrombus Formation on Atherosclerotic Plaques: Pathogenesis and Clinical Consequences. ANN INTERN MED 134: 224-238 [Abstract] [Full Text]  
• Patrono, C., Coller, B., Dalen, J. E., FitzGerald, G. A., Fuster, V., Gent, M., Hirsh, J., Roth, G. (2001). Platelet-Active Drugs : The Relationships Among Dose, Effectiveness, and Side Effects. Chest 119: 39S-63S [Full Text]  
• Manhapra, A., Borzak, S. (2000). Regular review: Treatment possibilities for unstable angina. BMJ 321: 1269-1275 [Full Text]  
• Ageno, W., Turpie, A. G. (2000). Therapy of unstable angina with the low molecular weight heparins. Vasc Med 5: 217-223 [Abstract]  
• Braunwald, E., Antman, E. M., Beasley, J. W., Califf, R. M., Cheitlin, M. D., Hochman, J. S., Jones, R. H., Kereiakes, D., Kupersmith, J., Levin, T. N., Pepine, C. J., Schaeffer, J. W., Smith, E. E. III, Steward, D. E., Theroux, P., Gibbons, R. J., Alpert, J. S., Eagle, K. A., Faxon, D. P., Fuster, V., Gardner, T. J., Gregoratos, G., Russell, R. O., Smith, S. C. Jr (2000). ACC/AHA guidelines for the management of patients with unstable angina and non-st-segment elevation myocardial infarction: A report of the american college of cardiology/ american heart association task force on practice guidelines (committee on the management of patients with unstable angina). J Am Coll Cardiol 36: 970-1062 [Full Text]  
• Pratico, D., Cheng, Y., FitzGerald, G. A. (2000). TP or Not TP: Primary Mediators in a Close Runoff?. Arterioscler. Thromb. Vasc. Bio. 20: 1695-1698 [Full Text]  
• Abrahamsson, P, Rosengren, A, Dellborg, M (2000). Improved long-term prognosis for patients with unstable coronary syndromes 1988-1995. Eur Heart J 21: 533-539 [Abstract]  
• Lincoff, A. M., Califf, R. M., Topol, E. J. (2000). Platelet glycoprotein IIb/IIIa receptor blockade in coronary artery disease. J Am Coll Cardiol 35: 1103-1115 [Abstract] [Full Text]  
• Awtry, E. H., Loscalzo, J. (2000). Aspirin. Circulation 101: 1206-1218 [Full Text]  
• Kawasaki, T., Ozeki, Y., Igawa, T., Kambayashi, J.-i. (2000). Increased Platelet Sensitivity to Collagen in Individuals Resistant to Low-Dose Aspirin. Stroke 31: 591-595 [Abstract] [Full Text]  
• Brodison, A., Katira, R., More, R. S, Chauhan, A. (2000). Current practice: Antiplatelet use in interventional cardiology. Postgrad. Med. J. 76: 70-79 [Abstract] [Full Text]  
• Yeghiazarians, Y., Braunstein, J. B., Askari, A., Stone, P. H. (2000). Unstable Angina Pectoris. NEJM 342: 101-114 [Full Text]  
• Ambrose, J. A., Dangas, G. (2000). Unstable Angina: Current Concepts of Pathogenesis and Treatment. Arch Intern Med 160: 25-37 [Abstract] [Full Text]  
• Oldgren, J., Linder, R., Grip, L., Siegbahn, A., Wallentin, L. (1999). Activated partial thromboplastin time and clinical outcome after thrombin inhibition in unstable coronary artery disease. Eur Heart J 20: 1657-1666 [Abstract]  
• Purcell, H., Fox, K.M. (1999). Improving outcome in acute coronary syndromes -- as good as it gets?. Eur Heart J 20: 1533-1537  
• Zhao, X.-Q., Theroux, P., Snapinn, S. M., Sax, F. L. (1999). Intracoronary Thrombus and Platelet Glycoprotein IIb/IIIa Receptor Blockade With Tirofiban in Unstable Angina or Non-Q-Wave Myocardial Infarction : Angiographic Results From the PRISM-PLUS Trial (Platelet Receptor Inhibition for Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms). Circulation 100: 1609-1615 [Abstract] [Full Text]  
• Klein, M., Keith, P.R., Dauben, H.-P., Schulte, H.D., Beckmann, H., Mayer, G., Elert, O., Gams, E. (1999). Aprotinin counterbalances an increased risk of peri-operative haemorrhage in CABG patients pre-treated with Aspirin. Eur. J. Cardiothorac. Surg. 14: 360-366 [Abstract] [Full Text]  
• Zed, P. J., Tisdale, J. E., Borzak, S. (1999). Low-Molecular-Weight Heparins in the Management of Acute Coronary Syndromes. Arch Intern Med 159: 1849-1857 [Abstract] [Full Text]  
• Gorelick, P. B., Born, G. V. R., D'Agostino, R. B., Hanley, D. F. Jr, Moye, L., Pepine, C. J. (1999). Therapeutic Benefit : Aspirin Revisited in Light of the Introduction of Clopidogrel. Stroke 30: 1716-1721 [Abstract] [Full Text]  
• Gibbons, R. J., Chatterjee, K., Daley, J., Douglas, J. S., Fihn, S. D., Gardin, J. M., Grunwald, M. A., Levy, D., Lytle, B. W., O'Rourke, R. A., Schafer, W. P., Williams, S. V., Ritchie, J. L., Gibbons, R. J., Cheitlin, M. D., Eagle, K. A., Gardner, T. J., Garson, A. Jr, Russell, R. O., Ryan, T. J., Smith, S. C. Jr (1999). ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Chronic Stable Angina). J Am Coll Cardiol 33: 2092-2197 [Full Text]  
• KENNON, S, TIMMIS, A (1999). Management of unstable angina: what role intervention, ask the RITA-3 trialists?. Heart 81: 565-566 [Full Text]  
• van der Loo, B., Martin, J. F. (1999). A Role for Changes in Platelet Production in the Cause of Acute Coronary Syndromes. Arterioscler. Thromb. Vasc. Bio. 19: 672-679 [Abstract] [Full Text]  
• Zaacks, S. M., Liebson, P. R., Calvin, J. E., Parrillo, J. E., Klein, L. W. (1999). Unstable angina and non-Q wave myocardial infarction: does the clinical diagnosis have therapeutic implications?. J Am Coll Cardiol 33: 107-118 [Abstract] [Full Text]  
• Reilly, M. P., Pratico, D., Delanty, N., DiMinno, G., Tremoli, E., Rader, D., Kapoor, S., Rokach, J., Lawson, J., FitzGerald, G. A. (1998). Increased Formation of Distinct F2 Isoprostanes in Hypercholesterolemia. Circulation 98: 2822-2828 [Abstract] [Full Text]  
• Alexander, K. P., Peterson, E. D., Granger, C. B., Casas, A. C., Van de Werf, F., Armstrong, P. W., Guerci, A., Topol, E. J., Califf, R. M., for the GUSTO-IIB Investigators, (1998). Potential impact of evidence-based medicine in acute coronary syndromes: insights from GUSTO-IIb. J Am Coll Cardiol 32: 2023-2030 [Abstract] [Full Text]  
• Halon, D. A., Flugelman, M. Y., Merdler, A., Rennert, H., Shahla, J., Lewis, B. S. (1998). Long-term (10-year) outcome in patients with unstable angina pectoris treated by coronary balloon angioplasty. J Am Coll Cardiol 32: 1603-1609 [Abstract] [Full Text]  
• Ritchie, M. E. (1998). Nuclear Factor-{kappa}B Is Selectively and Markedly Activated in Humans With Unstable Angina Pectoris. Circulation 98: 1707-1713 [Abstract] [Full Text]  
• Spaulding, C., Charbonnier, B., Cohen-Solal, A., Juilliere, Y., Kromer, E. P., Benhamda, K., Cador, R., Weber, S. (1998). Acute Hemodynamic Interaction of Aspirin and Ticlopidine With Enalapril : Results of a Double-Blind, Randomized Comparative Trial. Circulation 98: 757-765 [Abstract] [Full Text]  
• Giugliano, R. P., Camargo, C. A. Jr, Lloyd-Jones, D. M., Zagrodsky, J. D., Alexis, J. D., Eagle, K. A., Fuster, V., O'Donnell, C. J. (1998). Elderly Patients Receive Less Aggressive Medical and Invasive Management of Unstable Angina: Potential Impact of Practice Guidelines. Arch Intern Med 158: 1113-1120 [Abstract] [Full Text]  
• The Platelet Receptor Inhibition in Ischemic Syndr, (1998). A Comparison of Aspirin plus Tirofiban with Aspirin plus Heparin for Unstable Angina. NEJM 338: 1498-1505 [Abstract] [Full Text]  
• (1998). Management of unstable angina. DTB 36: 36-39 [Abstract] [Full Text]  
• Eccles, M., Freemantle, N., Mason, J., Group, t. N. o. E. A. G. D. (1998). North of England evidence based guideline development project: guideline on the use of aspirin as secondary prophylaxis for vascular disease in primary care. BMJ 316: 1303-1309 [Full Text]  
• Theroux, P., Fuster, V. (1998). Acute Coronary Syndromes : Unstable Angina and Non–Q-Wave Myocardial Infarction. Circulation 97: 1195-1206 [Full Text]  
• Braunwald, E. (1997). Cardiovascular Medicine at the Turn of the Millennium: Triumphs, Concerns, and Opportunities. NEJM 337: 1360-1369 [Full Text]  
• Lehmann, K. G., van Suylen, R. J., Stibbe, J., Slager, C. J., Oomen, J. A., Maas, A., di Mario, C., deFeyter, P., Serruys, P. W. (1997). Composition of Human Thrombus Assessed by Quantitative Colorimetric Angioscopic Analysis. Circulation 96: 3030-3041 [Abstract] [Full Text]  
• Owa, M., Origasa, H., Saito, M., Owa, M. (1997). Predictive Validity of the Braunwald Classification of Unstable Angina for Angiographic Findings, Short-Term Prognoses, and Treatment Selection. ANGIOLOGY 48: 663-671 [Abstract]  
• Van Miltenburg-Van Zijl, A. J.M., Bossuyt, P. M.M., Nette, R. W., Simoons, M. L., Taylor, T. R. (1997). Cardiologists' Use of Clinical Information for Management Decisions for Patients with Unstable Angina:: A Policy Analysis. Med Decis Making 17: 292-297 [Abstract]  
• Franco Gensini, G., Colella, A., Comeglio, M. (1997). State-of-the-Art Review: Antiplatelet Agents and Thrombin Inhibitors: Combined Modality Therapy. CLIN APPL THROMB HEMOST 3: 82-85  
• Knight, C. J., Panesar, M., Wilson, D. J., Chronos, N. A.F., Patel, D., Fox, K., Goodall, A. H. (1997). Different Effects of Calcium Antagonists, Nitrates, and ß-Blockers on Platelet Function: Possible Importance for the Treatment of Unstable Angina. Circulation 95: 125-132 [Abstract] [Full Text]  
• Schulman, S. P., Goldschmidt-Clermont, P. J., Topol, E. J., Califf, R. M., Navetta, F. I., Willerson, J. T., Chandra, N. C., Guerci, A. D., Ferguson, J. J., Harrington, R. A., Lincoff, A. M., Yakubov, S. J., Bray, P. F., Bahr, R. D., Wolfe, C. L., Yock, P. G., Anderson, H. V., Nygaard, T. W., Mason, S. J., Effron, M. B., Fatterpacker, A., Raskin, S., Smith, J., Brashears, L., Gottdiener, P., du Mee, C., Kitt, M. M., Gerstenblith, G. (1996). Effects of Integrelin, a Platelet Glycoprotein IIb/IIIa Receptor Antagonist, in Unstable Angina: A Randomized Multicenter Trial. Circulation 94: 2083-2089 [Abstract] [Full Text]  
• Lopez-Farre, A., Riesco, A., Digiuni, E., Mosquera, J. R., Caramelo, C., de Miguel, L. S., Millas, I., de Frutos, T., Cernadas, M. R., Monton, M., Alonso, J., Casado, S. (1996). Aspirin-Stimulated Nitric Oxide Production by Neutrophils After Acute Myocardial Ischemia in Rabbits. Circulation 94: 83-87 [Abstract] [Full Text]  
• Weiss, E. J., Bray, P. F., Tayback, M., Schulman, S. P., Kickler, T. S., Becker, L. C., Weiss, J. L., Gerstenblith, G., Goldschmidt-Clermont, P. J. (1996). A Polymorphism of a Platelet Glycoprotein Receptor as an Inherited Risk Factor for Coronary Thrombosis. NEJM 334: 1090-1094 [Abstract] [Full Text]  
• Langford, E.J., Wainwright, R.J., Martin, J.F. (1996). Platelet Activation in Acute Myocardial Infarction and Unstable Angina Is Inhibited by Nitric Oxide Donors. Arterioscler. Thromb. Vasc. Bio. 16: 51-55 [Abstract] [Full Text]  
• Savage, M. P., Goldberg, S., Bove, A. A., Deutsch, E., Vetrovec, G., Macdonald, R. G., Bass, T., Margolis, J. R., Whitworth, H. B., Taussig, A., Hirshfeld, J. W., Cowley, M., Hill, J. A., Marks, R. G., Fischman, D. L., Handberg, E., Herrmann, H., Pepine, C. J. (1995). Effect of Thromboxane A2 Blockade on Clinical Outcome and Restenosis After Successful Coronary Angioplasty : Multi-Hospital Eastern Atlantic Restenosis Trial (M-HEART II). Circulation 92: 3194-3200 [Abstract] [Full Text]  
• Wang, J.-s., Jen, C. J., Chen, H.-i. (1995). Effects of Exercise Training and Deconditioning on Platelet Function in Men. Arterioscler. Thromb. Vasc. Bio. 15: 1668-1674 [Abstract] [Full Text]  
• Fuchs, J., Cannon, C. P. (1995). Hirulog in the Treatment of Unstable Angina : Results of the Thrombin Inhibition in Myocardial Ischemia (TIMI) 7 Trial. Circulation 92: 727-733 [Abstract] [Full Text]  
• Ajayi, A. A. L., Mathur, R., Halushka, P. V. (1995). Testosterone Increases Human Platelet Thromboxane A2 Receptor Density and Aggregation Responses. Circulation 91: 2742-2747 [Abstract] [Full Text]  
• Szalony, J. A., Haas, N. F., Salyers, A. K., Taite, B. B., Nicholson, N. S., Mehrotra, D. V., Feigen, L. P. (1995). Extended Inhibition of Platelet Aggregation With the Orally Active Platelet Inhibitor SC-54684A. Circulation 91: 411-416 [Abstract] [Full Text]  
• Patrono, C. (1994). Aspirin as an Antiplatelet Drug. NEJM 330: 1287-1294 [Full Text]  
• Murkin, J. M., Lux, J., Shannon, N. A., Guiraudon, G. M., Menkis, A. H., McKenzie, F. N., Novick, R. J. (1994). Aprotinin significantly decreases bleeding and transfusion requirements in patients receiving aspirin and undergoing cardiac operations. J. Thorac. Cardiovasc. Surg. 107: 554-561 [Abstract] [Full Text]  
• Antiplatelet Trialists, (1994). Collaborative overview of randomised trials of antiplatelet therapy Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 308: 81-106 [Abstract] [Full Text]  
• Johnson, E., Ports, T. (1988). Unstable Angina Pectoris: An Interventional Approach to Management. J Intensive Care Med 3: 202-214 [Abstract]  
• Hirsh, J., Cairns, J. A. (1987). Analytic Reviews : Antithrombotic Tberapy in Acute Myocardial Infarction and Unstable Angina. J Intensive Care Med 2: 299-312