Efficacy of tonsillectomy for recurrent throat infection in severely affected children. Results of parallel randomized and nonrandomized clinical trials
JL Paradise, CD Bluestone, RZ Bachman, DK Colborn, BS Bernard, FH Taylor, KD Rogers, RH Schwarzbach, SE Stool, GA Friday, and et al.
We studied the efficacy of tonsillectomy, or tonsillectomy with adenoidectomy, in 187 children severely affected with recurrent throat infection. Ninety-one of the children were assigned randomly to either surgical or nonsurgical treatment groups, and 96 were assigned according to parental preference. In both the randomized and nonrandomized trials, the effects of tonsillectomy and of tonsillectomy with adenoidectomy were similar. By various measures, the incidence of throat infection during the first two years of follow-up was significantly lower (P less than or equal to 0.05) in the surgical groups than in the corresponding nonsurgical groups. Third-year differences, although in most cases not significant, also consistently favored the surgical groups. On the other hand, in each follow-up year many subjects in the nonsurgical groups had fewer than three episodes of infection, and most episodes among subjects in the nonsurgical groups were mild. Of the 95 subjects treated with surgery, 13 (14 per cent) had surgery-related complications, all of which were readily managed or self-limited. These results warrant the election of tonsillectomy for children meeting the trials' stringent eligibility criteria, but also provide support for nonsurgical management. Treatment for such children must therefore be individualized.
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Rovers, M. M., Hoes, A. W., Klinkhamer, S., Schilder, A. G. M.
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Alho, O.-P., Koivunen, P., Penna, T., Teppo, H., Koskela, M., Luotonen, J.
(2007). Tonsillectomy versus watchful waiting in recurrent streptococcal pharyngitis in adults: randomised controlled trial. BMJ
334: 939-939
[Abstract][Full Text]
Bisno, A. L., Kaplan, E. L.
(2006). Strep Throat Over and Over: How Frequent? How Real?. Mayo Clin Proc.
81: 1153-1154
[Full Text]
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(2005). Effectiveness of tonsillectomy depends on stringency of indications * Authors' reply. Arch. Dis. Child.
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[Full Text]
Gigante, J.
(2005). Tonsillectomy and Adenoidectomy. Pediatr. Rev.
26: 199-203
[Full Text]
Vist, G. E., Hagen, K. B., Devereaux, P J, Bryant, D., Kristoffersen, D. T., Oxman, A. D.
(2005). Systematic review to determine whether participation in a trial influences outcome. BMJ
330: 1175-
[Abstract][Full Text]
Kvestad, E., Kvaerner, K. J., Roysamb, E., Tambs, K., Harris, J. R., Magnus, P.
(2005). Heritability of Recurrent Tonsillitis. Arch Otolaryngol Head Neck Surg
131: 383-387
[Abstract][Full Text]
Constantin, E., Brouillette, R. T
(2005). Adenotonsillectomy marginally reduced sore throat episodes compared with watchful waiting in children. Evid. Based Med.
10: 52-52
[Full Text]
King, M., Nazareth, I., Lampe, F., Bower, P., Chandler, M., Morou, M., Sibbald, B., Lai, R.
(2005). Impact of Participant and Physician Intervention Preferences on Randomized Trials: A Systematic Review. JAMA
293: 1089-1099
[Abstract][Full Text]
van Staaij, B K, van den Akker, E H, van der Heijden, G J M G, Schilder, A G, Hoes, A W
(2005). Adenotonsillectomy for upper respiratory infections: evidence based?. Arch. Dis. Child.
90: 19-25
[Abstract][Full Text]
Little, P.
(2004). Watchful waiting is useful for children with recurrent throat infections. BMJ
329: 654-654
[Full Text]
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(2004). Effectiveness of adenotonsillectomy in children with mild symptoms of throat infections or adenotonsillar hypertrophy: open, randomised controlled trial. BMJ
329: 651-
[Abstract][Full Text]
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[Full Text]
Parikh, S. R., Reiter, E. R., Kenna, M. A., Roberson, D.
(2003). Utility of Tonsillectomy in 2 Patients With the Syndrome of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis. Arch Otolaryngol Head Neck Surg
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[Abstract][Full Text]
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(2002). Tonsillectomy and Adenotonsillectomy for Recurrent Throat Infection in Moderately Affected Children. Pediatrics
110: 7-15
[Abstract][Full Text]
Howel, D., Webster, S., Hayes, J., Barton, A., Donaldson, L.
(2002). The impact of recurrent throat infection on children and their families. Fam Pract
19: 242-246
[Abstract][Full Text]
West, J V
(2002). Acute upper airway infections: Childhood respiratory infections. Br Med Bull
61: 215-230
[Abstract][Full Text]
Bhattacharyya, N., Kepnes, L. J., Shapiro, J.
(2001). Efficacy and Quality-of-Life Impact of Adult Tonsillectomy. Arch Otolaryngol Head Neck Surg
127: 1347-1350
[Abstract][Full Text]
Wald, E. R.
(2001). Antibiotic Treatment of Pharyngitis. Pediatr. Rev.
22: 255-256
[Full Text]
Stewart, M. G., Friedman, E. M., Sulek, M., deJong, A., Hulka, G. F., Bautista, M. H., Anderson, S. E.
(2001). Validation of an Outcomes Instrument for Tonsil and Adenoid Disease. Arch Otolaryngol Head Neck Surg
127: 29-35
[Abstract][Full Text]
Stewart, M. G., Friedman, E. M., Sulek, M., Hulka, G. F., Kuppersmith, R. B., Harrill, W. C., Bautista, M. H.
(2000). Quality of Life and Health Status in Pediatric Tonsil and Adenoid Disease. Arch Otolaryngol Head Neck Surg
126: 45-48
[Abstract][Full Text]
Paradise, J. L., Bluestone, C. D., Colborn, D. K., Bernard, B. S., Smith, C. G., Rockette, H. E., Kurs-Lasky, M.
(1999). Adenoidectomy and Adenotonsillectomy for Recurrent Acute Otitis Media: Parallel Randomized Clinical Trials in Children Not Previously Treated With Tympanostomy Tubes. JAMA
282: 945-953
[Abstract][Full Text]
Paradise, J. L., Bernard, B. S., Colborn, D. K., Janosky, J. E.
(1998). Assessment of Adenoidal Obstruction in Children: Clinical Signs Versus Roentgenographic Findings. Pediatrics
101: 979-986
[Abstract][Full Text]
Hofer, C., Binns, H. J., Tanz, R. R.
(1997). Strategies for Managing Group A Streptococcal Pharyngitis: A Survey of Board-Certified Pediatricians. Arch Pediatr Adolesc Med
151: 824-829
[Abstract]
Taxy, J. B.
(1995). Granulomatous Tonsillitis: An Unusual Host Response With Benign Clinical Evolution. INT J SURG PATHOL
3: 23-27
[Abstract]
Berman, S.
(1995). Otitis Media in Children. NEJM
332: 1560-1565
[Full Text]
Suen, J. S., Arnold, J. E., Brooks, L. J.
(1995). Adenotonsillectomy for Treatment of Obstructive Sleep Apnea in Children. Arch Otolaryngol Head Neck Surg
121: 525-530
[Abstract]
Hemingway, H., Jacobson, B.
(1995). Queues for cure?. BMJ
310: 818-819
[Full Text]
Waters, V. V.
(1991). Group C {beta}-Hemolytic Streptococci in College Students With Pharyngitis. JAMA
265: 1526-1526
[Abstract]
Turner, J. C., Hayden, G. F.
(1991). Group C {beta}-Hemolytic Streptococci in College Students With Pharyngitis-Reply. JAMA
265: 1526-1527
[Abstract]
Paradise, J. L., Bluestone, C. D., Rogers, K. D., Taylor, F. H., Colborn, D. K., Bachman, R. Z., Bernard, B. S., Schwarzbach, R. H.
(1990). Efficacy of Adenoidectomy for Recurrent Otitis Media in Children Previously Treated With Tympanostomy-Tube Placement: Results of Parallel Randomized and Nonrandomized Trials. JAMA
263: 2066-2073
[Abstract]
GATES, G. A., FOLBRE, T. A.
(1986). Adenotonsillectomy-Reply. Arch Otolaryngol Head Neck Surg
112: 1301-1301
[Abstract]
HORTON, M. B.
(1986). Adenotonsillectomy. Arch Otolaryngol Head Neck Surg
112: 1300-1300
[Abstract]
GATES, G. A., FOLBRE, T. W.
(1986). Indications for Adenotonsillectomy. Arch Otolaryngol Head Neck Surg
112: 501-502
[Abstract]
Brook, I., Hirokawa, R.
(1985). Treatment of Patients with a History of Recurrent Tonsillitis Due to Group A Beta-hemolytic Streptococci: A Prospective Randomized Study Comparing Penicillin, Erythromycin, and Clindamycin. CLIN PEDIATR
24: 331-336
[Abstract]