FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 310:880-883 April 5, 1984 Number 14 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

Flat warts (condylomata) of the uterine cervix are sometimes cytologically atypical and have abnormal mitotic figures; they are thought to be possible precursors of cancer of the cervix. Flat warts are caused by any of a number of types of human papillomaviruses (HPVs), one of which (HPV 16) has been previously associated with invasive cancer of the cervix. To determine whether HPV 16 is also associated with flat warts with abnormal mitoses, we analyzed 23 flat warts by DNA-hybridization techniques for the presence of HPV 16 and other HPV types, and correlated the results with the histology. Of 10 lesions with abnormal mitotic figures, 7 contained HPV 16, and 1 contained another type of HPV. Of 13 lesions without abnormal mitotic figures, only 1 contained HPV 16, and 7 contained other types of HPV. We conclude that the presence of HPV 16 correlates with the presence of abnormal mitotic figures in flat warts of the cervix, and that this type of flat wart is a precursor of invasive cancer of the cervix.

This article has been cited by other articles:

• Nguyen, C. L., Eichwald, C., Nibert, M. L., Munger, K. (2007). Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Centrosomal Component {gamma}-Tubulin. J. Virol. 81: 13533-13543 [Abstract] [Full Text]  
• Crum, C. P., Drapkin, R., Kindelberger, D., Medeiros, F., Miron, A., Lee, Y. (2007). Lessons from BRCA: The Tubal Fimbria Emerges as an Origin for Pelvic Serous Cancer. Clin Med Res 5: 35-44 [Abstract] [Full Text]  
• Duensing, S., Munger, K. (2003). Human Papillomavirus Type 16 E7 Oncoprotein Can Induce Abnormal Centrosome Duplication through a Mechanism Independent of Inactivation of Retinoblastoma Protein Family Members. J. Virol. 77: 12331-12335 [Abstract] [Full Text]  
• Crum, C. P. (2002). The Beginning of the End for Cervical Cancer?. NEJM 347: 1703-1705 [Full Text]  
• Duensing, S., Duensing, A., Flores, E. R., Do, A., Lambert, P. F., Munger, K. (2001). Centrosome Abnormalities and Genomic Instability by Episomal Expression of Human Papillomavirus Type 16 in Raft Cultures of Human Keratinocytes. J. Virol. 75: 7712-7716 [Abstract] [Full Text]  
• Nakamura, Y., Mashima, Y., Kameyama, K., Mukai, M., Oguchi, Y. (1997). Detection of human papillomavirus infection in squamous tumours of the conjunctiva and lacrimal sac by immunohistochemistry, in situ hybridisation, and polymerase chain reaction. Br. J. Ophthalmol. 81: 308-313 [Abstract] [Full Text]  
• Cannistra, S. A., Niloff, J. M. (1996). Cancer of the Uterine Cervix. NEJM 334: 1030-1037 [Full Text]  
• Schnadig, V. J., Clark, W. D., Clegg, T. J., Yao, C. S. (1986). Invasive Papillomatosis and Squamous Carcinoma Complicating Juvenile Laryngeal Papillomatosis. Arch Otolaryngol Head Neck Surg 112: 966-971 [Abstract]  
• Abramson, A. L., Brandsma, J., Steinberg, B., Winkler, B. (1985). Verrucous Carcinoma of the Larynx: Possible Human Papillomavirus Etiology. Arch Otolaryngol Head Neck Surg 111: 709-715 [Abstract]