Of 2157 patients with the acquired immunodeficiency syndrome (AIDS) whose cases were reported to the Centers for Disease Control by August 22, 1983, 64 (3 per cent) with AIDS and Pneumocystis carinii pneumonia had no recognized risk factors for AIDS. Eighteen of these (28 per cent) had received blood components within five years before the onset of illness. These patients with transfusion-associated AIDS were more likely to be white (P = 0.00008) and older (P = 0.0013) than other patients with no known risk factors. They had received blood 15 to 57 months (median, 27.5) before the diagnosis of AIDS, from 2 to 48 donors (median, 14). At least one high-risk donor was identified by interview or T-cell-subset analysis in each of the seven cases in which investigation of the donors was complete; five of the six high-risk donors identified during interview also had low T-cell helper/suppressor ratios, and four had generalized lymphadenopathy according to history or examination. These findings strengthen the evidence that AIDS may be transmitted in blood.
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(2000). Transfusion Medicine: An Overview and Update. Clin. Chem.
46: 1270-1276
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Govitrapong, P., Suttitum, T., Kotchabhakdi, N., Uneklabh, T.
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[Abstract][Full Text]
King, S. M., Murphy, T., Corey, M., Newman, A. M., Major, C., McCrindle, B. W., Irwin, J., Stevens, M., Fearon, M., Poon, A. O.
(1995). The HIV Information Project for Transfusion Recipients a Decade After Transfusion. Arch Pediatr Adolesc Med
149: 680-685
[Abstract]
Fox, N. W., McArthur, C. P.
(1993). Acquired Immunodeficiency Syndrome-- A Review and Update: History, Characteristics of Human Immunodeficiency Virus Infection, Its Replication, Biologic Factors, and Pathogenicity. Arch Fam Med
2: 1068-1077
[Abstract]
Fujimoto, J., Okamoto, E., Yamanaka, N., Oriyama, T., Furukawa, K., Kawamura, E., Tanaka, T., Tomoda, F.
(1993). Efficacy of Autotransfusion in Hepatectomy for Hepatocellular Carcinoma. Arch Surg
128: 1065-1069
[Abstract]
Nelson, K. E., Donahue, J. G., Munoz, A., Cohen, N. D., Ness, P. M., Teague, A., Stambolis, V. A., Yawn, D. H., Callicott, B., McAllister, H., Reitz, B. A., Lee, H., Farzadegan, H., Hollingsworth, C. G.
(1992). Transmission of Retroviruses from Seronegative Donors by Transfusion during Cardiac Surgery: A Multicenter Study of HIV-1 and HTLV-I/II Infections. ANN INTERN MED
117: 554-559
[Abstract]
Goodnough, L. T., Wasman, J., Corlucci, K., Chernosky, A.
(1989). Limitations to Donating Adequate Autologous Blood Prior to Elective Orthopedic Surgery. Arch Surg
124: 494-496
[Abstract]
Jason, J., Lui, K.-J., Ragni, M. V., Hessol, N. A., Darrow, W. W.
(1989). Risk of Developing AIDS in HIV-Infected Cohorts of Hemophilic and Homosexual Men. JAMA
261: 725-727
[Abstract]
Schlech, W. F. III, Lee, S. H. S., Cook, J., Rozee, K. R., MacIntosh, N.
(1989). Passive Transfer of HIV Antibody by Hepatitis B Immune Globulin. JAMA
261: 411-413
[Abstract]
Lui, K., Darrow, W., Rutherford, G. 3rd
(1988). A model-based estimate of the mean incubation period for AIDS in homosexual men. Science
240: 1333-1335
[Abstract]
KNOWLES, D. M., CHAMULAK, G. A., SUBAR, M., BURKE, J. S., DUGAN, M., WERNZ, J., SLYWOTZKY, C., PELICCI, P., DALLA-FAVERA, R., RAPHAEL, B.
(1988). Lymphoid Neoplasia Associated with the Acquired Immunodeficiency Syndrome (AIDS) The New York University Medical Center Experience with 105 Patients (1981-1986). ANN INTERN MED
108: 744-753
[Abstract]
Greenberg, A. E., Nguyen-Dinh, P., Mann, J. M., Kabote, N., Colebunders, R. L., Francis, H., Quinn, T. C., Baudoux, P., Lyamba, B., Davachi, F., Roberts, J. M., Kabeya, N., Curran, J. W., Campbell, C. C.
(1988). The Association Between Malaria, Blood Transfusions, and HIV Seropositivity in a Pediatric Population in Kinshasa, Zaire. JAMA
259: 545-549
[Abstract]
The Collaborative Study Group of AIDS in Haitian-A,
(1987). Risk Factors for AIDS Among Haitians Residing in the United States: Evidence of Heterosexual Transmission. JAMA
257: 635-639
[Abstract]
Fischl, M. A., Dickinson, G. M., Scott, G. B., Klimas, N., Fletcher, M. A., Parks, W.
(1987). Evaluation of Heterosexual Partners, Children, and Household Contacts of Adults With AIDS. JAMA
257: 640-644
[Abstract]
WARD, J. W., DEPPE, D. A., SAMSON, S., PERKINS, H., HOLLAND, P., FERNANDO, L., FEORINO, P. M., THOMPSON, P., KLEINMAN, S., ALLEN, J. R.
(1987). Risk of Human Immunodeficiency Virus Infection from Blood Donors Who Later Developed the Acquired Immunodeficiency Syndrome. ANN INTERN MED
106: 61-62
[Abstract]
Lifson, A. R., Castro, K. G., McCray, E., Jaffe, H. W.
(1986). National Surveillance of AIDS in Health Care Workers. JAMA
256: 3231-3234
[Abstract]
Mann, J. M., Francis, H., Quinn, T. C., Bila, K., Asila, P. K., Bosenge, N., Nzilambi, N., Jansegers, L., Piot, P., Ruti, K., Curran, J. W.
(1986). HIV Seroprevalence Among Hospital Workers in Kinshasa, Zaire: Lack of Association With Occupational Exposure. JAMA
256: 3099-3102
[Abstract]
Mueller, N.
(1986). The Epidemiology of the Human Immunodeficiency Virus Infection. J Law Med Ethics
14: 250-258
Ginzburg, H. M.
(1986). Intravenous Drug Abusers and HIV Infections: A Consequence of Their Actions. J Law Med Ethics
14: 268-272
CONTE, J. E. Jr.
(1986). Infection with Human Immunodeficiency Virus in the Hospital: Epidemiology, Infection Control, and Biosafety Considerations. ANN INTERN MED
105: 730-736
[Abstract]
Jason, J., Holman, R. C., Dixon, G., Lawrence, D. N., Bozeman, L. H., Chorba, T. L., Tregillus, L., Evatt, B. L., The Hemophilia/AIDS Collaborative Study Group,
(1986). Effects of Exposure to Factor Concentrates Containing Donations From Identified AIDS Patients: A Matched Cohort Study. JAMA
256: 1758-1762
[Abstract]
Hiratzka, L. F, Richardson, J. V, Brandt, B., Doty, D. B, Rossi, N. P, Wright, C. B, Ehrenhaft, J.
(1986). The effect of autologous blood salvage techniques upon bank blood usage and the cost of routine coronary revascularization. Perfusion
1: 239-244
[Abstract]
ANDERSON, K. C., GORGONE, B. C., MARLINK, R. G., FERRIANI, R., ESSEX, M. E., BENZ, P. M., GROOPMAN, J. E.
(1986). Transfusion-Acquired Human Immunodeficiency Virus Infection Among Immunocompromised Persons. ANN INTERN MED
105: 519-527
[Abstract]
Mann, J. M., Quinn, T. C., Francis, H., Nzilambi, N., Bosenge, N., Bila, K., McCormick, J. B., Ruti, K., Asila, P. K., Curran, J. W.
(1986). Prevalence of HTLV-III/LAV in Household Contacts of Patients With Confirmed AIDS and Controls in Kinshasa, Zaire. JAMA
256: 721-724
[Abstract]
Gill, P. S., Levine, A. M., Meyer, P. R., Aguilar, S. L., Rarick, M., Parker, J. W., Rasheed, S.
(1986). Human T-Cell Lymphotropic Virus Type III Associated Disorders: The Spectrum in the Heterosexual Population. Arch Intern Med
146: 1501-1504
[Abstract]
Ward, J. W., Grindon, A. J., Feorino, P. M., Schable, C., Parvin, M., Allen, J. R.
(1986). Laboratory and Epidemiologic Evaluation of an Enzyme Immunoassay for Antibodies to HTLV-III. JAMA
256: 357-361
[Abstract]
Goedert, J., Biggar, R., Weiss, S., Eyster, M., Melbye, M, Wilson, S, Ginzburg, H., Grossman, R., DiGioia, R., Sanchez, W., et, al.
(1986). Three-year incidence of AIDS in five cohorts of HTLV-III-infected risk group members. Science
231: 992-995
[Abstract]
Harfi, H. A., Fakhry, B. M.
(1986). Acquired Immunodeficiency Syndrome in Saudi Arabia: The American-Saudi Connection. JAMA
255: 383-384
[Abstract]
Osborn, J. E.
(1986). AIDS, Social Sciences, and Health Education: A Personal Perspective. Health Educ Behav
13: 287-299
Peterman, T. A., Jaffe, H. W., Feorino, P. M., Getchell, J. P., Warfield, D. T., Haverkos, H. W., Stoneburner, R. L., Curran, J. W.
(1985). Transfusion-Associated Acquired Immunodeficiency Syndrome in the United States. JAMA
254: 2913-2917
[Abstract]
Clumeck, N., Robert-Guroff, M., Perre, P. V. D., Jennings, A., Sibomana, J., Demol, P., Cran, S., Gallo, R. C.
(1985). Seroepidemiological Studies of HTLV-III Antibody Prevalence Among Selected Groups of Heterosexual Africans. JAMA
254: 2599-2602
[Abstract]
JAFFE, H. W., HARDY, A. M., MORGAN, W. M., DARROW, W. W.
(1985). The Acquired Immunodeficiency Syndrome in Gay Men. ANN INTERN MED
103: 662-664
[Abstract]
BLATTNER, W. A., BIGGAR, R. J., WEISS, S. H., MELBYE, M., GOEDERT, J. J.
(1985). Epidemiology of Human T-Lymphotropic Virus Type III and the Risk of the Acquired Immunodeficiency Syndrome. ANN INTERN MED
103: 665-670
[Abstract]
JARLAIS, D. C. D., FRIEDMAN, S. R., HOPKINS, W.
(1985). Risk Reduction for the Acquired Immunodeficiency Syndrome Among Intravenous Drug Users. ANN INTERN MED
103: 755-759
[Abstract]
Redfield, R. R., Markham, P. D., Salahuddin, S. Z., Wright, D. C., Sarngadharan, M. G., Gallo, R. C.
(1985). Heterosexually Acquired HTLV-III/LAV Disease (AIDS-Related Complex and AIDS) Epidemiologic Evidence for Female-to-Male Transmission. JAMA
254: 2094-2096
[Abstract]
Curran, J., Morgan, W., Hardy, A., Jaffe, H., Darrow, W., Dowdle, W.
(1985). The epidemiology of AIDS: current status and future prospects. Science
229: 1352-1357
[Abstract]
Dienstag, J. L., Werner, B. G., McLane, M. F., Snydman, D. R., Grady, G. F., Craven, D. E., Crumpacker, C. S., Polk, B. F., Platt, R., Allan, J., Essex, M.
(1985). Absence of Antibodies to HTLV-III in Health Workers After Hepatitis B Vaccination. JAMA
254: 1064-1066
[Abstract]
Jaffe, H. W., Sarngadharan, M. G., DeVico, A. L., Bruch, L., Getchell, J. P., Kalyanaraman, V. S., Haverkos, H. W., Stoneburner, R. L., Gallo, R. C., Curran, J. W.
(1985). Infection With HTLV-III/LAV and Transfusion-Associated Acquired Immunodeficiency Syndrome: Serologic Evidence of an Association. JAMA
254: 770-773
[Abstract]
Laure, F, Zagury, D, Saimot, A., Gallo, R., Hahn, B., Brechot, C
(1985). Hepatitis B virus DNA sequences in lymphoid cells from patients with AIDS and AIDS-related complex. Science
229: 561-563
[Abstract]
JAFFE, H. W., DARROW, W. W., ECHENBERG, D. F., O'MALLEY, P. M., GETCHELL, J. P., KALYANARAMAN, V. S., BYERS, R. H., DRENNAN, D. P., BRAFF, E. H., CURRAN, J. W., FRANCIS, D. P.
(1985). The Acquired Immunodeficiency Syndrome in a Cohort of Homosexual Men: A Six-Year Follow-up Study. ANN INTERN MED
103: 210-214
[Abstract]
Barry, M. J., Mulley, A. G., Singer, D. E.
(1985). Screening for HTLV-III Antibodies: The Relation Between Prevalence and Positive Predictive Value and Its Social Consequences. JAMA
253: 3395-3396
[Abstract]
Jason, J., McDougal, J. S., Holman, R. C., Stein, S. F., Lawrence, D. N., Nicholson, J. K. A., Dixon, G., Doxey, M., Evatt, B. L., the Hemophilia/AIDS Collaborative Study Group,
(1985). Human T-Lymphotropic Retrovirus Type III / Lymphadenopathy-Associated Virus Antibody: Association With Hemophiliacs' Immune Status and Blood Component Usage. JAMA
253: 3409-3415
[Abstract]
Miller, P. J., O'Connell, J., Leipold, A., Wenzel, R. P.
(1985). Potential Liability for Transfusion-Associated AIDS. JAMA
253: 3419-3424
[Abstract]
McEvoy, M.
(1985). The Epidemiology of the Acquired Immune Deficiency Syndrome A.I.D.S. The Journal of the Royal Society for the Promotion of Health
105: 88-90
FAUCI, A. S., MASUR, H., GELMANN, E. P., MARKHAM, P. D., HAHN, B. H., LANE, H. C.
(1985). The Acquired Immunodeficiency Syndrome: An Update. ANN INTERN MED
102: 800-813
[Abstract]
KREISS, J. K., KITCHEN, L. W., PRINCE, H. E., KASPER, C. K., ESSEX, M.
(1985). Antibody to Human T-Lymphotropic Virus Type III in Wives of Hemophiliacs: Evidence for Heterosexual Transmission. ANN INTERN MED
102: 623-626
[Abstract]
Eyster, M. E., Goedert, J. J., Sarngadharan, M. G., Weiss, S. H., Gallo, R. C., Blattner, W. A.
(1985). Development and Early Natural History of HTLV-III Antibodies in Persons With Hemophilia. JAMA
253: 2219-2223
[Abstract]
Saxinger, W., Levine, P., Dean, A., de The, G, Lange-Wantzin, G, Moghissi, J, Laurent, F, Hoh, M, Sarngadharan, M., Gallo, R.
(1985). Evidence for exposure to HTLV-III in Uganda before 1973. Science
227: 1036-1038
[Abstract]
Goldsmith, J. M., Kalish, S. B., Green, D., Chmiel, J. S., Wallemark, C.-B., Phair, J. P.
(1985). Sequential Clinical and Immunologic Abnormalities in Hemophiliacs. Arch Intern Med
145: 431-434
[Abstract]
Jason, J., Hilgartner, M., Holman, R. C., Dixon, G., Spira, T. J., Aledort, L., Evatt, B.
(1985). Immune Status of Blood Product Recipients. JAMA
253: 1140-1145
[Abstract]
Scott, G. B., Fischl, M. A., Klimas, N., Fletcher, M. A., Dickinson, G. M., Levine, R. S., Parks, W. P.
(1985). Mothers of Infants With the Acquired Immunodeficiency Syndrome: Evidence for Both Symptomatic and Asymptomatic Carriers. JAMA
253: 363-366
[Abstract]
Hardy, A. M., Allen, J. R., Morgan, W. M., Curran, J. W.
(1985). The Incidence Rate of Acquired Immunodeficiency Syndrome in Selected Populations. JAMA
253: 215-220
[Abstract]
GROOPMAN, J. E., SARNGADHARAN, M. G., SALAHUDDIN, S. Z., BUXBAUM, R., HUBERMAN, M. S., KINNIBURGH, J., SLISKI, A., McLANE, M. F., ESSEX, M., GALLO, R. C.
(1985). Apparent Transmission of Human T-Cell Leukemia Virus Type III to a Heterosexual Woman with the Acquired Immunodeficiency Syndrome. ANN INTERN MED
102: 63-66
[Abstract]
(1984). Leads from the MMWR. JAMA
252: 3355-3356
Sacks, H. S., Rose, D. N., Chalmers, T. C.
(1984). Should the Risk of Acquired Immunodeficiency Syndrome Deter Hepatitis B Vaccination? A Decision Analysis. JAMA
252: 3375-3377
[Abstract]
(1984). Leads from the MMWR. JAMA
252: 2679-2680
McLeod, B. C., Scott, J. P.
(1984). Use of 'Single Donor' Factor VIII From Plasma Exchange Donation. JAMA
252: 2726-2729
[Abstract]
Alter, H., Eichberg, J., Masur, H, Saxinger, W., Gallo, R, Macher, A., Lane, H., Fauci, A.
(1984). Transmission of HTLV-III infection from human plasma to chimpanzees: an animal model for AIDS. Science
226: 549-552
[Abstract]
CHAMBERLAND, M. E., CASTRO, K. G., HAVERKOS, H. W., MILLER, B. I., THOMAS, P. A., REISS, R., WALKER, J., SPIRA, T. J., JAFFE, H. W., CURRAN, J. W.
(1984). Acquired Immunodeficiency Syndrome in the United States: An Analysis of Cases Outside High-Incidence Groups. ANN INTERN MED
101: 617-623
[Abstract]
Groopman, J., Salahuddin, S., Sarngadharan, M., Markham, P., Gonda, M, Sliski, A, Gallo, R.
(1984). HTLV-III in saliva of people with AIDS-related complex and healthy homosexual men at risk for AIDS. Science
226: 447-449
[Abstract]
Zagury, D, Bernard, J, Leibowitch, J, Safai, B, Groopman, J., Feldman, M, Sarngadharan, M., Gallo, R.
(1984). HTLV-III in cells cultured from semen of two patients with AIDS. Science
226: 449-451
[Abstract]
Council on Scientific Affairs,
(1984). The Acquired Immunodeficiency Syndrome: Commentary. JAMA
252: 2037-2043
[Abstract]
Ammann, A. J.
(1984). Etiology of AIDS. JAMA
252: 1281-1282
[Abstract]
Welch, K., Finkbeiner, W., Alpers, C. E., Blumenfeld, W., Davis, R. L., Smuckler, E. A., Beckstead, J. H.
(1984). Autopsy Findings in the Acquired Immune Deficiency Syndrome. JAMA
252: 1152-1159
[Abstract]
Arya, S., Gallo, R., Hahn, B., Shaw, G., Popovic, M, Salahuddin, S., Wong-Staal, F
(1984). Homology of genome of AIDS-associated virus with genomes of human T-cell leukemia viruses. Science
225: 927-930
[Abstract]
(1984). Leads from the MMWR. JAMA
252: 992-995
(1984). Leads from the MMWR. JAMA
252: 608-613
Thomas, P. A., Jaffe, H. W., Spira, T. J., Reiss, R., Guerrero, I. C., David,
(1984). Unexplained Immunodeficiency in Children: A Surveillance Report. JAMA
252: 639-644
[Abstract]
Popovic, M, Sarngadharan, M., Read, E, Gallo, R.
(1984). Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science
224: 497-500
[Abstract]
Gallo, R., Salahuddin, S., Popovic, M, Shearer, G., Kaplan, M, Haynes, B., Palker, T., Redfield, R, Oleske, J, Safai, B, et, al.
(1984). Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science
224: 500-503
[Abstract]
Sarngadharan, M., Popovic, M, Bruch, L, Schupbach, J, Gallo, R.
(1984). Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science
224: 506-508
[Abstract]
Jaffe, H., Francis, D., McLane, M., Cabradilla, C, Curran, J., Kilbourne, B., Lawrence, D., Haverkos, H., Spira, T., Dodd, R., et, al.
(1984). Transfusion-associated AIDS: serologic evidence of human T-cell leukemia virus infection of donors. Science
223: 1309-1312
[Abstract]
CURRAN, J. W., BARKER, L. F.
(1984). The Acquired Immunodeficiency Syndrome Associated with Transfusions: The Evolving Perspective. ANN INTERN MED
100: 298-300
[Abstract]
