To assess the effect of the duration of chronic hypoxemia on cognitive function, we studied 38 children with d-transposition of the great arteries and an intact ventricular septum who underwent corrective surgery at six months to six years of age (median, 1.6 years). Tests included the Wechsler Preschool and Primary Scale of Intelligence (WPPSI) in 33 children and the visual-association and auditory-association subtests of the Illinois Test of Psycholinguistic Abilities in 38 and 37 children, respectively. When controlled for social index, age at repair was inversely associated with the WPPSI intelligence-quotient score (P less than 0.01), the visual-association subtest score (P less than 0.01), and the auditory-association subtest score (P less than 0.1). In contrast, age at repair correlated poorly with cognitive function in children with ventricular septal defect, an acyanotic congenital heart defect. These data suggest that postponing repair of a cyanotic congenital heart disease, such as transposition of the great arteries, is associated with progressive impairment of cognitive function.
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[Full Text]
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[Abstract][Full Text]
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7: e363-e369
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[Abstract][Full Text]
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[Abstract][Full Text]
Bass, J. L., Stening, W., Nitsch, P., Roth, B.
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113: 169-170
[Full Text]
The Task Force on the Management of Grown Up Conge, , Task Force members, , Deanfield, J., Thaulow, E., Warnes, C., Webb, G., Kolbel, F., Hoffman, A., Sorenson, K., Kaemmerer, H., Thilen, U., Bink-Boelkens, M., Iserin, L., Daliento, L., Silove, E., Redington, A., Vouhe, P., ESC Committee for Practice Guidelines, , Priori, S., Alonso, M. A., Blanc, J.-J., Budaj, A., Cowie, M., Deckers, J., Fernandez Burgos, E., Lekakis, J., Lindahl, B., Mazzotta, G., Morais, J., Oto, A., Smiseth, O., Trappe, H. J., Document Reviewers, , Deckers, J., Klein, W., Angeles Alonso, M., Blomstrom-Lundqvist, C., de Backer, G., Hradec, J., Mazzotta, G., Parkhomenko, A., Presbitero, P., Torbicki, A.
(2003). Management of Grown Up Congenital Heart Disease. Eur Heart J
24: 1035-1084
[Full Text]
Griffin, K. J., Elkin, T. D., Smith, C. J.
(2003). Academic Outcomes in Children with Congenital Heart Disease. CLIN PEDIATR
42: 401-409
[Abstract]
Dittrich, H, Buhrer, C, Grimmer, I, Dittrich, S, Abdul-Khaliq, H, Lange, P E
(2003). Neurodevelopment at 1 year of age in infants with congenital heart disease. Heart
89: 436-441
[Abstract][Full Text]
Forbess, J. M., Visconti, K. J., Hancock-Friesen, C., Howe, R. C., Bellinger, D. C., Jonas, R. A.
(2002). Neurodevelopmental Outcome After Congenital Heart Surgery: Results From an Institutional Registry. Circulation
106: I-95-I-102
[Abstract][Full Text]
Forbess, J. M., Visconti, K. J., Bellinger, D. C., Jonas, R. A.
(2001). Neurodevelopmental Outcomes in Children After the Fontan Operation. Circulation
104
: I-127-I-132
[Abstract][Full Text]
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(2001). Developmental Screening of Children Diagnosed with Congenital Heart Defects. CLIN PEDIATR
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[Abstract]
Kurth, C. D., Steven, J. L., Montenegro, L. M., Watzman, H. M., Gaynor, J. W., Spray, T. L., Nicolson, S. C.
(2001). Cerebral oxygen saturation before congenital heart surgery. Ann. Thorac. Surg.
72: 187-192
[Abstract][Full Text]
ROBERTON, N.
(2001). Two sacred cows of neonatal intensive care. Arch. Dis. Child. Fetal Neonatal Ed.
85: F75b-75
[Full Text]
HEY, E.
(2001). Two sacred cows of neonatal intensive care{---}Authors' response. Arch. Dis. Child. Fetal Neonatal Ed.
85: F75c-75
[Full Text]
Wray, J, Sensky, T
(2001). Congenital heart disease and cardiac surgery in childhood: effects on cognitive function and academic ability. Heart
85: 687-691
[Abstract][Full Text]
Todaro, J. F., Fennell, E. B., Sears, S. F., Rodrigue, J. R., Roche, A. K.
(2000). Cognitive and Psychological Outcomes in Pediatric Heart Transplantation. J Pediatr Psychol
25: 567-576
[Abstract][Full Text]
Wernovsky, G., Stiles, K. M., Gauvreau, K., Gentles, T. L., duPlessis, A. J., Bellinger, D. C., Walsh, A. Z., Burnett, J., Jonas, R. A., Mayer, J. E. Jr, Newburger, J. W.
(2000). Cognitive Development After the Fontan Operation. Circulation
102: 883-889
[Abstract][Full Text]
Chang, R.-K. R., Chen, A. Y., Klitzner, T. S.
(2000). Factors Associated With Age at Operation for Children With Congenital Heart Disease. Pediatrics
105: 1073-1081
[Abstract][Full Text]
Mahle, W. T., Clancy, R. R., Moss, E. M., Gerdes, M., Jobes, D. R., Wernovsky, G.
(2000). Neurodevelopmental Outcome and Lifestyle Assessment in School-Aged and Adolescent Children With Hypoplastic Left Heart Syndrome. Pediatrics
105: 1082-1089
[Abstract][Full Text]
Williams, D. L., Gelijns, A. C., Moskowitz, A. J., Weinberg, A. D., Ng, J. H., Crawford, E., Hayes, C. J., Quaegebeur, J. M.
(2000). HYPOPLASTIC LEFT HEART SYNDROME: VALUING THE SURVIVAL. J. Thorac. Cardiovasc. Surg.
119: 720-731
[Abstract][Full Text]
Pigula, F. A., Khalil, P. N., Mayer, J. E., del Nido, P. J., Jonas, R. A.
(1999). Repair of Tetralogy of Fallot in Neonates and Young Infants. Circulation
100
: II-157-II-161
[Abstract][Full Text]
Beyens, T., Biarent, D., Bouton, J.M., Demanet, H., Viart, P., Dessy, H., Deville, A., Lamote, J., Deuvaert, F.E.
(1999). Cardiac surgery with extracorporeal circulation in 23 infants weighing 2500 g or less: short and intermediate term outcome. Eur. J. Cardiothorac. Surg.
14: 165-172
[Abstract][Full Text]
Elliott, M. J
(1999). Recent advances in paediatric cardiopulmonary bypass. Perfusion
14: 237-246
Wray, J., Sensky, T.
(1999). Controlled study of preschool development after surgery for congenital heart disease. Arch. Dis. Child.
80: 511-516
[Abstract][Full Text]
Kern, J. H., Hinton, V. J., Nereo, N. E., Hayes, C. J., Gersony, W. M.
(1998). Early Developmental Outcome After the Norwood Procedure for Hypoplastic Left Heart Syndrome. Pediatrics
102: 1148-1152
[Abstract][Full Text]
Rossi, A. F., Seiden, H. S., Sadeghi, A. M., Nguyen, K. H., Quintana, C. S., Gross, R. P., Griepp, R. B.
(1998). The outcome of cardiac operations in infants weighing two kilograms or less. J. Thorac. Cardiovasc. Surg.
116: 28-32
[Abstract][Full Text]
Uzark, K., Lincoln, A., Lamberti, J. J., Mainwaring, R. D., Spicer, R. L., Moore, J. W.
(1998). Neurodevelopmental Outcomes in Children With Fontan Repair of Functional Single Ventricle. Pediatrics
101: 630-633
[Abstract][Full Text]
Hovels-Gurich, H. H., Seghaye, M.-C., Dabritz, S., Messmer, B. J., von Bernuth, G.
(1997). COGNITIVE AND MOTOR DEVELOPMENT IN PRESCHOOL AND SCHOOL-AGED CHILDREN AFTER NEONATAL ARTERIAL SWITCH OPERATION. J. Thorac. Cardiovasc. Surg.
114: 578-585
[Abstract][Full Text]
Bloom, A. A., Wright, J. A., Morris, R. D., Campbell, R. M., Krawiecki, N. S.
(1997). Additive Impact of In-hospital Cardiac Arrest on the Functioning of Children With Heart Disease. Pediatrics
99: 390-398
[Abstract][Full Text]
Rodriguez, R. A., Austin III, E. H., Audenaert, S. M., Gray, S. b. L. A. Jr.
(1995). POSTBYPASS EFFECTS OF DELAYED REWARMING ON CEREBRAL BLOOD FLOW VELOCITIES IN INFANTS AFTER TOTAL CIRCULATORY ARREST. J. Thorac. Cardiovasc. Surg.
110: 1686-1691
[Abstract][Full Text]
Wray, J, Pot-Mees, C, Zeitlin, H, Radley-Smith, R, Yacoub, M
(1994). Cognitive function and behavioural status in paediatric heart and heart-lung transplant recipients: the Harefield experience. BMJ
309: 837-841
[Abstract][Full Text]
Newburger, J. W., Jonas, R. A., Wernovsky, G., Wypij, D., Hickey, P. R., Kuban, K., Farrell, D. M., Holmes, G. L., Helmers, S. L., Constantinou, J., Carrazana, E., Barlow, J. K., Walsh, A. Z., Lucius, K. C., Share, J. C., Wessel, D. L., Hanley, F. L., Mayer, J. E., Castaneda, A. R., Ware, J. H.
(1993). A Comparison of the Perioperative Neurologic Effects of Hypothermic Circulatory Arrest versus Low-Flow Cardiopulmonary Bypass in Infant Heart Surgery. NEJM
329: 1057-1064
[Abstract][Full Text]
Brown, R. T., Armstrong, F. D., Eckman, J. R.
(1993). Neurocognitive Aspects of Pediatric Sickle Cell Disease. J Learn Disabil
26: 33-45
[Abstract]
Mendoza, J. C., Wilkerson, S. A., Reese, A. H.
(1991). Follow-up of Patients Who Underwent Arterial Switch Repair for Transposition of the Great Arteries. Arch Pediatr Adolesc Med
145: 40-43
[Abstract]
MAYER, J. E. JR
(1991). Development, Growth, and Cardiac Surgery. Arch Pediatr Adolesc Med
145: 33-34
[Abstract]
Ferry, P. C.
(1987). Neurologic Sequelae of Cardiac Surgery in Children. Arch Pediatr Adolesc Med
141: 309-312
[Abstract]
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