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Previous Volume 311:753-759 September 20, 1984 Number 12 Next

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Abstract

To determine whether responses to dehydration are altered with age, we investigated the thirst, fluid and electrolyte responses, and hormonal responses to 24 hours of water deprivation in seven healthy active elderly men (67 to 75 years old) and seven healthy young men (20 to 31 years old) who were matched for weight loss during water deprivation. After water deprivation, the older men had greater increases in plasma osmolality, sodium concentration, and vasopressin levels. However, their urinary osmolality was lower and they were less thirsty and drank less after water deprivation, so that their plasma and urine were not diluted to predeprivation levels. Regression analysis indicated increased sensitivity of vasopressin osmoreceptors in the older group, although this difference was not statistically significant. We conclude that after 24 hours of water deprivation, there is a deficit in thirst and water intake in healthy elderly men, as compared with younger men, although vasopressin osmoreceptor responsiveness is maintained or even increased. Our findings also suggest that the well-known deficit in urinary concentrating ability that occurs with age reflects renal causes and not a lack of circulating vasopressin.

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• McCann, R. M., Hall, W. J., Groth-Juncker, A. (1994). Comfort Care for Terminally III Patients: The Appropriate Use of Nutrition and Hydration. JAMA 272: 1263-1266 [Abstract]  
• Kellerman, P. S. (1994). Perioperative Care of the Renal Patient. Arch Intern Med 154: 1674-1688 [Abstract]  
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• Bernat, J. L., Gert, B., Mogielnicki, R. P. (1993). Patient Refusal of Hydration and Nutrition: An Alternative to Physician-Assisted Suicide or Voluntary Active Euthanasia. Arch Intern Med 153: 2723-2731 [Abstract]  
• Board, A.S.P.E.N. (1993). Guidelines for the Use of Parenteral and Enteral Nutrition in Adult and Pediatric Patients. JPEN J Parenter Enteral Nutr 17: 1SA-52SA  
• Friedman, E., Shadel, M., Halkin, H., Farfel, Z. (1989). Thiazide-Induced Hyponatremia: Reproducibility by Single Dose Rechallenge and an Analysis of Pathogenesis. ANN INTERN MED 110: 24-30 [Abstract]  
• SOLOMON, D. H., JUDD, H. L., SIER, H. C., RUBENSTEIN, L. Z., MORLEY, J. E. (1988). New Issues in Geriatric Care. ANN INTERN MED 108: 718-732 [Abstract]  
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• BECK, L. H., LAVIZZO-MOUREY, R. (1987). Geriatric Hyponatremia. ANN INTERN MED 107: 768-769 [Abstract]  
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• Raskind, M. A., Peskind, i. R., Lampe, T. H., Risse, S. C., Taborsky, G. J. Jr, Dorsa, D. (1986). Cerebrospinal Fluid Vasopressin, Oxytocin, sopressin, Oxytoc in Alzheimer's Diseas{beta}-Endorphin. Arch Gen Psychiatry 43: 382-388 [Abstract]