Hemodynamics, plasma norepinephrine, and plasma renin activity were measured at supine rest in 106 patients (83 men and 23 women) with moderate to severe congestive heart failure. During follow-up lasting 1 to 62 months, 60 patients died (57 per cent); 47 per cent of the deaths were sudden, and 45 per cent were related to progressive heart failure. Statistically unrelated to the risk of mortality were cause of disease (60 patients had coronary disease, and 46 had cardiomyopathy), age (mean, 54.8 years), cardiac index (mean, 2.11 liters per minute per square meter of body-surface area), pulmonary wedge pressure (mean, 24.5 mm Hg), and mean arterial pressure (mean, 83.2 mm Hg). A multivariate analysis of the five significant univariate prognosticators--heart rate (mean, 84.4 beats per minute), plasma renin activity (mean, 15.4 ng per milliliter per hour), plasma norepinephrine (mean, 700 pg per milliliter), serum sodium (mean, 135.7 mmol per liter), and stroke-work index (mean, 21.0 g-meters per square meter)--found only plasma norepinephrine to be independently (P = 0.002) related to the subsequent risk of mortality. Norepinephrine was also higher in patients who died from progressive heart failure than in those who died suddenly. These data suggest that a single resting venous blood sample showing the plasma norepinephrine concentration provides a better guide to prognosis than other commonly measured indexes of cardiac performance.
This article has been cited by other articles:
Rengo, G., Lymperopoulos, A., Zincarelli, C., Donniacuo, M., Soltys, S., Rabinowitz, J. E., Koch, W. J.
(2009). Myocardial Adeno-Associated Virus Serotype 6-{beta}ARKct Gene Therapy Improves Cardiac Function and Normalizes the Neurohormonal Axis in Chronic Heart Failure. Circulation
119: 89-98
[Abstract][Full Text]
Herring, N., Paterson, D. J.
(2009). Neuromodulators of peripheral cardiac sympatho-vagal balance. Exp Physiol
94: 46-53
[Abstract][Full Text]
Feng, H.-Z., Chen, M., Weinstein, L. S., Jin, J.-P.
(2008). Removal of the N-terminal Extension of Cardiac Troponin I as a Functional Compensation for Impaired Myocardial {beta}-Adrenergic Signaling. J. Biol. Chem.
283: 33384-33393
[Abstract][Full Text]
Kobayashi, M., Izawa, H., Cheng, X. W., Asano, H., Hirashiki, A., Unno, K., Ohshima, S., Yamada, T., Murase, Y., Kato, T. S., Obata, K., Noda, A., Nishizawa, T., Isobe, S., Nagata, K., Matsubara, T., Murohara, T., Yokota, M.
(2008). Dobutamine Stress Testing as a Diagnostic Tool for Evaluation of Myocardial Contractile Reserve in Asymptomatic or Mildly Symptomatic Patients With Dilated Cardiomyopathy. J Am Coll Cardiol Img
1: 718-726
[Abstract][Full Text]
Francis, G. S., Desai, M. Y.
(2008). Contractile Reserve: Are We Beginning to Understand It?. J Am Coll Cardiol Img
1: 727-728
[Full Text]
Wright, C. D., Chen, Q., Baye, N. L., Huang, Y., Healy, C. L., Kasinathan, S., O'Connell, T. D.
(2008). Nuclear {alpha}1-Adrenergic Receptors Signal Activated ERK Localization to Caveolae in Adult Cardiac Myocytes. Circ. Res.
103: 992-1000
[Abstract][Full Text]
Michael, G., Xiao, L., Qi, X.-Y., Dobrev, D., Nattel, S.
(2008). Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis. Cardiovasc Res
0: cvn266v2-9
[Abstract][Full Text]
Stickland, M. K., Miller, J. D.
(2008). The best medicine: exercise training normalizes chemosensitivity and sympathoexcitation in heart failure. J. Appl. Physiol.
105: 779-781
[Full Text]
Wang, W.-Z., Gao, L., Wang, H.-J., Zucker, I. H., Wang, W.
(2008). Interaction between cardiac sympathetic afferent reflex and chemoreflex is mediated by the NTS AT1 receptors in heart failure. Am. J. Physiol. Heart Circ. Physiol.
295: H1216-H1226
[Abstract][Full Text]
Huang, Y., Wright, C. D., Kobayashi, S., Healy, C. L., Elgethun, M., Cypher, A., Liang, Q., O'Connell, T. D.
(2008). GATA4 is a survival factor in adult cardiac myocytes but is not required for {alpha}1A-adrenergic receptor survival signaling. Am. J. Physiol. Heart Circ. Physiol.
295: H699-H707
[Abstract][Full Text]
Dorn, G. W. II, Matkovich, S. J.
(2008). Put Your Chips on Transcriptomics. Circulation
118: 216-218
[Full Text]
Kasama, S., Toyama, T., Sumino, H., Nakazawa, M., Matsumoto, N., Sato, Y., Kumakura, H., Takayama, Y., Ichikawa, S., Suzuki, T., Kurabayashi, M.
(2008). Prognostic Value of Serial Cardiac 123I-MIBG Imaging in Patients with Stabilized Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction. JNM
49: 907-914
[Abstract][Full Text]
Braunwald, E.
(2008). Biomarkers in Heart Failure. NEJM
358: 2148-2159
[Full Text]
Schrier, R. W.
(2008). Blood Urea Nitrogen and Serum Creatinine: Not Married in Heart Failure. Circ Heart Fail
1: 2-5
[Full Text]
Gourine, A., Bondar, S. I., Spyer, K. M., Gourine, A. V.
(2008). Beneficial Effect of the Central Nervous System {beta}-Adrenoceptor Blockade on the Failing Heart. Circ. Res.
102: 633-636
[Abstract][Full Text]
Tsutsumi, T., Ide, T., Yamato, M., Kudou, W., Andou, M., Hirooka, Y., Utsumi, H., Tsutsui, H., Sunagawa, K.
(2008). Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction. Cardiovasc Res
77: 713-721
[Abstract][Full Text]
Yumino, D., Bradley, T. D.
(2008). Central Sleep Apnea and Cheyne-Stokes Respiration. Proc Am Thorac Soc
5: 226-236
[Abstract][Full Text]
Lykidis, C. K., White, M. J., Balanos, G. M.
(2008). The pulmonary vascular response to the sustained activation of the muscle metaboreflex in man. Exp Physiol
93: 247-253
[Abstract][Full Text]
Houssiere, A., Gujic, M., Deboeck, G., Ciarka, A., Naeije, R., van de Borne, P.
(2007). Increased metaboreflex activity is related to exercise intolerance in heart transplant patients. Am. J. Physiol. Heart Circ. Physiol.
293: H3699-H3706
[Abstract][Full Text]
Tsukamoto, T., Morita, K., Naya, M., Inubushi, M., Katoh, C., Nishijima, K., Kuge, Y., Okamoto, H., Tsutsui, H., Tamaki, N.
(2007). Decreased Myocardial {beta}-Adrenergic Receptor Density in Relation to Increased Sympathetic Tone in Patients with Nonischemic Cardiomyopathy. JNM
48: 1777-1782
[Abstract][Full Text]
Kioka, H., Yamada, T., Mine, T., Morita, T., Tsukamoto, Y., Tamaki, S., Masuda, M., Okuda, K., Hori, M., Fukunami, M.
(2007). Prediction of sudden death in patients with mild-to-moderate chronic heart failure by using cardiac iodine-123 metaiodobenzylguanidine imaging. Heart
93: 1213-1218
[Abstract][Full Text]
Otte, C., McCaffery, J., Ali, S., Whooley, M. A.
(2007). Association of a Serotonin Transporter Polymorphism (5-HTTLPR) With Depression, Perceived Stress, and Norepinephrine in Patients With Coronary Disease: The Heart and Soul Study. Am. J. Psychiatry
164: 1379-1384
[Abstract][Full Text]
Gould, P. A., Kong, G., Kalff, V., Duffy, S. J., Taylor, A. J., Kelly, M. J., Kaye, D. M.
(2007). Improvement in cardiac adrenergic function post biventricular pacing for heart failure. Europace
9: 751-756
[Abstract][Full Text]
Gilsbach, R., Brede, M., Beetz, N., Moura, E., Muthig, V., Gerstner, C., Barreto, F., Neubauer, S., Vieira-Coelho, M. A., Hein, L.
(2007). Heterozygous {alpha}2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction. Cardiovasc Res
75: 728-737
[Abstract][Full Text]
Li, D., Wang, L., Lee, C.-W., Dawson, T. A., Paterson, D. J.
(2007). Noradrenergic Cell Specific Gene Transfer With Neuronal Nitric Oxide Synthase Reduces Cardiac Sympathetic Neurotransmission in Hypertensive Rats. Hypertension
50: 69-74
[Abstract][Full Text]
Gao, L., Wang, W., Liu, D., Zucker, I. H.
(2007). Exercise Training Normalizes Sympathetic Outflow by Central Antioxidant Mechanisms in Rabbits With Pacing-Induced Chronic Heart Failure. Circulation
115: 3095-3102
[Abstract][Full Text]
Matus, M., Lewin, G., Stumpel, F., Buchwalow, I. B., Schneider, M. D., Schutz, G., Schmitz, W., Muller, F. U.
(2007). Cardiomyocyte-specific inactivation of transcription factor CREB in mice. FASEB J.
21: 1884-1892
[Abstract][Full Text]
Stickland, M. K., Miller, J. D., Smith, C. A., Dempsey, J. A.
(2007). Carotid Chemoreceptor Modulation of Regional Blood Flow Distribution During Exercise in Health and Chronic Heart Failure. Circ. Res.
100: 1371-1378
[Abstract][Full Text]
Ellison, G. M., Torella, D., Karakikes, I., Purushothaman, S., Curcio, A., Gasparri, C., Indolfi, C., Cable, N. T., Goldspink, D. F., Nadal-Ginard, B.
(2007). Acute beta-Adrenergic Overload Produces Myocyte Damage through Calcium Leakage from the Ryanodine Receptor 2 but Spares Cardiac Stem Cells. J. Biol. Chem.
282: 11397-11409
[Abstract][Full Text]
Wei, S.-k., Ruknudin, A. M., Shou, M., McCurley, J. M., Hanlon, S. U., Elgin, E., Schulze, D. H., Haigney, M. C.P.
(2007). Muscarinic Modulation of the Sodium-Calcium Exchanger in Heart Failure. Circulation
115: 1225-1233
[Abstract][Full Text]
Grassi, G., Seravalle, G., Quarti-Trevano, F., Scopelliti, F., Dell'Oro, R., Bolla, G., Mancia, G.
(2007). Excessive Sympathetic Activation in Heart Failure With Obesity and Metabolic Syndrome: Characteristics and Mechanisms. Hypertension
49: 535-541
[Abstract][Full Text]
Gao, L., Pan, Y.-X., Wang, W.-Z., Li, Y.-L., Schultz, H. D., Zucker, I. H., Wang, W.
(2007). Cardiac sympathetic afferent stimulation augments the arterial chemoreceptor reflex in anesthetized rats. J. Appl. Physiol.
102: 37-43
[Abstract][Full Text]
Najem, B., Unger, P., Preumont, N., Jansens, J.-L., Houssiere, A., Pathak, A., Xhaet, O., Gabriel, L., Friart, A., De Roy, L., Vandenbossche, J.-L., van de Borne, P.
(2006). Sympathetic control after cardiac resynchronization therapy: responders versus nonresponders. Am. J. Physiol. Heart Circ. Physiol.
291: H2647-H2652
[Abstract][Full Text]
Snyder, E. M., Turner, S. T., Johnson, B. D.
(2006). {beta}2-Adrenergic Receptor Genotype and Pulmonary Function in Patients With Heart Failure.. Chest
130: 1527-1534
[Abstract][Full Text]
Gustafsson, F, Torp-Pedersen, C, Seibaek, M, Burchardt, H, Nielsen, O W., Kober, L, for the DIAMOND study group,
(2006). A history of arterial hypertension does not affect mortality in patients hospitalised with congestive heart failure. Heart
92: 1430-1433
[Abstract][Full Text]
Kim, Y.-K., Hwang, G.-S., Huh, I.-Y., Hwang, J.-H., Park, J.-Y., Chung, S.-L., Kwon, T.-W., Han, S.-M.
(2006). Altered autonomic cardiovascular regulation after combined deep and superficial cervical plexus blockade for carotid endarterectomy.. Anesth. Analg.
103: 533-539
[Abstract][Full Text]
Heaton, D. A., Lei, M., Li, D., Golding, S., Dawson, T. A., Mohan, R. M., Paterson, D. J.
(2006). Remodeling of the Cardiac Pacemaker L-Type Calcium Current and Its {beta}-Adrenergic Responsiveness in Hypertension After Neuronal NO Synthase Gene Transfer. Hypertension
48: 443-452
[Abstract][Full Text]
Joyner, M. J.
(2006). Go with the flow: sympathetic control of blood flow during recovery from heart failure. J. Appl. Physiol.
101: 3-4
[Full Text]
Carter, S., Colyer, J., Sitsapesan, R.
(2006). Maximum Phosphorylation of the Cardiac Ryanodine Receptor at Serine-2809 by Protein Kinase A Produces Unique Modifications to Channel Gating and Conductance Not Observed at Lower Levels of Phosphorylation. Circ. Res.
98: 1506-1513
[Abstract][Full Text]
Silke, B.
(2006). Beta-blockade in CHF: pathophysiological considerations. Eur Heart J Suppl
8: C13-C18
[Abstract][Full Text]
Funck-Brentano, C.
(2006). Beta-blockade in CHF: from contraindication to indication. Eur Heart J Suppl
8: C19-C27
[Abstract][Full Text]
Ponikowski, P.
(2006). Rationale and design of CIBIS III. Eur Heart J Suppl
8: C35-C42
[Abstract][Full Text]
Vanoli, E., Adamson, P. B.
(2006). What does the future hold for the management of chronic heart failure?. Eur Heart J Suppl
8: C51-C57
[Abstract][Full Text]
Buss, S. J., Backs, J., Kreusser, M. M., Hardt, S. E., Maser-Gluth, C., Katus, H. A., Haass, M.
(2006). Spironolactone Preserves Cardiac Norepinephrine Reuptake in Salt-Sensitive Dahl Rats. Endocrinology
147: 2526-2534
[Abstract][Full Text]
Huang, P-H, Leu, H-B, Chen, J-W, Wu, T-C, Lu, T-M, Ding, Y-A, Lin, S-J
(2006). Comparison of endothelial vasodilator function, inflammatory markers, and N-terminal pro-brain natriuretic peptide in patients with or without chronotropic incompetence to exercise test. Heart
92: 609-614
[Abstract][Full Text]
Sinha, A.-M., Skobel, E. C., Breithardt, O.-A., Zheng, H., Zhan, H., Wilcox, I., Booth, V., Lattimore, J., Chhajed, P. N., Tamm, M., Strobel, W., Neuberger, H.-R., Bohm, M., Mewis, C., Bradley, T. D., Floras, J. S., Logan, A. G., Yaggi, H. K., Concato, J., Mohsenin, V.
(2006). Sleep apnea and heart disease.. NEJM
354: 1086-1089
[Full Text]
Regitz-Zagrosek, V., Hocher, B., Bettmann, M., Brede, M., Hadamek, K., Gerstner, C., Lehmkuhl, H. B., Hetzer, R., Hein, L.
(2006). {alpha}2C-Adrenoceptor polymorphism is associated with improved event-free survival in patients with dilated cardiomyopathy. Eur Heart J
27: 454-459
[Abstract][Full Text]
Kreusser, M. M., Haass, M., Buss, S. J., Hardt, S. E., Gerber, S. H., Kinscherf, R., Katus, H. A., Backs, J.
(2006). Injection of Nerve Growth Factor Into Stellate Ganglia Improves Norepinephrine Reuptake Into Failing Hearts. Hypertension
47: 209-215
[Abstract][Full Text]
Schrier, R. W.
(2006). Role of Diminished Renal Function in Cardiovascular Mortality: Marker or Pathogenetic Factor?. J Am Coll Cardiol
47: 1-8
[Abstract][Full Text]
Joyner, M. J
(2006). Baroreceptor function during exercise: resetting the record. Exp Physiol
91: 27-36
[Abstract][Full Text]
Gould, P. A., Yii, M., Esler, M. D., Power, J. M., Kaye, D. M.
(2005). Atrial fibrillation impairs cardiac sympathetic response to baroreceptor unloading in congestive heart failure. Eur Heart J
26: 2562-2567
[Abstract][Full Text]
Unterberg, C., Luthje, L., Szych, J., Vollmann, D., Hasenfuss, G., Andreas, S.
(2005). Atrial overdrive pacing compared to CPAP in patients with obstructive sleep apnoea syndrome. Eur Heart J
26: 2568-2575
[Abstract][Full Text]
Spaak, J., Egri, Z. J., Kubo, T., Yu, E., Ando, S.-I., Kaneko, Y., Usui, K., Bradley, T. D., Floras, J. S.
(2005). Muscle Sympathetic Nerve Activity During Wakefulness in Heart Failure Patients With and Without Sleep Apnea. Hypertension
46: 1327-1332
[Abstract][Full Text]
Otte, C., Neylan, T. C., Pipkin, S. S., Browner, W. S., Whooley, M. A.
(2005). Depressive Symptoms and 24-Hour Urinary Norepinephrine Excretion Levels in Patients With Coronary Disease: Findings From the Heart and Soul Study. Am. J. Psychiatry
162: 2139-2145
[Abstract][Full Text]
Cohen-Solal, A., Rouzet, F., Berdeaux, A., Le Guludec, D., Abergel, E., Syrota, A., Merlet, P.
(2005). Effects of Carvedilol on Myocardial Sympathetic Innervation in Patients with Chronic Heart Failure. JNM
46: 1796-1803
[Abstract][Full Text]
Sakai, K., Hirooka, Y., Shigematsu, H., Kishi, T., Ito, K., Shimokawa, H., Takeshita, A., Sunagawa, K.
(2005). Overexpression of eNOS in brain stem reduces enhanced sympathetic drive in mice with myocardial infarction. Am. J. Physiol. Heart Circ. Physiol.
289: H2159-H2166
[Abstract][Full Text]
Recchia, F. A., Giacca, M.
(2005). Targeted Uptake-1 Carrier to Rescue the Failing Heart. Circ. Res.
97: 847-849
[Full Text]
Munch, G., Rosport, K., Bultmann, A., Baumgartner, C., Li, Z., Laacke, L., Ungerer, M.
(2005). Cardiac Overexpression of the Norepinephrine Transporter Uptake-1 Results in Marked Improvement of Heart Failure. Circ. Res.
97: 928-936
[Abstract][Full Text]
Fang, J. C.
(2005). Angiotensin-Converting Enzyme Inhibitors or {beta}-Blockers in Heart Failure: Does It Matter Who Goes First?. Circulation
112: 2380-2382
[Full Text]
Naccarelli, G. V.
(2005). Antiadrenergic Therapy in the Control of Atrial Fibrillation. J CARDIOVASC PHARMACOL THER
10: S33-S43
[Abstract]
Kiriazis, H., Du, X.-J., Feng, X., Hotchkin, E., Marshall, T., Finch, S., Gao, X.-M., Lambert, G., Choate, J. K., Kaye, D. M.
(2005). Preserved left ventricular structure and function in mice with cardiac sympathetic hyperinnervation. Am. J. Physiol. Heart Circ. Physiol.
289: H1359-H1365
[Abstract][Full Text]
Wang, J.-F., Meissner, A., Malek, S., Chen, Y., Ke, Q., Zhang, J., Chu, V., Hampton, T. G., Crumpacker, C. S., Abelmann, W. H., Amende, I., Morgan, J. P.
(2005). Propranolol ameliorates and epinephrine exacerbates progression of acute and chronic viral myocarditis. Am. J. Physiol. Heart Circ. Physiol.
289: H1577-H1583
[Abstract][Full Text]
Motte, S., Mathieu, M., Brimioulle, S., Pensis, A., Ray, L., Ketelslegers, J.-M., Montano, N., Naeije, R., van de Borne, P., Entee, K. M.
(2005). Respiratory-related heart rate variability in progressive experimental heart failure. Am. J. Physiol. Heart Circ. Physiol.
289: H1729-H1735
[Abstract][Full Text]
Muller, F. U.
(2005). Increased eNOS expression as a compensatory mechanism reducing {beta}-adrenergic responsiveness?. Cardiovasc Res
67: 575-577
[Full Text]
Danson, E.J.F., Zhang, Y.H., Sears, C.E., Edwards, A.R., Casadei, B., Paterson, D.J.
(2005). Disruption of inhibitory G-proteins mediates a reduction in atrial {beta}-adrenergic signaling by enhancing eNOS expression. Cardiovasc Res
67: 613-623
[Abstract][Full Text]
Wehrens, X. H. T., Lehnart, S. E., Reiken, S., van der Nagel, R., Morales, R., Sun, J., Cheng, Z., Deng, S.-X., de Windt, L. J., Landry, D. W., Marks, A. R.
(2005). Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc. Natl. Acad. Sci. USA
102: 9607-9612
[Abstract][Full Text]
Sinoway, L. I., Li, J.
(2005). A perspective on the muscle reflex: implications for congestive heart failure. J. Appl. Physiol.
99: 5-22
[Abstract][Full Text]
Luthje, L., Unterberg-Buchwald, C., Dajani, D., Vollmann, D., Hasenfuss, G., Andreas, S.
(2005). Atrial Overdrive Pacing in Patients with Sleep Apnea with Implanted Pacemaker. Am. J. Respir. Crit. Care Med.
172: 118-122
[Abstract][Full Text]
Lehnart, S. E., Wehrens, X. H.T., Marks, A. R.
(2005). Defective Ryanodine Receptor Interdomain Interactions May Contribute to Intracellular Ca2+ Leak: A Novel Therapeutic Target in Heart Failure. Circulation
111: 3342-3346
[Full Text]
Petersson, M., Friberg, P., Eisenhofer, G., Lambert, G., Rundqvist, B.
(2005). Long-term outcome in relation to renal sympathetic activity in patients with chronic heart failure. Eur Heart J
26: 906-913
[Abstract][Full Text]
Braun, M U, Rauwolf, T, Zerm, T, Schulze, M, Schnabel, A, Strasser, R H
(2005). Long term biventricular resynchronisation therapy in advanced heart failure: effect on neurohormones. Heart
91: 601-605
[Abstract][Full Text]
Kaye, D., Esler, M.
(2005). Sympathetic neuronal regulation of the heart in aging and heart failure. Cardiovasc Res
66: 256-264
[Abstract][Full Text]
Camici, P G
(2005). Coronary recanalisation, myocardial viability, and ventricular remodelling after infarction. Heart
91: 421-422
[Abstract][Full Text]
Joyner, M. J.
(2005). Treating Hypertension: When to Say Win. Hypertension
45: 487-488
[Full Text]
Anavekar, N. S, Solomon, S. D
(2005). Angiotensin II receptor blockade and ventricular remodelling. Journal of Renin-Angiotensin-Aldosterone System
6: 43-48
[Abstract]
Muller, F. U., Lewin, G., Baba, H. A., Boknik, P., Fabritz, L., Kirchhefer, U., Kirchhof, P., Loser, K., Matus, M., Neumann, J., Riemann, B., Schmitz, W.
(2005). Heart-directed Expression of a Human Cardiac Isoform of cAMP-Response Element Modulator in Transgenic Mice. J. Biol. Chem.
280: 6906-6914
[Abstract][Full Text]
Morisco, C., Condorelli, G., Trimarco, V., Bellis, A., Marrone, C., Condorelli, G., Sadoshima, J., Trimarco, B.
(2005). Akt Mediates the Cross-Talk Between {beta}-Adrenergic and Insulin Receptors in Neonatal Cardiomyocytes. Circ. Res.
96: 180-188
[Abstract][Full Text]
Tulppo, M. P., Huikuri, H. V., Tutungi, E., Kimmerly, D. S., Gelb, A. W., Hughson, R. L., Makikallio, T. H., Kevin Shoemaker, J.
(2005). Feedback effects of circulating norepinephrine on sympathetic outflow in healthy subjects. Am. J. Physiol. Heart Circ. Physiol.
288: H710-H715
[Abstract][Full Text]
Yan, A. T., Yan, R. T., Liu, P. P.
(2005). Narrative Review: Pharmacotherapy for Chronic Heart Failure: Evidence from Recent Clinical Trials. ANN INTERN MED
142: 132-145
[Abstract][Full Text]
Ozdemir, O., Alyan, O., Soylu, M., Metin, F., Kacmaz, F., Demir, A. D., Geyik, B., Aras, D., Sasmaz, H., Korkmaz, S.
(2005). Improvement in sympatho-vagal imbalance and heart rate variability in patients with mitral stenosis after percutaneous balloon commissurotomy. Europace
7: 204-210
[Abstract][Full Text]
Wang, Y., Liu, X.-F., Cornish, K. G., Zucker, I. H., Patel, K. P.
(2005). Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure. Am. J. Physiol. Heart Circ. Physiol.
288: H205-H213
[Abstract][Full Text]
Ohta, T., Hasebe, N., Tsuji, S., Izawa, K., Jin, Y.-T., Kido, S., Natori, S., Sato, M., Kikuchi, K.
(2004). Unequal effects of renin-angiotensin system inhibitors in acute cardiac dysfunction induced by isoproterenol. Am. J. Physiol. Heart Circ. Physiol.
287: H2914-H2921
[Abstract][Full Text]
Kaye, D. M., Smirk, B., Finch, S., Williams, C., Esler, M. D.
(2004). Interaction between cardiac sympathetic drive and heart rate in heart failure: Modulation by adrenergic receptor genotype. J Am Coll Cardiol
44: 2008-2015
[Abstract][Full Text]
Siecke, N. W., Insel, P. A.
(2004). Clarifying the effects of adrenergic receptor polymorphisms by measuring synaptic parameters. J Am Coll Cardiol
44: 2016-2018
[Full Text]
Joyner, M. J.
(2004). Congestive Heart Failure: More Bad News From Exercising Muscle?. Circulation
110: 2978-2979
[Full Text]
Zhu, G.-Q., Gao, L., Patel, K. P., Zucker, I. H., Wang, W.
(2004). ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure. J. Appl. Physiol.
97: 1746-1754
[Abstract][Full Text]
Shehab, A M A, MacFadyen, R J, McLaren, M, Tavendale, R, Belch, J J F, Struthers, A D
(2004). Sudden unexpected death in heart failure may be preceded by short term, intraindividual increases in inflammation and in autonomic dysfunction: a pilot study. Heart
90: 1263-1268
[Abstract][Full Text]
Emdin, M., Marini, C., Passino, C., Giuggioli, D., Formichi, B., Ferri, C., Khabirinejad, J., Poletti, R., Prontera, C., Iervasi, A., L'Abbate, A.
(2004). Right ventricular overload and cardiovascular neuroendocrine derangement in systemic sclerosis. Eur Heart J Suppl
6: F68-F73
[Abstract][Full Text]
Grassi, G., Vincenti, A., Brambilla, R., Trevano, F. Q., Dell'Oro, R., Ciro, A., Trocino, G., Vincenzi, A., Mancia, G.
(2004). Sustained Sympathoinhibitory Effects of Cardiac Resynchronization Therapy in Severe Heart Failure. Hypertension
44: 727-731
[Abstract][Full Text]
Ohuchi, H., Takasugi, H., Ohashi, H., Yamada, O., Watanabe, K., Yagihara, T., Echigo, S.
(2004). Abnormalities of Neurohormonal and Cardiac Autonomic Nervous Activities Relate Poorly to Functional Status in Fontan Patients. Circulation
110: 2601-2608
[Abstract][Full Text]
Adamson, P. B., Smith, A. L., Abraham, W. T., Kleckner, K. J., Stadler, R. W., Shih, A., Rhodes, M. M., on behalf of the InSync III Model 8042 and Attain,
(2004). Continuous Autonomic Assessment in Patients With Symptomatic Heart Failure: Prognostic Value of Heart Rate Variability Measured by an Implanted Cardiac Resynchronization Device. Circulation
110: 2389-2394
[Abstract][Full Text]
Zhu, G.-Q., Gao, L., Li, Y., Patel, K. P., Zucker, I. H., Wang, W.
(2004). AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure. Am. J. Physiol. Heart Circ. Physiol.
287: H1828-H1835
[Abstract][Full Text]
Hartmann, F., Packer, M., Coats, A. J.S., Fowler, M. B., Krum, H., Mohacsi, P., Rouleau, J. L., Tendera, M., Castaigne, A., Anker, S. D., Amann-Zalan, I., Hoersch, S., Katus, H. A.
(2004). Prognostic Impact of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Severe Chronic Congestive Heart Failure: A Substudy of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Trial. Circulation
110: 1780-1786
[Abstract][Full Text]
Iwatsubo, K., Minamisawa, S., Tsunematsu, T., Nakagome, M., Toya, Y., Tomlinson, J. E., Umemura, S., Scarborough, R. M., Levy, D. E., Ishikawa, Y.
(2004). Direct Inhibition of Type 5 Adenylyl Cyclase Prevents Myocardial Apoptosis without Functional Deterioration. J. Biol. Chem.
279: 40938-40945
[Abstract][Full Text]
Bristow, M.R., Krause-Steinrauf, H., Nuzzo, R., Liang, C.-S., Lindenfeld, J., Lowes, B.D., Hattler, B., Abraham, W.T., Olson, L., Krueger, S., Thaneemit-Chen, S., Hare, J.M., Loeb, H.S., Domanski, M.J., Eichhorn, E.J., Zelis, R., Lavori, P.
(2004). Effect of Baseline or Changes in Adrenergic Activity on Clinical Outcomes in the {beta}-Blocker Evaluation of Survival Trial. Circulation
110: 1437-1442
[Abstract][Full Text]
Previous
