FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 311:1345-1349 November 22, 1984 Number 21 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

In a crossover study conducted over a six-month period in eight patients with well-characterized premenstrual syndrome, physical and behavioral symptoms were relieved by daily administration of an agonist of gonadotropin-releasing hormone. The reversible "medical ovariectomy" attained with this agonist suggests that it may be an effective and rational treatment for this distressing syndrome in the short term. Whether prolonged therapy would be safe and effective, or even necessary, remains to be determined.

This article has been cited by other articles:

• Becker, J. B., Arnold, A. P., Berkley, K. J., Blaustein, J. D., Eckel, L. A., Hampson, E., Herman, J. P., Marts, S., Sadee, W., Steiner, M., Taylor, J., Young, E. (2005). Strategies and Methods for Research on Sex Differences in Brain and Behavior. Endocrinology 146: 1650-1673 [Abstract] [Full Text]  
• Hochberg, Z.'e., Pacak, K., Chrousos, G. P. (2003). Endocrine Withdrawal Syndromes. Endocr. Rev. 24: 523-538 [Abstract] [Full Text]  
• Thys-Jacobs, S. (2000). Micronutrients and the Premenstrual Syndrome: The Case for Calcium. J. Am. Coll. Nutr. 19: 220-227 [Abstract] [Full Text]  
• Schmidt, P. J., Nieman, L. K., Danaceau, M. A., Adams, L. F., Rubinow, D. R. (1998). Differential Behavioral Effects of Gonadal Steroids in Women with and in Those without Premenstrual Syndrome. NEJM 338: 209-216 [Abstract] [Full Text]  
• Mortola, J. F. (1998). Premenstrual Syndrome -- Pathophysiologic Considerations. NEJM 338: 256-257 [Full Text]  
• Steiner, M., Steinberg, S., Stewart, D., Carter, D., Berger, C., Reid, R., Grover, D., Streiner, D., The Canadian Fluoxetine/Premenstrual Dysphoria Col, (1995). Fluoxetine in the Treatment of Premenstrual Dysphoria. NEJM 332: 1529-1534 [Abstract] [Full Text]  
• Letterie, G. S., Fredlund, P. N. (1994). Catamenial Insulin Reactions Treated With a Long-Acting Gonadotropin Releasing Hormone Agonist. Arch Intern Med 154: 1868-1870 [Abstract]  
• Rubinow, D. R. (1992). The Premenstrual Syndrome: New Views. JAMA 268: 1908-1912 [Abstract]  
• Harrison, W. M., Endicott, J., Nee, J. (1990). Treatment of Premenstrual Dysphoria With Alprazolam: A Controlled Study. Arch Gen Psychiatry 47: 270-275 [Abstract]  
• Kashkin, K. B., Kleber, H. D. (1989). Hooked on Hormones? An Anabolic Steroid Addiction Hypothesis. JAMA 262: 3166-3170 [Abstract]