Over the past four decades, a great deal has been learned about the pharmacology and mechanisms of action of antithyroid drugs. Their ability to inhibit hormone biosynthesis involves complex interactions with thyroid peroxidase and thyroglobulin, many of which are still poorly understood. Their spectrum of activity is much wider than previously thought, and a number of clinically important extrathyroidal actions have been identified. Despite a greater appreciation for the intricacies of antithyroid-drug pharmacology, controversies still surround the use of these agents in the treatment of thyrotoxicosis. These controversies are apt to continue until the pathophysiology of Graves' disease is fully elucidated.
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[Abstract][Full Text]
Ginsberg, J.
(2003). Diagnosis and management of Graves' disease. CMAJ
168: 575-585
[Abstract][Full Text]
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(2001). Methimazole As an Antioxidant and Immunomodulator in Thyroid Cells: Mechanisms Involving Interferon-gamma Signaling and H2O2 Scavenging. Mol. Pharmacol.
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[Abstract][Full Text]
Sato, H., Hattori, M., Fujieda, M., Sugihara, S., Inomata, H., Hoshi, M., Miyamoto, S.
(2000). High Prevalence of Antineutrophil Cytoplasmic Antibody Positivity in Childhood Onset Graves' Disease Treated with Propylthiouracil. J. Clin. Endocrinol. Metab.
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[Abstract][Full Text]
Lee, A., Moretti, M. E., Collantes, A., Chong, D., Mazzotta, P., Koren, G., Merchant, S. S., Ito, S.
(2000). Choice of Breastfeeding and Physicians' Advice: A Cohort Study of Women Receiving Propylthiouracil. Pediatrics
106: 27-30
[Abstract][Full Text]
Khurshid, I., Sher, J.
(2000). Disseminated intravascular coagulation and vasculitis during propylthiouracil therapy. Postgrad. Med. J.
76: 185-186
[Full Text]
Derwahl, M., Broecker, M., Kraiem, Z.
(1999). Thyrotropin May Not Be the Dominant Growth Factor in Benign and Malignant Thyroid Tumors. J. Clin. Endocrinol. Metab.
84: 829-834
[Full Text]
Rivkees, S. A., Sklar, C., Freemark, M.
(1998). The Management of Graves' Disease in Children, with Special Emphasis on Radioiodine Treatment. J. Clin. Endocrinol. Metab.
83: 3767-3776
[Full Text]
Wortsman, J., McConnachie, P., Tahara, K., Kohn, L. D.
(1998). Thyrotropin Receptor Epitopes Recognized by Graves' Autoantibodies Developing under Immunosuppressive Therapy. J. Clin. Endocrinol. Metab.
83: 2302-2308
[Abstract][Full Text]
Montani, V., Taniguchi, S.-i., Shong, M., Suzuki, K., Ohmori, M., Giuliani, C., Napolitano, G., Saji, M., Fiorentino, B., Reimold, A. M., Ting, J. P.-Y., Kohn, L. D., Singer, D. S.
(1998). Major Histocompatibility Class II HLA-DR{alpha} Gene Expression in Thyrocytes: Counter Regulation by the Class II Transactivator and the Thyroid Y Box Protein. Endocrinology
139: 280-289
[Abstract][Full Text]
Montani, V., Shong, M., Taniguchi, S.-i., Suzuki, K., Giuliani, C., Napolitano, G., Saito, J., Saji, M., Fiorentino, B., Reimold, A. M., Singer, D. S., Kohn, L. D.
(1998). Regulation of Major Histocompatibility Class II Gene Expression in FRTL-5 Thyrocytes: Opposite Effects of Interferon and Methimazole. Endocrinology
139: 290-302
[Abstract][Full Text]
Momotani, N., Yoshimura Noh, J., Ishikawa, N., Ito, K.
(1997). Effects of Propylthiouracil and Methimazole on Fetal Thyroid Status in Mothers with Graves' Hyperthyroidism. J. Clin. Endocrinol. Metab.
82: 3633-3636
[Abstract][Full Text]
Williams, K. V., Nayak, S., Becker, D., Reyes, J., Burmeister, L. A.
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82: 1727-1733
[Abstract][Full Text]
Hansen, B. A.
(1990). Antithyroid Drugs and Breastfeeding. J Hum Lact
6: 130-131
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