In a prospective epidemiologic study of 1001 middle-aged men, we examined the relation between dietary information collected approximately 20 years ago and subsequent mortality from coronary heart disease. The men were initially enrolled in three cohorts: one of men born and living in Ireland, another of those born in Ireland who had emigrated to Boston, and the third of those born in the Boston area of Irish immigrants. There were no differences in mortality from coronary heart disease among the three cohorts. In within-population analyses, those who died of coronary heart disease had higher Keys (P = 0.06) and modified Hegsted (P = 0.02) dietary scores than did those who did not (a high score indicates a high intake of saturated fatty acids and cholesterol and a relatively low intake of polyunsaturated fatty acids). These associations were significant (P = 0.03 for the Keys and P = 0.04 for the modified Hegsted scores) after adjustment for other risk factors for coronary heart disease. Fiber intake (P = 0.04) and a vegetable-foods score, which rose with increased intake of fiber, vegetable protein, and starch (P = 0.02), were lower among those who died from coronary heart disease, though not significantly so after adjustment for other risk factors. A higher Keys score carried an increased risk of coronary heart disease (relative risk, 1.60), and a higher fiber intake carried a decreased risk (relative risk, 0.57). Overall, these results tend to support the hypothesis that diet is related, albeit weakly, to the development of coronary heart disease.
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[Abstract][Full Text]
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[Abstract][Full Text]
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70: 221-227
[Abstract][Full Text]
Anderson, J. W., Hanna, T. J.
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129: 1457-1457
[Abstract][Full Text]
Wolk, A., Manson, J. E., Stampfer, M. J., Colditz, G. A., Hu, F. B., Speizer, F. E., Hennekens, C. H., Willett, W. C.
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281: 1998-2004
[Abstract][Full Text]
Kushi, L. H
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69
: 1322S-1329S
[Abstract][Full Text]
Sempos, C. T, Liu, K., Ernst, N. D
(1999). Food and nutrient exposures: what to consider when evaluating epidemiologic evidence. Am. J. Clin. Nutr.
69
: 1330S-1338S
[Abstract][Full Text]
Hu, F. B., Stampfer, M. J., Rimm, E. B., Manson, J. E., Ascherio, A., Colditz, G. A., Rosner, B. A., Spiegelman, D., Speizer, F. E., Sacks, F. M., Hennekens, C. H., Willett, W. C.
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281: 1387-1394
[Abstract][Full Text]
Brown, L., Rosner, B., Willett, W. W, Sacks, F. M
(1999). Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am. J. Clin. Nutr.
69: 30-42
[Abstract][Full Text]
Mennen, L. I., de Maat, M. P. M., Schouten, E. G., Kluft, C., Witteman, J. C. M., Hofman, A., Grobbee, D. E.
(1998). Dietary Effects on Coagulation Factor VII Vary across Genotypes of the R/Q353 Polymorphism in Elderly People. J. Nutr.
128: 870-874
[Abstract][Full Text]
Ginsberg, H. N., Kris-Etherton, P., Dennis, B., Elmer, P. J., Ershow, A., Lefevre, M., Pearson, T., Roheim, P., Ramakrishnan, R., Reed, R., Stewart, K., Stewart, P., Phillips, K., Anderson, N.
(1998). Effects of Reducing Dietary Saturated Fatty Acids on Plasma Lipids and Lipoproteins in Healthy Subjects : The Delta Study, Protocol 1. Arterioscler. Thromb. Vasc. Bio.
18: 441-449
[Abstract][Full Text]
Hu, F. B., Stampfer, M. J., Manson, J. E., Rimm, E., Colditz, G. A., Rosner, B. A., Hennekens, C. H., Willett, W. C.
(1997). Dietary Fat Intake and the Risk of Coronary Heart Disease in Women. NEJM
337: 1491-1499
[Abstract][Full Text]
Olson, B. H., Anderson, S. M., Becker, M. P., Anderson, J. W., Hunninghake, D. B., Jenkins, D. J. A., LaRosa, J. C., Rippe, J. M., Roberts, D. C. K., Stoy, D. B., Summerbell, C. D., Truswell, A. S., Wolever, T. M. S., Morris, D. H., Fulgoni III, V. L.
(1997). Psyllium-Enriched Cereals Lower Blood Total Cholesterol and LDL Cholesterol, but Not HDL Cholesterol, in Hypercholesterolemic Adults: Results of a Meta-Analysis. J. Nutr.
127: 1973-1980
[Abstract][Full Text]
Van Horn, L.
(1997). Fiber, Lipids, and Coronary Heart Disease : A Statement for Healthcare Professionals From the Nutrition Committee, American Heart Association. Circulation
95: 2701-2704
[Full Text]
Walden, C. E., Retzlaff, B. M., Buck, B. L., McCann, B. S., Knopp, R. H.
(1997). Lipoprotein Lipid Response to the National Cholesterol Education Program Step II Diet by Hypercholesterolemic and Combined Hyperlipidemic Women and Men. Arterioscler. Thromb. Vasc. Bio.
17: 375-382
[Abstract][Full Text]
De Bourdeaudhuij, I.
(1997). Family Food Rules and Healthy Eating in Adolescents. J Health Psychol
2: 45-56
[Abstract]
Pietinen, P., Rimm, E. B., Korhonen, P., Hartman, A. M., Willett, W. C., Albanes, D., Virtamo, J.
(1996). Intake of Dietary Fiber and Risk of Coronary Heart Disease in a Cohort of Finnish Men: The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Circulation
94: 2720-2727
[Abstract][Full Text]
Krauss, R. M., Deckelbaum, R. J., Ernst, N., Fisher, E., Howard, B. V., Knopp, R. H., Kotchen, T., Lichtenstein, A. H., McGill, H. C., Pearson, T. A., Prewitt, T. E., Stone, N. J., Van Horn, L., Weinberg, R.
(1996). Dietary Guidelines for Healthy American Adults: A Statement for Health Professionals From the Nutrition Committee, American Heart Association. Circulation
94: 1795-1800
[Full Text]
Ascherio, A., Rimm, E. B, Giovannucci, E. L, Spiegelman, D., Stampfer, M., Willett, W. C
(1996). Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. BMJ
313: 84-90
[Abstract][Full Text]
Rogers, R. L., Meyer, J. S., McClintic, K., Mortel, K. F.
(1989). Reducing Hypertriglyceridemia in Elderly Patients with Cerebrovascular Disease Stabilizes or Improves Cognition and Cerebral Perfusion. ANGIOLOGY
40: 260-269
[Abstract]
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