It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion injury. Although there are certainly multiple components to clinical ischemic and reperfusion injury, it appears likely that free-radical production may make a major contribution at certain stages in the progression of the injury. The primary source of superoxide in reperfused reoxygenated tissues appears to be the enzyme xanthine oxidase, released during ischemia by a calcium-triggered proteolytic attack on xanthine dehydrogenase. Reperfused tissues are protected in a variety of laboratory models by scavengers of superoxide radicals or hydroxyl radicals or by allopurinol or other inhibitors of xanthine oxidase. Dysfunction induced by free radicals may thus be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain.
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[Abstract][Full Text]
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87: 315-424
[Abstract][Full Text]
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[Abstract][Full Text]
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291: L345-L353
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[Abstract][Full Text]
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[Abstract][Full Text]
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66: 2257-2263
[Abstract][Full Text]
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47: 195-202
[Abstract][Full Text]
Liu, J. Q., Zelko, I. N., Erbynn, E. M., Sham, J. S. K., Folz, R. J.
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290: L2-L10
[Abstract][Full Text]
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(2006). Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition. Am. J. Physiol. Heart Circ. Physiol.
290: H128-H136
[Abstract][Full Text]
Zhang, Q., Matsuzaki, I., Chatterjee, S., Fisher, A. B.
(2005). Activation of endothelial NADPH oxidase during normoxic lung ischemia is KATP channel dependent. Am. J. Physiol. Lung Cell. Mol. Physiol.
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[Abstract][Full Text]
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20: 557-570
[Abstract]
Moreno, J. M., Gomez, I. R., Wangensteen, R., Osuna, A., Bueno, P., Vargas, F.
(2005). Cardiac and renal antioxidant enzymes and effects of tempol in hyperthyroid rats. Am. J. Physiol. Endocrinol. Metab.
289: E776-E783
[Abstract][Full Text]
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[Abstract][Full Text]
Demirbag, S., Cetinkursun, S., Tasdemir, U., Ozturk, H., Pekcan, M., Yesildaglar, N.
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[Abstract][Full Text]
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280: 24888-24894
[Abstract][Full Text]
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172: 1685-1690
[Abstract][Full Text]
Yamauchi, M., Nakano, H., Maekawa, J., Okamoto, Y., Ohnishi, Y., Suzuki, T., Kimura, H.
(2005). Oxidative Stress in Obstructive Sleep Apnea. Chest
127: 1674-1679
[Abstract][Full Text]
Xie, H., Ray, P. E., Short, B. L.
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36: 1047-1052
[Abstract][Full Text]
Niebauer, J., Clark, A. L., Webb-Peploe, K. M., Boger, R., Coats, A. J.S.
(2005). Home-based exercise training modulates pro-oxidant substrates in patients with chronic heart failure. Eur J Heart Fail
7: 183-188
[Abstract][Full Text]
Vallejo, J. G., Nemoto, S., Ishiyama, M., Yu, B., Knuefermann, P., Diwan, A., Baker, J. S., Defreitas, G., Tweardy, D. J., Mann, D. L.
(2005). Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock. Am. J. Physiol. Heart Circ. Physiol.
288: H1272-H1277
[Abstract][Full Text]
Arimoto, T., Kadiiska, M. B., Sato, K., Corbett, J., Mason, R. P.
(2005). Synergistic Production of Lung Free Radicals by Diesel Exhaust Particles and Endotoxin. Am. J. Respir. Crit. Care Med.
171: 379-387
[Abstract][Full Text]
Lewis, D. N., Nyska, A., Johnson, K., Malarkey, D. E., Ward, S., Streicker, M., Shabat, S., Peddada, S., Nyska, M.
(2005). 2-Butoxyethanol Female-Rat Model of Hemolysis and Disseminated Thrombosis: X-Ray Characterization of Osteonecrosis and Growth-Plate Suppression. Toxicol Pathol
33: 272-282
[Abstract][Full Text]
Kwon, A-H., Inoue, T., Ha-Kawa, S. K.
(2005). Characterization of the Asialoglycoprotein Receptor Under Hypoxic Conditions in Primary Cultured Rat Hepatocytes. JNM
46: 321-325
[Abstract][Full Text]
Paraskevaidis, I. A., Iliodromitis, E. K., Vlahakos, D., Tsiapras, D. P., Nikolaidis, A., Marathias, A., Michalis, A., Kremastinos, D. Th.
(2005). Deferoxamine infusion during coronary artery bypass grafting ameliorates lipid peroxidation and protects the myocardium against reperfusion injury: immediate and long-term significance. Eur Heart J
26: 263-270
[Abstract][Full Text]
van der A, D. L., Peeters, P. H.M., Grobbee, D. E., Marx, J. J.M., van der Schouw, Y. T.
(2005). Dietary haem iron and coronary heart disease in women. Eur Heart J
26: 257-262
[Abstract][Full Text]
Oshima, Y., Fujio, Y., Nakanishi, T., Itoh, N., Yamamoto, Y., Negoro, S., Tanaka, K., Kishimoto, T., Kawase, I., Azuma, J.
(2005). STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart. Cardiovasc Res
65: 428-435
[Abstract][Full Text]
Bonini, M. G., Miyamoto, S., Mascio, P. D., Augusto, O.
(2004). Production of the Carbonate Radical Anion during Xanthine Oxidase Turnover in the Presence of Bicarbonate. J. Biol. Chem.
279: 51836-51843
[Abstract][Full Text]
Grichnik, K. P., D'Amico, T. A.
(2004). Acute Lung Injury and Acute Respiratory Distress Syndrome After Pulmonary Resection. SEMIN CARDIOTHORAC VASC ANESTH
8: 317-334
[Abstract]
Khan, S. A., Lee, K., Minhas, K. M., Gonzalez, D. R., Raju, S. V. Y., Tejani, A. D., Li, D., Berkowitz, D. E., Hare, J. M.
(2004). From the Cover: Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling. Proc. Natl. Acad. Sci. USA
101: 15944-15948
[Abstract][Full Text]
Fukunari, A., Okamoto, K., Nishino, T., Eger, B. T., Pai, E. F., Kamezawa, M., Yamada, I., Kato, N.
(2004). Y-700 [1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic Acid]: A Potent Xanthine Oxidoreductase Inhibitor with Hepatic Excretion. J. Pharmacol. Exp. Ther.
311: 519-528
[Abstract][Full Text]
Stocker, R., Keaney, J. F. Jr.
(2004). Role of Oxidative Modifications in Atherosclerosis. Physiol. Rev.
84: 1381-1478
[Abstract][Full Text]
Fujimoto, H., Ohno, M., Ayabe, S., Kobayashi, H., Ishizaka, N., Kimura, H., Yoshida, K.-i., Nagai, R.
(2004). Carbon Monoxide Protects Against Cardiac Ischemia--Reperfusion Injury In Vivo via MAPK and Akt--eNOS Pathways. Arterioscler. Thromb. Vasc. Bio.
24: 1848-1853
[Abstract][Full Text]
Leimkuhler, S., Stockert, A. L., Igarashi, K., Nishino, T., Hille, R.
(2004). The Role of Active Site Glutamate Residues in Catalysis of Rhodobacter capsulatus Xanthine Dehydrogenase. J. Biol. Chem.
279: 40437-40444
[Abstract][Full Text]
Chen, Y.-W., Hwang, K. C., Yen, C.-C., Lai, Y.-L.
(2004). Fullerene derivatives protect against oxidative stress in RAW 264.7 cells and ischemia-reperfused lungs. Am. J. Physiol. Regul. Integr. Comp. Physiol.
287: R21-R26
[Abstract][Full Text]
Liu, J. Q., Zelko, I. N., Folz, R. J.
(2004). Reoxygenation-induced Constriction in Murine Coronary Arteries: THE ROLE OF ENDOTHELIAL NADPH OXIDASE (gp91phox) AND INTRACELLULAR SUPEROXIDE. J. Biol. Chem.
279: 24493-24497
[Abstract][Full Text]
Ohta, T., Sakano, T., Igarashi, T., Itami, N., Ogawa, T.
(2004). Exercise-induced acute renal failure associated with renal hypouricaemia: results of a questionnaire-based survey in Japan. Nephrol Dial Transplant
19: 1447-1453
[Abstract][Full Text]
Hokamaki, J., Kawano, H., Yoshimura, M., Soejima, H., Miyamoto, S., Kajiwara, I., Kojima, S., Sakamoto, T., Sugiyama, S., Hirai, N., Shimomura, H., Nagayoshi, Y., Tsujita, K., Shioji, I., Sasaki, S., Ogawa, H.
(2004). Urinary biopyrrins levels are elevated in relation to severity of heart failure. J Am Coll Cardiol
43: 1880-1885
[Abstract][Full Text]
Hesberg, C., Hansch, R., Mendel, R. R., Bittner, F.
(2004). Tandem Orientation of Duplicated Xanthine Dehydrogenase Genes from Arabidopsis thaliana: DIFFERENTIAL GENE EXPRESSION AND ENZYME ACTIVITIES. J. Biol. Chem.
279: 13547-13554
[Abstract][Full Text]
Cairns, R. A., Hill, R. P.
(2004). Acute Hypoxia Enhances Spontaneous Lymph Node Metastasis in an Orthotopic Murine Model of Human Cervical Carcinoma. Cancer Res.
64: 2054-2061
[Abstract][Full Text]
Berry, C. E., Hare, J. M.
(2004). Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications. J. Physiol.
555: 589-606
[Abstract][Full Text]
Palatianos, G. M., Balentine, G., Papadakis, E. G., Triantafillou, C. D., Vassili, M. I., Lidoriki, A., Dinopoulos, A., Astras, G. M.
(2004). Neutrophil depletion reduces myocardial reperfusion morbidity. Ann. Thorac. Surg.
77: 956-961
[Abstract][Full Text]
Masini, E., Nistri, S., Vannacci, A., Sacchi, T. B., Novelli, A., Bani, D.
(2004). Relaxin Inhibits the Activation of Human Neutrophils: Involvement of the Nitric Oxide Pathway. Endocrinology
145: 1106-1112
[Abstract][Full Text]
Canton, M., Neverova, I., Menabo, R., Van Eyk, J., Di Lisa, F.
(2004). Evidence of myofibrillar protein oxidation induced by postischemic reperfusion in isolated rat hearts. Am. J. Physiol. Heart Circ. Physiol.
286: H870-H877
[Abstract][Full Text]
Maxey, T. S., Enelow, R. I., Gaston, B., Kron, I. L., Laubach, V. E., Doctor, A.
(2004). Tumor necrosis factor-{alpha} from resident lung cells is a key initiating factor in pulmonary ischemia-reperfusion injury. J. Thorac. Cardiovasc. Surg.
127: 541-547
[Abstract][Full Text]
Aller, M. A., Arias, J. L., Nava, M. P., Arias, J.
(2004). Posttraumatic Inflammation Is a Complex Response Based on the Pathological Expression of the Nervous, Immune, and Endocrine Functional Systems. Exp. Biol. Med.
229: 170-181
[Abstract][Full Text]
Budhiraja, R., Tuder, R. M., Hassoun, P. M.
(2004). Endothelial Dysfunction in Pulmonary Hypertension. Circulation
109: 159-165
[Full Text]
Gianetti, J., Del Sarto, P., Bevilacqua, S., Vassalle, C., De Filippis, R., Kacila, M., Farneti, P. A., Clerico, A., Glauber, M., Biagini, A.
(2004). Supplemental nitric oxide and its effect on myocardial injury and function in patients undergoing cardiac surgery with extracorporeal circulation. J. Thorac. Cardiovasc. Surg.
127: 44-50
[Abstract][Full Text]
Laffey, J. G., Jankov, R. P., Engelberts, D., Tanswell, A. K., Post, M., Lindsay, T., Mullen, J. B., Romaschin, A., Stephens, D., McKerlie, C., Kavanagh, B. P.
(2003). Effects of Therapeutic Hypercapnia on Mesenteric Ischemia-Reperfusion Injury. Am. J. Respir. Crit. Care Med.
168: 1383-1390
[Abstract][Full Text]
Sato, A., Sakuma, I., Gutterman, D. D.
(2003). Mechanism of dilation to reactive oxygen species in human coronary arterioles. Am. J. Physiol. Heart Circ. Physiol.
285: H2345-H2354
[Abstract][Full Text]
Garin, G., Badid, C., McGregor, B., Vincent, M., Guerret, S., Zibara, K., Hurlstone, A., Laville, M., McGregor, J. L.
(2003). Ischemia Induces Early Expression of a New Transcription Factor (6A3-5) in Kidney Vascular Smooth Muscle Cells: Studies in Rat and Human Renal Pathology. Am. J. Pathol.
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[Abstract][Full Text]
Khadaroo, R. G., Kapus, A., Powers, K. A., Cybulsky, M. I., Marshall, J. C., Rotstein, O. D.
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[Abstract][Full Text]
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Ozcelik, B., Serin, I.S., Basbug, M., Uludag, S., Narin, F., Tayyar, M.
(2003). Effect of melatonin in the prevention of post-operative adhesion formation in a rat uterine horn adhesion model. Hum Reprod
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[Abstract][Full Text]
Nonaka-Sarukawa, M, Yamamoto, K, Aoki, H, Takano, H, Katsuki, T, Ikeda, U, Shimada, K
(2003). Increased urinary 15-F2t-isoprostane concentrations in patients with non-ischaemic congestive heart failure: a marker of oxidative stress. Heart
89: 871-874
[Abstract][Full Text]
Kuwabara, Y., Nishino, T., Okamoto, K., Matsumura, T., Eger, B. T., Pai, E. F., Nishino, T.
(2003). Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase. Proc. Natl. Acad. Sci. USA
100: 8170-8175
[Abstract][Full Text]
Linder, N., Martelin, E., Lapatto, R., Raivio, K. O.
(2003). Posttranslational inactivation of human xanthine oxidoreductase by oxygen under standard cell culture conditions. Am. J. Physiol. Cell Physiol.
285: C48-C55
[Abstract][Full Text]
Powell, C. S., Jackson, R. M.
(2003). Mitochondrial complex I, aconitase, and succinate dehydrogenase during hypoxia-reoxygenation: modulation of enzyme activities by MnSOD. Am. J. Physiol. Lung Cell. Mol. Physiol.
285: L189-L198
[Abstract][Full Text]
Vogalis, F., Harvey, J. R.
(2003). Altered Excitability of Intestinal Neurons in Primary Culture Caused by Acute Oxidative Stress. J. Neurophysiol.
89: 3039-3050
[Abstract][Full Text]
Gao, B., Flores, S. C., Leff, J. A., Bose, S. K., McCord, J. M.
(2003). Synthesis and anti-inflammatory activity of a chimeric recombinant superoxide dismutase: SOD2/3. Am. J. Physiol. Lung Cell. Mol. Physiol.
284: L917-L925
[Abstract][Full Text]
Chen, Y.-H., Yet, S.-F., Perrella, M. A.
(2003). Role of Heme Oxygenase-1 in the Regulation of Blood Pressure and Cardiac Function. Exp. Biol. Med.
228: 447-453
[Abstract][Full Text]
Facchini, F. S., Saylor, K. L.
(2003). A Low-Iron-Available, Polyphenol-Enriched, Carbohydrate-Restricted Diet to Slow Progression of Diabetic Nephropathy. Diabetes
52: 1204-1209
[Abstract][Full Text]
Chevion, S., Moran, D. S., Heled, Y., Shani, Y., Regev, G., Abbou, B., Berenshtein, E., Stadtman, E. R., Epstein, Y.
(2003). Plasma antioxidant status and cell injury after severe physical exercise. Proc. Natl. Acad. Sci. USA
100: 5119-5123
[Abstract][Full Text]
Hare, J. M., Johnson, R. J.
(2003). Uric Acid Predicts Clinical Outcomes in Heart Failure: Insights Regarding the Role of Xanthine Oxidase and Uric Acid in Disease Pathophysiology. Circulation
107: 1951-1953
[Full Text]
Bowler, R. P., Arcaroli, J., Abraham, E., Patel, M., Chang, L.-Y., Crapo, J. D.
(2003). Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol.
284: L680-L687
[Abstract][Full Text]
de Perrot, M., Liu, M., Waddell, T. K., Keshavjee, S.
(2003). Ischemia-Reperfusion-induced Lung Injury. Am. J. Respir. Crit. Care Med.
167: 490-511
[Abstract][Full Text]
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