Between February and May 1984, we conducted a pilot study to examine the methods for a larger study of a previously reported relation between Reye's syndrome and medications. Thirty patients with Reye's syndrome, whose diagnosis was confirmed by an expert panel, and 145 controls were matched for age, race (black or not black), and antecedent illness (respiratory infection, chickenpox, or diarrhea) and selected from the same hospital, emergency room, or school, or identified by random digit dialing. Significantly more cases (93 per cent, 28 of 30) than members of each of the four control groups or all controls combined (46 per cent, 66 of 145) had received salicylates during matched antecedent illnesses (odds ratio of all 30 cases vs. all controls = 16.1; lower 95 per cent confidence limit = 4.6). The prevalence and mean severity score of signs, symptoms, and selected events during the antecedent illness tended to be lower among cases than controls. Thus, differences in the severity of this illness between cases and controls did not explain differences in medication exposures. This pilot study suggests an association between Reye's syndrome and the use of salicylates during an antecedent illness.
This article has been cited by other articles:
Plaisance, K. I., Mackowiak, P. A.
(2000). Antipyretic Therapy: Physiologic Rationale, Diagnostic Implications, and Clinical Consequences. Arch Intern Med
160: 449-456
[Abstract][Full Text]
Hall, S. M., Lynn, R., Johnson, G. M., Belay, E. D., Schonberger, L. B., Monto, A. S.
(1999). Reye's Syndrome. NEJM
341: 845-847
[Full Text]
Belay, E. D., Bresee, J. S., Holman, R. C., Khan, A. S., Shahriari, A., Schonberger, L. B.
(1999). Reye's Syndrome in the United States from 1981 through 1997. NEJM
340: 1377-1382
[Abstract][Full Text]
Monto, A. S.
(1999). The Disappearance of Reye's Syndrome -- A Public Health Triumph. NEJM
340: 1423-1424
[Full Text]
Kauffman, R. E.
(1998). Reye's Syndrome and Salicylate Use, by Karen M. Starko, MD, et al, Pediatrics, 1980;66:859-864; and National Patterns of Aspirin Use and Reye Syndrome Reporting, United States, 1980 to 1985, by Janet B. Arrowsmith et al, Pediatrics, 1987;79:858-863. Pediatrics
102: 259-262
[Full Text]
Walson, P. D., Galletta, G., Chomilo, F., Braden, N. J., Sawyer, L. A., Scheinbaum, M. L.
(1992). Comparison of Multidose Ibuprofen and Acetaminophen Therapy in Febrile Children. Arch Pediatr Adolesc Med
146: 626-632
[Abstract]
(1989). Reye Syndrome Surveillance-- United States, 1987 and 1988. JAMA
261: 3520-3523
Forsyth, B. W., Horwitz, R. I., Acampora, D., Shapiro, E. D., Viscoli, C. M., Feinstein, A. R., Henner, R., Holabird, N. B., Jones, B. A., Karabelas, A. D. E., Kramer, M. S., Miclette, M., Wells, J. A.
(1989). New Epidemiologic Evidence Confirming That Bias Does Not Explain the Aspirin/Reye's Syndrome Association. JAMA
261: 2517-2524
[Abstract]
Hurwitz, E. S.
(1988). The Changing Epidemiology of Reye's Syndrome in the United States: Further Evidence for a Public Health Success. JAMA
260: 3178-3180
[Abstract]
Pinsky, P. F., Hurwitz, E. S., Schonberger, L. B., Gunn, W. J.
(1988). Reye's Syndrome and Aspirin: Evidence for a Dose-Response Effect. JAMA
260: 657-661
[Abstract]
Sienko, D. G., Anda, R. F., McGee, H. B., Remington, P. L.
(1987). Reye's Syndrome and Salicylates. JAMA
258: 3119-3119
[Abstract]
Hurwitz, E. S., Barrett, M. J., Bregman, D., Gunn, W. J., Pinsky, P., Schonberger, L. B., Drage, J. S., Kaslow, R. A., Burlington, D. B., Quinnan, G. V., LaMontagne, J. R., Fairweather, W. R., Dayton, D., Dowdle, W. R.
(1987). Public Health Service Study of Reye's Syndrome and Medications: Report of the Main Study. JAMA
257: 1905-1911
[Abstract]
(1987). Leads from the MMWR. JAMA
257: 157-166
Glass, R.
(1986). New prospects for epidemiologic investigations. Science
234: 951-955
[Abstract]
Previous
