FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 313:1498-1504 December 12, 1985 Number 24 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

Intra-blood-brain-barrier production of virus-specific antibody is good evidence of infection within the blood-brain barrier. Patients with the acquired immuno-deficiency syndrome (AIDS) have an increased incidence of neurologic abnormalities--i.e., unexplained, diffuse encephalopathy manifested clinically as chronic progressive dementia. To define the role of human T-cell lymphotropic virus Type III (HTLV-III), the etiologic agent of AIDS, in the pathogenesis of neurologic dysfunction, we compared cerebrospinal fluid and serum from patients with neurologic symptoms associated with AIDS and the AIDS-related complex for the presence of antibodies directed against HTLV-III. Antibodies directed against HTLV-III antigens were detected by four immunologic tests: a fixed-cell immunofluorescence assay, an enzyme-linked immunosorbent assay, immunoblots of viral lysates, and immunoprecipitation of cellular lysates. All patients were seropositive, and 22 of 23 (96 per cent) had HTLV-III-specific antibodies in their cerebrospinal fluid. Unique oligoclonal IgG bands were detected in the cerebrospinal fluid, and the rate of IgG synthesis within the blood-brain barrier was elevated. In eight of nine patients tested, the enzyme-linked immunosorbent assay showed that the percentage of HTLV-III-specific IgG in cerebrospinal fluid was higher than in serum, suggesting that HTLV-III infection of neurologic tissue occurs in the majority of patients with neurologic disease associated with AIDS or its related complex.

This article has been cited by other articles:

• Roberts, E. S., Huitron-Resendiz, S., Taffe, M. A., Marcondes, M. C. G., Flynn, C. T., Lanigan, C. M., Hammond, J. A., Head, S. R., Henriksen, S. J., Fox, H. S. (2006). Host response and dysfunction in the CNS during chronic simian immunodeficiency virus infection.. J. Neurosci. 26: 4577-4585 [Abstract] [Full Text]  
• McGavern, D. B. (2006). Immunotherapeutic relief from persistent infections and amyloid disorders. Neurology 66: S59-S64 [Abstract] [Full Text]  
• Stebbing, J., Gazzard, B., Douek, D. C. (2004). Where Does HIV Live?. NEJM 350: 1872-1880 [Full Text]  
• Desai, A., Ravi, V, Satishchandra, P, Khanna, N, Rao, S., Gourie-Devi, M, Chandramuki, A (2000). HIV antibody profiles in serum and CSF of patients with neurological disease can serve as predictors of outcome. J. Neurol. Neurosurg. Psychiatry 68: 86-88 [Abstract] [Full Text]  
• Sopper, S., Sauer, U., Hemm, S., Demuth, M., Muller, J., Stahl-Hennig, C., Hunsmann, G., ter Meulen, V., Dorries, R. (1998). Protective Role of the Virus-Specific Immune Response for Development of Severe Neurologic Signs in Simian Immunodeficiency Virus-Infected Macaques. J. Virol. 72: 9940-9947 [Abstract] [Full Text]  
• Armstrong, F. D., Seidel, J. F., Swales, T. P. (1993). Pediatric HIV Infection: A Neuropsychological and Educational Challenge. J Learn Disabil 26: 92-103 [Abstract]  
• Burns, D. K. (1992). Topical Review Article: The Neuropathology of Pediatric Acquired Immunodeficiency Syndrome. J Child Neurol 7: 332-346 [Abstract]  
• Pagano, M. A., Cahn, P. E., Garau, M. L., Mangone, C. A., Figini, H. A., Yorio, A. A., Dellepiane, M. C., Amores, M. G., Perez, H. M., Casiro, A. D. (1992). Brain-Stem Auditory Evoked Potentials in Human Immunodeficiency Virus-Seropositive Patients With and Without Acquired Immunodeficiency Syndrome. Arch Neurol 49: 166-169 [Abstract]  
• Zabinski, R. A., Vance-Bryan, K., Rotschafer, J. C. (1991). The Management of Central Nervous System Infections. Journal of Pharmacy Practice 4: 170-191  
• Blanche, S., Tardieu, M., Duliege, A.-M., Rouzioux, C., Le Deist, F., Fukunaga, K., Caniglia, M., Jacomet, C., Messiah, A., Griscelli, C. (1990). Longitudinal Study of 94 Symptomatic Infants With Perinatally Acquired Human Immunodeficiency Virus Infection: Evidence for a Bimodal Expression of Clinical and Biological Symptoms. Arch Pediatr Adolesc Med 144: 1210-1215 [Abstract]  
• Tunkel, A. R., Wispelwey, B., Scheld, W. M. (1990). Bacterial Meningitis: Recent Advances in Pathophysiology and Treatment. ANN INTERN MED 112: 610-623 [Abstract]  
• Ho, D. D., Bredesen, D. E., Vinters, H. V., Daar, E. S. (1989). The Acquired Immunodeficiency Syndrome (AIDS) Dementia Complex. ANN INTERN MED 111: 400-410 [Abstract]  
• Portegies, P., Epstein, L. G., Hung, S. T. A., Gans, J. d., Goudsmit, J. (1989). Human Immunodeficiency Virus Type 1 Antigen in Cerebrospinal Fluid: Correlation With Clinical Neurologic Status. Arch Neurol 46: 261-264 [Abstract]  
• Byers, J. (1989). Aids In Children: Effects On Neurological Development And Implications For The Future. Journal of Special Education 23: 5-16 [Abstract]  
• Dokecki, P. R., Baumeister, A. A., Kupstas, F. D. (1989). Biomedical and Social Aspects of Pediatric AIDS. Journal of Early Intervention 13: 99-113 [Abstract]  
• Marshall, D. W., Brey, R. L., Cahill, W. T., Houk, R. W., Zajac, R. A., Boswell, R. N. (1988). Spectrum of Cerebrospinal Fluid Findings in Various Stages of Human Immunodeficiency Virus Infection. Arch Neurol 45: 954-958 [Abstract]  
• Norman, S. E., Resnick, L., Cohn, M. A., Duara, R., Herbst, J., Berger, J. R. (1988). Sleep Disturbances in HIV-Seropositive Patients. JAMA 260: 922-922 [Abstract]  
• Jarvik, J. G., Hesselink, J. R., Kennedy, C., Teschke, R., Wiley, C., Spector, S., Richman, D., McCutchan, J. A. (1988). Acquired Immunodeficiency Syndrome: Mangnetic Resonance Patterns of Brain Involvement With Pathologic Correlation. Arch Neurol 45: 731-736 [Abstract]  
• Price, R., Brew, B, Sidtis, J, Rosenblum, M, Scheck, A., Cleary, P (1988). The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 239: 586-592 [Abstract]  
• Resnick, L., Herbst, J. S., Ablashi, D. V., Atherton, S., Frank, B., Rosen, L., Horwitz, S. N. (1988). Regression of Oral Hairy Leukoplakia After Orally Administered Acyclovir Therapy. JAMA 259: 384-388 [Abstract]  
• Belman, A. L., Diamond, G., Dickson, D., Horoupian, D., Llena, J., Lantos, G., Rubinstein, A. (1988). Pediatric Acquired Immunodeficiency Syndrome: Neurologic Syndromes. Arch Pediatr Adolesc Med 142: 29-35 [Abstract]  
• POTASMAN, I., RESNICK, L., LUFT, B. J., REMINGTON, J. S. (1988). Intrathecal Production of Antibodies Against Toxoplasma gondii in Patients with Toxoplasmic Encephalitis and the Acquired Immunodeficiency Syndrome (AIDS). ANN INTERN MED 108: 49-51 [Abstract]  
• GRANT, I., ATKINSON, J. H., HESSELINK, J. R., KENNEDY, C. J., RICHMAN, D. D., SPECTOR, S. A., McCUTCHAN, J. A. (1987). Evidence for Early Central Nervous System Involvement in the Acquired Immunodeficiency Syndrome (AIDS) and Other Human Immunodeficiency Virus (HIV) Infections: Studies with Neuropsychologic Testing and Magnetic Resonance Imaging. ANN INTERN MED 107: 828-836 [Abstract]  
• GABUZDA, D. H., HIRSCH, M. S. (1987). Neurologic Manifestations of Infection with Human Immunodeficiency Virus: Clinical Features and Pathogenesis. ANN INTERN MED 107: 383-391 [Abstract]  
• Roman, G. C. (1987). Retrovirus-Associated Myelopathies. Arch Neurol 44: 659-663 [Abstract]  
• Koyanagi, Y, Miles, S, Mitsuyasu, R., Merrill, J., Vinters, H., Chen, I. (1987). Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms. Science 236: 819-822 [Abstract]  
• Kouns, D. M., Marty, A. M., Sharpe, R. W. (1986). Oligoclonal Bands in Serum Protein Electrophoretograms of Individuals With Human Immunodeficiency Virus Antibodies. JAMA 256: 2343-2343 [Abstract]  
• Stoler, M. H., Eskin, T. A., Benn, S., Angerer, R. C., Angerer, L. M. (1986). Human T-Cell Lymphotropic Virus Type III Infection of the Central Nervous System: A Preliminary In Situ Analysis. JAMA 256: 2360-2364 [Abstract]  
• Berger, J. R., Bender, A., Resnick, L., Perlmutter, D. (1986). Spinal Myoclonus Associated With HTLV III/LAV Infection. Arch Neurol 43: 1203-1204 [Abstract]  
• Gurney, M., Apatoff, B., Spear, G., Baumel, M., Antel, J., Bania, M., Reder, A. (1986). Neuroleukin: a lymphokine product of lectin-stimulated T cells. Science 234: 574-581 [Abstract]  
• Barnes, D. (1986). AIDS-related brain damage unexplained. Science 232: 1091-1093  
• (1986). Acquired Immunodeficiency Syndrome. ANN INTERN MED 104: 575-581 [Abstract]  
• McDougal, J.S., Maddon, P.J., Dalgleish, A.G., Clapham, P.R., Littman, D.R., Godfrey, M., Maddon, D.E., Chess, L., Weiss, R.A., Axel, R. (1986). The T4 Glycoprotein Is a Cell-surface Receptor for the AIDS Virus. Cold Spring Harb Symp Quant Biol 51: 703-711 [Abstract]