To examine the effects of dietary fatty acids and carbohydrate on plasma lipids and lipoproteins, 11 patients with a mean plasma total cholesterol level of 251 +/- 10 mg per deciliter were studied on a metabolic ward during three dietary periods, each lasting four weeks. A liquid diet rich in monounsaturated fatty acids ("High-Mono") and a diet low in fat ("Low-Fat") were compared with a diet high in saturated fatty acids ("High-Sat"). The High-Sat and High-Mono diets contained 40 percent of their total calories as fat and 43 percent as carbohydrate; the Low-Fat diet had 20 percent fat and 63 percent carbohydrate. Body weight was kept constant by adjusting total caloric intake. As compared with the High-Sat diet, both the High-Mono and Low-Fat diets lowered plasma total cholesterol (by 13 percent and 8 percent, respectively) and low-density lipoprotein cholesterol (by 21 percent and 15 percent, respectively). As compared with the High-Sat diet, the Low-Fat diet raised triglyceride levels and significantly reduced plasma high-density lipoprotein cholesterol. In contrast, the High-Mono diet had no effect on levels of triglycerides or high-density lipoprotein cholesterol. The ratio of low-density to high-density lipoprotein cholesterol was also significantly lower when the High-Mono diet rather than the Low-Fat diet was followed. Therefore, in short-term studies in which liquid diets are used and body weight is kept constant, a diet rich in monounsaturated fatty acids appears to be at least as effective in lowering plasma cholesterol as a diet low in fat and high in carbohydrate.
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(2002). Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects. J. Lipid Res.
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Rebetzke, G. J., Pantalone, V. R., Burton, J. W., Carter, T. E. Jr., Wilson, R. F.
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Zhou, L., Nilsson, A.
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[Abstract][Full Text]
Schierholt, A., Rucker, B., Becker, H. C.
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[Abstract][Full Text]
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Ashton, E. L., Best, J. D., Ball, M. J.
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(2001). High-protein diets in hyperlipidemia: effect of wheat gluten on serum lipids, uric acid, and renal function. Am. J. Clin. Nutr.
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[Abstract][Full Text]
Hargrove, R. L., Etherton, T. D., Pearson, T. A., Harrison, E. H., Kris-Etherton, P. M.
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131: 1758-1763
[Abstract][Full Text]
Vidon, C., Boucher, P., Cachefo, A., Peroni, O., Diraison, F., Beylot, M.
(2001). Effects of isoenergetic high-carbohydrate compared with high-fat diets on human cholesterol synthesis and expression of key regulatory genes of cholesterol metabolism. Am. J. Clin. Nutr.
73: 878-884
[Abstract][Full Text]
Mittendorfer, B., Sidossis, L. S
(2001). Mechanism for the increase in plasma triacylglycerol concentrations after consumption of short-term, high-carbohydrate diets. Am. J. Clin. Nutr.
73: 892-899
[Abstract][Full Text]
Fernandez, M. L.
(2001). Guinea Pigs as Models for Cholesterol and Lipoprotein Metabolism. J. Nutr.
131: 10-20
[Abstract][Full Text]
Jansen, S., Lopez-Miranda, J., Castro, P., Lopez-Segura, F., Marin, C., Ordovas, J. M, Paz, E., Jimenez-Pereperez, J., Fuentes, F., Perez-Jimenez, F.
(2000). Low-fat and high-monounsaturated fatty acid diets decrease plasma cholesterol ester transfer protein concentrations in young, healthy, normolipemic men. Am. J. Clin. Nutr.
72: 36-41
[Abstract][Full Text]
Kasim-Karakas, S. E, Almario, R. U, Mueller, W. M, Peerson, J.
(2000). Changes in plasma lipoproteins during low-fat, high-carbohydrate diets: effects of energy intake. Am. J. Clin. Nutr.
71: 1439-1447
[Abstract][Full Text]
Curb, J. D., Wergowske, G., Dobbs, J. C., Abbott, R. D., Huang, B.
(2000). Serum Lipid Effects of a High-Monounsaturated Fat Diet Based on Macadamia Nuts. Arch Intern Med
160: 1154-1158
[Abstract][Full Text]
Ferrara, L. A., Raimondi, A. S., d'Episcopo, L., Guida, L., Dello Russo, A., Marotta, T.
(2000). Olive Oil and Reduced Need for Antihypertensive Medications. Arch Intern Med
160: 837-842
[Abstract][Full Text]
Berglund, L., Oliver, E. H, Fontanez, N., Holleran, S., Matthews, K., Roheim, P. S, Ginsberg, H. N, Ramakrishnan, R., Lefevre, M.
(1999). HDL-subpopulation patterns in response to reductions in dietary total and saturated fat intakes in healthy subjects. Am. J. Clin. Nutr.
70: 992-1000
[Abstract][Full Text]
Kris-Etherton, P. M, Pearson, T. A, Wan, Y., Hargrove, R. L, Moriarty, K., Fishell, V., Etherton, T. D
(1999). High-monounsaturated fatty acid diets lower both plasma cholesterol and triacylglycerol concentrations. Am. J. Clin. Nutr.
70: 1009-1015
[Abstract][Full Text]
Weber, N., Schönwiese, S., Klein, E., Mukherjee, K. D.
(1999). Adipose Tissue Triacylglycerols of Rats Are Modulated Differently by Dietary Isomeric Octadecenoic Acids from Coriander Oil and High Oleic Sunflower Oil. J. Nutr.
129: 2206-2211
[Abstract][Full Text]
Kris-Etherton, P. M.
(1999). AHA Science Advisory: Monounsaturated Fatty Acids and Risk of Cardiovascular Disease. J. Nutr.
129: 2280-2284
[Full Text]
Ostlund, R. E Jr, Spilburg, C. A, Stenson, W. F
(1999). Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans. Am. J. Clin. Nutr.
70: 826-831
[Abstract][Full Text]
Kris-Etherton, P. M.
(1999). Monounsaturated Fatty Acids and Risk of Cardiovascular Disease. Circulation
100: 1253-1258
[Full Text]
Thomsen, C., Rasmussen, O., Lousen, T., Holst, J. J, Fenselau, S., Schrezenmeir, J., Hermansen, K.
(1999). Differential effects of saturated and monounsaturated fatty acids on postprandial lipemia and incretin responses in healthy subjects. Am. J. Clin. Nutr.
69: 1135-1143
[Abstract][Full Text]
Jenkins, D. J., Kendall, C. W., Vuksan, V., Augustin, L. S., Mehling, C., Parker, T., Vidgen, E., Lee, B., Faulkner, D., Seyler, H., Josse, R., Leiter, L. A, Connelly, P. W, Fulgoni, V. III
(1999). Effect of Wheat Bran on Serum Lipids: Influence of Particle Size and Wheat Protein. J. Am. Coll. Nutr.
18: 159-165
[Abstract][Full Text]
Lichtenstein, A. H., Van Horn, L.
(1998). Very Low Fat Diets. Circulation
98: 935-939
[Full Text]
Vergara-Jimenez, M., Conde, K., Erickson, S. K., Fernandez, M. L.
(1998). Hypolipidemic mechanisms of pectin and psyllium in guinea pigs fed high fat–sucrose diets: alterations on hepatic cholesterol metabolism. J. Lipid Res.
39: 1455-1465
[Abstract][Full Text]
Connor, W. E., Connor, S. L., Katan, M. B., Grundy, S. M., Willett, W. C., Connor, W. E., Connor, S. L., Katan, M. B., Grundy, S. M., Willett, W. C.
(1997). Should a Low-Fat, High-Carbohydrate Diet Be Recommended for Everyone?. NEJM
337: 562-567
[Full Text]
Vega, G. L., Grundy, S. M.
(1996). Hypercholesterolemia With Cholesterol-Enriched LDL and Normal Levels of LDL–Apolipoprotein B : Effects of the Step I Diet and Bile Acid Sequestrants on the Cholesterol Content of LDL. Arterioscler. Thromb. Vasc. Bio.
16: 517-522
[Abstract][Full Text]
Council on Scientific Affairs,
(1995). Management of Disorders of Cholesterol, Triglyceride, and Lipoprotein Metabolism: Report 6 of the Council on Scientific Affairs. Arch Fam Med
4: 869-878
[Abstract]
Schaefer, E. J., Lichtenstein, A. H., Lamon-Fava, S., Contois, J. H., Li, Z., Rasmussen, H., McNamara, J. R., Ordovas, J. M.
(1995). Efficacy of a National Cholesterol Education Program Step 2 Diet in Normolipidemic and Hypercholesterolemic Middle-Aged and Elderly Men and Women. Arterioscler. Thromb. Vasc. Bio.
15: 1079-1085
[Abstract][Full Text]
Beau, P., Labat, J.
(1994). Continuous vs Discontinuous Enteral Nutrition: Compared Effects on Serum Lipids and Lipoproteins in Humans. JPEN J Parenter Enteral Nutr
18: 331-334
[Abstract]
Garg, A., Bantle, J. P., Henry, R. R., Coulston, A. M., Griver, K. A., Raatz, S. K., Brinkley, L., Chen, Y-D. I., Grundy, S. M., Huet, B. A., Reaven, G. M.
(1994). Effects of Varying Carbohydrate Content of Diet in Patients With Non--Insulin-Dependent Diabetes Mellitus. JAMA
271: 1421-1428
[Abstract]
Rivellese, A A, Auletta, P, Marotta, G, Saldalamacchia, G, Giacoo, A, Mastrilli, V, Vaccaro, O, Riccardi, G
(1994). Long term metabolic effects of two dietary methods of treating hyperlipidaemia. BMJ
308: 227-231
[Abstract][Full Text]
Jenkins, D., Wolever, T., Rao, A. V., Hegele, R. A., Mitchell, S. J., Ransom, T., Boctor, D. L., Spadafora, P. J., Jenkins, A. L., Mehling, C., Relle, L. K., Connelly, P. W., Story, J. A., Furumoto, E. J., Corey, P., Wursch, P.
(1993). Effect on Blood Lipids of Very High Intakes of Fiber in Diets Low in Saturated Fat and Cholesterol. NEJM
329: 21-26
[Abstract][Full Text]
Peters, A. L., Davidson, M. B.
(1992). Effects of Various Enteral Feeding Products on Postprandial Blood Glucose Response in Patients With Type I Diabetes. JPEN J Parenter Enteral Nutr
16: 69-74
[Abstract]
Garber, A. M., Littenberg, B., Sox, H. C. Jr, Wagner, J. L., Gluck, M.
(1991). Costs and Health Consequences of Cholesterol Screening for Asymptomatic Older Americans. Arch Intern Med
151: 1089-1095
[Abstract]
Posner, B. M., Cobb, J. L., Belanger, A. J., Cupples, L. A., D'Agostino, R. B., Stokes, J. III
(1991). Dietary Lipid Predictors of Coronary Heart Disease in Men: The Framingham Study. Arch Intern Med
151: 1181-1187
[Abstract]
Cobb, M. M., Teitelbaum, H. S., Breslow, J. L.
(1991). Lovastatin Efficacy in Reducing Low-Density Lipoprotein Cholesterol Levels on High- vs Low-Fat Diets. JAMA
265: 997-1001
[Abstract]
Grundy, S. M.
(1990). Cholesterol and Coronary Heart Disease: Future Directions. JAMA
264: 3053-3059
[Abstract]
Vega, G. L., Grundy, S. M.
(1990). Management of Primary Mixed Hyperlipidemia With Lovastatin. Arch Intern Med
150: 1313-1319
[Abstract]
Denke, M. A., Grundy, S. M.
(1990). Hypercholesterolemia in Elderly Persons: Resolving the Treatment Dilemma. ANN INTERN MED
112: 780-792
[Abstract]
Dreon, D. M., Vranizan, K. M., Krauss, R. M., Austin, M. A., Wood, P. D.
(1990). The Effects of Polyunsaturated Fat vs Monounsaturated Fat on Plasma Lipoproteins. JAMA
263: 2462-2466
[Abstract]
Trevisan, M., Krogh, V., Freudenheim, J., Blake, A., Muti, P., Panico, S., Farinaro, E., Mancini, M., Menotti, A., Ricci, G.
(1990). Consumption of Olive Oil, Butter, and Vegetable Oils and Coronary Heart Disease Risk Factors. JAMA
263: 688-692
[Abstract]
Blum, C. B., Levy, R. I.
(1989). Current Therapy for Hypercholesterolemia. JAMA
261: 3582-3587
[Abstract]
Maryniuk, M. D.
(1989). Hyperlipidemia and Diabetes: The Role of Dietary Fats. The Diabetes Educator
15: 258-264
Franz, M. J.
(1989). How Enthusiastically Should. the Use of Monounsaturated Fats be Encouraged?. The Diabetes Educator
15: 494-497
Austin, M. A., Breslow, J. L., Hennekens, C. H., Buring, J. E., Willett, W. C., Krauss, R. M.
(1988). Low-Density Lipoprotein Subclass Patterns and Risk of Myocardial Infarction. JAMA
260: 1917-1921
[Abstract]
Radack, K. L.
(1988). Omega-3 Fatty Acids. ANN INTERN MED
109: 81-82
[Abstract]
Grundy, S. M.
(1986). Cholesterol and Coronary Heart Disease: A New Era. JAMA
256: 2849-2858
[Abstract]
Barness, L. A.
(1986). Cholesterol and Children. JAMA
256: 2871-2871
[Abstract]
Grundy, S. M., Nix, D., Whelan, M. F., Franklin, L.
(1986). Comparison of Three Cholesterol-Lowering Diets in Normolipidemic Men. JAMA
256: 2351-2355
[Abstract]
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