We examined the contributions of genetic factors and the family environment to human fatness in a sample of 540 adult Danish adoptees who were selected from a population of 3580 and divided into four weight classes: thin, median weight, overweight, and obese. There was a strong relation between the weight class of the adoptees and the body-mass index of their biologic parents - for the mothers, P less than 0.0001; for the fathers, P less than 0.02. There was no relation between the weight class of the adoptees and the body-mass index of their adoptive parents. Cumulative distributions of the body-mass index of parents showed similar results; there was a strong relation between the body-mass index of biologic parents and adoptee weight class and no relation between the index of adoptive parents and adoptee weight class. Furthermore, the relation between biologic parents and adoptees was not confined to the obesity weight class, but was present across the whole range of body fatness - from very thin to very fat. We conclude that genetic influences have an important role in determining human fatness in adults, whereas the family environment alone has no apparent effect.
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Bouchard, C.
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127: 1887-1887
[Abstract][Full Text]
Rosenbaum, M., Leibel, R. L., Hirsch, J.
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Nagase, T., Aoki, A., Yamamoto, M., Yasuda, H., Kado, S., Nishikawa, M., Kugai, N., Akatsu, T., Nagata, N.
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Ottley, C.
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56: 313-320
Group, W., Gidding, S. S., Leibel, R. L., Daniels, S., Rosenbaum, M., Van Horn, L., Marx, G. R.
(1996). Understanding Obesity in Youth: A Statement for Healthcare Professionals From the Committee on Atherosclerosis and Hypertension in the Young of the Council on Cardiovascular Disease in the Young and the Nutrition Committee, American Heart Association. Circulation
94: 3383-3387
[Full Text]
Crandall, C. S., Martinez, R.
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Chung, W K, Power-Kehoe, L, Chua, M, Leibel, R L
(1996). Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human.. Genome Res
6: 431-438
[Abstract]
Amine, E.K., Samy, M.
(1996). Obesity among female university students in the United Arab Emirates. The Journal of the Royal Society for the Promotion of Health
116: 91-96
[Abstract]
Miller, C. T., Rothblum, E. D., Felicio, D., Brand, P.
(1995). Compensating for Stigma: Obese and Nonobese Women's Reactions to Being Visible. Pers Soc Psychol Bull
21: 1093-1106
[Abstract]
Walston, J., Silver, K., Bogardus, C., Knowler, W. C., Celi, F. S., Austin, S., Manning, B., Strosberg, A. D., Stern, M. P., Raben, N., Sorkin, J. D., Roth, J., Shuldiner, A. R.
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333: 343-347
[Abstract][Full Text]
Crandall, C. S.
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21: 724-735
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Bennett, W. I.
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332: 673-674
[Full Text]
Hopper, J.
(1993). Review papers : Variance components for statistical genetics: applications in medical research to characteristics related to human diseases and health. Stat Methods Med Res
2: 199-223
[Abstract]
Brooks-Gunn, J., Attie, I., Burrow, C., Rosso, J. T., Warren, M. P.
(1989). The Impact of Puberty on Body and Eating Concerns in Athletic and Nonathletic Contexts. The Journal of Early Adolescence
9: 269-290
[Abstract]
