13-cis-Retinoic acid has been reported to be effective in treating oral leukoplakia. We randomly assigned 44 patients with this disease to receive 13-cis-retinoic acid (24 patients) or placebo (20), 1 to 2 mg per kilogram of body weight per day for three months, and followed them for six months. There were major decreases in the size of the lesions in 67 percent (16 patients) of those given the drug and in 10 percent (2 patients) of those given placebo (P = 0.0002); dysplasia was reversed in 54 percent (13 patients) of the drug group and in 10 percent (2 patients) of the placebo group (P = 0.01). The clinical response to the drug correlated with the histologic response in 56 percent (9 of 16) of the patients evaluated. Relapse occurred in 9 of 16 patients two to three months after treatment ended. The toxic effects of the drug were acceptable in all but two patients. Cheilitis, facial erythema, and dryness and peeling of the skin were common; conjunctivitis and hypertriglyceridemia also occurred. All adverse reactions could be reversed by reducing the dose or temporarily discontinuing the drug. We conclude that 13-cis-retinoic acid, even in short-term use, appears to be an effective treatment for oral leukoplakia and has an acceptable level of toxicity.
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[Abstract][Full Text]
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[Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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Garattini, S.
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95: 178-179
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123: 60S-71S
[Abstract][Full Text]
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11: 1605-1610
[Abstract][Full Text]
Soprano, K. J., Soprano, D. R.
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132: 3809S-3813
[Abstract][Full Text]
Rizvi, N. A., Marshall, J. L., Ness, E., Hawkins, M. J., Kessler, C., Jacobs, H., Brenckman, W. D. Jr, Lee, J. S., Petros, W., Hong, W. K., Kurie, J. M.
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[Abstract][Full Text]
Suzui, M., Masuda, M., Lim, J. T. E., Albanese, C., Pestell, R. G., Weinstein, I. B.
(2002). Growth Inhibition of Human Hepatoma Cells by Acyclic Retinoid Is Associated with Induction of p21CIP1 and Inhibition of Expression of Cyclin D1. Cancer Res.
62: 3997-4006
[Abstract][Full Text]
Lippman, S. M., Ki Hong, W.
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8: 305-313
[Full Text]
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(2002). Treatment and Prevention of Intraepithelial Neoplasia: An Important Target for Accelerated New Agent Development : Recommendations of the American Association for Cancer Research Task Force on the Treatment and Prevention of Intraepithelial Neoplasia. Clin. Cancer Res.
8: 314-346
[Abstract][Full Text]
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8: 11-16
[Abstract][Full Text]
Schwartz, S. M., Doody, D. R., Fitzgibbons, E. D., Ricks, S., Porter, P. L., Chen, C.
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10: 1137-1144
[Abstract][Full Text]
Papadimitrakopoulou, V. A., Izzo, J., Mao, L., Keck, J., Hamilton, D., Shin, D. M., El-Naggar, A., den Hollander, P., Liu, D., Hittelman, W. N., Hong, W. K.
(2001). Cyclin D1 and p16 Alterations in Advanced Premalignant Lesions of the Upper Aerodigestive Tract: Role in Response to Chemoprevention and Cancer Development. Clin. Cancer Res.
7: 3127-3134
[Abstract][Full Text]
Lippman, S. M., Spitz, M. R.
(2001). Lung Cancer Chemoprevention: An Integrated Approach. JCO
19: 74s-82
[Abstract][Full Text]
Pastorino, U.
(2001). Molecular Targeting: the New Challenge in Lung Cancer Prevention. JNCI J Natl Cancer Inst
93: 1190-1191
[Full Text]
Song, J. I., Lango, M. N., Hwang, J. D., Drenning, S. D., Zeng, Q., Lamph, W. W., Grandis, J. R.
(2001). Abrogation of Transforming Growth Factor-{alpha}/Epidermal Growth Factor Receptor Autocrine Signaling by an RXR-selective Retinoid (LGD1069, Targretin) in Head and Neck Cancer Cell Lines. Cancer Res.
61: 5919-5925
[Abstract][Full Text]
Szabo, E.
(2001). Lung Epithelial Proliferation: a Biomarker for Chemoprevention Trials?. JNCI J Natl Cancer Inst
93: 1042-1043
[Full Text]
Shin, D. M., Khuri, F. R., Murphy, B., Garden, A. S., Clayman, G., Francisco, M., Liu, D., Glisson, B. S., Ginsberg, L., Papadimitrakopoulou, V., Myers, J., Morrison, W., Gillenwater, A., Ang, K. K., Lippman, S. M., Goepfert, H., Hong, W. K.
(2001). Combined Interferon-Alfa, 13-cis-Retinoic Acid, and Alpha-Tocopherol in Locally Advanced Head and Neck Squamous Cell Carcinoma: Novel Bioadjuvant Phase II Trial. JCO
19: 3010-3017
[Abstract][Full Text]
Khuri, F. R., Rigas, J. R., Figlin, R. A., Gralla, R. J., Shin, D. M., Munden, R., Fox, N., Huyghe, M. R., Kean, Y., Reich, S. D., Hong, W. K.
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19: 2626-2637
[Abstract][Full Text]
Sudbo, J., Kildal, W., Risberg, B., Koppang, H. S., Danielsen, H. E., Reith, A.
(2001). DNA Content as a Prognostic Marker in Patients with Oral Leukoplakia. NEJM
344: 1270-1278
[Abstract][Full Text]
Lippman, S. M., Lee, J. J., Karp, D. D., Vokes, E. E., Benner, S. E., Goodman, G. E., Khuri, F. R., Marks, R., Winn, R. J., Fry, W., Graziano, S. L., Gandara, D. R., Okawara, G., Woodhouse, C. L., Williams, B., Perez, C., Kim, H. W., Lotan, R., Roth, J. A., Hong, W. K.
(2001). Randomized Phase III Intergroup Trial of Isotretinoin to Prevent Second Primary Tumors in Stage I Non-Small-Cell Lung Cancer. JNCI J Natl Cancer Inst
93: 605-618
[Abstract][Full Text]
Shiotani, H., Denda, A., Yamamoto, K., Kitayama, W., Endoh, T., Sasaki, Y., Tsutsumi, M., Sugimura, M., Konishi, Y.
(2001). Increased Expression of Cyclooxygenase-2 Protein in 4-Nitroquinoline-1-oxide-induced Rat Tongue Carcinomas and Chemopreventive Efficacy of a Specific Inhibitor, Nimesulide. Cancer Res.
61: 1451-1456
[Abstract][Full Text]
Pili, R., Kruszewski, M. P., Hager, B. W., Lantz, J., Carducci, M. A.
(2001). Combination of Phenylbutyrate and 13-cis Retinoic Acid Inhibits Prostate Tumor Growth and Angiogenesis. Cancer Res.
61: 1477-1485
[Abstract][Full Text]
Thaller, C., Shalev, M., Frolov, A., Eichele, G., Thompson, T. C., Williams, R. H., Dillioglugil, O., Kadmon, D.
(2000). Fenretinide Therapy in Prostate Cancer: Effects on Tissue and Serum Retinoid Concentration. JCO
18: 3804-3808
[Abstract][Full Text]
Hong, W. K., Spitz, M. R., Lippman, S. M.
(2000). Cancer Chemoprevention in the 21st Century: Genetics, Risk Modeling, and Molecular Targets. JCO
18: 9s-18
[Full Text]
Dragnev, K. H., Rigas, J. R., Dmitrovsky, E.
(2000). The Retinoids and Cancer Prevention Mechanisms. The Oncologist
5: 361-368
[Abstract][Full Text]
Wang, D. L., Marko, M., Dahl, A. R., Engelke, K. S., Placke, M. E., Imondi, A. R., Mulshine, J. L., De Luca, L. M.
(2000). Topical Delivery of 13-cis-Retinoic Acid by Inhalation Up-Regulates Expression of Rodent Lung but not Liver Retinoic Acid Receptors. Clin. Cancer Res.
6: 3636-3645
[Abstract][Full Text]
van Zandwijk, N., Dalesio, O., Pastorino, U., de Vries, N., van Tinteren, H.
(2000). EUROSCAN, a Randomized Trial of Vitamin A and N-Acetylcysteine in Patients With Head and Neck Cancer or Lung Cancer. JNCI J Natl Cancer Inst
92: 977-986
[Abstract][Full Text]
Zeng, Q., Smith, D. C., Suscovich, T. J., Gooding, W. E., Trump, D. L., Grandis, J. R.
(2000). Determination of Intermediate Biomarker Expression Levels by Quantitative Reverse Transcription-Polymerase Chain Reaction in Oral Mucosa of Cancer Patients Treated with Liarozole. Clin. Cancer Res.
6: 2245-2251
[Abstract][Full Text]
Lee, J. J., Hong, W. K., Hittelman, W. N., Mao, L., Lotan, R., Shin, D. M., Benner, S. E., Xu, X.-C., Lee, J. S., Papadimitrakopoulou, V. M., Geyer, C., Perez, C., Martin, J. W., El-Naggar, A. K., Lippman, Scott. M.
(2000). Predicting Cancer Development in Oral Leukoplakia: Ten Years of Translational Research. Clin. Cancer Res.
6: 1702-1710
[Abstract][Full Text]
Lippman, S. M., Lotan, R.
(2000). Advances in the Development of Retinoids as Chemopreventive Agents. J. Nutr.
130: 479-479
[Abstract][Full Text]
Shin, D. M., Mao, L., Papadimitrakopoulou, V. M., Clayman, G., El-Naggar, A., Shin, H. J. C., Lee, J. J., Lee, J. S., Gillenwater, A., Myers, J., Lippman, S. M., Hittelman, W. N., Hong, W. K.
(2000). Biochemopreventive Therapy for Patients With Premalignant Lesions of the Head and Neck and p53 Gene Expression. JNCI J Natl Cancer Inst
92: 69-73
[Full Text]
Lotan, Y., Xu, X. C., Shalev, M., Lotan, R., Williams, R., Wheeler, T. M., Thompson, T. C., Kadmon, D.
(2000). Differential Expression of Nuclear Retinoid Receptors in Normal and Malignant Prostates. JCO
18: 116-116
[Abstract][Full Text]
McCaskill-Stevens, W., Hawk, E. T., Flynn, P. J., Lippman, S. M.
(1999). National Cancer Institute-Supported Cancer Chemoprevention Research: Coming of Age. JCO
17: 53-62
[Full Text]
(1999). Prevention of Cancer in the Next Millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research. Cancer Res.
59: 4743-4758
[Full Text]
Papadimitrakopoulou, V. A., Clayman, G. L., Shin, D. M., Myers, J. N., Gillenwater, A. M., Goepfert, H., El-Naggar, A. K., Lewin, J. S., Lippman, S. M., Hong, W. K.
(1999). Biochemoprevention for Dysplastic Lesions of the Upper Aerodigestive Tract. Arch Otolaryngol Head Neck Surg
125: 1083-1089
[Abstract][Full Text]
Rizvi, N. A., Marshall, J. L., Dahut, W., Ness, E., Truglia, J. A., Loewen, G., Gill, G. M., Ulm, E. H., Geiser, R., Jaunakais, D., Hawkins, M. J.
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5: 1658-1664
[Abstract][Full Text]
Xu, X.-C., Liu, X., Tahara, E., Lippman, S. M., Lotan, R.
(1999). Expression and Up-Regulation of Retinoic Acid Receptor-{beta} Is Associated with Retinoid Sensitivity and Colony Formation in Esophageal Cancer Cell Lines. Cancer Res.
59: 2477-2483
[Abstract][Full Text]
Sun, S.-Y., Kurie, J. M., Yue, P., Dawson, M. I., Shroot, B., Chandraratna, R. A. S., Hong, W. K., Lotan, R.
(1999). Differential Responses of Normal, Premalignant, and Malignant Human Bronchial Epithelial Cells to Receptor-selective Retinoids. Clin. Cancer Res.
5: 431-437
[Abstract][Full Text]
Cheng, Y., Lotan, R.
(1998). Molecular Cloning and Characterization of a Novel Retinoic Acid-inducible Gene That Encodes a Putative G Protein-coupled Receptor. J. Biol. Chem.
273: 35008-35015
[Abstract][Full Text]
Asou, H., Koike, M., Elstner, E., Cambell, M., Le, J., Uskokovic, M. R., Kamada, N., Koeffler, H. P.
(1998). 19-nor Vitamin-D Analogs: A New Class of Potent Inhibitors of Proliferation and Inducers of Differentiation of Human Myeloid Leukemia Cell Lines. Blood
92: 2441-2449
[Abstract][Full Text]
Hong, W. K., Sporn, M. B.
(1997). Recent Advances in Chemoprevention of Cancer. Science
278: 1073-1077
[Abstract][Full Text]
Langenfeld, J., Kiyokawa, H., Sekula, D., Boyle, J., Dmitrovsky, E.
(1997). Posttranslational regulation of cyclin D1 by retinoic acid: A chemoprevention mechanism. Proc. Natl. Acad. Sci. USA
94: 12070-12074
[Abstract][Full Text]
van der Leede, B.-j. M., van den Brink, C. E., Pijnappel, W. W. M., Sonneveld, E., van der Saag, P. T., van der Burg, B.
(1997). Autoinduction of Retinoic Acid Metabolism to Polar Derivatives with Decreased Biological Activity in Retinoic Acid-sensitive, but Not in Retinoic Acid-resistant Human Breast Cancer Cells. J. Biol. Chem.
272: 17921-17928
[Abstract][Full Text]
Shih, T.-W., Lin, T.-H., Shealy, Y. F., Hill, D. L.
(1997). Nonenzymatic Isomerization of 9-CIS-Retinoic Acid Catalyzed by Sulfhydryl Compounds. Drug Metab. Dispos.
25: 27-32
[Abstract][Full Text]
Lotan, R., Xu, X.-C., Lippman, S. M., Ro, J. Y., Lee, J. S., Lee, J. J., Hong, W. K.
(1995). Suppression of Retinoic Acid Receptor-{beta} in Premalignant Oral Lesions and Its Up-Regulation by Isotretinoin. NEJM
332: 1405-1411
[Abstract][Full Text]
Vokes, E. E., Weichselbaum, R. R., Lippman, S. M., Hong, W. K.
(1993). Head and Neck Cancer. NEJM
328: 184-194
[Full Text]
Lippman, S. M., Batsakis, J. G., Toth, B. B., Weber, R. S., Lee, J. J., Martin, J. W., Hays, G. L., Goepfert, H., Hong, W. K.
(1993). Comparison of Low-Dose Isotretinoin with Beta Carotene to Prevent Oral Carcinogenesis. NEJM
328: 15-20
[Abstract][Full Text]
