The term "benign lymphoepithelial lesion" is used to describe the salivary-gland lymphocytic infiltration and epithelial changes typically found in association with Sjogren's syndrome. We used Southern blot hybridization techniques to examine the immunoglobulin genes in salivary-gland tissue derived from eight patients with benign lymphoepithelial lesions. Three of these patients had intrasalivary non-Hodgkin's lymphoma complicating the lesions, whereas the lesions in the remaining five were all histologically benign. Ten samples from the eight patients all revealed rearrangement of both the heavy-chain and light-chain immunoglobulin genes. In one of the patients in whom non-Hodgkin's lymphoma involved both the salivary-gland lesion and an ipsilateral lymph node, the rearrangements of the heavy-chain and light-chain immunoglobulin genes detected at the two sites were identical. One other patient had two distinct benign lymphoepithelial lesions removed two years apart. The rearrangements of the heavy-chain as well as the kappa light-chain genes detected in these two lesions were entirely different. These data suggest that B-cell clonal expansion has an integral role in the pathophysiology of the benign lymphoepithelial lesion and may explain the increased incidence of lymphoma noted in association with this disorder.
This article has been cited by other articles:
Saxena, A, Alport, E C, Moshynska, O, Kanthan, R, Boctor, M A
(2004). Clonal B cell populations in a minority of patients with Hashimoto's thyroiditis. J. Clin. Pathol.
57: 1258-1263
[Abstract][Full Text]
Gniadecki, R., Lukowsky, A., Rossen, K., Madsen, H. O., Thomsen, K., Wulf, H. C.
(2003). Bone marrow precursor of extranodal T-cell lymphoma. Blood
102: 3797-3799
[Abstract][Full Text]
Schmidt, J., Lumniczky, K., Tzschaschel, B. D., Guenther, H. L., Luz, A., Riemann, S., Gimbel, W., Erfle, V., Erben, R. G.
(1999). Onset and Dynamics of Osteosclerosis in Mice Induced by Reilly-Finkel-Biskis (RFB) Murine Leukemia Virus : Increase in Bone Mass Precedes Lymphomagenesis. Am. J. Pathol.
155: 557-570
[Abstract][Full Text]
Fend, F., Quintanilla-Martinez, L., Kumar, S., Beaty, M. W., Blum, L., Sorbara, L., Jaffe, E. S., Raffeld, M.
(1999). Composite Low Grade B-Cell Lymphomas with Two Immunophenotypically Distinct Cell Populations Are True Biclonal Lymphomas : A Molecular Analysis Using Laser Capture Microdissection. Am. J. Pathol.
154: 1857-1866
[Abstract][Full Text]
Shiokawa, S., Nishimura, J., Ohshima, K., Uike, N., Yamamoto, K.
(1998). Establishment of a Novel B Cell Clonality Analysis Using Single-Strand Conformation Polymorphism of Immunoglobulin Light Chain Messenger Signals. Am. J. Pathol.
153: 1393-1400
[Abstract][Full Text]
Bahler, D. W., Swerdlow, S. H.
(1998). Clonal Salivary Gland Infiltrates Associated With Myoepithelial Sialadenitis (Sjogren's Syndrome) Begin as Nonmalignant Antigen-Selected Expansions. Blood
91: 1864-1872
[Abstract][Full Text]
Royer, B., Cazals-Hatem, D., Sibilia, J., Agbalika, F., Cayuela, J.-M., Soussi, T., Maloisel, F., Clauvel, J.-P., Brouet, J.-C., Mariette, X.
(1997). Lymphomas in Patients With Sjogren's Syndrome Are Marginal Zone B-Cell Neoplasms, Arise in Diverse Extranodal and Nodal Sites, and Are Not Associated With Viruses. Blood
90: 766-775
[Abstract][Full Text]
Fox, P.C., Speight, P.M.
(1996). Current Concepts of Autoimmune Exocrinopathy: Immunologic Mechanisms in the Salivary Pathology of Sjogren's Syndrome. CROBM
7: 144-158
[Abstract][Full Text]
Stevenson, F. K.
(1995). Hodgkin's Disease -- New Insights from Immunoglobulin Genetics. NEJM
333: 934-936
[Full Text]
Diss, T. C., Peng, H., Wotherspoon, A. C., Pan, L., Speight, P. M., Isaacson, P. G.
(1993). A Single Neoplastic Clone in Sequential Biopsy Specimens from a Patient with Primary Gastric-Mucosa-Associated Lymphoid-Tissue Lymphoma and Sjogren's Syndrome. NEJM
329: 172-175
[Full Text]
Previous
