In 1980, 89,538 U.S. women 34 to 59 years of age, with no history of cancer, completed an independently validated dietary questionnaire that included the use of beer, wine, and liquor. During the ensuring four years, 601 cases of breast cancer were diagnosed among cohort members. Among the women consuming 5 to 14 g of alcohol daily (about three to nine drinks per week), the age-adjusted relative risk of breast cancer was 1.3 (95 percent confidence limits, 1.1 and 1.7). Consumption of 15 g of alcohol or more per day was associated with a relative risk of 1.6 (95 percent confidence limits, 1.3 and 2.0; Mantel extension chi for linear trend = +4.2; P less than 0.0001). Adjustment for known breast cancer risk factors and a variety of nutritional variables did not materially alter this relation. Significant associations were observed for beer and liquor when considered separately. Among women without risk factors for breast cancer who were under 55 years of age, the relative risk associated with consumption of 15 g of alcohol or more per day was 2.5 (95 percent confidence limits, 1.5 and 4.2). These prospective data derived from measurements of alcohol intake recorded before the diagnosis of breast cancer confirm the findings of several previous case-control studies. Viewed collectively, they suggest that alcohol intake may contribute to the risk of breast cancer.
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[Abstract][Full Text]
Byrne, C., Rockett, H., Holmes, M. D.
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[Abstract][Full Text]
Singletary, K. W., Gapstur, S. M.
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[Abstract][Full Text]
Ellison, R. C., Zhang, Y., McLennan, C. E., Rothman, K. J.
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[Abstract][Full Text]
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[Full Text]
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[Abstract][Full Text]
Zhang, S., Hunter, D. J., Hankinson, S. E., Giovannucci, E. L., Rosner, B. A., Colditz, G. A., Speizer, F. E., Willett, W. C.
(1999). A Prospective Study of Folate Intake and the Risk of Breast Cancer. JAMA
281: 1632-1637
[Abstract][Full Text]
Cauley, J. A., Lucas, F. L., Kuller, L. H., Stone, K., Browner, W., Cummings, S. R., for the Study of Osteoporotic Fractures Research G,
(1999). Elevated Serum Estradiol and Testosterone Concentrations Are Associated with a High Risk for Breast Cancer. ANN INTERN MED
130: 270-277
[Abstract][Full Text]
Smith-Warner, S. A., Spiegelman, D., Yaun, S.-S., van den Brandt, P. A., Folsom, A. R., Goldbohm, R. A., Graham, S., Holmberg, L., Howe, G. R., Marshall, J. R., Miller, A. B., Potter, J. D., Speizer, F. E., Willett, W. C., Wolk, A., Hunter, D. J.
(1998). Alcohol and Breast Cancer in Women: A Pooled Analysis of Cohort Studies. JAMA
279: 535-540
[Abstract][Full Text]
Fuchs, C. S., Stampfer, M. J., Colditz, G. A., Giovannucci, E. L., Manson, J. E., Kawachi, I., Hunter, D. J., Hankinson, S. E., Hennekens, C. H., Rosner, B., Speizer, F. E., Willett, W. C.
(1995). Alcohol Consumption and Mortality among Women. NEJM
332: 1245-1250
[Abstract][Full Text]
Clevidence, B. A., Reichman, M. E., Judd, J. T., Muesing, R. A., Schatzkin, A., Schaefer, E. J., Li, Z., Jenner, J., Brown, C. C., Sunkin, M., Campbell, W. S., Taylor, P. R.
(1995). Effects of Alcohol Consumption on Lipoproteins of Premenopausal Women : A Controlled Diet Study. Arterioscler. Thromb. Vasc. Bio.
15: 179-184
[Abstract][Full Text]
Fuchs, C. S., Giovannucci, E. L., Colditz, G. A., Hunter, D. J., Speizer, F. E., Willett, W. C.
(1994). A Prospective Study of Family History and the Risk of Colorectal Cancer. NEJM
331: 1669-1674
[Abstract][Full Text]
Angell, M., Kassirer, J. P.
(1994). Clinical Research -- What Should the Public Believe?. NEJM
331: 189-190
[Full Text]
Feinstein, A.
(1988). Scientific standards in epidemiologic studies of the menace of daily life. Science
242: 1257-1263
[Abstract]
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