We recently reported the isolation of a new retrovirus, termed human immunodeficiency virus type 2 (HIV-2), from two West African patients with the acquired immunodeficiency syndrome (AIDS). This virus is related to but distinct from the well-characterized AIDS retrovirus, human immunodeficiency virus type 1 (HIV-1). We report here evidence of infection with HIV-2 in 30 patients, almost all from West Africa. Seventeen of them had a clinical syndrome indistinguishable from AIDS (7 of these 17 died). Others had either the AIDS-related complex or no HIV-related symptoms. All patients had serum antibodies reacting with HIV-2 in an indirect immunofluorescence assay. All serum tested contained antibodies reacting with the envelope glycoprotein of the virus in an immunoprecipitation assay. Cross-reactivity of serum antibodies with HIV-1 was detected in a minority of patients and varied according to the assay used. Retroviral isolates were obtained from the blood lymphocytes of 11 patients and were all identified as HIV-2 by nucleic acid hybridization; none hybridized with an HIV-1 probe. These findings indicate that some cases of AIDS in West Africa may be caused by HIV-2, but the extent of the spread of this virus and its clinical correlates will require careful epidemiologic investigation.
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Marchant, D., Neil, S. J. D., McKnight, A.
(2006). Human immunodeficiency virus types 1 and 2 have different replication kinetics in human primary macrophage culture. J. Gen. Virol.
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Ribeiro, A. C., Maia e Silva, A., Santa-Marta, M., Pombo, A., Moniz-Pereira, J., Goncalves, J., Barahona, I.
(2005). Functional Analysis of Vif Protein Shows Less Restriction of Human Immunodeficiency Virus Type 2 by APOBEC3G. J. Virol.
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Sousa, A. E., Carneiro, J., Meier-Schellersheim, M., Grossman, Z., Victorino, R. M. M.
(2002). CD4 T Cell Depletion Is Linked Directly to Immune Activation in the Pathogenesis of HIV-1 and HIV-2 but Only Indirectly to the Viral Load. J. Immunol.
169: 3400-3406
[Abstract][Full Text]
Pöhlmann, S., Baribaud, F., Lee, B., Leslie, G. J., Sanchez, M. D., Hiebenthal-Millow, K., Münch, J., Kirchhoff, F., Doms, R. W.
(2001). DC-SIGN Interactions with Human Immunodeficiency Virus Type 1 and 2 and Simian Immunodeficiency Virus. J. Virol.
75: 4664-4672
[Abstract][Full Text]
Smith, M. J., Gitlin, S. D., Browning, C. M., Lane, B. R., Clark, N. M., Shah, N., Rainier, S., Markovitz, D. M.
(2001). GLI-2 Modulates Retroviral Gene Expression. J. Virol.
75: 2301-2313
[Abstract][Full Text]
Travers, K, Mboup, S, Marlink, R, Gueye-Nidaye, A, Siby, T, Thior, I, Traore, I, Dieng-Sarr, A, Sankale, J., Mullins, C, et, al.
(1995). Natural protection against HIV-1 infection provided by HIV-2. Science
268: 1612-1615
[Abstract]
Marlink, R, Kanki, P, Thior, I, Travers, K, Eisen, G, Siby, T, Traore, I, Hsieh, C., Dia, M., Gueye, E., et, al.
(1994). Reduced rate of disease development after HIV-2 infection as compared to HIV-1. Science
265: 1587-1590
[Abstract]
Maguire, J. H., Tierney, M. R.
(1993). Case 8-1993- A 62-Year-Old Cape Verdean Woman with Blurred Vision, Diplopia, a Suprasellar Mass, and Lymphocytic Meningitis. NEJM
328: 566-573
[Full Text]
Koff, W., Hoth, D.
(1988). Development and testing of AIDS vaccines. Science
241: 426-432
[Abstract]
Evans, L., Moreau, J, Odehouri, K, Legg, H, Barboza, A, Cheng-Mayer, C, Levy, J.
(1988). Characterization of a noncytopathic HIV-2 strain with unusual effects on CD4 expression. Science
240: 1522-1525
[Abstract]
Kong, L., Lee, S., Kappes, J., Parkin, J., Decker, D, Hoxie, J., Hahn, B., Shaw, G.
(1988). West African HIV-2-related human retrovirus with attenuated cytopathicity. Science
240: 1525-1529
[Abstract]
Mitsuya, H, Looney, D., Kuno, S, Ueno, R, Wong-Staal, F, Broder, S
(1988). Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells. Science
240: 646-649
[Abstract]
Piot, P, Plummer, F., Mhalu, F., Lamboray, J., Chin, J, Mann, J.
(1988). AIDS: an international perspective. Science
239: 573-579
[Abstract]
Fauci, A.
(1988). The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. Science
239: 617-622
[Abstract]
Gnann, J. Jr, McCormick, J., Mitchell, S, Nelson, J., Oldstone, M.
(1987). Synthetic peptide immunoassay distinguishes HIV type 1 and HIV type 2 infections. Science
237: 1346-1349
[Abstract]
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