FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 316:1573-1577 June 18, 1987 Number 25 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

This study examined the hypothesis that altered binding of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) to parathyroid receptors might be involved in the pathogenesis of secondary hyperparathyroidism associated with chronic renal failure. The binding of [3H]1,25-(OH)2D3 to hyperplastic parathyroid glands obtained from seven patients with chronic renal failure was measured. These values were compared with those for binding to hyperplastic parathyroid tissue obtained from six patients who had received renal transplants and for binding to parathyroid adenomas removed from five patients who had primary hyperparathyroidism. We found that Nmax (an estimate of the concentration of 1,25-(OH)2D3 receptors) was reduced (42 +/- 15 fmol per milligram of protein) in patients with chronic renal failure as compared with patients with transplanted kidneys (78 +/- 24 fmol per milligram of protein) and patients with primary hyperparathyroidism (114 +/- 30). Nmax correlated inversely with the severity of renal dysfunction, the serum level of phosphorus, and the logarithm of the serum level of immunoreactive parathyroid hormone. These observations suggest that 1,25-(OH)2D3 binding by parathyroid tissue is reduced in chronic renal failure. This may contribute to the pathogenesis of secondary hyperparathyroidism by reducing the inhibition by 1,25-(OH)2D of parathyroid hormone secretion. The low serum levels of 1,25-(OH)2D in chronic renal failure may accentuate this effect.

This article has been cited by other articles:

• Shinaberger, C. S., Kopple, J. D., Kovesdy, C. P., McAllister, C. J., van Wyck, D., Greenland, S., Kalantar-Zadeh, K. (2008). Ratio of Paricalcitol Dosage to Serum Parathyroid Hormone Level and Survival in Maintenance Hemodialysis Patients. CJASN 3: 1769-1776 [Abstract] [Full Text]  
• Koleganova, N., Piecha, G., Ritz, E., Gross, M.-L. (2008). Calcitriol ameliorates capillary deficit and fibrosis of the heart in subtotally nephrectomized rats. Nephrol Dial Transplant 0: gfn549v1-gfn549 [Abstract] [Full Text]  
• Kovesdy, C. P., Ahmadzadeh, S., Anderson, J. E., Kalantar-Zadeh, K. (2007). Obesity Is Associated with Secondary Hyperparathyroidism in Men with Moderate and Severe Chronic Kidney Disease. CJASN 2: 1024-1029 [Abstract] [Full Text]  
• Martin, K. J., Gonzalez, E. A. (2007). Metabolic Bone Disease in Chronic Kidney Disease. J. Am. Soc. Nephrol. 18: 875-885 [Abstract] [Full Text]  
• Canadillas, S., Canalejo, A., Santamaria, R., Rodriguez, M. E., Estepa, J. C., Martin-Malo, A., Bravo, J., Ramos, B., Aguilera-Tejero, E., Rodriguez, M., Almaden, Y. (2005). Calcium-Sensing Receptor Expression and Parathyroid Hormone Secretion in Hyperplastic Parathyroid Glands from Humans. J. Am. Soc. Nephrol. 16: 2190-2197 [Abstract] [Full Text]  
• Healy, K. D., Vanhooke, J. L., Prahl, J. M., DeLuca, H. F. (2005). Parathyroid hormone decreases renal vitamin D receptor expression in vivo. Proc. Natl. Acad. Sci. USA 102: 4724-4728 [Abstract] [Full Text]  
• Koszewski, N. J., Alimov, A. P., Park-Sarge, O.-K., Malluche, H. H. (2004). Suppression of the Human Parathyroid Hormone Promoter by Vitamin D Involves Displacement of NF-Y Binding to the Vitamin D Response Element. J. Biol. Chem. 279: 42431-42437 [Abstract] [Full Text]  
• Tokumoto, M., Tsuruya, K., Fukuda, K., Kanai, H., Kuroki, S., Hirakata, H., Iida, M. (2003). Parathyroid cell growth in patients with advanced secondary hyperparathyroidism: vitamin D receptor and cyclin-dependent kinase inhibitors, p21 and p27. Nephrol Dial Transplant 18: iii9-12 [Abstract] [Full Text]  
• Iwasaki, Y., Kakuta, T., Haruguchi, H., Fukuda, N., Kurokawa, K., Fukagawa, M. (2003). Adenovirus-mediated functional gene transfer into parathyroid cells in vivo and in vitro. Nephrol Dial Transplant 18: iii18-22 [Abstract] [Full Text]  
• Nakanishi, S., Yano, S., Nomura, R., Tsukamoto, T., Shimizu, Y., Shin, J., Fukagawa, M. (2003). Efficacy of direct injection of calcitriol into the parathyroid glands in uraemic patients with moderate to severe secondary hyperparathyroidism. Nephrol Dial Transplant 18: iii47-49 [Abstract] [Full Text]  
• Lewin, E., Garfia, B., Recio, F. L., Rodriguez, M., Olgaard, K. (2002). Persistent Downregulation of Calcium-Sensing Receptor mRNA in Rat Parathyroids when Severe Secondary Hyperparathyroidism Is Reversed by an Isogenic Kidney Transplantation. J. Am. Soc. Nephrol. 13: 2110-2116 [Abstract] [Full Text]  
• DELUCA, H. F., CANTORNA, M. T. (2001). Vitamin D: its role and uses in immunology. FASEB J. 15: 2579-2585 [Abstract] [Full Text]  
• Semba, R. D, Garrett, E., Johnson, B. A, Guralnik, J. M, Fried, L. P (2000). Vitamin D deficiency among older women with and without disability. Am. J. Clin. Nutr. 72: 1529-1534 [Abstract] [Full Text]  
• CANALEJO, A., ALMADÉN, Y., TORREGROSA, V., GOMEZ-VILLAMANDOS, J. C., RAMOS, B., CAMPISTOL, J. M., FELSENFELD, A. J., RODRÍGUEZ, M. (2000). The In Vitro Effect of Calcitriol on Parathyroid Cell Proliferation and Apoptosis. J. Am. Soc. Nephrol. 11: 1865-1872 [Abstract] [Full Text]  
• Mihai, R., Farndon, J. R. (2000). Parathyroid disease and calcium metabolism. Br J Anaesth 85: 29-43 [Full Text]  
• Carling, T., Rastad, J., Szabó, E., Westin, G., Åkerström, G. (2000). Reduced Parathyroid Vitamin D Receptor Messenger Ribonucleic Acid Levels in Primary and Secondary Hyperparathyroidism. J. Clin. Endocrinol. Metab. 85: 2000-2003 [Abstract] [Full Text]  
• CHIN, J., MILLER, S. C., WADA, M., NAGANO, N., NEMETH, E. F., FOX, J. (2000). Activation of the Calcium Receptor by a Calcimimetic Compound Halts the Progression of Secondary Hyperparathyroidism in Uremic Rats. J. Am. Soc. Nephrol. 11: 903-911 [Abstract] [Full Text]  
• Brown, S. B., Brierley, T. T., Palanisamy, N., Salusky, I. B., Goodman, W., Brandi, M. L., Drüeke, T. B., Sarfati, E., Ureña, P., Chaganti, R. S. K., Pike, J. W., Arnold, A. (2000). Vitamin D Receptor as a Candidate Tumor-Suppressor Gene in Severe Hyperparathyroidism of Uremia. J. Clin. Endocrinol. Metab. 85: 868-872 [Abstract] [Full Text]  
• Vanholder, R., Glorieux, G. (1999). Molecular mechanisms of vitamin D hyporesponsiveness in renal failure. Nephrol Dial Transplant 14: 16-19 [Abstract]  
• Koike, N., Hayakawa, N., Kumaki, K., Stumpf, W. E. (1998). In Vivo Dose-related Receptor Binding of the Vitamin D Analogue [3H]-1,25-dihydroxy-22-oxavitamin D3 (OCT) in Rat Parathyroid, Kidney Distal and Proximal Tubules, Duodenum, and Skin, Studied by Quantitative Receptor Autoradiography. J. Histochem. Cytochem. 46: 1351-1358 [Abstract] [Full Text]