FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 317:482-485 August 20, 1987 Number 8 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

Although an immediate asthmatic response after exercise is known to occur in some patients with asthma, the existence of a delayed asthmatic response after exercise is controversial. Accordingly, we studied 53 patients who had an immediate mean (+/- SD) decrease in forced expiratory volume at one second (FEV1) of 36 +/- 13 percent, which was maximal 13 +/- 12 minutes after the completion of treadmill exercise. Eight of these patients also had a delayed asthmatic response (a 32 +/- 5 percent decrease in FEV1 occurring 5.0 +/- 1.8 hours after exercise). During a control day, on which the FEV1 was measured serially but no exercise was performed, the same delayed asthmatic response was observed in all but one patient. This finding suggests that the delayed asthmatic response observed in these patients after exercise was not specifically related to the performance of exercise. We conclude that in patients who have bronchoconstriction immediately after exercise, a second asthmatic response occurring later after the exercise is uncommon.

This article has been cited by other articles:

• Drazen, J. M., Israel, E., O'Byrne, P. M. (1999). Treatment of Asthma with Drugs Modifying the Leukotriene Pathway. NEJM 340: 197-206 [Full Text]  
• McFadden, E.R., Gilbert, I. A. (1994). Exercise-Induced Asthma. NEJM 330: 1362-1367 [Full Text]  
• (1987). DELAYED BRONCHOSPASM AFTER EXERCISE: FACT OR FICTION?. JWatch General 1987: 7-7 [Full Text]