We tested the usefulness of aspirin (325 mg twice daily), heparin (1000 units per hour by intravenous infusion), and a combination of the two in the early management of acute unstable angina pectoris in a double-blind, randomized, placebo-controlled trial involving 479 patients. The patients entered the study as soon as possible after hospital admission (at a mean [+/- SD] of 7.9 +/- 8.0 hours after the last episode of pain), and the study was ended after 6 +/- 3 days, when definitive therapy had been selected. Major end points--refractory angina, myocardial infarction, and death--occurred in 23, 12, and 1.7 percent of the 118 patients receiving placebo, respectively. Heparin was associated with a decrease in the occurrence of refractory angina (P = 0.002). The incidence of myocardial infarction was significantly reduced in the groups receiving aspirin (3 percent; P = 0.01), heparin (0.8 percent; P less than 0.001), and aspirin plus heparin (1.6 percent, P = 0.003), and no deaths occurred in these groups. There were too few deaths overall to permit evaluation of the effect of treatment on this end point. The combination of aspirin and heparin had no greater protective effect than heparin alone but was associated with slightly more serious bleeding (3.3 vs. 1.7 percent). We conclude that in the acute phase of unstable angina, either aspirin or heparin treatment is associated with a reduced incidence of myocardial infarction, and there is a trend favoring heparin over aspirin. Heparin treatment is also associated with a reduced incidence of refractory angina.
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Montreal Heart Institute, Que., Canada.
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107: 2640-2645
[Full Text]
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[Abstract][Full Text]
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23: 1282-1290
[Abstract]
Harding, S A, Boon, N A, Flapan, A D
(2002). Antiplatelet treatment in unstable angina: aspirin, clopidogrel, glycoprotein IIb/IIIa antagonist, or all three?. Heart
88: 11-14
[Abstract][Full Text]
Hebert, P. C., Cook, D. J., Wells, G., Marshall, J.
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121: 1290-1300
[Abstract][Full Text]
Borja, J., Paz, M. A., Olivella, P., O'Rourke, R. A.
(2002). New Approaches to Diagnosis and Management of Unstable Angina and Non-ST Segment Elevation Myocardial Infarction: Controversial Data. Arch Intern Med
162: 485-486
[Full Text]
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[Abstract][Full Text]
Kher, A., Samama, M.M.
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7: 314-320
[Abstract]
Gum, P. A., Thamilarasan, M., Watanabe, J., Blackstone, E. H., Lauer, M. S.
(2001). Aspirin Use and All-Cause Mortality Among Patients Being Evaluated for Known or Suspected Coronary Artery Disease: A Propensity Analysis. JAMA
286: 1187-1194
[Abstract][Full Text]
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3: I23-I30
[Abstract]
Hirsh, J., Anand, S. S., Halperin, J. L., Fuster, V.
(2001). Guide to Anticoagulant Therapy: Heparin : A Statement for Healthcare Professionals From the American Heart Association. Arterioscler. Thromb. Vasc. Bio.
21
: e9-e9
[Full Text]
Turpie, A. G. G., Antman, E. M.
(2001). Low-Molecular-Weight Heparins in the Treatment of Acute Coronary Syndromes. Arch Intern Med
161: 1484-1490
[Abstract][Full Text]
Cannon, C. P., Weintraub, W. S., Demopoulos, L. A., Vicari, R., Frey, M. J., Lakkis, N., Neumann, F.-J., Robertson, D. H., DeLucca, P. T., DiBattiste, P. M., Gibson, C. M., Braunwald, E., the TACTICS-Thrombolysis in Myocardial Infarction,
(2001). Comparison of Early Invasive and Conservative Strategies in Patients with Unstable Coronary Syndromes Treated with the Glycoprotein IIb/IIIa Inhibitor Tirofiban. NEJM
344: 1879-1887
[Abstract][Full Text]
Hirsh, J., Anand, S. S., Halperin, J. L., Fuster, V.
(2001). Guide to Anticoagulant Therapy: Heparin : A Statement for Healthcare Professionals From the American Heart Association. Circulation
103: 2994-3018
[Full Text]
Fitchett, D., Goodman, S., Langer, A.
(2001). New advances in the management of acute coronary syndromes: 1. Matching treatment to risk. CMAJ
164: 1309-1316
[Full Text]
Levine, G. N., Ali, M. N., Schafer, A. I.
(2001). Antithrombotic Therapy in Patients With Acute Coronary Syndromes. Arch Intern Med
161: 937-948
[Abstract][Full Text]
Kennon, S., Price, C. P., Mills, P. G., Ranjadayalan, K., Cooper, J., Clarke, H., Timmis, A. D.
(2001). The effect of aspirin on C-reactive protein as a marker of risk in unstable angina. J Am Coll Cardiol
37: 1266-1270
[Abstract][Full Text]
De Lorenzo, F., Noorani, A., Kakkar, V.V.
(2001). Current trends in the management of thromboembolic events. QJM
94: 179-185
[Full Text]
O'Rourke, R. A., Hochman, J. S., Cohen, M. C., Lucore, C. L., Popma, J. J., Cannon, C. P.
(2001). New Approaches to Diagnosis and Management of Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction. Arch Intern Med
161: 674-682
[Abstract][Full Text]
British Cardiac Society Guidelines and Medical Pra, , Royal College of Physicians Clinical Effectiveness,
(2001). Guideline for the management of patients with acute coronary syndromes without persistent ECG ST segment elevation. Heart
85: 133-142
[Full Text]
Patrono, C., Coller, B., Dalen, J. E., FitzGerald, G. A., Fuster, V., Gent, M., Hirsh, J., Roth, G.
(2001). Platelet-Active Drugs : The Relationships Among Dose, Effectiveness, and Side Effects. Chest
119
: 39S-63S
[Full Text]
Hirsh, J., Warkentin, T. E., Shaughnessy, S. G., Anand, S. S., Halperin, J. L., Raschke, R., Granger, C., Ohman, E. M., Dalen, J. E.
(2001). Heparin and Low-Molecular-Weight Heparin Mechanisms of Action, Pharmacokinetics, Dosing, Monitoring, Efficacy, and Safety. Chest
119
: 64S-94S
[Full Text]
Levine, M. N., Raskob, G., Landefeld, S., Kearon, C.
(2001). Hemorrhagic Complications of Anticoagulant Treatment. Chest
119
: 108S-121S
[Full Text]
Cairns, J. A., Theroux, P., Lewis, H. D. Jr., Ezekowitz, M., Meade, T. W.
(2001). Antithrombotic Agents in Coronary Artery Disease. Chest
119
: 228S-252S
[Full Text]
Azar, R.R, Rinfret, S, Theroux, P, Stone, P.H, Dakshinamurthy, R, Feng, Y.-J, Wu, A.H.B, Range, G, Waters, D.D
(2000). A randomized placebo-controlled trial to assess the efficacy of antiinflammatory therapy with methylprednisolone in unstable angina (MUNA trial). Eur Heart J
21: 2026-2032
[Abstract]
Manhapra, A., Borzak, S.
(2000). Regular review: Treatment possibilities for unstable angina. BMJ
321: 1269-1275
[Full Text]
Ageno, W., Turpie, A. G.
(2000). Therapy of unstable angina with the low molecular weight heparins. Vasc Med
5: 217-223
[Abstract]
Sonel, A., Sasseen, B. M., Fineberg, N., Bang, N., Wilensky, R. L.
(2000). Prospective Study Correlating Fibrinopeptide A, Troponin I, Myoglobin, and Myosin Light Chain Levels With Early and Late Ischemic Events in Consecutive Patients Presenting to the Emergency Department With Chest Pain. Circulation
102: 1107-1113
[Abstract][Full Text]
Braunwald, E., Antman, E. M., Beasley, J. W., Califf, R. M., Cheitlin, M. D., Hochman, J. S., Jones, R. H., Kereiakes, D., Kupersmith, J., Levin, T. N., Pepine, C. J., Schaeffer, J. W., Smith, E. E. III, Steward, D. E., Theroux, P., Gibbons, R. J., Alpert, J. S., Eagle, K. A., Faxon, D. P., Fuster, V., Gardner, T. J., Gregoratos, G., Russell, R. O., Smith, S. C. Jr
(2000). ACC/AHA guidelines for the management of patients with unstable angina and non-st-segment elevation myocardial infarction: A report of the american college of cardiology/ american heart association task force on practice guidelines (committee on the management of patients with unstable angina). J Am Coll Cardiol
36: 970-1062
[Full Text]
Bertrand, M.E, Simoons, M.L, Fox, K.A.A, Wallentin, L.C, Hamm, C.W, McFadden, E, de Feyter, P.J, Specchia, G, Ruzyllo, W
(2000). Management of acute coronary syndromes: acute coronary syndromes without persistent ST segment elevation. Recommendations of the Task Force of the European Society of Cardiology: Recommendations of the Task Force of the European Society of Cardiology. Eur Heart J
21: 1406-1432
Abrahamsson, P, Rosengren, A, Dellborg, M
(2000). Improved long-term prognosis for patients with unstable coronary syndromes 1988-1995. Eur Heart J
21: 533-539
[Abstract]
Lincoff, A. M., Califf, R. M., Topol, E. J.
(2000). Platelet glycoprotein IIb/IIIa receptor blockade in coronary artery disease. J Am Coll Cardiol
35: 1103-1115
[Abstract][Full Text]
Awtry, E. H., Loscalzo, J.
(2000). Aspirin. Circulation
101: 1206-1218
[Full Text]
Doucet, S., Malekianpour, M., Theroux, P., Bilodeau, L., Cote, G., Pierre de Guise, , Dupuis, J., Joyal, M., Gosselin, G., Tanguay, J.-F., Juneau, M., Harel, F., Nattel, S., Tardif, J.-C., Lesperance, J.
(2000). Randomized Trial Comparing Intravenous Nitroglycerin and Heparin for Treatment of Unstable Angina Secondary to Restenosis After Coronary Artery Angioplasty. Circulation
101: 955-961
[Abstract][Full Text]
Kleiman, N. S., Lincoff, A. M., Flaker, G. C., Pieper, K. S., Wilcox, R. G., Berdan, L. G., Lorenz, T. J., Cokkinos, D. V., Simoons, M. L., Boersma, E., Topol, E. J., Califf, R. M., Harrington, R. A.
(2000). Early Percutaneous Coronary Intervention, Platelet Inhibition With Eptifibatide, and Clinical Outcomes in Patients With Acute Coronary Syndromes. Circulation
101: 751-757
[Abstract][Full Text]
Bidstrup, B. P., Hunt, B. J., Sheikh, S., Parratt, R. N., Bidstrup, J. M., Sapsford, R. N.
(2000). Amelioration of the bleeding tendency of preoperative aspirin after aortocoronary bypass grafting. Ann. Thorac. Surg.
69: 541-547
[Abstract][Full Text]
Brodison, A., Katira, R., More, R. S, Chauhan, A.
(2000). Current practice: Antiplatelet use in interventional cardiology. Postgrad. Med. J.
76: 70-79
[Abstract][Full Text]
Yeghiazarians, Y., Braunstein, J. B., Askari, A., Stone, P. H.
(2000). Unstable Angina Pectoris. NEJM
342: 101-114
[Full Text]
Ambrose, J. A., Dangas, G.
(2000). Unstable Angina: Current Concepts of Pathogenesis and Treatment. Arch Intern Med
160: 25-37
[Abstract][Full Text]
Rossi, M., Martinelli, L., Storti, S., Corrado, M., Marra, R., Varano, C., Schiavello, R.
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[Abstract][Full Text]
Oldgren, J., Linder, R., Grip, L., Siegbahn, A., Wallentin, L.
(1999). Activated partial thromboplastin time and clinical outcome after thrombin inhibition in unstable coronary artery disease. Eur Heart J
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[Abstract]
van den Brand, M, Laarman, G.J, Steg, P.G, De Scheerder, I, Heyndrickx, G, Beatt, K, Kootstra, J, Simoons, M.L
(1999). Assessment of coronary angiograms prior to and after treatment with abciximab, and the outcome of angioplasty in refractory unstable angina patients. Angiographic results from the CAPTURE trial. Eur Heart J
20: 1572-1578
[Abstract]
Sackett, D. L.
(1999). Time to put the Canadian Institutes of Health Research on trial. CMAJ
161: 1414-1415
[Full Text]
Antman, E. M., McCabe, C. H., Gurfinkel, E. P., Turpie, A. G. G., Bernink, P. J. L. M., Salein, D., Bayes de Luna, A., Fox, K., Lablanche, J.-M., Radley, D., Premmereur, J., Braunwald, E.
(1999). Enoxaparin Prevents Death and Cardiac Ischemic Events in Unstable Angina/Non-Q-Wave Myocardial Infarction : Results of the Thrombolysis In Myocardial Infarction (TIMI) 11B Trial. Circulation
100: 1593-1601
[Abstract][Full Text]
Antman, E. M., Cohen, M., Radley, D., McCabe, C., Rush, J., Premmereur, J., Braunwald, E.
(1999). Assessment of the Treatment Effect of Enoxaparin for Unstable Angina/Non-Q-Wave Myocardial Infarction : TIMI 11B-ESSENCE Meta-Analysis. Circulation
100: 1602-1608
[Abstract][Full Text]
Zhao, X.-Q., Theroux, P., Snapinn, S. M., Sax, F. L.
(1999). Intracoronary Thrombus and Platelet Glycoprotein IIb/IIIa Receptor Blockade With Tirofiban in Unstable Angina or Non-Q-Wave Myocardial Infarction : Angiographic Results From the PRISM-PLUS Trial (Platelet Receptor Inhibition for Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms). Circulation
100: 1609-1615
[Abstract][Full Text]
Klein, M., Keith, P.R., Dauben, H.-P., Schulte, H.D., Beckmann, H., Mayer, G., Elert, O., Gams, E.
(1999). Aprotinin counterbalances an increased risk of peri-operative haemorrhage in CABG patients pre-treated with Aspirin. Eur. J. Cardiothorac. Surg.
14: 360-366
[Abstract][Full Text]
Becker, R. C., Spencer, F. A., Li, Y., Ball, S. P., Ma, Y., Hurley, T., Hebert, J.
(1999). Thrombin generation after the abrupt cessation of intravenous unfractionated heparin among patients with acute coronary syndromes: Potential mechanisms for heightened prothrombotic potential. J Am Coll Cardiol
34: 1020-1027
[Abstract][Full Text]
Zed, P. J., Tisdale, J. E., Borzak, S.
(1999). Low-Molecular-Weight Heparins in the Management of Acute Coronary Syndromes. Arch Intern Med
159: 1849-1857
[Abstract][Full Text]
Rabah, M., Mason, D., Muller, D. W. M., Hundley, R., Kugelmass, A. D., Weiner, B., Cannon, L., O'Neill, W. W., Safian, R. D.
(1999). Heparin after percutaneous intervention (HAPI): a prospective multicenter randomized trial of three heparin regimens after successful coronary intervention. J Am Coll Cardiol
34: 461-467
[Abstract][Full Text]
Zaidi, A M, Fitzpatrick, A P, Keenan, D J M, Odom, N J, Grotte, G J
(1999). Good outcomes from cardiac surgery in the over 70s. Heart
82: 134-137
[Abstract][Full Text]
De Candia, E., De Cristofaro, R., Landolfi, R.
(1999). Thrombin-Induced Platelet Activation Is Inhibited by High- and Low-Molecular-Weight Heparin. Circulation
99: 3308-3314
[Abstract][Full Text]
KENNON, S, TIMMIS, A
(1999). Management of unstable angina: what role intervention, ask the RITA-3 trialists?. Heart
81: 565-566
[Full Text]
Satre, H., Holmvang, L., Wagner, G.S., Lindahl, B., Wallentin, L.
(1999). Reduction of myocardial damage by prolonged treatment with subcutaneous low molecular weight heparin in unstable coronary artery disease. Eur Heart J
20: 645-652
[Abstract]
Zaacks, S. M., Liebson, P. R., Calvin, J. E., Parrillo, J. E., Klein, L. W.
(1999). Unstable angina and non-Q wave myocardial infarction: does the clinical diagnosis have therapeutic implications?. J Am Coll Cardiol
33: 107-118
[Abstract][Full Text]
