We studied separately the influence of two methods for losing fat weight on the levels of plasma lipids and lipoproteins in overweight sedentary men--decreasing energy intake without increasing exercise (diet), and increasing energy expenditure without altering energy intake (exercise, primarily running)--in a one-year randomized controlled trial. As compared with controls (n = 42), dieters (n = 42) had significant loss of total body weight (-7.8 +/- 0.9 kg [mean +/- SE]), fat weight (-5.6 +/- 0.8 kg), and lean (non-fat) weight (-2.1 +/- 0.5 kg) (P less than 0.001 for each variable), and exercisers (n = 47) had significant loss of total body weight (-4.6 +/- 0.8 kg) and fat weight (-3.8 +/- 0.7 kg) (P less than 0.001 for both variables) but not lean weight (-0.7 +/- 0.4 kg). Fat-weight loss did not differ significantly between dieters and exercisers. All subjects were discouraged from altering their diet composition; however, dieters and exercisers had slight reductions in the percentage of kilojoules derived from fat. As compared with the control group, both weight-loss groups had significant increases (P less than 0.01) in plasma concentrations of high-density lipoprotein (HDL) cholesterol (diet vs. exercise, 0.13 +/- 0.03 vs. 0.12 +/- 0.03 mmol per liter), HDL2 cholesterol (0.07 +/- 0.02 vs. 0.07 +/- 0.02 mmol per liter), and HDL3 cholesterol (0.07 +/- 0.02 vs. 0.06 +/- 0.02 mmol per liter) and significant decreases (P less than 0.05) in triglyceride levels (diet vs. exercise, -0.35 +/- 0.14 vs. -0.24 +/- 0.12 mmol per liter). Levels of total and low-density lipoprotein cholesterol were not significantly changed, relative to values in controls. None of these changes were significantly different between dieters and exercisers. Thus, we conclude that fat loss through dieting or exercising produces comparable and favorable changes in plasma lipoprotein concentrations.
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Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, Calif.
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17: 359-369
[Abstract][Full Text]
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[Abstract][Full Text]
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79: 204-212
[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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(2001). Long-term Weight Loss With Sibutramine: A Randomized Controlled Trial. JAMA
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[Abstract][Full Text]
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[Abstract][Full Text]
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(2000). Effects of Exercise and Weight Loss on Mental Stress-Induced Cardiovascular Responses in Individuals With High Blood Pressure. Hypertension
36: 171-176
[Abstract][Full Text]
Metz, J. A., Stern, J. S., Kris-Etherton, P., Reusser, M. E., Morris, C. D., Hatton, D. C., Oparil, S., Haynes, R. B., Resnick, L. M., Pi-Sunyer, F. X., Clark, S., Chester, L., McMahon, M., Snyder, G. W., McCarron, D. A.
(2000). A Randomized Trial of Improved Weight Loss With a Prepared Meal Plan in Overweight and Obese Patients: Impact on Cardiovascular Risk Reduction. Arch Intern Med
160: 2150-2158
[Abstract][Full Text]
Williams, P. T., Winett, R. A., Carpinelli, R. N., Smith, G. D., Ebrahim, S., Dunn, A. L., Blair, S. N., Kampert, J. B., Marcus, B. H., Garcia, M. E., Kohl III, H. W., Andersen, R., Pratt, M.
(1999). Lifestyle and Structured Interventions to Increase Physical Activity. JAMA
282: 1515-1517
[Full Text]
Segasothy, M., Phillips, P.A.
(1999). Vegetarian diet: panacea for modern lifestyle diseases?. QJM
92: 531-544
[Abstract][Full Text]
Di Buono, M., Hannah, J. S., Katzel, L. I., Jones, P. J. H.
(1999). Weight Loss Due to Energy Restriction Suppresses Cholesterol Biosynthesis in Overweight, Mildly Hypercholesterolemic Men. J. Nutr.
129: 1545-1548
[Abstract][Full Text]
Harper, C. R., Jacobson, T. A.
(1999). New Perspectives on the Management of Low Levels of High-Density Lipoprotein Cholesterol. Arch Intern Med
159: 1049-1057
[Abstract][Full Text]
James, K.
(1999). Exercise plus diet improved cholesterol concentrations in high risk adults. Evid. Based Nurs.
2: 45-45
[Full Text]
Jousilahti, P., Vartiainen, E., Tuomilehto, J., Puska, P.
(1999). Sex, Age, Cardiovascular Risk Factors, and Coronary Heart Disease : A Prospective Follow-Up Study of 14 786 Middle-Aged Men and Women in Finland. Circulation
99: 1165-1172
[Abstract][Full Text]
Lee, C. D., Blair, S. N, Jackson, A. S
(1999). Cardiorespiratory fitness, body composition, and all-cause and cardiovascular disease mortality in men. Am. J. Clin. Nutr.
69: 373-380
[Abstract][Full Text]
Daniels, S. R., Morrison, J. A., Sprecher, D. L., Khoury, P., Kimball, T. R.
(1999). Association of Body Fat Distribution and Cardiovascular Risk Factors in Children and Adolescents. Circulation
99: 541-545
[Abstract][Full Text]
Wei, M., Gibbons, L. W., Mitchell, T. L., Kampert, J. B., Lee, C. D., Blair, S. N.
(1999). The Association between Cardiorespiratory Fitness and Impaired Fasting Glucose and Type 2 Diabetes Mellitus in Men. ANN INTERN MED
130: 89-96
[Abstract][Full Text]
Benzer, W., Bitschnau, R., Groechenig, E., Aczel, S., Drexel, H., Hsieh, S. D., Yoshinaga, H., Muto, T., Sakurai, Y.
(1998). Regular Physical Activity and Risk Factors for Coronary Heart Disease • Response. Circulation
98: 2356-2356
[Full Text]
Stefanick, M. L., Mackey, S., Sheehan, M., Ellsworth, N., Haskell, W. L., Wood, P. D.
(1998). Effects of Diet and Exercise in Men and Postmenopausal Women with Low Levels of HDL Cholesterol and High Levels of LDL Cholesterol. NEJM
339: 12-20
[Abstract][Full Text]
Williams, P. T.
(1998). Relationships of Heart Disease Risk Factors to Exercise Quantity and Intensity. Arch Intern Med
158: 237-245
[Abstract][Full Text]
Crouse, S. F., O'Brien, B. C., Grandjean, P. W., Lowe, R. C., Rohack, J. J., Green, J. S.
(1997). Effects of training and a single session of exercise on lipids and apolipoproteins in hypercholesterolemic men. J. Appl. Physiol.
83: 2019-2028
[Abstract][Full Text]
Schwartz, M. W., Brunzell, J. D.
(1997). Regulation of Body Adiposity and the Problem of Obesity. Arterioscler. Thromb. Vasc. Bio.
17: 233-238
[Abstract][Full Text]
Williams, P. T.
(1997). Relationship of Distance Run per Week to Coronary Heart Disease Risk Factors in 8283 Male Runners: The National Runners' Health Study. Arch Intern Med
157: 191-198
[Abstract]
Crouse, S. F., O'Brien, B. C., Grandjean, P. W., Lowe, R. C., Rohack, J. J., Green, J. S., Tolson, H.
(1997). Training intensity, blood lipids, and apolipoproteins in men with high cholesterol. J. Appl. Physiol.
82: 270-277
[Abstract][Full Text]
Goldbourt, U., Yaari, S., Medalie, J. H.
(1997). Isolated Low HDL Cholesterol As a Risk Factor for Coronary Heart Disease Mortality: A 21-Year Follow-up of 8000 Men. Arterioscler. Thromb. Vasc. Bio.
17: 107-113
[Abstract][Full Text]
Tanne, D., Yaari, S., Goldbourt, U.
(1997). High-Density Lipoprotein Cholesterol and Risk of Ischemic Stroke Mortality: A 21-Year Follow-up of 8586 Men From the Israeli Ischemic Heart Disease Study. Stroke
28: 83-87
[Abstract][Full Text]
Fitzgerald, J. T., Singleton, S. P., Engels, H.-J., Cardinal, B. J., Prasad, A. S., Hess, J. W.
(1996). Reported Exercise Patterns and their Relationship to Lipid Levels among Healthy Older Adults. Research on Aging
18: 477-493
[Abstract]
Katzel, L. I., Goldberg, A. P.
(1996). Weight Loss vs Exercise to Reduce Coronary Artery Disease Risk Factors-Reply. JAMA
275: 1546-1547
[Abstract]
Katzel, L. I., Bleecker, E. R., Colman, E. G., Rogus, E. M., Sorkin, J. D., Goldberg, A. P.
(1995). Effects of Weight Loss vs Aerobic Exercise Training on Risk Factors for Coronary Disease in Healthy, Obese, Middle-aged and Older Men: A Randomized Controlled Trial. JAMA
274: 1915-1921
[Abstract]
Warner, J. G. Jr, Brubaker, P. H., Zhu, Y., Morgan, T. M., Ribisl, P. M., Miller, H. S., Herrington, D. M.
(1995). Long-term (5-Year) Changes in HDL Cholesterol in Cardiac Rehabilitation Patients : Do Sex Differences Exist?. Circulation
92: 773-777
[Abstract][Full Text]
King, A. C., Haskell, W. L., Young, D. R., Oka, R. K., Stefanick, M. L.
(1995). Long-term Effects of Varying Intensities and Formats of Physical Activity on Participation Rates, Fitness, and Lipoproteins in Men and Women Aged 50 to 65 Years. Circulation
91: 2596-2604
[Abstract][Full Text]
Vega, G. L., Grundy, S. M.
(1994). Lipoprotein Responses to Treatment With Lovastatin, Gemfibrozil, and Nicotinic Acid in Normolipidemic Patients With Hypoalphalipoproteinemia. Arch Intern Med
154: 73-82
[Abstract]
Rosenson, R. S.
(1993). Low Levels of High-Density Lipoprotein Cholesterol (Hypoalphalipoproteinemia) An Approach to Management. Arch Intern Med
153: 1528-1538
[Abstract]
Taylor, P. A., Ward, A.
(1993). Women, High-Density Lipoprotein Cholesterol, and Exercise. Arch Intern Med
153: 1178-1184
[Abstract]
Denke, M. A., Sempos, C. T., Grundy, S. M.
(1993). Excess Body Weight: An Underrecognized Contributor to High Blood Cholesterol Levels in White American Men. Arch Intern Med
153: 1093-1103
[Abstract]
Lavie, C. J., Milani, R. V.
(1993). Factors Predicting Improvements in Lipid Values Following Cardiac Rehabilitation and Exercise Training. Arch Intern Med
153: 982-988
[Abstract]
Boyden, T. W., Pamenter, R. W., Going, S. B., Lohman, T. G., Hall, M. C., Houtkooper, L. B., Bunt, J. C., Ritenbaugh, C., Aickin, M.
(1993). Resistance Exercise Training Is Associated With Decreases in Serum Low-Density Lipoprotein Cholesterol Levels in Premenopausal Women. Arch Intern Med
153: 97-100
[Abstract]
Endo, H., Takagi, Y., Nozue, T., Kuwahata, K., Uemasu, F., Kobayashi, A.
(1992). Beneficial Effects of Dietary Intervention on Serum Lipid and Apolipoprotein Levels in Obese Children. Arch Pediatr Adolesc Med
146: 303-305
[Abstract]
Duncan, J. J., Gordon, N. F., Scott, C. B.
(1991). Women Walking for Health and Fitness: How Much Is Enough?. JAMA
266: 3295-3299
[Abstract]
Wadden, T. A.
(1991). Long-term Glycemic Control in Patients With Type II Diabetes. Arch Intern Med
151: 1269-1270
[Abstract]
Wing, R. R., Marcus, M. D., Salata, R., Epstein, L. H., Miaskiewicz, S., Blair, E. H.
(1991). Effects of a Very-Low-Calorie Diet on Long-term Glycemic Control in Obese Type 2 Diabetic Subjects. Arch Intern Med
151: 1334-1340
[Abstract]
Working Group on Management of Patients with Hyper,
(1991). National Education Programs Working Group Report on the Management of Patients with Hypertension and High Blood Cholesterol. ANN INTERN MED
114: 224-237
[Abstract]
Denke, M. A., Grundy, S. M.
(1990). Hypercholesterolemia in Elderly Persons: Resolving the Treatment Dilemma. ANN INTERN MED
112: 780-792
[Abstract]
Dreon, D. M., Vranizan, K. M., Krauss, R. M., Austin, M. A., Wood, P. D.
(1990). The Effects of Polyunsaturated Fat vs Monounsaturated Fat on Plasma Lipoproteins. JAMA
263: 2462-2466
[Abstract]
Giral, Ph., Bruckert, E., Boyer, H.
(1990). Systeme International Units and Familiar Formulas: The Case of Lipids. JAMA
263: 2302-2302
[Abstract]
Leighton, R. F., Repka, F. J., Birk, T. J., Lynch, D. J., Bingle, J. F., Gohara, A. F., Saffran, J., Weaver, M. T., Brewster, P. M., Walsh, M. E.
(1990). The Toledo Exercise and Diet Study: Results at 26 Weeks. Arch Intern Med
150: 1016-1020
[Abstract]
Choi, E. S. K., McGandy, R. B., Dallal, G. E., Russell, R. M., Jacob, R. A., Schaefer, E. J., Sadowski, J. A.
(1990). The Prevalence of Cardiovascular Risk Factors Among Elderly Chinese Americans. Arch Intern Med
150: 413-418
[Abstract]
King, A. C., Frey-Hewitt, B., Dreon, D. M., Wood, P. D.
(1989). Diet vs Exercise in Weight Maintenance: The Effects of Minimal Intervention Strategies on Long-term Outcomes in Men. Arch Intern Med
149: 2741-2746
[Abstract]
Gore, J. M., Dalen, J. E.
(1989). Cardiovascular Disease. JAMA
261: 2829-2831
[Abstract]
Simopoulos, A. P.
(1989). Nutrition and Fitness. JAMA
261: 2862-2863
[Abstract]
(1988). EXERCISE OR DIET? THE VIRTUES ARE EQUIVALENT. JWatch General
1988: 4-4
[Full Text]
