We conducted a double-blind, placebo-controlled trial to determine whether ventricular dilatation continues during the late convalescent phase after myocardial infarction and whether therapy with captopril alters this process. Fifty-nine patients with a first anterior myocardial infarction and a radionuclide ejection fraction of 45 percent or less underwent cardiac catheterization 11 to 31 days after infarction, when they were not in overt congestive heart failure. They were randomly assigned to placebo or captopril and were followed for one year. A repeat catheterization was performed to evaluate interval changes in hemodynamic function and left ventricular volume. Thirty-eight male patients were evaluated with maximal-exercise treadmill tests every three months. No differences were detected at base line in clinical, hemodynamic, or quantitative ventriculographic variables. During one year of follow-up, the end-diastolic volume of the left ventricle increased by a mean [+/- SEM] of 21 +/- 8 ml (P less than 0.02) in the placebo group, but by only 10 +/- 6 ml (P not significant) in the captopril group. The left ventricular filling pressure remained elevated with placebo but decreased (P less than 0.01) with captopril. In a subset of 36 patients who were at high risk for ventricular enlargement because they had persistent occlusion of the left anterior descending coronary artery, captopril prevented further ventricular dilatation (P less than 0.05). Patients given captopril also had increased exercise capacity (P less than 0.05). This preliminary study indicates that after anterior myocardial infarction, ventricular enlargement is progressive and that captopril may attenuate this process, reduce filling pressures, and improve exercise tolerance.
Source Information
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115.
This article has been cited by other articles:
Frohlich, E. D.
(2008). Excitement of Clinical Investigation: New Basic Mechanisms of Action After Drug Introduction. Hypertension
52: 465-466
[Full Text]
Kloner, R. A., Hwang, H.
(2008). New Insights Into the Open Artery Hypothesis. Circ. Res.
103: 1-3
[Full Text]
Nakagawa, M., Takemura, G., Kanamori, H., Goto, K., Maruyama, R., Tsujimoto, A., Ohno, T., Okada, H., Ogino, A., Esaki, M., Miyata, S., Li, L., Ushikoshi, H., Aoyama, T., Kawasaki, M., Nagashima, K., Fujiwara, T., Minatoguchi, S., Fujiwara, H.
(2008). Mechanisms by Which Late Coronary Reperfusion Mitigates Postinfarction Cardiac Remodeling. Circ. Res.
103: 98-106
[Abstract][Full Text]
Schocken, D. D., Benjamin, E. J., Fonarow, G. C., Krumholz, H. M., Levy, D., Mensah, G. A., Narula, J., Shor, E. S., Young, J. B., Hong, Y.
(2008). Prevention of Heart Failure: A Scientific Statement From the American Heart Association Councils on Epidemiology and Prevention, Clinical Cardiology, Cardiovascular Nursing, and High Blood Pressure Research; Quality of Care and Outcomes Research Interdisciplinary Working Group; and Functional Genomics and Translational Biology Interdisciplinary Working Group. Circulation
117: 2544-2565
[Abstract][Full Text]
Greenberg, B.
(2008). Molecular Imaging of the Remodeling Heart: The Next Step Forward. J Am Coll Cardiol Img
1: 363-365
[Full Text]
Lewis, E. F., Velazquez, E. J., Solomon, S. D., Hellkamp, A. S., McMurray, J. J.V., Mathias, J., Rouleau, J.-L., Maggioni, A. P., Swedberg, K., Kober, L., White, H., Dalby, A. J., Francis, G. S., Zannad, F., Califf, R. M., Pfeffer, M. A.
(2008). Predictors of the first heart failure hospitalization in patients who are stable survivors of myocardial infarction complicated by pulmonary congestion and/or left ventricular dysfunction: a VALIANT study. Eur Heart J
29: 748-756
[Abstract][Full Text]
Isbell, D. C., Voros, S., Yang, Z., DiMaria, J. M., Berr, S. S., French, B. A., Epstein, F. H., Bishop, S. P., Wang, H., Roy, R. J., Kemp, B. A., Matsubara, H., Carey, R. M., Kramer, C. M.
(2007). Interaction between bradykinin subtype 2 and angiotensin II type 2 receptors during post-MI left ventricular remodeling. Am. J. Physiol. Heart Circ. Physiol.
293: H3372-H3378
[Abstract][Full Text]
de Teresa, E., Gomez-Doblas, J. J., Lamas, G., Alzueta, J., Fernandez-Lozano, I., Cobo, E., Navarro, X., Navarro-Lopez, F., Stockburger, M.
(2007). Preventing ventricular dysfunction in pacemaker patients without advanced heart failure: rationale and design of the PREVENT-HF study. Europace
9: 442-446
[Abstract][Full Text]
Dzavik, V., Buller, C. E., Lamas, G. A., Rankin, J. M., Mancini, G.B. J., Cantor, W. J., Carere, R. J., Ross, J. R., Atchison, D., Forman, S., Thomas, B., Buszman, P., Vozzi, C., Glanz, A., Cohen, E. A., Meciar, P., Devlin, G., Mascette, A., Sopko, G., Knatterud, G. L., Hochman, J. S., for the TOSCA-2 Investigators,
(2006). Randomized Trial of Percutaneous Coronary Intervention for Subacute Infarct-Related Coronary Artery Occlusion to Achieve Long-Term Patency and Improve Ventricular Function: The Total Occlusion Study of Canada (TOSCA)-2 Trial. Circulation
114: 2449-2457
[Abstract][Full Text]
Pfeffer, M. A., Frohlich, E. D.
(2006). Improvements in clinical outcomes with the use of angiotensin-converting enzyme inhibitors: cross-fertilization between clinical and basic investigation. Am. J. Physiol. Heart Circ. Physiol.
291: H2021-H2025
[Abstract][Full Text]
Moller, J. E., Pellikka, P. A., Hillis, G. S., Oh, J. K.
(2006). Prognostic Importance of Diastolic Function and Filling Pressure in Patients With Acute Myocardial Infarction. Circulation
114: 438-444
[Full Text]
Dhalla, N. S., Dent, M. R., Tappia, P. S., Sethi, R., Barta, J., Goyal, R. K.
(2006). Subcellular Remodeling as a Viable Target for the Treatment of Congestive Heart Failure. J CARDIOVASC PHARMACOL THER
11: 31-45
[Abstract]
Voros, S., Yang, Z., Bove, C. M., Gilson, W. D., Epstein, F. H., French, B. A., Berr, S. S., Bishop, S. P., Conaway, M. R., Matsubara, H., Carey, R. M., Kramer, C. M.
(2006). Interaction between AT1 and AT2 receptors during postinfarction left ventricular remodeling. Am. J. Physiol. Heart Circ. Physiol.
290: H1004-H1010
[Abstract][Full Text]
Baks, T., van Geuns, R.-J., Duncker, D. J., Cademartiri, F., Mollet, N. R., Krestin, G. P., Serruys, P. W., de Feyter, P. J.
(2006). Prediction of Left Ventricular Function After Drug-Eluting Stent Implantation for Chronic Total Coronary Occlusions. J Am Coll Cardiol
47: 721-725
[Abstract][Full Text]
Dore, A., Houde, C., Chan, K.-L., Ducharme, A., Khairy, P., Juneau, M., Marcotte, F., Mercier, L.-A.
(2005). Angiotensin Receptor Blockade and Exercise Capacity in Adults With Systemic Right Ventricles: A Multicenter, Randomized, Placebo-Controlled Clinical Trial. Circulation
112: 2411-2416
[Abstract][Full Text]
Leri, A., Kajstura, J., Anversa, P.
(2005). Cardiac Stem Cells and Mechanisms of Myocardial Regeneration. Physiol. Rev.
85: 1373-1416
[Abstract][Full Text]
Levine, R. A., Schwammenthal, E.
(2005). Ischemic Mitral Regurgitation on the Threshold of a Solution: From Paradoxes to Unifying Concepts. Circulation
112: 745-758
[Full Text]
Solomon, S. D., Skali, H., Anavekar, N. S., Bourgoun, M., Barvik, S., Ghali, J. K., Warnica, J. W., Khrakovskaya, M., Arnold, J. M. O., Schwartz, Y., Velazquez, E. J., Califf, R. M., McMurray, J. V., Pfeffer, M. A.
(2005). Changes in Ventricular Size and Function in Patients Treated With Valsartan, Captopril, or Both After Myocardial Infarction. Circulation
111: 3411-3419
[Abstract][Full Text]
Trueblood, N. A., Inscore, P. R., Brenner, D., Lugassy, D., Apstein, C. S., Sawyer, D. B., Colucci, W. S.
(2005). Biphasic temporal pattern in exercise capacity after myocardial infarction in the rat: relationship to left ventricular remodeling. Am. J. Physiol. Heart Circ. Physiol.
288: H244-H249
[Abstract][Full Text]
de Kam, P. J, Voors, A. A, Fici, F., van Veldhuisen, D. J, van Gilst, W. H
(2004). Review: The revised role of ACE-inhibition after myocardial infarction in the thrombolytic/primary PCI era. Journal of Renin-Angiotensin-Aldosterone System
5: 161-168
[Abstract]
Pieske, B.
(2004). Reverse remodeling in heart failure - fact or fiction?. Eur Heart J Suppl
6: D66-D78
[Abstract][Full Text]
Phillips, S. A., Drenjancevic-Peric, I., Frisbee, J. C., Lombard, J. H.
(2004). Chronic AT1 receptor blockade alters mechanisms mediating responses to hypoxia in rat skeletal muscle resistance arteries. Am. J. Physiol. Heart Circ. Physiol.
287: H545-H552
[Abstract][Full Text]
Fieno, D. S., Hillenbrand, H. B., Rehwald, W. G., Harris, K. R., Decker, R. S., Parker, M. A., Klocke, F. J., Kim, R. J., Judd, R. M.
(2004). Infarct resorption, compensatory hypertrophy, and differing patterns of ventricular remodeling following myocardial infarctions of varying size. J Am Coll Cardiol
43: 2124-2131
[Abstract][Full Text]
Jin, H., Fedorowicz, G., Yang, R., Ogasawara, A., Peale, F., Pham, T., Paoni, N. F.
(2004). Thyrotropin-Releasing Hormone Is Induced in the Left Ventricle of Rats With Heart Failure and Can Provide Inotropic Support to the Failing Heart. Circulation
109: 2240-2245
[Abstract][Full Text]
Doughty, R. N., Whalley, G. A., Walsh, H. A., Gamble, G. D., Lopez-Sendon, J., Sharpe, N., on behalf of the CAPRICORN Echo Substudy Investiga,
(2004). Effects of Carvedilol on Left Ventricular Remodeling After Acute Myocardial Infarction: The CAPRICORN Echo Substudy. Circulation
109: 201-206
[Abstract][Full Text]
Pilla, J. J., Blom, A. S., Brockman, D. J., Ferrari, V. A., Yuan, Q., Acker, M. A.
(2003). Passive ventricular constraint to improve left ventricular function and mechanics in an ovine model of heart failure secondary to acute myocardial infarction. J. Thorac. Cardiovasc. Surg.
126: 1467-1475
[Abstract][Full Text]
Bolooki, H., DeMarchena, E., Mallon, S. M., Katariya, K., Barron, M., Bolooki, H. M., Thurer, R. J., Novak, S., Duncan, R. C.
(2003). Factors affecting late survival after surgical remodeling of left ventricular aneurysms. J. Thorac. Cardiovasc. Surg.
126: 374-385
[Abstract][Full Text]
Stevenson, L. W.
(2003). Clinical Use of Inotropic Therapy for Heart Failure: Looking Backward or Forward? Part I: Inotropic Infusions During Hospitalization. Circulation
108: 367-372
[Full Text]
Delepine, S., Furber, A. P., Beygui, F., Prunier, F., Balzer, P., Le Jeune, J.-J., Geslin, P.
(2003). 3-D MRI assessment of regional left ventricular systolic wall stress in patients with reperfused MI. Am. J. Physiol. Heart Circ. Physiol.
284: H1190-H1197
[Abstract][Full Text]
Buckberg, G. D.
(2003). Congestive heart failure: Treat the disease, not the symptom--return to normalcy. J. Thorac. Cardiovasc. Surg.
125: S41-49
[Full Text]
Kaye, D. M., Parnell, M. M., Ahlers, B. A.
(2002). Reduced Myocardial and Systemic L-Arginine Uptake in Heart Failure. Circ. Res.
91: 1198-1203
[Abstract][Full Text]
Braunwald, E.
(2002). Personal reflections on efforts to reduce ischemic myocardial damage. Cardiovasc Res
56: 332-338
[Full Text]
Shamim, W., Yousufuddin, M., Wang, D., Henein, M., Seggewiss, H., Flather, M., Coats, A. J.S., Sigwart, U.
(2002). Nonsurgical Reduction of the Interventricular Septum in Patients with Hypertrophic Cardiomyopathy. NEJM
347: 1326-1333
[Abstract][Full Text]
Solomon, S. D., Pfeffer, M. A.
(2002). Renin-Angiotensin System and Cardiac Rupture After Myocardial Infarction. Circulation
106: 2167-2169
[Full Text]
Pilla, J. J., Blom, A. S., Brockman, D. J., Bowen, F., Yuan, Q., Giammarco, J., Ferrari, V. A., Gorman, J. H. III, Gorman, R. C., Acker, M. A.
(2002). Ventricular Constraint Using the Acorn Cardiac Support Device Reduces Myocardial Akinetic Area in an Ovine Model of Acute Infarction. Circulation
106: I-207-I-211
[Abstract][Full Text]
Solomon, S. D., Sutton, M. S. J., Lamas, G. A., Plappert, T., Rouleau, J. L., Skali, H., Moye, L., Braunwald, E., Pfeffer, M. A., for the Survival And Ventricular Enlargement (SAVE,
(2002). Ventricular Remodeling Does Not Accompany the Development of Heart Failure in Diabetic Patients After Myocardial Infarction. Circulation
106: 1251-1255
[Abstract][Full Text]
Jugdutt, B. I., Menon, V.
(2002). Beneficial Effects of Therapy on the Progression of Structural Remodeling During Healing After Reperfused and Nonreperfused Myocardial Infarction: Different Effects on Different Parameters. J CARDIOVASC PHARMACOL THER
7: 95-107
[Abstract]
Watzinger, N., Lund, G. K., Higgins, C. B., Chujo, M., Saeed, M.
(2002). Noninvasive assessment of the effects of nicorandil on left ventricular volumes and function in reperfused myocardial infarction. Cardiovasc Res
54: 77-84
[Abstract][Full Text]
Nohria, A., Lewis, E., Stevenson, L. W.
(2002). Medical Management of Advanced Heart Failure. JAMA
287: 628-640
[Abstract][Full Text]
Jugdutt, B. I.
(2002). Monocytosis and adverse left ventricular remodeling after reperfused myocardial infarction. J Am Coll Cardiol
39: 247-250
[Full Text]
Nijland, F, Kamp, O, Verhorst, P M J, de Voogt, W G, Bosch, H G, Visser, C A
(2002). Myocardial viability: impact on left ventricular dilatation after acute myocardial infarction. Heart
87: 17-22
[Abstract][Full Text]
Pouzet, B., Ghostine, S., Vilquin, J.-T., Garcin, I., Scorsin, M., Hagege, A. A., Duboc, D., Schwartz, K., Menasche, P.
(2001). Is Skeletal Myoblast Transplantation Clinically Relevant in the Era of Angiotensin-Converting Enzyme Inhibitors?. Circulation
104: I-223-228
[Abstract][Full Text]
Matsubara, H.
(2001). Renin-Angiotensin System in Human Failing Hearts : Message From Nonmyocyte Cells to Myocytes. Circ. Res.
88: 861-863
[Full Text]
Braunwald, E.
(2001). Congestive heart failure: a half century perspective. Eur Heart J
22: 825-836
Opie, L. H., Sack, M. N.
(2001). Enhanced Angiotensin II Activity in Heart Failure : Reevaluation of the Counterregulatory Hypothesis of Receptor Subtypes. Circ. Res.
88: 654-658
[Abstract][Full Text]
Buckberg, G. D.
(2001). Congestive heart failure: Treat the disease, not the symptom--Return to normalcy. J. Thorac. Cardiovasc. Surg.
121: 628-637
[Full Text]
Pathak, M., Sarkar, S., Vellaichamy, E., Sen, S.
(2001). Role of Myocytes in Myocardial Collagen Production. Hypertension
37: 833-840
[Abstract][Full Text]
Gomberg-Maitland, M., Baran, D. A., Fuster, V.
(2001). Treatment of Congestive Heart Failure: Guidelines for the Primary Care Physician and the Heart Failure Specialist. Arch Intern Med
161: 342-352
[Abstract][Full Text]
Jin, H., Yang, R., Awad, T. A., Wang, F., Li, W., Williams, S.-P., Ogasawara, A., Shimada, B., Williams, P. M., de Feo, G., Paoni, N. F.
(2001). Effects of Early Angiotensin-Converting Enzyme Inhibition on Cardiac Gene Expression After Acute Myocardial Infarction. Circulation
103: 736-742
[Abstract][Full Text]
de Kam, P. J., Voors, A. A., van den Berg, M. P., van Veldhuisen, D. J., Brouwer, J., Crijns, H. J. G. M., Borghi, C., Ambrosioni, E., Hochman, J. S., LeJemtel, T. H., Kingma, J.-H., St. John Sutton, M., van Gilst, W. H., on behalf of the FAMIS CAPTIN and CATS Investigato,
(2000). Effect of very early angiotensin-converting enzyme inhibition on left ventricular dilation after myocardial infarction in patients receiving thrombolysis: Results of a meta-analysis of 845 patients. J Am Coll Cardiol
36: 2047-2053
[Abstract][Full Text]
Oxenham, H., Sharpe, N.
(2000). Angiotensin-converting enzyme inhibitor treatment after myocardial infarction: A selective approach for maximum benefit. J Am Coll Cardiol
36: 2054-2055
[Full Text]
Chaudhry, P. A., Mishima, T., Sharov, V. G., Hawkins, J., Alferness, C., Paone, G., Sabbah, H. N.
(2000). Passive epicardial containment prevents ventricular remodeling in heart failure. Ann. Thorac. Surg.
70: 1275-1280
[Abstract][Full Text]
Waring, W. S.
(2000). Early initiation of ACE inhibitor treatment after acute myocardial infarction - a missed therapeutic opportunity?. Journal of Renin-Angiotensin-Aldosterone System
1: 245-251
Sutton, M. G. St. J., Sharpe, N.
(2000). Left Ventricular Remodeling After Myocardial Infarction : Pathophysiology and Therapy. Circulation
101: 2981-2988
[Full Text]
Quinones, M. A., Greenberg, B. H., Kopelen, H. A., Koilpillai, C., Limacher, M. C., Shindler, D. M., Shelton, B. J., Weiner, D. H., for the SOLVD Investigators,
(2000). Echocardiographic predictors of clinical outcome in patients with left ventricular dysfunction enrolled in the SOLVD registry and trials: significance of left ventricular hypertrophy. J Am Coll Cardiol
35: 1237-1244
[Abstract][Full Text]
Sabbah, H. N.
(2000). Apoptotic cell death in heart failure. Cardiovasc Res
45: 704-712
[Full Text]
Hugel, S., Reincke, M., Stromer, H., Winning, J., Horn, M., Dienesch, C., Mora, P., Schmidt, H. H. H. W., Allolio, B., Neubauer, S.
(1999). Evidence against a role of physiological concentrations of estrogen in post-myocardial infarction remodeling. J Am Coll Cardiol
34: 1427-1434
[Abstract][Full Text]
Cleutjens, J. P.M, Blankesteijn, W.M., Daemen, M. J.A.P, Smits, J. F.M
(1999). The infarcted myocardium: Simply dead tissue, or a lively target for therapeutic interventions. Cardiovasc Res
44: 232-241
[Full Text]
Filippatos, G., Leche, C., Sunga, R., Tsoukas, A., Anthopoulos, P., Joshi, I., Bifero, A., Pick, R., Uhal, B. D.
(1999). Expression of FAS adjacent to fibrotic foci in the failing human heart is not associated with increased apoptosis. Am. J. Physiol. Heart Circ. Physiol.
277: H445-H451
[Abstract][Full Text]
Kannel, W. B., D'Agostino, R. B., Silbershatz, H., Belanger, A. J., Wilson, P. W. F., Levy, D.
(1999). Profile for Estimating Risk of Heart Failure. Arch Intern Med
159: 1197-1204
[Abstract][Full Text]
Domanski, M. J., Exner, D. V., Borkowf, C. B., Geller, N. L., Rosenberg, Y., Pfeffer, M. A.
(1999). Effect of angiotensin converting enzyme inhibition on sudden cardiac death in patients following acute myocardial infarction: A meta-analysis of randomized clinical trials. J Am Coll Cardiol
33: 598-604
[Abstract][Full Text]
Tobin, K., Stomel, R., Harber, D., Karavite, D., Sievers, J., Eagle, K.
(1999). Validation in a Community Hospital Setting of a Clinical Rule to Predict Preserved Left Ventricular Ejection Fraction in Patients After Myocardial Infarction. Arch Intern Med
159: 353-357
[Abstract][Full Text]
Becker, R. C., Hochman, J. S., Cannon, C. P., Spencer, F. A., Ball, S. P., Rizzo, M. J., Antman, E. M., for the TIMI 9 Investigators,
(1999). Fatal cardiac rupture among patients treated with thrombolytic agents and adjunctive thrombin antagonists: Observations from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction 9 Study. J Am Coll Cardiol
33: 479-487
[Abstract][Full Text]
French, J. K., Amos, D. J., Williams, B. F., Cross, D. B., Elliott, J. M., Hart, H. H., Williams, M. G., Norris, R. M., Ashton, N. G., Whitlock, R. M. L., McLaughlin, S. C., White, H. D.
(1999). Effects of early captopril administration after thrombolysis on regional wall motion in relation to infarct artery blood flow. J Am Coll Cardiol
33: 139-145
[Abstract][Full Text]
Dodge, S. M., Beardslee, M. A., Darrow, B. J., Green, K. G., Beyer, E. C., Saffitz, J. E.
(1998). Effects of angiotensin II on expression of the gap junction channel protein connexin43 in neonatal rat ventricular myocytes. J Am Coll Cardiol
32: 800-807
[Abstract][Full Text]
Abraham, W. T.
(1998). Pharmacologic Management of Chronic Heart Failure: A Review. SEMIN CARDIOTHORAC VASC ANESTH
2: 168-190
[Abstract]
Katz, A. M.
(1998). Regression of Left Ventricular Hypertrophy : New Hope for Dying Hearts. Circulation
98: 623-624
[Full Text]
Barron, H. V., Michaels, A. D., Maynard, C., Every, N. R., for the National Registry of Myocardial Infarction,
(1998). Use of angiotensin-converting enzyme inhibitors at discharge in patients with acute myocardial infarction in the United States: data from the National Registry of Myocardial Infarction 2. J Am Coll Cardiol
32: 360-367
[Abstract][Full Text]
Goussev, A., Sharov, V. G., Shimoyama, H., Tanimura, M., Lesch, M., Goldstein, S., Sabbah, H. N.
(1998). Effects of ACE inhibition on cardiomyocyte apoptosis in dogs with heart failure. Am. J. Physiol. Heart Circ. Physiol.
275: H626-H631
[Abstract][Full Text]
Hu, K., Gaudron, P., Anders, H.-J., Weidemann, F., Turschner, O., Nahrendorf, M., Ertl, G.
(1998). Chronic effects of early started angiotensin converting enzyme inhibition and angiotensin AT1-receptor subtype blockade in rats with myocardial infarction: role of bradykinin. Cardiovasc Res
39: 401-412
[Abstract][Full Text]
Liu, Y., Leri, A., Li, B., Wang, X., Cheng, W., Kajstura, J., Anversa, P.
(1998). Angiotensin II Stimulation In Vitro Induces Hypertrophy of Normal and Postinfarcted Ventricular Myocytes. Circ. Res.
82: 1145-1159
[Abstract][Full Text]
Pfeffer, M. A.
(1998). ACE Inhibitors in Acute Myocardial Infarction : Patient Selection and Timing. Circulation
97: 2192-2194
[Full Text]
(1998). Indications for ACE Inhibitors in the Early Treatment of Acute Myocardial Infarction : Systematic Overview of Individual Data From 100 000 Patients in Randomized Trials. Circulation
97: 2202-2212
[Abstract][Full Text]
Mahmarian, J. J., Moye, L. A., Chinoy, D. A., Sequeira, R. F., Habib, G. B., Henry, W. J., Jain, A., Chaitman, B. R., Weng, C. S. W., Morales-Ballejo, H., Pratt, C. M.
(1998). Transdermal Nitroglycerin Patch Therapy Improves Left Ventricular Function and Prevents Remodeling After Acute Myocardial Infarction : Results of a Multicenter Prospective Randomized, Double-Blind, Placebo-Controlled Trial. Circulation
97: 2017-2024
[Abstract][Full Text]
Brown, N. J., Vaughan, D. E.
(1998). Angiotensin-Converting Enzyme Inhibitors. Circulation
97: 1411-1420
[Abstract][Full Text]
Garvey, C. W., Garvey III, T. Q., Siegel, D., Lopez, J.
(1998). Antihypertensive Therapy: Recommendations and Realities. JAMA
279: 746-747
[Full Text]
Anand, I. S., Liu, D., Chugh, S. S., Prahash, A. J.C., Gupta, S., John, R., Popescu, F., Chandrashekhar, Y.
(1997). Isolated Myocyte Contractile Function Is Normal in Postinfarct Remodeled Rat Heart With Systolic Dysfunction. Circulation
96: 3974-3984
[Abstract][Full Text]
Ferrari, R.
(1997). The new ischemic syndromes--an old phenomenon disguised with a new glossary?. Cardiovasc Res
36: 298-300
[Full Text]
Sutton, M. St. J., Pfeffer, M. A., Moye, L., Plappert, T., Rouleau, J. L., Lamas, G., Rouleau, J., Parker, J. O., Arnold, M. O., Sussex, B., Braunwald, E., Investigators, f. t. S.
(1997). Cardiovascular Death and Left Ventricular Remodeling Two Years After Myocardial Infarction : Baseline Predictors and Impact of Long-term Use of Captopril: Information From the Survival and Ventricular Enlargement (SAVE) Trial. Circulation
96: 3294-3299
[Abstract][Full Text]
Westaby, S., Jin, X. Y., Katsumata, T., Taggart, D. P., Coats, A. J. S., Frazier, O. H.
(1997). Mechanical Support in Dilated Cardiomyopathy: Signs of Early Left Ventricular Recovery. Ann. Thorac. Surg.
64: 1303-1308
[Abstract][Full Text]
Uusimaa, P., Risteli, J., Niemela, M., Lumme, J., Ikaheimo, M., Jounela, A., Peuhkurinen, K.
(1997). Collagen Scar Formation After Acute Myocardial Infarction : Relationships to Infarct Size, Left Ventricular Function, and Coronary Artery Patency. Circulation
96: 2565-2572
[Abstract][Full Text]
Pfeffer, M. A., Greaves, S. C., Arnold, J. M. O., Glynn, R. J., LaMotte, F. S., Lee, R. T., Menapace, F. J. Jr, Rapaport, E., Ridker, P. M., Rouleau, J.-L., Solomon, S. D., Hennekens, C. H.
(1997). Early Versus Delayed Angiotensin-Converting Enzyme Inhibition Therapy in Acute Myocardial Infarction : The Healing and Early Afterload Reducing Therapy Trial. Circulation
95: 2643-2651
[Abstract][Full Text]
Hein, L., Stevens, M. E., Barsh, G. S., Pratt, R. E., Kobilka, B. K., Dzau, V. J.
(1997). Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. Proc. Natl. Acad. Sci. USA
94: 6391-6396
[Abstract][Full Text]
Loh, E., Sutton, M. St. J., Wun, C.-C. C., Rouleau, J. L., Flaker, G. C., Gottlieb, S. S., Lamas, G. A., Moye, L. A., Goldhaber, S. Z., Pfeffer, M. A.
(1997). Ventricular Dysfunction and the Risk of Stroke after Myocardial Infarction. NEJM
336: 251-257
[Abstract][Full Text]
Nijland, F., Kamp, O., Verheugt, F. W.A., Veen, G., Visser, C. A.
(1997). Long-term Implications of Reocclusion on Left Ventricular Size and Function After Successful Thrombolysis for First Anterior Myocardial Infarction. Circulation
95: 111-117
[Abstract][Full Text]
Eichhorn, E. J., Bristow, M. R.
(1996). Medical Therapy Can Improve the Biological Properties of the Chronically Failing Heart: A New Era in the Treatment of Heart Failure. Circulation
94: 2285-2296
[Abstract][Full Text]
Hokimoto, S., Yasue, H., Fujimoto, K., Yamamoto, H., Nakao, K., Kaikita, K., Sakata, R., Miyamoto, E.
(1996). Expression of Angiotensin-Converting Enzyme in Remaining Viable Myocytes of Human Ventricles After Myocardial Infarction. Circulation
94: 1513-1518
[Abstract][Full Text]
Melillo, G., Lima, J. A.C., Judd, R. M., Goldschmidt-Clermont, P. J., Silverman, H. S.
(1996). Intrinsic Myocyte Dysfunction and Tyrosine Kinase Pathway Activation Underlie the Impaired Wall Thickening of Adjacent Regions During Postinfarct Left Ventricular Remodeling. Circulation
93: 1447-1458
[Abstract][Full Text]
Iwai, N., Inagami, T., Ohmichi, N., Kinoshita, M.
(1996). Renin Is Expressed in Rat Macrophage/Monocyte Cells. Hypertension
27: 399-403
[Abstract][Full Text]
Kajstura, J., Zhang, X., Liu, Y., Szoke, E., Cheng, W., Olivetti, G., Hintze, T. H., Anversa, P.
(1995). The Cellular Basis of Pacing-Induced Dilated Cardiomyopathy : Myocyte Cell Loss and Myocyte Cellular Reactive Hypertrophy. Circulation
92: 2306-2317
[Abstract][Full Text]
Lamas, G. A., Flaker, G. C., Mitchell, G., Smith, S. C. Jr, Gersh, B. J., Wun, C.-C., Moye, L., Rouleau, J. L., Rutherford, J. D., Pfeffer, M. A., Braunwald, E., Investigators, f. t. S. V. E.
(1995). Effect of Infarct Artery Patency on Prognosis After Acute Myocardial Infarction. Circulation
92: 1101-1109
[Abstract][Full Text]
Eaton, G. M., Cody, R. J., Nunziata, E., Binkley, P. F.
(1995). Early Left Ventricular Dysfunction Elicits Activation of Sympathetic Drive and Attenuation of Parasympathetic Tone in the Paced Canine Model of Congestive Heart Failure. Circulation
92: 555-561
[Abstract][Full Text]
Levin, H. R., Oz, M. C., Chen, J. M., Packer, M., Rose, E. A., Burkhoff, D.
(1995). Reversal of Chronic Ventricular Dilation in Patients With End-Stage Cardiomyopathy by Prolonged Mechanical Unloading. Circulation
91: 2717-2720
[Abstract][Full Text]
Cohn, J. N.
(1995). Structural Basis for Heart Failure : Ventricular Remodeling and Its Pharmacological Inhibition. Circulation
91: 2504-2507
[Full Text]
Greenberg, B., Quinones, M. A., Koilpillai, C., Limacher, M., Shindler, D., Benedict, C., Shelton, B.
(1995). Effects of Long-term Enalapril Therapy on Cardiac Structure and Function in Patients With Left Ventricular Dysfunction : Results of the SOLVD Echocardiography Substudy. Circulation
91: 2573-2581
[Abstract][Full Text]
McDonald, K. M., Mock, J., D'Aloia, A., Parrish, T., Hauer, K., Francis, G., Stillman, A., Cohn, J. N.
(1995). Bradykinin Antagonism Inhibits the Antigrowth Effect of Converting Enzyme Inhibition in the Dog Myocardium After Discrete Transmural Myocardial Necrosis. Circulation
91: 2043-2048
[Abstract][Full Text]
Previous
