Although 1 million institutionalized elderly persons have urinary incontinence, little is known about the causes of this problem. We conducted clinical and physiologic studies to determine the causes of established incontinence in a representative sample of 605 institutionalized elderly persons (mean age, 89 years), of whom 40 percent were chronically incontinent of urine. Detailed urodynamic studies in 94 of the 245 incontinent patients (77 women and 17 men; 38 percent) showed that detrusor overactivity was the predominant cause in 61 percent, with concomitant impaired detrusor contractility present in half these patients. Other causes among women were stress incontinence (21 percent), underactive detrusor (8 percent), and outlet obstruction (4 percent). Among the relatively few men in this sample, outlet obstruction accounted for 29 percent of the cases. In 35 percent of the patients, at least two coexisting probable causes of incontinence were identified. Diagnoses among patients with impaired mobility or mentation differed little from those in unimpaired patients. We conclude that the pathophysiology of incontinence in this population is complex; that detrusor hyperreflexia with normal contractility ("uninhibited bladder") accounts for the minority of cases (29 percent), even among patients with dementia; and that the causes of incontinence are as diverse in severely impaired elderly persons as in those who are unimpaired.
Source Information
Gerontology Division of the Joint Department of Medicine, Beth Israel and Brigham and Women's Hospitals, Boston, MA 02115.
This article has been cited by other articles:
Heppner, T. J., Werner, M. E., Nausch, B., Vial, C., Evans, R. J., Nelson, M. T.
(2009). Nerve-evoked purinergic signalling suppresses action potentials, Ca2+ flashes and contractility evoked by muscarinic receptor activation in mouse urinary bladder smooth muscle. J. Physiol.
587: 5275-5288
[Abstract][Full Text]
Kuchel, G. A., Moscufo, N., Guttmann, C. R., Zeevi, N., Wakefield, D., Schmidt, J., DuBeau, C. E., Wolfson, L.
(2009). Localization of Brain White Matter Hyperintensities and Urinary Incontinence in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci
64A: 902-909
[Abstract][Full Text]
Fink, H. A., Taylor, B. C., Tacklind, J. W., Rutks, I. R., Wilt, T. J.
(2008). Treatment Interventions in Nursing Home Residents With Urinary Incontinence: A Systematic Review of Randomized Trials. Mayo Clin Proc.
83: 1332-1343
[Abstract][Full Text]
Woodford, H., George, J.
(2007). NICE guidelines on urinary incontinence in women. Age Ageing
36: 349-350
[Full Text]
Taylor, J. A., Zhu, Q., Irwin, B., Maghaydah, Y., Tsimikas, J., Pilbeam, C., Leng, L., Bucala, R., Kuchel, G. A.
(2006). Null mutation in macrophage migration inhibitory factor prevents muscle cell loss and fibrosis in partial bladder outlet obstruction. Am. J. Physiol. Renal Physiol.
291: F1343-F1353
[Abstract][Full Text]
Lluel, P., Deplanne, V., Heudes, D., Bruneval, P., Palea, S.
(2003). Age-related changes in urethrovesical coordination in male rats: relationship with bladder instability?. Am. J. Physiol. Regul. Integr. Comp. Physiol.
284: R1287-R1295
[Abstract][Full Text]
Schnelle, J.F., Smith, R. L.
(2001). Quality Indicators for the Management of Urinary Incontinence in Vulnerable Community-Dwelling Elders. ANN INTERN MED
135: 752-758
[Full Text]
Lluel, P., Palea, S., Barras, M., Grandadam, F., Heudes, D., Bruneval, P., Corman, B., Martin, D. J.
(2000). Functional and morphological modifications of the urinary bladder in aging female rats. Am. J. Physiol. Regul. Integr. Comp. Physiol.
278: R964-R972
[Abstract][Full Text]
Fowler, C. J.
(1999). Neurological disorders of micturition and their treatment. Brain
122: 1213-1231
[Abstract][Full Text]
Kobashi, K. C., Leach, G. E.
(1999). Bladder Dysfunction in Multiple Sclerosis. Neurorehabil Neural Repair
13: 117-123
[Abstract]
DiMauro, S.
(1998). Commentary. Neurology
51: 1525-1525
[Full Text]
Zahn, C. A., Morrell, M. J., Collins, S. D., Labiner, D. M., Yerby, M. S.
(1998). Management issues for women with epilepsy: A review of the literature. Neurology
51: 949-956
[Abstract][Full Text]
(1998). Management of Parkinson's disease. Neurology
50: S2-S57
[Full Text]
Stayer, C., Tronnier, V., Dressnandt, J., Mauch, E., Marquardt, G., Rieke, K., Muller-Schwefe, G., Schumm, F., Meinck, H.-M.
(1997). Intrathecal baclofen therapy for stiff-man syndrome and progressive encephalomyelopathy with rigidity and myoclonus. Neurology
49: 1591-1597
[Abstract][Full Text]
Chinnery, P. F., Johnson, M. A., Taylor, R. W., Durward, W. F., Turnbull, D. M.
(1997). A novel mitochondrial tRNA isoleucine gene mutation causing chronic progressive external ophthalmoplegia. Neurology
49: 1166-1168
[Abstract][Full Text]
Abe, K., Matsuo, Y., Kadekawa, J., Inoue, S., Yanagihara, T.
(1997). Measurement of tissue oxygen consumption in patients with mitochondrial myopathy by noninvasive tissue oximetry. Neurology
49: 837-841
[Abstract][Full Text]
Barohn, R. J.
(1997). The therapeutic dilemma of inclusion body myositis. Neurology
48: 567-568
[Full Text]
Moore, K. N.
(1997). Commentary. Clin Nurs Res
6: 21-24
Harrison, L. H., Vaz, B., Taveira, D. M., Quinn, T. C., Gibbs, C. J., de Souza, S. H., McArthur, J. C., Schechter, M.
(1997). Myelopathy Among Brazilians Coinfected with Human T-cell Lymphotropic Virus Type I and HIV. Neurology
48: 13-18
[Abstract][Full Text]
(1997). A Prospective, Quantitative Study of the Natural History of Facioscapulohumeral Muscular Dystrophy (FSHD): Implications for Therapeutic Trials. Neurology
48: 38-46
[Abstract][Full Text]
Tawil, R., McDermott, M. P., Pandya, S., King, W., Kissel, J., Mendell, J. R., Griggs, R. C.
(1997). A Pilot Trial of Prednisone in Facioscapulohumeral Muscular Dystrophy. Neurology
48: 46-49
[Abstract][Full Text]
Resnick, N. M.
(1996). An 89-Year-Old Woman With Urinary Incontinence. JAMA
276: 1832-1840
[Abstract]
Govoni, S., Bergamaschi, S., Gasparini, L., Quaglia, C., Racchi, M., Cattaneo, E., Binetti, G., Bianchetti, A., Giovetti, F., Battaini, F., Trabucchi, M.
(1996). Fibroblasts of patients affected by Down's syndrome oversecrete amyloid precursor protein and are hyporesponsive to protein kinase C stimulation. Neurology
47: 1069-1075
[Abstract][Full Text]
Simpson, D. M., Alexander, D. N., O'Brien, C. F., Tagliati, M., Aswad, A. S., Leon, J. M., Gibson, J., Mordaunt, J. M., Monaghan, E. P.
(1996). Botulinum toxin type A in the treatment of upper extremity spasticity: A randomized, double-blind, placebo-controlled trial. Neurology
46: 1306-1306
[Abstract][Full Text]
Bohlega, S., Tanji, K., Santorelli, F. M., Hirano, M., al-Jishi, A., DiMauro, S.
(1996). Multiple mitochondria1 DNA deletions associated with autosomal recessive ophthalmoplegia and severe cardiomyopathy. Neurology
46: 1329-1329
[Abstract][Full Text]
Verma, A., Moraes, C. T., Shebert, R. T., Bradley, W. G.
(1996). A MERRF/PEO overlap syndrome associated with the mitochondria1 DNA 3243 mutation. Neurology
46: 1334-1334
[Abstract][Full Text]
Provenzale, J. M., VanLandingham, K.
(1996). Cerebral infarction associated with Kearns-Sayre syndrome-related cardiomyopathy. Neurology
46: 826-828
[Full Text]
Mackenzie, I. R.A., McLachlan, R. S., Kubu, C. S., Miller, L. A.
(1996). Prospective neuropsychological assessment of nondemented patients with biopsy proven senile plaques. Neurology
46: 425-429
[Abstract][Full Text]
Young, R. R.
(1995). Reply from the Supplement Editor: Tizanidine and spasticity. Neurology
45: 2296-2296
[Full Text]
Tinetti, M. E., Inouye, S. K., Gill, T. M., Doucette, J. T.
(1995). Shared Risk Factors for Falls, Incontinence, and Functional Dependence: Unifying the Approach to Geriatric Syndromes. JAMA
273: 1348-1353
[Abstract]
Ouslander, J. G., Schnelle, J. F., Uman, G., Fingold, S., Nigam, J. G., Tuico, E., Bates-Jensen, B.
(1995). Predictors of Successful Prompted Voiding Among Incontinent Nursing Home Residents. JAMA
273: 1366-1370
[Abstract]
Hadley, E. C.
(1995). The Science of the Art of Geriatric Medicine. JAMA
273: 1381-1383
[Abstract]
Pegoraro, E., Schimke, R. N., Garcia, C., Stern, H., Cadaldini, M., Angelini, C., Barbosa, E., Carroll, J., Marks, W. A., Neville, H. E., Marks, H., Appleton, S., Toriello, H., Wessel, H. B., Donnelly, J., Bernes, S. M., Taber, J. W., Weiss, L., Hoffman, E. P.
(1995). Genetic and biochemical normalization in female carriers of Duchenne muscular dystrophy: Evidence for failure of dystrophin production in dystrophin-competent myonuclei. Neurology
45: 677-690
[Abstract][Full Text]
Grazko, M. A., Polo, K. B., Jabbari, B.
(1995). Botulinum toxin A for spasticity, muscle spasms, and rigidity. Neurology
45: 712-717
[Abstract][Full Text]
Sharma, K. R., Kent- Braun, J. A., Majumdar, S., Huang, Y., Mynhier, M., Weiner, M. W., Miller, R. G.
(1995). Physiology of fatigue in amyotrophic lateral sclerosis. Neurology
45: 733-740
[Abstract][Full Text]
Manfredi, G., Servidei, S., Bonilla, E., Shanske, S., Schon, E. A., DiMauro, S., Moraes, C. T.
(1995). High levels of mitochondrial DNA with an unstable 260-bp duplication in a patient with a mitochondrial myopathy. Neurology
45: 762-768
[Abstract][Full Text]
Parker, W. D. Jr., Parks, J. K.
(1995). Cytochrome C Oxidase in Alzheimer's Disease Brain: Purification and Characterization. Neurology
45: 482-486
[Abstract][Full Text]
Rizzo, J. F. III, MD
(1995). Adenosine triphosphate deficiency: A genre of optic neuropathy. Neurology
45: 11-16
[Abstract][Full Text]
Greenspan, S. L., Myers, E. R., Maitland, L. A., Resnick, N. M., Hayes, W. C.
(1994). Fall Severity and Bone Mineral Density as Risk Factors for Hip Fracture in Ambulatory Elderly. JAMA
271: 128-133
[Abstract]
Rovner, B. W., German, P. S., Brant, L. J., Clark, R., Burton, L., Folstein, M. F.
(1991). Depression and Mortality. JAMA
265: 993-996
[Abstract]
Starer, P., Libow, L. S.
(1991). Importance of Complete Cytometric Evaluation of Vesical Dysfunction in Elderly Diabetic Patients-Reply. Arch Intern Med
151: 202-203
[Abstract]
Resnick, N. M.
(1989). Behavioral Therapy for Urinary Incontinence. JAMA
262: 2538-2538
[Abstract]
Ouslander, J. G.
(1989). Urinary Incontinence: Out of the Closet. JAMA
261: 2695-2696
[Abstract]
(1989). CAUSES OF URINARY INCONTINENCE IN THE ELDERLY. JWatch General
1989: 2-2
[Full Text]