Between January 12 and February 7, 1987, an outbreak of gastroenteritis affected an estimated 13,000 people in a county of 64,900 residents in western Georgia. Cryptosporidium oocysts were identified in the stools of 58 of 147 patients with gastroenteritis (39 percent) tested during the outbreak. Studies for bacterial, viral, and other parasitic pathogens failed to implicate any other agent. In a random telephone survey, 299 of 489 household members exposed to the public water supply (61 percent) reported gastrointestinal illness, as compared with 64 of 322 (20 percent) who were not exposed (relative risk, 3.1; 95 percent confidence interval, 2.4 to 3.9). The prevalence of IgG to cryptosporidium was significantly higher among exposed respondents to the survey who had become ill than among nonresident controls. Cryptosporidium oocysts were identified in samples of treated public water with use of a monoclonal-antibody test. Although the sand-filtered and chlorinated water system met all regulatory-agency quality standards, sub-optimal flocculation and filtration probably allowed the parasite to pass into the drinking-water supply. Low-level cryptosporidium infection in cattle in the watershed and a sewage overflow were considered as possible contributors to the contamination of the surface-water supply. We conclude that current standards for the treatment of public water supplies may not prevent the contamination of drinking water by cryptosporidium, with consequent outbreaks of cryptosporidiosis.
Source Information
Centers for Disease Control, Division of Parasitic Diseases, Atlanta, GA 30333.
This article has been cited by other articles:
Youn, S., Kabir, M., Haque, R., Petri, W. A. Jr.
(2009). Evaluation of a Screening Test for Detection of Giardia and Cryptosporidium Parasites. J. Clin. Microbiol.
47: 451-452
[Abstract][Full Text]
Searcy, K. E., Packman, A. I., Atwill, E. R., Harter, T.
(2006). Capture and Retention of Cryptosporidium parvum Oocysts by Pseudomonas aeruginosa Biofilms. Appl. Environ. Microbiol.
72: 6242-6247
[Abstract][Full Text]
Searcy, K. E., Packman, A. I., Atwill, E. R., Harter, T.
(2006). Deposition of cryptosporidium oocysts in streambeds.. Appl. Environ. Microbiol.
72: 1810-1816
[Abstract][Full Text]
ONG, C. S., LI, A. S., PRIEST, J. W., COPES, R., KHAN, M., FYFE, M. W., MARION, S. A., ROBERTS, J. M., LAMMIE, P. J., ISAAC-RENTON, J. L.
(2005). ENZYME IMMUNOASSAY OF CRYPTOSPORIDIUM-SPECIFIC IMMUNOGLOBULIN G ANTIBODIES TO ASSESS LONGITUDINAL INFECTION TRENDS IN SIX COMMUNITIES IN BRITISH COLUMBIA, CANADA. Am J Trop Med Hyg
73: 288-295
[Abstract][Full Text]
(2004). Nitrogen variations in the Little Tallapoosa River of west Georgia: The effect of seasonality, land usage, withdrawals, and point and nonpoint sources on water quality. Environmental Geosciences
11: 1-15
Darnault, C. J. G., Steenhuis, T. S., Garnier, P., Kim, Y.-J., Jenkins, M. B., Ghiorse, W. C., Baveye, P. C., Parlange, J.-Y.
(2004). Preferential Flow and Transport of Cryptosporidium parvum Oocysts through the Vadose Zone: Experiments and Modeling. Vadose Zone J
3: 262-270
[Abstract][Full Text]
Priest, J. W., Mehlert, A., Arrowood, M. J., Riggs, M. W., Ferguson, M. A. J.
(2003). Characterization of a Low Molecular Weight Glycolipid Antigen from Cryptosporidium parvum. J. Biol. Chem.
278: 52212-52222
[Abstract][Full Text]
Barwick, R. S., Mohammed, H. O., White, M. E., Bryant, R. B.
(2003). Factors Associated with the Likelihood of Giardia spp. and Cryptosporidium spp. in Soil from Dairy Farms. J DAIRY SCI
86: 784-791
[Abstract][Full Text]
Priest, J. W., Li, A., Khan, M., Arrowood, M. J., Lammie, P. J., Ong, C. S., Roberts, J. M., Isaac-Renton, J.
(2001). Enzyme Immunoassay Detection of Antigen-Specific Immunoglobulin G Antibodies in Longitudinal Serum Samples from Patients with Cryptosporidiosis. CVI
8: 415-423
[Abstract][Full Text]
Muller, T. B., Frost, F. J., Craun, G. F., Calderon, R. L., Chappell, C. L., Okhuysen, P. C., Dann, S. M.
(2001). Serological Responses to Cryptosporidium Infection. Infect. Immun.
69: 1974-1975
[Full Text]
Kozwich, D., Johansen, K. A., Landau, K., Roehl, C. A., Woronoff, S., Roehl, P. A.
(2000). Development of a Novel, Rapid Integrated Cryptosporidium parvum Detection Assay. Appl. Environ. Microbiol.
66: 2711-2717
[Abstract][Full Text]
Orlandi, P. A., Lampel, K. A.
(2000). Extraction-Free, Filter-Based Template Preparation for Rapid and Sensitive PCR Detection of Pathogenic Parasitic Protozoa. J. Clin. Microbiol.
38: 2271-2277
[Abstract][Full Text]
Atiga, W. L., Fananapazir, L., McAreavey, D., Calkins, H., Berger, R. D.
(2000). Temporal Repolarization Lability in Hypertrophic Cardiomyopathy Caused by {beta}-Myosin Heavy-Chain Gene Mutations. Circulation
101: 1237-1242
[Abstract][Full Text]
Neumann, N. F., Gyürek, L. L., Gammie, L., Finch, G. R., Belosevic, M.
(2000). Comparison of Animal Infectivity and Nucleic Acid Staining for Assessment of Cryptosporidium parvum Viability in Water. Appl. Environ. Microbiol.
66: 406-412
[Abstract][Full Text]
Schwartz, J., Levin, R., Goldstein, R.
(2000). Drinking water turbidity and gastrointestinal illness in the elderly of Philadelphia. J. Epidemiol. Community Health
54: 45-51
[Abstract][Full Text]
Priest, J. W., Kwon, J. P., Moss, D. M., Roberts, J. M., Arrowood, M. J., Dworkin, M. S., Juranek, D. D., Lammie, P. J.
(1999). Detection by Enzyme Immunoassay of Serum Immunoglobulin G Antibodies That Recognize Specific Cryptosporidium parvum Antigens. J. Clin. Microbiol.
37: 1385-1392
[Abstract][Full Text]
Doing, K. M., Hamm, J. L., Jellison, J. A., Marquis, J. A., Kingsbury, C.
(1999). False-Positive Results Obtained with the Alexon ProSpecT Cryptosporidium Enzyme Immunoassay. J. Clin. Microbiol.
37: 1582-1583
[Abstract][Full Text]
Cole, D. J., Snowden, K., Cohen, N. D., Smith, R.
(1999). Detection of Cryptosporidium parvum in Horses: Thresholds of Acid-Fast Stain, Immunofluorescence Assay, and Flow Cytometry. J. Clin. Microbiol.
37: 457-460
[Abstract][Full Text]
Seydel, K. B., Zhang, T., Champion, G. A., Fichtenbaum, C., Swanson, P. E., Tzipori, S., Griffiths, J. K., Stanley, S. L. Jr.
(1998). Cryptosporidium parvum Infection of Human Intestinal Xenografts in SCID Mice Induces Production of Human Tumor Necrosis Factor Alpha and Interleukin-8. Infect. Immun.
66: 2379-2382
[Abstract][Full Text]
Pereira, M. d. G. C., Atwill, E. R., Crawford, M. R., Lefebvre, R. B.
(1998). DNA Sequence Similarity between California Isolates of Cryptosporidium parvum. Appl. Environ. Microbiol.
64: 1584-1586
[Abstract][Full Text]
Robinson, J. K.
(1997). A 28-Year-Old Fair-Skinned Woman With Multiple Moles. JAMA
278: 1693-1699
[Abstract]
Vakil, N. B., Schwartz, S. M., Buggy, B. P., Brummitt, C. F., Kherellah, M., Letzer, D. M., Gilson, I. H., Jones, P. G.
(1996). Biliary Cryptosporidiosis in HIV-Infected People after the Waterborne Outbreak of Cryptosporidiosis in Milwaukee. NEJM
334: 19-23
[Abstract][Full Text]
DuPont, H. L., Chappell, C. L., Sterling, C. R., Okhuysen, P. C., Rose, J. B., Jakubowski, W.
(1995). The Infectivity of Cryptosporidium parvum in Healthy Volunteers. NEJM
332: 855-859
[Abstract][Full Text]
Millard, P. S., Gensheimer, K. F., Addiss, D. G., Sosin, D. M., Beckett, G. A., Houck-Jankoski, A., Hudson, A.
(1994). An Outbreak of Cryptosporidiosis From Fresh-Pressed Apple Cider. JAMA
272: 1592-1596
[Abstract]
McAnulty, J. M., Fleming, D. W., Gonzalez, A. H.
(1994). A Community-wide Outbreak of Cryptosporidiosis Associated With Swimming at a Wave Pool. JAMA
272: 1597-1600
[Abstract]
Mac Kenzie, W. R., Hoxie, N. J., Proctor, M. E., Gradus, M. S., Blair, K. A., Peterson, D. E., Kazmierczak, J. J., Addiss, D. G., Fox, K. R., Rose, J. B., Davis, J. P.
(1994). A Massive Outbreak in Milwaukee of Cryptosporidium Infection Transmitted through the Public Water Supply. NEJM
331: 161-167
[Abstract][Full Text]