Epstein-Barr virus (EBV) has been associated with serious or fatal lymphoproliferative disease in immunocompromised patients. EBV nuclear protein 2 and latent membrane protein are characteristically expressed in B lymphocytes proliferating in vitro in response to growth transformation by EBV. These two proteins are thought to be effectors of lymphocyte growth since they increase the expression of B-lymphocyte activation (CD23) and cell-adhesion (LFA 3 and ICAM 1) molecules in vitro. Using monoclonal antibody-immune microscopy, we have demonstrated that these two EBV proteins and their associated B-lymphocyte activation or adhesion molecules are expressed in the infiltrating B lymphocytes in immunocompromised patients with EBV lymphoproliferative disease. These monoclonal antibodies should be useful in the early diagnosis of EBV lymphoproliferative disease and in distinguishing it from other B-lymphocyte cancers associated with EBV, such as Burkitt's lymphoma. The finding of EBV nuclear protein 2 and latent membrane protein and their associated activation or adhesion molecules provides a further pathophysiologic link between EBV and the proliferation of B lymphocytes in immunocompromised patients.
Source Information
Department of Cancer Studies, University of Birmingham, United Kingdom.
This article has been cited by other articles:
Everly, D. N. Jr., Mainou, B. A., Raab-Traub, N.
(2009). Transcriptional Downregulation of p27KIP1 through Regulation of E2F Function during LMP1-Mediated Transformation. J. Virol.
83: 12671-12679
[Abstract][Full Text]
Ong, K. W., Teo, M., Lee, V., Ong, D., Lee, A., Tan, C. S., Vathsala, A., Toh, H. C.
(2009). Expression of EBV Latent Antigens, Mammalian Target of Rapamycin, and Tumor Suppression Genes in EBV-Positive Smooth Muscle Tumors: Clinical and Therapeutic Implications. Clin. Cancer Res.
15: 5350-5358
[Abstract][Full Text]
Knight, J. S., Tsodikov, A., Cibrik, D. M., Ross, C. W., Kaminski, M. S., Blayney, D. W.
(2009). Lymphoma After Solid Organ Transplantation: Risk, Response to Therapy, and Survival at a Transplantation Center. JCO
27: 3354-3362
[Abstract][Full Text]
Edwards, R. H., Marquitz, A. R., Raab-Traub, N.
(2008). Epstein-Barr Virus BART MicroRNAs Are Produced from a Large Intron prior to Splicing. J. Virol.
82: 9094-9106
[Abstract][Full Text]
Kung, C.-P., Raab-Traub, N.
(2008). Epstein-Barr Virus Latent Membrane Protein 1 Induces Expression of the Epidermal Growth Factor Receptor through Effects on Bcl-3 and STAT3. J. Virol.
82: 5486-5493
[Abstract][Full Text]
Bhaduri-McIntosh, S., Rotenberg, M. J., Gardner, B., Robert, M., Miller, G.
(2008). Repertoire and frequency of immune cells reactive to Epstein-Barr virus-derived autologous lymphoblastoid cell lines. Blood
111: 1334-1343
[Abstract][Full Text]
Mainou, B. A., Everly, D. N. Jr., Raab-Traub, N.
(2007). Unique Signaling Properties of CTAR1 in LMP1-Mediated Transformation. J. Virol.
81: 9680-9692
[Abstract][Full Text]
Xing, L., Kieff, E.
(2007). Epstein-Barr Virus BHRF1 Micro- and Stable RNAs during Latency III and after Induction of Replication. J. Virol.
81: 9967-9975
[Abstract][Full Text]
Day, L., Chau, C. M., Nebozhyn, M., Rennekamp, A. J., Showe, M., Lieberman, P. M.
(2007). Chromatin Profiling of Epstein-Barr Virus Latency Control Region. J. Virol.
81: 6389-6401
[Abstract][Full Text]
Lin, J.-H., Tsai, C.-H., Chu, J.-S., Chen, J.-Y., Takada, K., Shew, J.-Y.
(2007). Dysregulation of HER2/HER3 Signaling Axis in Epstein-Barr Virus-Infected Breast Carcinoma Cells. J. Virol.
81: 5705-5713
[Abstract][Full Text]
Shore, A. M., White, P. C., Hui, R. C.-Y., Essafi, A., Lam, E. W.-F., Rowe, M., Brennan, P.
(2006). Epstein-Barr Virus Represses the FoxO1 Transcription Factor through Latent Membrane Protein 1 and Latent Membrane Protein 2A. J. Virol.
80: 11191-11199
[Abstract][Full Text]
Jimenez-Ramirez, C., Brooks, A. J., Forshell, L. P., Yakimchuk, K., Zhao, B., Fulgham, T. Z., Sample, C. E.
(2006). Epstein-Barr Virus EBNA-3C Is Targeted to and Regulates Expression from the Bidirectional LMP-1/2B Promoter. J. Virol.
80: 11200-11208
[Abstract][Full Text]
Hutchings, I. A., Tierney, R. J., Kelly, G. L., Stylianou, J., Rickinson, A. B., Bell, A. I.
(2006). Methylation Status of theEpstein-Barr Virus (EBV) BamHI W Latent Cycle Promoter and Promoter Activity: Analysis with Novel EBV-Positive Burkitt and Lymphoblastoid Cell Lines. J. Virol.
80: 10700-10711
[Abstract][Full Text]
Bell, A. I., Groves, K., Kelly, G. L., Croom-Carter, D., Hui, E., Chan, A. T. C., Rickinson, A. B.
(2006). Analysis of Epstein-Barr virus latent gene expression in endemic Burkitt's lymphoma and nasopharyngeal carcinoma tumour cells by using quantitative real-time PCR assays.. J. Gen. Virol.
87: 2885-2890
[Abstract][Full Text]
Mainou, B. A., Raab-Traub, N.
(2006). LMP1 Strain Variants: Biological and Molecular Properties.. J. Virol.
80: 6458-6468
[Abstract][Full Text]
Chau, C. M., Zhang, X.-Y., McMahon, S. B., Lieberman, P. M.
(2006). Regulation of Epstein-Barr Virus Latency Type by the Chromatin Boundary Factor CTCF.. J. Virol.
80: 5723-5732
[Abstract][Full Text]
Schaft, N., Lankiewicz, B., Drexhage, J., Berrevoets, C., Moss, D. J., Levitsky, V., Bonneville, M., Lee, S. P., McMichael, A. J., Gratama, J.-W., Bolhuis, R. L. H., Willemsen, R., Debets, R.
(2006). T cell re-targeting to EBV antigens following TCR gene transfer: CD28-containing receptors mediate enhanced antigen-specific IFN{gamma} production. Int Immunol
18: 591-601
[Abstract][Full Text]
Yuan, J., Cahir-McFarland, E., Zhao, B., Kieff, E.
(2006). Virus and Cell RNAs Expressed during Epstein-Barr Virus Replication. J. Virol.
80: 2548-2565
[Abstract][Full Text]
Chaganti, S., Bell, A. I., Pastor, N. B., Milner, A. E., Drayson, M., Gordon, J., Rickinson, A. B.
(2005). Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes. Blood
106: 4249-4252
[Abstract][Full Text]
Shannon-Lowe, C., Baldwin, G., Feederle, R., Bell, A., Rickinson, A., Delecluse, H.-J.
(2005). Epstein-Barr virus-induced B-cell transformation: quantitating events from virus binding to cell outgrowth. J. Gen. Virol.
86: 3009-3019
[Abstract][Full Text]
Kelly, G. L., Milner, A. E., Tierney, R. J., Croom-Carter, D. S. G., Altmann, M., Hammerschmidt, W., Bell, A. I., Rickinson, A. B.
(2005). Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) Gene Deletion Is Consistently Linked with EBNA3A, -3B, and -3C Expression in Burkitt's Lymphoma Cells and with Increased Resistance to Apoptosis. J. Virol.
79: 10709-10717
[Abstract][Full Text]
Fukuda, M., Longnecker, R.
(2005). Epstein-Barr Virus (EBV) Latent Membrane Protein 2A Regulates B-Cell Receptor-Induced Apoptosis and EBV Reactivation through Tyrosine Phosphorylation. J. Virol.
79: 8655-8660
[Abstract][Full Text]
Thornburg, N. J., Kusano, S., Raab-Traub, N.
(2004). Identification of Epstein-Barr Virus RK-BARF0-Interacting Proteins and Characterization of Expression Pattern. J. Virol.
78: 12848-12856
[Abstract][Full Text]
Chang, Y., Lee, H.-H., Chang, S.-S., Hsu, T.-Y., Wang, P.-W., Chang, Y.-S., Takada, K., Tsai, C.-H.
(2004). Induction of Epstein-Barr Virus Latent Membrane Protein 1 by a Lytic Transactivator Rta. J. Virol.
78: 13028-13036
[Abstract][Full Text]
Kwiatkowski, B., Chen, S. Y. J., Schubach, W. H.
(2004). CKII Site in Epstein-Barr Virus Nuclear Protein 2 Controls Binding to hSNF5/Ini1 and Is Important for Growth Transformation. J. Virol.
78: 6067-6072
[Abstract][Full Text]
Katano, H., Pesnicak, L., Cohen, J. I.
(2004). Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. Proc. Natl. Acad. Sci. USA
101: 4960-4965
[Abstract][Full Text]
Yue, W., Davenport, M. G., Shackelford, J., Pagano, J. S.
(2004). Mitosis-Specific Hyperphosphorylation of Epstein-Barr Virus Nuclear Antigen 2 Suppresses Its Function. J. Virol.
78: 3542-3552
[Abstract][Full Text]
Knight, J. S., Robertson, E. S.
(2004). Epstein-Barr Virus Nuclear Antigen 3C Regulates Cyclin A/p27 Complexes and Enhances Cyclin A-Dependent Kinase Activity. J. Virol.
78: 1981-1991
[Abstract][Full Text]
Peng, C.-W., Xue, Y., Zhao, B., Johannsen, E., Kieff, E., Harada, S.
(2004). Direct interactions between Epstein-Barr virus leader protein LP and the EBNA2 acidic domain underlie coordinate transcriptional regulation. Proc. Natl. Acad. Sci. USA
101: 1033-1038
[Abstract][Full Text]
Edwards, R. H., Sitki-Green, D., Moore, D. T., Raab-Traub, N.
(2004). Potential Selection of LMP1 Variants in Nasopharyngeal Carcinoma. J. Virol.
78: 868-881
[Abstract][Full Text]
Atkinson, P. G. P., Coope, H. J., Rowe, M., Ley, S. C.
(2003). Latent Membrane Protein 1 of Epstein-Barr Virus Stimulates Processing of NF-{kappa}B2 p100 to p52. J. Biol. Chem.
278: 51134-51142
[Abstract][Full Text]
Thornburg, N. J., Pathmanathan, R., Raab-Traub, N.
(2003). Activation of Nuclear Factor-{kappa}B p50 Homodimer/Bcl-3 Complexes in Nasopharyngeal Carcinoma. Cancer Res.
63: 8293-8301
[Abstract][Full Text]
Sisk, E. A., Bradford, C. R., Carey, T. E., Paulino, A., Robertson, E.
(2003). Epstein-Barr Virus Detected in a Head and Neck Squamous Cell Carcinoma Cell Line Derived From an Immunocompromised Patient. Arch Otolaryngol Head Neck Surg
129: 1115-1124
[Abstract][Full Text]
Nepomuceno, R. R., Balatoni, C. E., Natkunam, Y., Snow, A. L., Krams, S. M., Martinez, O. M.
(2003). Rapamycin Inhibits the Interleukin 10 Signal Transduction Pathway and the Growth of Epstein Barr Virus B-cell Lymphomas. Cancer Res.
63: 4472-4480
[Abstract][Full Text]
Knight, J. S., Lan, K., Subramanian, C., Robertson, E. S.
(2003). Epstein-Barr Virus Nuclear Antigen 3C Recruits Histone Deacetylase Activity and Associates with the Corepressors mSin3A and NCoR in Human B-Cell Lines. J. Virol.
77: 4261-4272
[Abstract][Full Text]
Porcu, P., Eisenbeis, C. F., Pelletier, R. P., Davies, E. A., Baiocchi, R. A., Roychowdhury, S., Vourganti, S., Nuovo, G. J., Marsh, W. L., Ferketich, A. K., Henry, M. L., Ferguson, R. M., Caligiuri, M. A.
(2002). Successful treatment of posttransplantation lymphoproliferative disorder (PTLD) following renal allografting is associated with sustained CD8+ T-cell restoration. Blood
100: 2341-2348
[Abstract][Full Text]
Otieno, M. W., Banura, C., Katongole-Mbidde, E., Johnson, J. L., Ghannoum, M., Dowlati, A., Renne, R., Arts, E., Whalen, C., Lederman, M. M., Remick, S. C.
(2002). Therapeutic Challenges of AIDS-Related Non-Hodgkin's Lymphoma in the United States and East Africa. JNCI J Natl Cancer Inst
94: 718-732
[Abstract][Full Text]
Lin, J., Johannsen, E., Robertson, E., Kieff, E.
(2002). Epstein-Barr Virus Nuclear Antigen 3C Putative Repression Domain Mediates Coactivation of the LMP1 Promoter with EBNA-2. J. Virol.
76: 232-242
[Abstract][Full Text]
Wingard, J. R., Vogelsang, G. B., Deeg, H. J.
(2002). Stem Cell Transplantation: Supportive Care and Long-Term Complications. ASH Education Book
2002: 422-444
[Abstract][Full Text]
Harris, R. S., Croom-Carter, D. S. G., Rickinson, A. B., Neuberger, M. S.
(2001). Epstein-Barr Virus and the Somatic Hypermutation of Immunoglobulin Genes in Burkitt's Lymphoma Cells. J. Virol.
75: 10488-10492
[Abstract][Full Text]
Fielding, C. A., Sandvej, K., Mehl, A., Brennan, P., Jones, M., Rowe, M.
(2001). Epstein-Barr Virus LMP-1 Natural Sequence Variants Differ in Their Potential To Activate Cellular Signaling Pathways. J. Virol.
75: 9129-9141
[Abstract][Full Text]
Groves, A. K., Cotter, M. A., Subramanian, C., Robertson, E. S.
(2001). The Latency-Associated Nuclear Antigen Encoded by Kaposi's Sarcoma-Associated Herpesvirus Activates Two Major Essential Epstein-Barr Virus Latent Promoters. J. Virol.
75: 9446-9457
[Abstract][Full Text]
Ikeda, M., Ikeda, A., Longnecker, R.
(2001). PY Motifs of Epstein-Barr Virus LMP2A Regulate Protein Stability and Phosphorylation of LMP2A-Associated Proteins. J. Virol.
75: 5711-5718
[Abstract][Full Text]
Brink, A A T P, Meijer, C J L M, Nicholls, J M, Middeldorp, J M, van den Brule, A J C
(2001). Activity of the EBNA1 promoter associated with lytic replication (Fp) in Epstein-Barr virus associated disorders. Mol. Pathol.
54: 98-102
[Abstract][Full Text]
Kusano, S., Raab-Traub, N.
(2001). An Epstein-Barr Virus Protein Interacts with Notch. J. Virol.
75: 384-395
[Abstract][Full Text]
Yang, J., Tao, Q., Flinn, I. W., Murray, P. G., Post, L. E., Ma, H., Piantadosi, S., Caligiuri, M. A., Ambinder, R. F.
(2000). Characterization of Epstein-Barr virus-infected B cells in patients with posttransplantation lymphoproliferative disease: disappearance after rituximab therapy does not predict clinical response. Blood
96: 4055-4063
[Abstract][Full Text]
Joseph, A. M., Babcock, G. J., Thorley-Lawson, D. A.
(2000). Cells Expressing the Epstein-Barr Virus Growth Program Are Present in and Restricted to the Naive B-Cell Subset of Healthy Tonsils. J. Virol.
74: 9964-9971
[Abstract][Full Text]
Krithivas, A., Young, D. B., Liao, G., Greene, D., Hayward, S. D.
(2000). Human Herpesvirus 8 LANA Interacts with Proteins of the mSin3 Corepressor Complex and Negatively Regulates Epstein-Barr Virus Gene Expression in Dually Infected PEL Cells. J. Virol.
74: 9637-9645
[Abstract][Full Text]
Merchant, M., Caldwell, R. G., Longnecker, R.
(2000). The LMP2A ITAM Is Essential for Providing B Cells with Development and Survival Signals In Vivo. J. Virol.
74: 9115-9124
[Abstract][Full Text]
Young, L S, Dawson, C W, Eliopoulos, A G
(2000). The expression and function of Epstein-Barr virus encoded latent genes. Mol. Pathol.
53: 238-247
[Abstract][Full Text]
Herr, W., Ranieri, E., Olson, W., Zarour, H., Gesualdo, L., Storkus, W. J.
(2000). Mature dendritic cells pulsed with freeze-thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4+ and CD8+ T lymphocyte responses. Blood
96: 1857-1864
[Abstract][Full Text]
Quaia, M., Zancai, P., Cariati, R., Rizzo, S., Boiocchi, M., Dolcetti, R.
(2000). Glucocorticoids promote the proliferation and antagonize the retinoic acid-mediated growth suppression of Epstein-Barr virus-immortalized B lymphocytes. Blood
96: 711-718
[Abstract][Full Text]
Lee, S. P., Chan, A. T. C., Cheung, S.-T., Thomas, W. A., CroomCarter, D., Dawson, C. W., Tsai, C.-H., Leung, S.-F., Johnson, P. J., Huang, D. P.
(2000). CTL Control of EBV in Nasopharyngeal Carcinoma (NPC): EBV-Specific CTL Responses in the Blood and Tumors of NPC Patients and the Antigen-Processing Function of the Tumor Cells. J. Immunol.
165: 573-582
[Abstract][Full Text]
Vineis, P., Crosignani, P., Sacerdote, C., Fontana, A., Masala, G., Miligi, L., Nanni, O., Ramazzotti, V., Rodella, S., Stagnaro, E., Tumino, R., Vigano, C., Vindigni, C., Costantini, A. S.
(2000). Haematopoietic cancer and medical history: a multicentre case control study. J. Epidemiol. Community Health
54: 431-436
[Abstract][Full Text]
Peacock, J. W., Bost, K. L.
(2000). Infection of intestinal epithelial cells and development of systemic disease following gastric instillation of murine gammaherpesvirus-68. J. Gen. Virol.
81: 421-429
[Abstract][Full Text]
Zhang, L., Pagano, J. S.
(2000). Interferon Regulatory Factor 7 Is Induced by Epstein-Barr Virus Latent Membrane Protein 1. J. Virol.
74: 1061-1068
[Abstract][Full Text]
Yang, J., Lemas, V. M., Flinn, I. W., Krone, C., Ambinder, R. F.
(2000). Application of the ELISPOT assay to the characterization of CD8+ responses to Epstein-Barr virus antigens. Blood
95: 241-248
[Abstract][Full Text]
Ranieri, E., Herr, W., Gambotto, A., Olson, W., Rowe, D., Robbins, P. D., Kierstead, L. S., Watkins, S. C., Gesualdo, L., Storkus, W. J.
(1999). Dendritic Cells Transduced with an Adenovirus Vector Encoding Epstein-Barr Virus Latent Membrane Protein 2B: a New Modality for Vaccination. J. Virol.
73: 10416-10425
[Abstract][Full Text]
Cho, Y.-G., Gordadze, A. V., Ling, P. D., Wang, F.
(1999). Evolution of Two Types of Rhesus Lymphocryptovirus Similar to Type 1 and Type 2 Epstein-Barr Virus. J. Virol.
73: 9206-9212
[Abstract][Full Text]
Chang, Y., Tung, C.-H., Huang, Y.-T., Lu, J., Chen, J.-Y., Tsai, C.-H.
(1999). Requirement for Cell-to-Cell Contact in Epstein-Barr Virus Infection of Nasopharyngeal Carcinoma Cells and Keratinocytes. J. Virol.
73: 8857-8866
[Abstract][Full Text]
Menet, A., Speth, C., Larcher, C., Prodinger, W. M., Schwendinger, M. G., Chan, P., Jäger, M., Schwarzmann, F., Recheis, H., Fontaine, M., Dierich, M. P.
(1999). Epstein-Barr Virus Infection of Human Astrocyte Cell Lines. J. Virol.
73: 7722-7733
[Abstract][Full Text]
Tao, Q., Swinnen, L. J., Yang, J., Srivastava, G., Robertson, K. D., Ambinder, R. F.
(1999). Methylation Status of the Epstein-Barr Virus Major Latent Promoter C in Iatrogenic B Cell Lymphoproliferative Disease : Application of PCR-Based Analysis. Am. J. Pathol.
155: 619-625
[Abstract][Full Text]
Takeshita, H., Yoshizaki, T., Miller, W. E., Sato, H., Furukawa, M., Pagano, J. S., Raab-Traub, N.
(1999). Matrix Metalloproteinase 9 Expression Is Induced by Epstein-Barr Virus Latent Membrane Protein 1 C-Terminal Activation Regions 1 and 2. J. Virol.
73: 5548-5555
[Abstract][Full Text]
Fujiwara, S., Nitadori, Y., Nakamura, H., Nagaishi, T., Ono, Y.
(1999). Epstein-Barr Virus (EBV) Nuclear Protein 2-Induced Disruption of EBV Latency in the Burkitt's Lymphoma Cell Line Akata: Analysis by Tetracycline-Regulated Expression. J. Virol.
73: 5214-5219
[Abstract][Full Text]
Holmgren, L., Szeles, A., Rajnavolgyi, E., Folkman, J., Klein, G., Ernberg, I., Falk, K. I.
(1999). Horizontal Transfer of DNA by the Uptake of Apoptotic Bodies. Blood
93: 3956-3963
[Abstract][Full Text]
Knisely, B. L., Mastey, L. A., Collins, J., Kuhlman, J. E., Leung, A. N.
(1999). Imaging of Cardiac Transplantation Complications. RadioGraphics
19: 321-341
[Abstract][Full Text]
Nishikawa, J., Imai, S., Oda, T., Kojima, T., Okita, K., Takada, K.
(1999). Epstein-Barr Virus Promotes Epithelial Cell Growth in the Absence of EBNA2 and LMP1 Expression. J. Virol.
73: 1286-1292
[Abstract][Full Text]
Hunt, S. A.
(1998). Current Status of Cardiac Transplantation. JAMA
280: 1692-1698
[Abstract][Full Text]
Murray, P. G., Constandinou, C. M., Crocker, J., Young, L. S., Ambinder, R. F.
(1998). Analysis of Major Histocompatibility Complex Class I, TAP Expression, and LMP2 Epitope Sequence in Epstein-Barr Virus-Positive Hodgkin's Disease. Blood
92: 2477-2483
[Abstract][Full Text]
Yao, Q. Y., Croom-Carter, D. S. G., Tierney, R. J., Habeshaw, G., Wilde, J. T., Hill, F. G. H., Conlon, C., Rickinson, A. B.
(1998). Epidemiology of Infection with Epstein-Barr Virus Types 1 and 2: Lessons from the Study of a T-Cell-Immunocompromised Hemophilic Cohort. J. Virol.
72: 4352-4363
[Abstract][Full Text]
Imai, S., Nishikawa, J., Takada, K.
(1998). Cell-to-Cell Contact as an Efficient Mode of Epstein-Barr Virus Infection of Diverse Human Epithelial Cells. J. Virol.
72: 4371-4378
[Abstract][Full Text]
Miller, W. E., Cheshire, J. L., Raab-Traub, N.
(1998). Interaction of Tumor Necrosis Factor Receptor-Associated Factor Signaling Proteins with the Latent Membrane Protein 1 PXQXT Motif Is Essential for Induction of Epidermal Growth Factor Receptor Expression. Mol. Cell. Biol.
18: 2835-2844
[Abstract][Full Text]
Moghaddam, A., Koch, J., Annis, B., Wang, F.
(1998). Infection of Human B Lymphocytes with Lymphocryptoviruses Related to Epstein-Barr Virus. J. Virol.
72: 3205-3212
[Abstract][Full Text]
Yoshizaki, T., Sato, H., Furukawa, M., Pagano, J. S.
(1998). The expression of matrix metalloproteinase 9 is enhanced by Epstein-Barr virus latent membrane protein 1. Proc. Natl. Acad. Sci. USA
95: 3621-3626
[Abstract][Full Text]
Deeg, H. J., Socie, G.
(1998). Malignancies After Hematopoietic Stem Cell Transplantation: Many Questions, Some Answers. Blood
91: 1833-1844
[Full Text]
Cohen, J. I.
(1997). Epstein-Barr Virus and the Immune System: Hide and Seek. JAMA
278: 510-513
[Abstract]
Horenstein, M. G., Nador, R. G., Chadburn, A., Hyjek, E. M., Inghirami, G., Knowles, D. M., Cesarman, E.
(1997). Epstein-Barr Virus Latent Gene Expression in Primary Effusion Lymphomas Containing Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus-8. Blood
90: 1186-1191
[Abstract][Full Text]
Moghaddam, A., Rosenzweig, M., Lee-Parritz, D., Annis, B., Johnson, R. P., Wang, F.
(1997). An Animal Model for Acute and Persistent Epstein-Barr Virus Infection. Science
276: 2030-2033
[Abstract][Full Text]
Nishigaki, H., Ito, C., Manabe, A., Kumagai, M.-a., Coustan-Smith, E., Yanishevski, Y., Behm, F. G., Raimondi, S. C., Pui, C.-H., Campana, D.
(1997). Prevalence and Growth Characteristics of Malignant Stem Cells in B-Lineage Acute Lymphoblastic Leukemia. Blood
89: 3735-3744
[Abstract][Full Text]
Delecluse, H.J., Anagnostopoulos, I., Dallenbach, F., Hummel, M., Marafioti, T., Schneider, U., Huhn, D., Schmidt-Westhausen, A., Reichart, P.A., Gross, U., Stein, H.
(1997). Plasmablastic Lymphomas of the Oral Cavity: A New Entity Associated With the Human Immunodeficiency Virus Infection. Blood
89: 1413-1420
[Abstract][Full Text]
Pathmanathan, R., Prasad, U., Sadler, R., Flynn, K., Raab-Traub, N.
(1995). Clonal Proliferations of Cells Infected with Epstein-Barr Virus in Preinvasive Lesions Related to Nasopharyngeal Carcinoma. NEJM
333: 693-698
[Abstract][Full Text]
Lee, E. S., Locker, J., Nalesnik, M., Reyes, J., Jaffe, R., Alashari, M., Nour, B., Tzakis, A., Dickman, P. S.
(1995). The Association of Epstein-Barr Virus with Smooth-Muscle Tumors Occurring after Organ Transplantation. NEJM
332: 19-25
[Abstract][Full Text]
Ritter, J. H., Wick, M. R.
(1994). Posttransplant Lymphoproliferative Disorders: Immunohistologic Differential Diagnosis With Severe Allograft Rejection. INT J SURG PATHOL
2: 105-115
[Abstract]
Huang, A., Golumbek, P, Ahmadzadeh, M, Jaffee, E, Pardoll, D, Levitsky, H
(1994). Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science
264: 961-965
[Abstract]
Cunningham, M. J., Eavey, R. D.
(1992). The Tan Tonsil Sign: A Clinical Marker of Lymphoproliferative Disease. CLIN PEDIATR
31: 237-240
Aviel, S., Winberg, G., Massucci, M., Ciechanover, A.
(2000). Degradation of the Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) by the Ubiquitin-Proteasome Pathway. TARGETING VIA UBIQUITINATION OF THE N-TERMINAL RESIDUE. J. Biol. Chem.
275: 23491-23499
[Abstract][Full Text]
Babcock, G. J., Thorley-Lawson, D. A.
(2000). Tonsillar memory B cells, latently infected with Epstein-Barr virus, express the restricted pattern of latent genes previously found only in Epstein-Barr virus-associated tumors. Proc. Natl. Acad. Sci. USA
97: 12250-12255
[Abstract][Full Text]
Previous
