It has been suggested that platelet hyperreactivity in patients with diabetes mellitus is associated with increased platelet production of thromboxane. We therefore compared the excretion of a thromboxane metabolite and platelet function in 50 patients with Type II diabetes mellitus who had normal renal function and clinical evidence of macrovascular disease and in 32 healthy controls. The mean (+/- SD) excretion rate of urinary 11-dehydro-thromboxane B2 was significantly higher in the patients than in the controls (5.94 +/- 3.68 vs. 1.50 +/- 0.79 nmol per day; P less than 0.001), irrespective of the type of macrovascular complication. Tight metabolic control achieved with insulin therapy reduced the levels of 11-dehydro-thromboxane B2 by approximately 50 percent. The fractional conversion of exogenous thromboxane B2 (infused at a rate of 4.5, 45.3, or 226.4 fmol per kilogram of body weight per second) to urinary 11-dehydro-thromboxane B2 was assessed in four patients, in whom it averaged 5.4 +/- 0.1 percent; this value did not differ from that measured in healthy subjects. Aspirin in low doses (50 mg per day for seven days) reduced urinary excretion of the metabolite by approximately 80 percent in four patients. The fact that thromboxane biosynthesis recovered over the following 10 days was consistent with a platelet origin of the urinary metabolite.(ABSTRACT TRUNCATED AT 250 WORDS)
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Department of Medicine, University of Chieti, Rome, Italy.
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[Abstract][Full Text]
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[Abstract][Full Text]
Nowak, S. N, Jaber, L. A
(2003). Aspirin Dose for Prevention of Cardiovascular Disease in Diabetics. The Annals of Pharmacotherapy
37: 116-121
[Abstract][Full Text]
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[Abstract][Full Text]
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40: 410-417
[Abstract][Full Text]
Lazar, H. L.
(2002). The Insulin Cardioplegia Trial. J. Thorac. Cardiovasc. Surg.
123: 842-844
[Full Text]
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[Abstract][Full Text]
Eldor, A., Rachmilewitz, E. A.
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99: 36-43
[Abstract][Full Text]
Sabatine, M. S., Braunwald, E.
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104: 2759-2761
[Full Text]
Capes, S. E., Hunt, D., Malmberg, K., Pathak, P., Gerstein, H. C.
(2001). Stress Hyperglycemia and Prognosis of Stroke in Nondiabetic and Diabetic Patients: A Systematic Overview. Stroke
32: 2426-2432
[Abstract][Full Text]
Abizaid, A., Costa, M. A., Centemero, M., Abizaid, A. S., Legrand, V. M.G., Limet, R. V., Schuler, G., Mohr, F. W., Lindeboom, W., Sousa, A. G.M.R., Sousa, J. E., van Hout, B., Hugenholtz, P. G., Unger, F., Serruys, P. W.
(2001). Clinical and Economic Impact of Diabetes Mellitus on Percutaneous and Surgical Treatment of Multivessel Coronary Disease Patients: Insights From the Arterial Revascularization Therapy Study (ARTS) Trial. Circulation
104: 533-538
[Abstract][Full Text]
Nitenberg, A., Ledoux, S., Valensi, P., Sachs, R., Attali, J.-R., Antony, I.
(2001). Impairment of Coronary Microvascular Dilation in Response to Cold Pressor-Induced Sympathetic Stimulation in Type 2 Diabetic Patients With Abnormal Stress Thallium Imaging. Diabetes
50: 1180-1185
[Abstract][Full Text]
Sobel, B. E.
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103: 1185-1187
[Full Text]
Rolka, D. B., Fagot-Campagna, A., Narayan, K.M. V.
(2001). Aspirin Use Among Adults With Diabetes: Estimates from the Third National Health and Nutrition Examination Survey. Diabetes Care
24: 197-201
[Abstract][Full Text]
McGuire, D.K, Emanuelsson, H, Granger, C.B, Magnus Ohman, E, Moliterno, D.J, White, H.D, Ardissino, D, Box, J.W, Califf, R.M, Topol, E.J
(2000). Influence of diabetes mellitus on clinical outcomes across the spectrum of acute coronary syndromes. Findings from the GUSTO-IIb Study. Eur Heart J
21: 1750-1758
[Abstract]
CIABATTONI, G., DAVI, G., COLLURA, M., IAPICHINO, L., PARDO, F., GANCI, A., ROMAGNOLI, R., MACLOUF, J., PATRONO, C.
(2000). In Vivo Lipid Peroxidation and Platelet Activation in Cystic Fibrosis. Am. J. Respir. Crit. Care Med.
162: 1195-1201
[Abstract][Full Text]
Mezzetti, A., Cipollone, F., Cuccurullo, F.
(2000). Oxidative stress and cardiovascular complications in diabetes: isoprostanes as new markers on an old paradigm. Cardiovasc Res
47: 475-488
[Abstract][Full Text]
Hammoud, T., Tanguay, J.-F., Bourassa, M. G.
(2000). Management of coronary artery disease: therapeutic options in patients with diabetes. J Am Coll Cardiol
36: 355-365
[Abstract][Full Text]
Lazar, H. L., Chipkin, S., Philippides, G., Bao, Y., Apstein, C.
(2000). Glucose-insulin-potassium solutions improve outcomes in diabetics who have coronary artery operations. Ann. Thorac. Surg.
70: 145-150
[Abstract][Full Text]
Kajubi, S. K.
(2000). Aspirin in the Treatment of Type 2 Diabetes. Arch Intern Med
160: 394-394
[Full Text]
Abizaid, A. S., Mintz, G. S., Abizaid, A., Mehran, R., Lansky, A. J., Pichard, A. D., Satler, L. F., Wu, H., Kent, K. M., Leon, M. B.
(1999). One-year follow-up after intravascular ultrasound assessment of moderate left main coronary artery disease in patients with ambiguous angiograms. J Am Coll Cardiol
34: 707-715
[Abstract][Full Text]
Abizaid, A. S., Mintz, G. S., Mehran, R., Abizaid, A., Lansky, A. J., Pichard, A. D., Satler, L. F., Wu, H., Pappas, C., Kent, K. M., Leon, M. B.
(1999). Long-Term Follow-Up After Percutaneous Transluminal Coronary Angioplasty Was Not Performed Based on Intravascular Ultrasound Findings : Importance of Lumen Dimensions. Circulation
100: 256-261
[Abstract][Full Text]
Kaseta, J. R., Skafar, D. F., Ram, J. L., Jacober, S. J., Sowers, J. R.
(1999). Cardiovascular Disease in the Diabetic Woman. J. Clin. Endocrinol. Metab.
84: 1835-1838
[Abstract][Full Text]
van Kooten, F., Ciabattoni, G., Koudstaal, P. J., Dippel, D. W. J., Patrono, C.
(1999). Increased Platelet Activation in the Chronic Phase After Cerebral Ischemia and Intracerebral Hemorrhage. Stroke
30: 546-549
[Abstract][Full Text]
Davi, G., Ciabattoni, G., Consoli, A., Mezzetti, A., Falco, A., Santarone, S., Pennese, E., Vitacolonna, E., Bucciarelli, T., Costantini, F., Capani, F., Patrono, C.
(1999). In Vivo Formation of 8-Iso-Prostaglandin F2{alpha} and Platelet Activation in Diabetes Mellitus : Effects of Improved Metabolic Control and Vitamin E Supplementation. Circulation
99: 224-229
[Abstract][Full Text]
Elezi, S., Kastrati, A., Pache, J.u., Wehinger, A., Hadamitzky, M., Dirschinger, J., Neumann, F.-J., Schomig, A.
(1998). Diabetes mellitus and the clinical and angiographic outcome after coronary stent placement. J Am Coll Cardiol
32: 1866-1873
[Abstract][Full Text]
Kleiman, N. S., Lincoff, A. M., Kereiakes, D. J., Miller, D. P., Aguirre, F. V., Anderson, K. M., Weisman, H. F., Califf, R. M., Topol, E. J.
(1998). Diabetes Mellitus, Glycoprotein IIb/IIIa Blockade, and Heparin : Evidence for a Complex Interaction in a Multicenter Trial. Circulation
97: 1912-1920
[Abstract][Full Text]
Sowers, J. R.
(1998). Diabetes Mellitus and Cardiovascular Disease in Women. Arch Intern Med
158: 617-621
[Abstract][Full Text]
Davi, G., Romano, M., Mezzetti, A., Procopio, A., Iacobelli, S., Antidormi, T., Bucciarelli, T., Alessandrini, P., Cuccurullo, F., Bon, G. B.
(1998). Increased Levels of Soluble P-Selectin in Hypercholesterolemic Patients. Circulation
97: 953-957
[Abstract][Full Text]
Gaster, B., Hirsch, I. B.
(1998). The Effects of Improved Glycemic Control on Complications in Type 2 Diabetes. Arch Intern Med
158: 134-140
[Abstract][Full Text]
KOONER, J. S
(1997). Coronary heart disease in UK Indian Asians: the potential for reducing mortality. Heart
78: 530-532
[Full Text]
Van Belle, E., Bauters, C., Hubert, E., Bodart, J.-C., Abolmaali, K., Meurice, T., McFadden, E. P., Lablanche, J.-M., Bertrand, M. E.
(1997). Restenosis Rates in Diabetic Patients : A Comparison of Coronary Stenting and Balloon Angioplasty in Native Coronary Vessels. Circulation
96: 1454-1460
[Abstract][Full Text]
Cipollone, F., Patrignani, P., Greco, A., Panara, M. R., Padovano, R., Cuccurullo, F., Patrono, C., Rebuzzi, A. G., Liuzzo, G., Quaranta, G., Maseri, A.
(1997). Differential Suppression of Thromboxane Biosynthesis by Indobufen and Aspirin in Patients With Unstable Angina. Circulation
96: 1109-1116
[Abstract][Full Text]
Fath-Ordoubadi, F., Beatt, K. J.
(1997). Glucose-Insulin-Potassium Therapy for Treatment of Acute Myocardial Infarction : An Overview of Randomized Placebo-Controlled Trials. Circulation
96: 1152-1156
[Abstract][Full Text]
Davi, G., Gresele, P., Violi, F., Basili, S., Catalano, M., Giammarresi, C., Volpato, R., Nenci, G. G., Ciabattoni, G., Patrono, C.
(1997). Diabetes Mellitus, Hypercholesterolemia, and Hypertension but Not Vascular Disease Per Se Are Associated With Persistent Platelet Activation In Vivo : Evidence Derived From the Study of Peripheral Arterial Disease. Circulation
96: 69-75
[Abstract][Full Text]
Goldberg, S., Savage, M. P., Fischman, D. L.
(1996). The Interventional Cardiologist and the Diabetic Patient: Have We Pushed the Envelope Too Far or Not Far Enough?. Circulation
94: 1804-1806
[Full Text]
Silva, J. A., Escobar, A., Collins, T. J., Ramee, S. R., White, C. J.
(1995). Unstable Angina : A Comparison of Angioscopic Findings Between Diabetic and Nondiabetic Patients. Circulation
92: 1731-1736
[Abstract][Full Text]
Aranki, S. F., Rizzo, R. J., Adams, D. H., Couper, G. S., Kinchla, N. M., Collins, J. J. Jr., Cohn, L. H.
(1995). Internal Thoracic Artery Flow in Diabetic Patients. VASC ENDOVASCULAR SURG
29: 83-89
[Abstract]
Stein, B., Weintraub, W. S., Gebhart, S. S.P., Cohen-Bernstein, C. L., Grosswald, R., Liberman, H. A., Douglas, J. S. Jr, Morris, D. C., King, S. B. III
(1995). Influence of Diabetes Mellitus on Early and Late Outcome After Percutaneous Transluminal Coronary Angioplasty. Circulation
91: 979-989
[Abstract][Full Text]
Patrono, C.
(1994). Aspirin as an Antiplatelet Drug. NEJM
330: 1287-1294
[Full Text]
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