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Previous Volume 323:1308-1312 November 8, 1990 Number 19 Next

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Abstract

BACKGROUND. The p24 antigen of human immunodeficiency virus type 1 (HIV-1) is sometimes detected before antibody (anti-HIV-1) is detectable in the serum of recently infected persons. This has led to the consideration of p24-antigen testing for routine screening of blood donors. METHODS. To estimate how many HIV-infected seronegative donors would be identified if p24-antigen screening was introduced, we tested selected donations from a repository of 200,000 serum samples from voluntary donors that was established in late 1984 and early 1985. The 8597 serum samples selected for p24-antigen screening were chosen because their donors had demographic characteristics known to be associated with a high prevalence of seropositivity. RESULTS. The prevalence of anti-HIV-1 antibodies in the 1984-1985 serum samples selected for p24-antigen screening was 1.54 percent--more than 100 times the 0.012 percent prevalence in present-day donations in the United States. The antigen was detected in 15 of 132 serum samples (11.4 percent) from donors who had already been confirmed as seropositive. No instance of confirmed positivity for p24 antigen was found among the 8465 seronegative serum samples. CONCLUSIONS. These data indicate that the yield of screening for p24 antigen in volunteer donors to identify HIV-1 carriers would be negligible. We therefore recommend against routine screening with currently available p24-antigen assays.

Source Information

Irwin Memorial Blood Center, San Francisco, CA.

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• Sloand, E. M., Pitt, E., Chiarello, R. J., Nemo, G. J. (1991). HIV Testing: State of the Art. JAMA 266: 2861-2866 [Abstract]  
• (1990). DETECTION OF HIV p24 ANTIGEN IS OF LITTLE USE IN BLOOD-DONOR SCREENING. JWatch General 1990: 6-6 [Full Text]