BACKGROUND AND METHODS. The cause of childhood hyperactivity (attention deficit-hyperactivity disorder) is unknown. We investigated the hypothesis that cerebral glucose metabolism might differ between normal adults (controls) and adults with histories of hyperactivity in childhood who continued to have symptoms. Each patient was also the biologic parent of a hyperactive child. None of the adults had ever been treated with stimulant medication. To measure cerebral glucose metabolism, we administered 148 to 185 MBq (4 to 5 mCi) of [18F]fluoro-2-deoxy-D-glucose intravenously to 50 normal adults and 25 hyperactive adults while they performed an auditory-attention task. Images were obtained for 30 minutes with a Scanditronix positron-emission tomograph with a resolution of 5 to 6 mm. Whole-brain and regional rates of glucose metabolism were measured with computer assistance by two trained research assistants, working independently, who were blinded to the subjects' status (control or hyperactive). RESULTS. Global cerebral glucose metabolism was 8.1 percent lower in the adults with hyperactivity than in the normal controls (mean +/- SD, 9.05 +/- 1.20 mg per minute per 100 g vs. 9.85 +/- 1.68 mg per minute per 100 g; P = 0.034). In the adults with hyperactivity, glucose metabolism was significantly reduced, as compared with the values for the controls, in 30 of 60 specific regions of the brain (P less than 0.05). Among the regions of the brain with the greatest reductions in glucose metabolism were the premotor cortex and the superior prefrontal cortex. When the seven women with hyperactivity or the six patients with learning disabilities were omitted from the analysis, the results were similar. CONCLUSIONS. Glucose metabolism, both global and regional, was reduced in adults who had been hyperactive since childhood. The largest reductions were in the premotor cortex and the superior prefrontal cortex--areas earlier shown to be involved in the control of attention and motor activity.
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Section on Clinical Brain Imaging, National Institute of Mental Health, NIH, Bethesda, MD 20892.
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[Abstract]
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[Abstract][Full Text]
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[Abstract][Full Text]
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8: 839-857
[Abstract]
Milberger, S., Faraone, S. V., Biederman, J., Chu, M. P., Wilens, T.
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[Abstract][Full Text]
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280: 1086-1092
[Full Text]
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[Abstract]
Ernst, M., Zametkin, A. J., Matochik, J. A., Jons, P. H., Cohen, R. M.
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[Abstract][Full Text]
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(1998). Growth Deficits in Children With Attention Deficit Hyperactivity Disorder. Pediatrics
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[Abstract][Full Text]
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[Abstract][Full Text]
Wolraich, M. L., Baumgaertel, A.
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36: 497-504
[Abstract]
Mataro, M., Garcia-Sanchez, C., Junque, C., Estevez-Gonzalez, A., Pujol, J.
(1997). Magnetic Resonance Imaging Measurement of the Caudate Nucleus in Adolescents With Attention-Deficit Hyperactivity Disorder and Its Relationship With Neuropsychological and Behavioral Measures. Arch Neurol
54: 963-968
[Abstract]
Castellanos, F. X.
(1997). Toward a Pathophysiology of Attention-Deficit/Hyperactivint Disorder. CLIN PEDIATR
36: 381-393
[Abstract]
Glod, C. A.
(1997). Attention Deficit Hyperactivity Disorder Throughout the Lifespan: Diagnosis, Etiology, and Treatment. J Am Psychiatr Nurses Assoc
3: 89-92
Conners, C.K.
(1997). Is ADHD a disease?. J Atten Disord
2: 3-17
Miller, D.C., Kavcic, V., Leslie, J.E.
(1996). ERP changes induced by methylphenidate in boys with Attention Deficit Hyperactivity Disorder. J Atten Disord
1: 95-113
[Abstract]
Castellanos, F. X., Giedd, J. N., Marsh, W. L., Hamburger, S. D., Vaituzis, A. C., Dickstein, D. P., Sarfatti, S. E., Vauss, Y. C., Snell, J. W., Lange, N., Kaysen, D., Krain, A. L., Ritchie, G. F., Rajapakse, J. C., Rapoport, J. L.
(1996). Quantitative Brain Magnetic Resonance Imaging in Attention-Deficit Hyperactivity Disorder. Arch Gen Psychiatry
53: 607-616
[Abstract]
Zametkin, A. J.
(1995). Attention-Deficit Disorder: Born to Be Hyperactive?. JAMA
273: 1871-1874
[Abstract]
Spencer, T., Wilens, T., Biederman, J., Faraone, S. V., Ablon, J. S., Lapey, K.
(1995). A Double-blind, Crossover Comparison of Methylphenidate and Placebo in Adults With Childhood-Onset Attention-Deficit Hyperactivity Disorder. Arch Gen Psychiatry
52: 434-443
[Abstract]
Rappley, M. D., Gardiner, J. C., Jetton, J. R., Houang, R. T.
(1995). The Use of Methylphenidate in Michigan. Arch Pediatr Adolesc Med
149: 675-679
[Abstract]
Malone, M. A., Kershner, J. R., Swanson, J. M.
(1994). Hemispheric Processing and Methylphenidate Effects in Attention-Deficit Hyperactivity Disorder. J Child Neurol
9: 181-189
[Abstract]
Safer, D. J., Krager, J. M.
(1993). Treatment of Attention-Deficit Hyperactivity Disorder-Reply. JAMA
269: 2369-2369
[Abstract]
Zametkin, A. J., Liebenauer, L. L., Fitzgerald, G. A., King, A. C., Minkunas, D. V., Herscovitch, P., Yamada, E. M., Cohen, R. M.
(1993). Brain Metabolism in Teenagers With Attention-Deficit Hyperactivity Disorder. Arch Gen Psychiatry
50: 333-340
[Abstract]
Ciaranello, R. D.
(1993). Attention Deficit-Hyperactivity Disorder and Resistance to Thyroid Hormone -- A New Idea?. NEJM
328: 1038-1039
[Full Text]
Malone, M. A., Swanson, J. M.
(1993). Effects of Methylphenidate on Impulsive Responding in Children With Attention-Deficit Hyperactivity Disorder. J Child Neurol
8: 157-163
[Abstract]
Weinberg, W. A., Brumback, R. A.
(1992). The Myth of Attention Deficit- Hyperactivity Disorder: Symptoms Resulting from Multiple Causes. J Child Neurol
7: 431-445
Bigler, E. D.
(1992). The Neurobiology and Neuropsychology of Adult Learning Disorders. J Learn Disabil
25: 488-506
[Abstract]
Biederman, J., Faraone, S. V., Keenan, K., Benjamin, J., Krifcher, B., Moore, C., Sprich-Buckminster, S., Ugaglia, K., Jellinek, M. S., Steingard, R., Spencer, T., Norman, D., Kolodny, R., Kraus, I., Perrin, J., Keller, M. B., Tsuang, M. T.
(1992). Further Evidence for Family-Genetic Risk Factors in Attention Deficit Hyperactivity Disorder: Patterns of Comorbidity in Probands and Relatives in Psychiatrically and Pediatrically Referred Samples. Arch Gen Psychiatry
49: 728-738
[Abstract]
Elliott, F. A.
(1992). Violence: The Neurologic Contribution: An Overview. Arch Neurol
49: 595-603
[Abstract]
Blackman, J. A., Westervelt, V. D., Stevenson, R., Welch, A.
(1991). Management of Preschool Children with Attention Deficit-Hyperactivity Disorder. Topics in Early Childhood Special Education
11: 91-104
[Abstract]
Voeller, K. K.S.
(1991). Toward a Neurobiologic Nosology of Attention Deficit Hyperactivity Disorder. J Child Neurol
6: S2-S8
Denckla, M. B.
(1991). Attention Deficit Hyperactivity Disorder- Residual Type. J Child Neurol
6: S44-S50
[Abstract]
(1990). EVIDENCE THAT HYPERACTIVITY HAS AN ORGANIC BASIS. JWatch General
1990: 3-3
[Full Text]
