BACKGROUND. The rates of colon cancer in various countries are strongly correlated with the per capita consumption of red meat and animal fat and, to a lesser degree, inversely associated with the consumption of fiber. METHODS. We conducted a prospective study among 88,751 women 34 to 59 years old and without a history of cancer, inflammatory bowel disease, or familial polyposis who completed a dietary questionnaire in 1980. By 1986, during 512,488 person-years of follow-up, 150 incident cases of colon cancer had been documented. RESULTS. After adjustment for total energy intake, animal fat was positively associated with the risk of colon cancer (P for trend = 0.01); the relative risk for the highest as compared with the lowest quintile was 1.89 (95 percent confidence interval, 1.13 to 3.15). No association was found for vegetable fat. The relative risk of colon cancer in women who ate beef, pork, or lamb as a main dish every day was 2.49 (95 percent confidence interval, 1.24 to 5.03), as compared with those reporting consumption less than once a month. Processed meats and liver were also significantly associated with increased risk, whereas fish and chicken without skin were related to decreased risk. The ratio of the intake of red meat to the intake of chicken and fish was particularly strongly associated with an increased incidence of colon cancer (P for trend = 0.0005); the relative risk for women in the highest quintile of this ratio as compared with those in the lowest quintile was 2.49 (95 percent confidence interval, 1.50 to 4.13). A low intake of fiber from fruits appeared to contribute to the risk of colon cancer, but this relation was not statistically independent of meat intake. CONCLUSIONS. These prospective data provide evidence for the hypothesis that a high intake of animal fat increases the risk of colon cancer, and they support existing recommendations to substitute fish and chicken for meats high in fat.
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Channing Laboratory, Department of Medicine, Harvard Medical School, Boston.
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
Lupton, J. R.
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134: 479-482
[Abstract][Full Text]
Bailey, L. B.
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[Abstract][Full Text]
Fan, Y.-Y., Spencer, T. E., Wang, N., Moyer, M. P., Chapkin, R. S.
(2003). Chemopreventive n-3 fatty acids activate RXR{alpha} in colonocytes. Carcinogenesis
24: 1541-1548
[Abstract][Full Text]
Flood, A., Velie, E. M., Sinha, R., Chaterjee, N., Lacey, J. V. Jr., Schairer, C., Schatzkin, A.
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158: 59-68
[Abstract][Full Text]
Khare, S., Cerda, S., Wali, R. K., von Lintig, F. C., Tretiakova, M., Joseph, L., Stoiber, D., Cohen, G., Nimmagadda, K., Hart, J., Sitrin, M. D., Boss, G. R., Bissonnette, M.
(2003). Ursodeoxycholic Acid Inhibits Ras Mutations, Wild-type Ras Activation, and Cyclooxygenase-2 Expression in Colon Cancer. Cancer Res.
63: 3517-3523
[Abstract][Full Text]
VAN DER MEER-VAN KRAAIJ, C., VAN LIESHOUT, E. M. M., KRAMER, E., VAN DER MEER, R., KEIJER, J.
(2003). Mucosal pentraxin (Mptx), a novel rat gene 10-fold down-regulated in colon by dietary heme. FASEB J.
17: 1277-1285
[Abstract][Full Text]
Michaud, D. S., Giovannucci, E., Willett, W. C., Colditz, G. A., Fuchs, C. S.
(2003). Dietary Meat, Dairy Products, Fat, and Cholesterol and Pancreatic Cancer Risk in a Prospective Study. Am J Epidemiol
157: 1115-1125
[Abstract][Full Text]
Lawlor, D. A, Ness, A. R
(2003). Commentary: The rough world of nutritional epidemiology: Does dietary fibre prevent large bowel cancer?. Int J Epidemiol
32: 239-243
[Full Text]
Chiu, B. C-H., Ji, B.-T., Dai, Q., Gridley, G., McLaughlin, J. K., Gao, Y.-T., Fraumeni, J. F. Jr., Chow, W.-H.
(2003). Dietary Factors and Risk of Colon Cancer in Shanghai, China. Cancer Epidemiol. Biomarkers Prev.
12: 201-208
[Abstract][Full Text]
Lee, J. Y., Plakidas, A., Lee, W. H., Heikkinen, A., Chanmugam, P., Bray, G., Hwang, D. H.
(2003). Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J. Lipid Res.
44: 479-486
[Abstract][Full Text]
Butler, L. M., Sinha, R., Millikan, R. C., Martin, C. F., Newman, B., Gammon, M. D., Ammerman, A. S., Sandler, R. S.
(2003). Heterocyclic Amines, Meat Intake, and Association with Colon Cancer in a Population-based Study. Am J Epidemiol
157: 434-445
[Abstract][Full Text]
Fung, T., Hu, F. B., Fuchs, C., Giovannucci, E., Hunter, D. J., Stampfer, M. J., Colditz, G. A., Willett, W. C.
(2003). Major Dietary Patterns and the Risk of Colorectal Cancer in Women. Arch Intern Med
163: 309-314
[Abstract][Full Text]
Chung, H., Wu, D., Han, S. N., Gay, R., Goldin, B., Bronson, R. E., Mason, J. B., Smith, D. E., Meydani, S. N.
(2003). Vitamin E Supplementation Does Not Alter Azoxymethane-Induced Colonic Aberrant Crypt Foci Formation in Young or Old Mice. J. Nutr.
133: 528-532
[Abstract][Full Text]
Boyle, P., Leon, M. E.
(2002). Epidemiology of colorectal cancer. Br Med Bull
64: 1-25
[Abstract][Full Text]
McCullough, M. L, Feskanich, D., Stampfer, M. J, Giovannucci, E. L, Rimm, E. B, Hu, F. B, Spiegelman, D., Hunter, D. J, Colditz, G. A, Willett, W. C
(2002). Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am. J. Clin. Nutr.
76: 1261-1271
[Abstract][Full Text]
de Jong, M. M., Nolte, I. M., te Meerman, G. J., van der Graaf, W. T. A., de Vries, E. G. E., Sijmons, R. H., Hofstra, R. M. W., Kleibeuker, J. H.
(2002). Low-penetrance Genes and Their Involvement in Colorectal Cancer Susceptibility. Cancer Epidemiol. Biomarkers Prev.
11: 1332-1352
[Abstract][Full Text]
Bingham, S. A., Hughes, R., Cross, A. J.
(2002). Effect of White Versus Red Meat on Endogenous N-Nitrosation in the Human Colon and Further Evidence of a Dose Response. J. Nutr.
132: 3522S-3525
[Abstract][Full Text]
Summerhayes, M.
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Peters, U., McGlynn, K. A., Chatterjee, N., Gunter, E., Garcia-Closas, M., Rothman, N., Sinha, R.
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10: 1267-1274
[Abstract][Full Text]
Yuan, J.-M., Ross, R. K., Gao, Y.-T., Yu, M. C.
(2001). Fish and Shellfish Consumption in Relation to Death from Myocardial Infarction among Men in Shanghai, China. Am J Epidemiol
154: 809-816
[Abstract][Full Text]
Sesink, A. L. A., Termont, D. S. M. L., Kleibeuker, J. H., Van der Meer, R.
(2001). Red meat and colon cancer: dietary haem-induced colonic cytotoxicity and epithelial hyperproliferation are inhibited by calcium. Carcinogenesis
22: 1653-1659
[Abstract][Full Text]
Sandhu, M. S., White, I. R., McPherson, K.
(2001). Systematic Review of the Prospective Cohort Studies on Meat Consumption and Colorectal Cancer Risk: A Meta-Analytical Approach. Cancer Epidemiol. Biomarkers Prev.
10: 439-446
[Abstract][Full Text]
Kono, S.
(2001). All epidemiological evidence is important in colorectal cancer. BMJ
322: 611-611
[Full Text]
Boudreau, M. D., Sohn, K. H., Rhee, S. H., Lee, S. W., Hunt, J. D., Hwang, D. H.
(2001). Suppression of Tumor Cell Growth Both in Nude Mice and in Culture by n-3 Polyunsaturated Fatty Acids: Mediation through Cyclooxygenase-independent Pathways. Cancer Res.
61: 1386-1391
[Abstract][Full Text]
Tung, B. Y., Emond, M. J., Haggitt, R. C., Bronner, M. P., Kimmey, M. B., Kowdley, K. V., Brentnall, T. A.
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134: 89-95
[Abstract][Full Text]
Willett, W. C.
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10: 3-8
[Abstract][Full Text]
Le Leu, R. K., Young, G. P., McIntosh, G. H.
(2000). Folate deficiency reduces the development of colorectal cancer in rats. Carcinogenesis
21: 2261-2265
[Abstract][Full Text]
Kulldorff, M., Sinha, R., Chow, W.-H., Rothman, N.
(2000). Comparing odds ratios for nested subsets of dietary components. Int J Epidemiol
29: 1060-1064
[Abstract][Full Text]
Voorrips, L. E., Goldbohm, R. A., van Poppel, G., Sturmans, F., Hermus, R. J. J., van den Brandt, P. A.
(2000). Vegetable and Fruit Consumption and Risks of Colon and Rectal Cancer in a Prospective Cohort Study The Netherlands Cohort Study on Diet and Cancer. Am J Epidemiol
152: 1081-1092
[Abstract][Full Text]
McCullough, M. L, Feskanich, D., Rimm, E. B, Giovannucci, E. L, Ascherio, A., Variyam, J. N, Spiegelman, D., Stampfer, M. J, Willett, W. C
(2000). Adherence to the Dietary Guidelines for Americans and risk of major chronic disease in men. Am. J. Clin. Nutr.
72: 1223-1231
[Abstract][Full Text]
Law, M.
(2000). Dietary fat and adult diseases and the implications for childhood nutrition: an epidemiologic approach. Am. J. Clin. Nutr.
72
: 1291S-1296S
[Abstract][Full Text]
Petrik, M. B. H., McEntee, M. F., Johnson, B. T., Obukowicz, M. G., Whelan, J.
(2000). Highly Unsaturated (n-3) Fatty Acids, but Not {alpha}-Linolenic, Conjugated Linoleic or {gamma}-Linolenic Acids, Reduce Tumorigenesis in ApcMin/+ Mice. J. Nutr.
130: 2434-2443
[Abstract][Full Text]
Willett, W. C.
(2000). Diet and Cancer. The Oncologist
5: 393-404
[Abstract][Full Text]
Janne, P. A., Mayer, R. J.
(2000). Chemoprevention of Colorectal Cancer. NEJM
342: 1960-1968
[Full Text]
McKean-Cowdin, R., Feigelson, H. S., Ross, R. K., Pike, M. C., Henderson, B. E.
(2000). Declining Cancer Rates in the 1990s. JCO
18: 2258-2268
[Abstract][Full Text]
Jacobs, D. R. Jr, Pereira, M. A., Meyer, K. A., Kushi, L. H.
(2000). Fiber from Whole Grains, but not Refined Grains, Is Inversely Associated with All-Cause Mortality in Older Women: The Iowa Women's Health Study. J. Am. Coll. Nutr.
19: 326S-330
[Abstract][Full Text]
Gazelle, G. S., McMahon, P. M., Scholz, F. J.
(2000). Screening for Colorectal Cancer. Radiology
215: 327-335
[Abstract][Full Text]
Sugimura, T.
(2000). Nutrition and dietary carcinogens. Carcinogenesis
21: 387-395
[Abstract][Full Text]
Bartoli, R, Fernandez-Banares, F, Navarro, E, Castella, E, Mane, J, Alvarez, M, Pastor, C, Cabre, E, Gassull, M A
(2000). Effect of olive oil on early and late events of colon carcinogenesis in rats: modulation of arachidonic acid metabolism and local prostaglandin E2 synthesis. Gut
46: 191-199
[Abstract][Full Text]
Sesink, A. L. A., Termont, D. S. M. L., Kleibeuker, J. H., Van der Meer, R.
(1999). Red Meat and Colon Cancer: The Cytotoxic and Hyperproliferative Effects of Dietary Heme. Cancer Res.
59: 5704-5709
[Abstract][Full Text]
Voskuil, D. W., Augustsson, K., Dickman, P. W., van’t Veer, P., Steineck, G.
(1999). Assessing the Human Intake of Heterocyclic Amines: Limited Loss of Information Using Reduced Sets of Questions. Cancer Epidemiol. Biomarkers Prev.
8: 809-814
[Abstract][Full Text]
Kushi, L. H, Meyer, K. A, Jacobs, D. R Jr
(1999). Cereals, legumes, and chronic disease risk reduction: evidence from epidemiologic studies. Am. J. Clin. Nutr.
70: 451S-458
[Abstract][Full Text]
Hart, A. R
(1999). Classic diseases revisited: Pancreatic cancer: any prospects for prevention?. Postgrad. Med. J.
75: 521-526
[Abstract][Full Text]
Tanaka, T., Kawabata, K., Kakumoto, M., Makita, H., Ushida, J., Honjo, S., Hara, A., Tsuda, H., Mori, H.
(1999). Modifying effects of a flavonoid morin on azoxymethane-induced large bowel tumorigenesis in rats. Carcinogenesis
20: 1477-1484
[Abstract][Full Text]
Gonder, U., Truswell, A S., Barber, M. D, Gurr, M I, Cummings, J. H, Bingham, S. A
(1999). Diet and the prevention of cancer. BMJ
319: 186a-186
[Full Text]
Schoen, R. E., Tangen, C. M., Kuller, L. H., Burke, G. L., Cushman, M., Tracy, R. P., Dobs, A., Savage, P. J.
(1999). Increased Blood Glucose and Insulin, Body Size, and Incident Colorectal Cancer. JNCI J Natl Cancer Inst
91: 1147-1154
[Abstract][Full Text]
Fernandez, E., Chatenoud, L., La Vecchia, C., Negri, E., Franceschi, S.
(1999). Fish consumption and cancer risk. Am. J. Clin. Nutr.
70: 85-90
[Abstract][Full Text]
Sheth, T., Nair, C., Nargundkar, M., Anand, S., Yusuf, S.
(1999). Cardiovascular and cancer mortality among Canadians of European, south Asian and Chinese origin from 1979 to 1993: an analysis of 1.2 million deaths. CMAJ
161: 132-138
[Abstract][Full Text]
Davidson, L. A., Lupton, J. R., Jiang, Y.-H., Chapkin, R. S.
(1999). Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics. Carcinogenesis
20: 785-791
[Abstract][Full Text]
Schut, H. A.J., Snyderwine, E. G.
(1999). DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis. Carcinogenesis
20: 353-368
[Abstract][Full Text]
Lund, E. K, Wharf, S G., Fairweather-Tait, S. J, Johnson, I. T
(1999). Oral ferrous sulfate supplements increase the free radical–generating capacity of feces from healthy volunteers. Am. J. Clin. Nutr.
69: 250-255
[Abstract][Full Text]
Kawamori, T., Lubet, R., Steele, V. E., Kelloff, G. J., Kaskey, R. B., Rao, C. V.
(1999). Chemopreventive Effect of Curcumin, a Naturally Occurring Anti-Inflammatory Agent, during the Promotion/Progression Stages of Colon Cancer. Cancer Res.
59: 597-601
[Abstract][Full Text]
Chen, J., Giovannucci, E. L., Hunter, D. J.
(1999). MTHFR Polymorphism, Methyl-Replete Diets and the Risk of Colorectal Carcinoma and Adenoma among U.S. Men and Women: An Example of Gene-Environment Interactions in Colorectal Tumorigenesis. J. Nutr.
129: 560-560
[Abstract][Full Text]
Fuchs, C. S., Giovannucci, E. L., Colditz, G. A., Hunter, D. J., Stampfer, M. J., Rosner, B., Speizer, F. E., Willett, W. C.
(1999). Dietary Fiber and the Risk of Colorectal Cancer and Adenoma in Women. NEJM
340: 169-176
[Abstract][Full Text]
Kampman, E., Slattery, M. L., Bigler, J., Leppert, M., Samowitz, W., Caan, B. J., Potter, J. D.
(1999). Meat Consumption, Genetic Susceptibility, and Colon Cancer Risk: A United States Multicenter Case-Control Study. Cancer Epidemiol. Biomarkers Prev.
8: 15-24
[Abstract][Full Text]
Chang, W.-C. L., Chapkin, R. S., Lupton, J. R.
(1998). Fish Oil Blocks Azoxymethane-Induced Rat Colon Tumorigenesis by Increasing Cell Differentiation and Apoptosis Rather Than Decreasing Cell Proliferation. J. Nutr.
128: 491-497
[Abstract][Full Text]
Chan, T. A., Morin, P. J., Vogelstein, B., Kinzler, K. W.
(1998). Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis. Proc. Natl. Acad. Sci. USA
95: 681-686
[Abstract][Full Text]
Albert, C. M., Hennekens, C. H., O'Donnell, C. J., Ajani, U. A., Carey, V. J., Willett, W. C., Ruskin, J. N., Manson, J. E.
(1998). Fish Consumption and Risk of Sudden Cardiac Death. JAMA
279: 23-28
[Abstract][Full Text]
Macrae, F A, Kilias, D, Selbie, L, Abbott, M, Sharpe, K, Young, G P
(1997). Effect of cereal fibre source and processing on rectal epithelial cell proliferation. Gut
41: 239-244
[Abstract][Full Text]
Wasan, H. S., Novelli, M., Bee, J., Bodmer, W. F.
(1997). Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice. Proc. Natl. Acad. Sci. USA
94: 3308-3313
[Abstract][Full Text]
Summerhayes, M.
(1996). Raltitrexed and the treatment of advanced colorectal cancer. J Oncol Pharm Pract
2: 225-235
[Abstract]
Hunter, D. J., Spiegelman, D., Adami, H.-O., Beeson, L., van den Brandt, P. A., Folsom, A. R., Fraser, G. E., Goldbohm, R. A., Graham, S., Howe, G. R., Kushi, L. H., Marshall, J. R., McDermott, A., Miller, A. B., Speizer, F. E., Wolk, A., Yaun, S.-S., Willett, W.
(1996). Cohort Studies of Fat Intake and the Risk of Breast Cancer -- A Pooled Analysis. NEJM
334: 356-361
[Abstract][Full Text]
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